Ligustilide enhances hippocampal neural stem cells activation to restore cognitive function in the context of postoperative cognitive dysfunction

ESC‐sEVs Rejuvenate Senescent Hippocampal NSCs by Activating Lysosomes to Improve Cognitive Dysfunction in Vascular Dementia

(2020) Guowen Hu et al.   Advanced Science

Linc-FOXD3 knockdown enhances hippocampal NSCs activation through upregulation of the Wnt/β-catenin pathway

(2020) Haili Lang et al.   NEUROSCIENCE LETTERS

Ligustilide modulates oxidative stress, apoptosis, and immunity to avoid pathological damages in bleomycin induced pulmonary fibrosis rats via inactivating TLR4/MyD88/NF-KB P65

(2020) Shu Luo et al.   Annals of Translational Medicine

N-Palmitoylethanolamine-oxazoline (PEA-OXA): A new therapeutic strategy to reduce neuroinflammation, oxidative stress associated to vascular dementia in an experimental model of repeated bilateral common carotid arteries occlusion

(2019) Daniela Impellizzeri et al.   NEUROBIOLOGY OF DISEASE

Postoperative Delirium and Postoperative Cognitive Dysfunction

(2019) Lori A. Daiello et al.   ANESTHESIOLOGY

ERK Pathway in Activated, Myofibroblast-Like, Hepatic Stellate Cells: A Critical Signaling Crossroad Sustaining Liver Fibrosis

(2019) Beatrice Foglia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting protein kinase inhibitors with Traditional Chinese Medicine

(2019) Yangyang Zhang et al.   CURRENT DRUG TARGETS

Effects of autophagy on synaptic-plasticity-related protein expression in the hippocampus CA1 of a rat model of vascular dementia

(2019) Bin Liu et al.   NEUROSCIENCE LETTERS

EphA4 receptor regulates outwardly rectifying chloride channel in CA1 hippocampal neurons after ischemia-reperfusion

(2019) Jianguo Li et al.   NEUROREPORT

Klotho upregulation contributes to the neuroprotection of ligustilide against cerebral ischemic injury in mice

(2018) Fang-Yi Long et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Post-Operative Cognitive Dysfunction: An exploration of the inflammatory hypothesis and novel therapies

(2018) David R. Skvarc et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The neuroprotective effects and probable mechanisms of Ligustilide and its degradative products on intracerebral hemorrhage in mice

(2018) Li Han et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Postoperative cognitive dysfunction and neuroinflammation; Cardiac surgery and abdominal surgery are not the same

(2016) Iris B. Hovens et al.   BRAIN BEHAVIOR AND IMMUNITY

Analyzing ERK 1/2 signalling and targets

(2016) Alexandra Brietz et al.   Molecular BioSystems

The Post-Anaesthesia N-acetylcysteine Cognitive Evaluation (PANACEA) trial: study protocol for a randomised controlled trial

(2016) David R. Skvarc et al.   Trials

Peri-operative cognitive dysfunction and protection

(2015) J. Steinmetz et al.   ANAESTHESIA

Ligustilide prevents cognitive impairment and attenuates neurotoxicity in d-galactose induced aging mice brain

(2015) Jie-Jia Li et al.   BRAIN RESEARCH

Ligustilide Ameliorates Inflammatory Pain and Inhibits TLR4 Upregulation in Spinal Astrocytes Following Complete Freund’s Adjuvant Peripheral Injection

(2015) Bin Qian et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Neuroprotective agents target molecular mechanisms of disease in ALS

(2015) Yongjin Zhu et al.   DRUG DISCOVERY TODAY

Ketamine-mediated alleviation of electroconvulsive shock-induced memory impairment is associated with the regulation of neuroinflammation and soluble amyloid-beta peptide in depressive-like rats

(2015) Xianlin Zhu et al.   NEUROSCIENCE LETTERS

Ligustilide inhibits microglia-mediated proinflammatory cytokines production and inflammatory pain

(2014) Ming-Di Zhu et al.   BRAIN RESEARCH BULLETIN

Ligustilide ameliorates neuroinflammation and brain injury in focal cerebral ischemia/reperfusion rats: involvement of inhibition of TLR4/peroxiredoxin 6 signaling

(2014) Xi Kuang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Global Cerebral Ischemia: Synaptic and Cognitive Dysfunction

(2013) Jake T. Neumann et al.   CURRENT DRUG TARGETS

Systematic review of recent advances in pharmacokinetics of four classical Chinese medicines used for the treatment of cerebrovascular disease

(2013) Mingfei Zeng et al.   FITOTERAPIA

A review of postoperative cognitive dysfunction and neuroinflammation associated with cardiac surgery and anaesthesia

(2012) A. E. van Harten et al.   ANAESTHESIA

Neuroprotective effect of ligustilide against ischaemia-reperfusion injury via up-regulation of erythropoietin and down-regulation of RTP801

(2011) Xiao-mei Wu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Postoperative cognitive disorders

(2011) Terri G. Monk et al.   Current Opinion in Critical Care

Role of interleukin-1β in postoperative cognitive dysfunction

(2010) Mario Cibelli et al.   ANNALS OF NEUROLOGY

Spred1, a negative regulator of Ras-MAPK-ERK, is enriched in CNS germinal zones, dampens NSC proliferation, and maintains ventricular zone structure

(2010) T. N. Phoenix et al.   GENES & DEVELOPMENT

Tumor necrosis factor-  triggers a cytokine cascade yielding postoperative cognitive decline

(2010) N. Terrando et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sustained activation of ERK1/2 by NGF induces microRNA-221 and 222 in PC12 cells

(2009) Kazuya Terasawa et al.   FEBS Journal

Folate stimulates ERK1/2 phosphorylation and cell proliferation in fetal neural stem cells

(2009) Xu-Mei Zhang et al.   NUTRITIONAL NEUROSCIENCE