Article
Biochemistry & Molecular Biology
Lin Xu, Jiaqi Zhang, Yifan Wang, Zedan Zhang, Fengyun Wang, Xudong Tang
Summary: This study investigated the pharmacological mechanisms of Ge-Gen-Qin-Lian Decoction (GGQLD) against ulcerative colitis (UC) using network pharmacology. The research identified potential therapeutic targets and active ingredients of GGQLD, revealing its anti-inflammatory, antioxidative, and immunomodulatory effects. The results suggest that GGQLD may regulate cytokine balance and inflammation-related pathways to treat UC effectively.
BIOSCIENCE REPORTS
(2021)
Article
Endocrinology & Metabolism
Yixin Zhang, Lingying Dai, Tianyou Tang, Feng Jiang, Renjie Shi
Summary: The study found that GGQL decoction treatment reduced levels of IL-1 beta, HMGB1, IL-6, and TNF-alpha, protected rat intestinal epithelial cells and human umbilical vein endothelial cells from radiation-induced apoptosis by increasing HO-1 levels and decreasing TLR4 and HMGB1 levels, and increased AKT phosphorylation for exerting protective effects.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Biochemistry & Molecular Biology
Beatrix Paton, Elisabet Foguet-Romero, Manuel Suarez, Jordi Mayneris-Perxachs, Noemi Boque, Antoni Caimari, Nuria Canela, Pol Herrero
Summary: The consumption of diets rich in saturated fats is associated with higher mortality. Adopting healthy habits, such as adhering to a Mediterranean diet, has been shown to have a preventive effect on cardiovascular diseases and dyslipidemia. However, the effects of an suboptimal diet on brain function and structure are still poorly understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Clare Stradling, G. Neil Thomas, Karla Hemming, Stephen Taylor, Shahrad Taheri
Summary: The study demonstrated the feasibility of adopting a Mediterranean Portfolio diet in people living with HIV, which may lead to short-term improvements in diet quality, blood pressure, and LDL-cholesterol.
CLINICAL NUTRITION
(2021)
Article
Immunology
Yazhen Xie, Jianqiang Qian
Summary: This study found that Ge-Gen decoction (GGD) has a therapeutic effect on primary dysmenorrhea (PD) by reducing the level of heat shock protein 90 (HSP90) in uterine tissues. The potential role of HSP90 in the anti-PD effect of GGD has not been explored.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Agriculture, Multidisciplinary
Xincen Wang, Qinsheng Chen, Xiaoxu Wang, Peixu Cong, Jie Xu, Changhu Xue
Summary: Ether-phospholipids in sea urchins, particularly PE-P and PC-O, have potential lipid-regulating effects in high-fat-induced atherosclerotic hamsters. PE-P is more effective than PC-O in decreasing total cholesterol and LDL cholesterol concentrations in serum. These lipid effects may be attributed to modulation of lipid metabolism and regulation of gene expression.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Plant Sciences
Xinhao Wan, Wenting Wu, Zhenzhong Zang, Kang Li, Abid Naeem, Yulu Zhu, Lihua Chen, Lingyun Zhong, Weifeng Zhu, Yongmei Guan
Summary: This study aimed to investigate the potential curative effect of Gui-Zhi-Jia-Ge-Gen decoction on wind-type of common cold using multidimensional qualitative analysis. The results showed that GJGD is effective against a cold-wind type of common cold, and 8 compounds were identified as potential pharmacodynamic ingredients.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Amira E. Farage, Walied Abdo, Amira Osman, Mona A. Abdel-Kareem, Zaki H. Hakami, Ahmad Alsulimani, Albandari Bin-Ammar, Ashwag S. Alanazi, Bader Alsuwayt, Mohammed M. Alanazi, Samar A. Antar, Emadeldin M. Kamel, Ayman M. Mahmoud
Summary: This study investigated the effect of betulin, a terpenoid compound with antioxidant, anti-inflammatory, and insulin-sensitizing effects, on non-alcoholic fatty liver disease (NAFLD) induced by a high-fat diet. The results showed that betulin could ameliorate hyperlipidemia, liver lipid accumulation, and fibrosis, as well as inhibit inflammation and oxidative stress. It also enhanced the activity of antioxidants and improved insulin resistance.
Article
Biochemistry & Molecular Biology
Sunmin Park, Ting Zhang, Yu Yue, Xuangao Wu
Summary: Modulation of bile acid metabolism can influence energy, glucose, and lipid metabolism, potentially through changes in the gut microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Physiology
Aiany Cibelle Simoes-Alves, Ana Paula Fonseca Cabral Arcoverde-Mello, Jessica de Oliveira Campos, Almir Goncalves Wanderley, Carol Virginia Gois Leandro, Joao Henrique da Costa-Silva, Viviane de Oliveira Nogueira Souza
Summary: In recent years, the worldwide phenomenon of a nutritional transition, characterized by a shift in diet from undernutrition to the excessive consumption of hypercaloric and ultra-processed foods, has caused concerns due to the replacement of infectious and parasitic diseases with chronic and degenerative diseases. This transition has also led to the coexistence of malnutrition and obesity in the same population, posing significant health risks.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yugo Kato, Yoshinori Aoki, Chikako Kiyose, Koji Fukui
Summary: T3s attenuate obesity by inhibiting body fat and serum cholesterol increase, and also improve cognitive function.
Article
Plant Sciences
Minqi Xiong, Zilong Zhang, Jingang Cui, Xiaoye Du, Yu Chen, Teng Zhang
Summary: This study evaluated the potential impact of DYNT treatment on atherosclerosis. The results showed that DYNT treatment reduced the size of atherosclerotic plaques, lowered lipid retention, and mitigated macrophagic burden. Additionally, DYNT treatment offered protection against dyslipidemia, fatty liver pathologies, dysbiosis, and impairment in the intestinal epithelial barrier associated with atherosclerosis.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Xingming Li, Yuliang Cheng, Jiayi Li, Chang Liu, He Qian, Genyi Zhang
Summary: Torularhodin, a beta-carotene-like compound from Sporidiobolus pararoseus, has a protective effect against hepatic dyslipidemia and inflammation induced by high-fat diet. It can prevent health problems caused by high-fat diet.
Article
Plant Sciences
Mei-Lian Yang, Can Lu, Zhi-Feng Fan, Tian-Rui Zhao, Gui-Guang Cheng, Yu-Dan Wang, Jian-Xin Cao, Ya-Ping Liu
Summary: The extract from Epigynum auritum showed significant hypoglycemic and hypolipidemic effects in high-fat diet and streptozocin-induced type 2 diabetic rats, possibly through regulating metabolism and signaling pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Luisa Mueller, Nicole Power Guerra, Anna Schildt, Tobias Lindner, Jan Stenzel, Newshan Behrangi, Carina Bergner, Teresa Alberts, Daniel Buehler, Jens Kurth, Bernd Joachim Krause, Deborah Janowitz, Stefan Teipel, Brigitte Vollmar, Angela Kuhla
Summary: Obesity is characterized by excessive fat accumulation, which increases the risk of neurodegenerative disorders and metabolic disturbances. Chronic neuroinflammation plays a crucial role in linking obesity to neurodegenerative disorders. In this study, using PET imaging, we found abnormal brain glucose metabolism and neuroinflammation in female mice with diet-induced obesity. These results suggest that a long-term high-fat diet may induce a metabolically activated state in brain-resident immune cells.
Article
Chemistry, Analytical
Li Jiang, Yanling Xiong, Lanbin Yu, Yu Chen, Qiyun Zhang, Xue Ding, Xiaojun Yan, Peng Nie, Guoliang Xu
INTERNATIONAL JOURNAL OF ANALYTICAL CHEMISTRY
(2019)
Article
Mathematical & Computational Biology
Canyi Huang, Keding Li, Jianqiang Du, Bin Nie, Guoliang Xu, Wangping Xiong, Jigen Luo
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
(2020)
Article
Integrative & Complementary Medicine
Xia Xu, Weiwei Wang, Yaxi Chen, Qiyun Zhang, Bingtao Li, Yiwen Zhong, Yu Tu, Wentong Zhang, Guoliang Xu, Li Jiang
Summary: A rapid and accurate UHPLC-MS/MS method was developed for the simultaneous determination of ten active constituents in rat plasma, showing significant pharmacokinetic differences among normal and two rat models of ulcerative colitis. The study could provide a scientific basis for further research on pharmacokinetics and clinical differential application of SDDR-UC and P-UC patients.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Integrative & Complementary Medicine
Chaodong Huang, Yufeng Chen, Bingtao Li, Qiyun Zhang, Li Jiang, Bin Nie, Lihua Chen, Hui Jian, Guoliang Xu
Summary: This study establishes a special method for data processing and uses an algorithm to construct a discrimination model for traditional Chinese medicine constitutions. The model accurately identifies the nine constitutions of traditional Chinese medicine, providing an objective approach and scientific basis for the classification and judgment of constitutions in traditional Chinese medicine.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)