Review
Immunology
Chen Chen, Spencer R. Haupert, Lauren Zimmermann, Xu Shi, Lars G. Fritsche, Bhramar Mukherjee
Summary: This study reveals a substantial prevalence of post-COVID-19 condition worldwide. Hospitalized patients have a higher prevalence compared to non-hospitalized ones. Fatigue is the most commonly reported symptom.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Medicine, General & Internal
Cesar Fernandez-de-las-Penas, Domingo Palacios-Cena, Victor Gomez-Mayordomo, Lidiane L. Florencio, Maria L. Cuadrado, Gustavo Plaza-Manzano, Marcos Navarro-Santana
Summary: This meta-analysis revealed that more than 60% of patients with SARS-CoV-2 infection experienced post-COVID-19 symptoms. Fatigue and dyspnea were the most prevalent post-COVID-19 symptoms, especially at 60 and >= 90 days after onset.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Medicine, General & Internal
Ellen de Bock, Mando D. Filipe, Roger K. J. Simmermacher, A. Christiaan Kroese, Menno R. Vriens, Milan C. Richir
Summary: This study aims to determine the prevalence of preoperative COVID-19 in asymptomatic patients. The results show that the COVID-19 prevalence in asymptomatic patients tested preoperatively was 0.76%, with low positive predictive value.
Review
Clinical Neurology
Ramya Nagarajan, Yuvaraj Krishnamoorthy, Vanitha Basavarachar, Raghul Dakshinamoorthy
Summary: This study investigated the prevalence of PTSD among severe cases of COVID-19, finding a prevalence rate of 16%. Significant variation in prevalence rates between regions was observed, indicating a need for region-specific interventions to address PTSD risks following severe COVID-19 infection.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Gastroenterology & Hepatology
Giovanni Marasco, Marcello Maida, Cesare Cremon, Maria Raffaella Barbaro, Vincenzo Stanghellini, Giovanni Barbara
Summary: This meta-analysis aimed to estimate the incidence of post-COVID-19 functional dyspepsia (FD) and irritable bowel syndrome (IBS). The analysis found that COVID-19 survivors are at a higher risk of developing IBS compared to controls, while data for FD are inconclusive.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Medicine, General & Internal
Mi Sun, Xian Jin, Mingxiao Zang, Weijia Jiang, Chunxiao Zhao, Jieyu Bi, Huijuan Yu, Qiwen Tan
Summary: This study aims to evaluate the effectiveness and safety of acupuncture for headache in COVID-19 patients. Randomized controlled trials from December 2019 to July 2021 will be included for assessment, and statistical analyses will be conducted to draw conclusions on the treatment outcome.
Review
Infectious Diseases
Mohamad Salim Alkodaymi, Osama Ali Omrani, Nader A. Fawzy, Bader Abou Shaar, Raghed Almamlouk, Muhammad Riaz, Mustafa Obeidat, Yasin Obeidat, Dana Gerberi, Rand M. Taha, Zakaria Kashour, Tarek Kashour, Elie F. Berbari, Khaled Alkattan, Imad M. Tleyjeh
Summary: This study aimed to estimate the prevalence of persistent symptoms and signs at least 12 weeks after acute COVID-19 and found that a large proportion of patients experience post-acute COVID-19 syndrome 3 to 12 months after recovery from the acute phase of COVID-19. However, available studies of post-acute COVID-19 syndrome are highly heterogeneous. Future studies need to have appropriate comparator groups, standardized symptom definitions and measurements, and longer follow-up.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Review
Respiratory System
Bang Zheng, Luke Daines, Qing Han, John R. Hurst, Paul Pfeffer, Manu Shankar-Hari, Omer Elneima, Samantha Walker, Jeremy S. Brown, Salman Siddiqui, Jennifer K. Quint, Christopher E. Brightling, Rachael A. Evans, Louise Wain, Liam G. Heaney, Aziz Sheikh
Summary: Persistent breathlessness after acute COVID-19 infection is a highly debilitating post-COVID symptom. However, its prevalence, risk factors, mechanisms, and treatments are poorly understood. A meta-analysis of 42,872 patients reported an overall prevalence of post-COVID breathlessness of 26%. The prevalence decreased significantly from 1-6 months to 7-12 months post-infection. Severe/critical acute infection, hospitalization, and female gender were associated with higher prevalence, while patients in Asia were less likely to report breathlessness compared to those in Europe or North America. Multiple mechanisms have been proposed, but the evidence remains inconclusive. Rehabilitation exercises may reduce post-COVID breathlessness based on some studies. Further research is urgently needed to understand the mechanisms and develop interventions for post-COVID breathlessness.
EUROPEAN RESPIRATORY REVIEW
(2022)
Article
Psychiatry
Jenney Zhu, Nicole Racine, Elisabeth Bailin Xie, Julianna Park, Julianna Watt, Rachel Eirich, Keith Dobson, Sheri Madigan
Summary: The study found that during the COVID-19 pandemic, the prevalence rates of clinically significant depression and anxiety among post-secondary students were 30.6% and 28.2% respectively. The month of data collection and geographical region were significant moderators influencing these rates.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Public, Environmental & Occupational Health
Golnesa Kazemioula, Shayan Golestani, Seyed Mohammad Amin Alavi, Forough Taheri, Reza Ghanei Gheshlagh, Mohammad Hassan Lotfalizadeh
Summary: This study conducted a global systematic review and meta-analysis to estimate the pooled prevalence of self-medication during the COVID-19 pandemic. The results showed that self-medication was highly prevalent, with nearly half of the people resorting to self-medication. The prevalence varied among different regions and populations.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Immunology
Jonny Karunia Fajar, Malik Sallam, Gatot Soegiarto, Yani Jane Sugiri, Muhammad Anshory, Laksmi Wulandari, Stephanie Astrid Puspitasari Kosasih, Muhammad Ilmawan, Kusnaeni Kusnaeni, Muhammad Fikri, Frilianty Putri, Baitul Hamdi, Izza Dinalhaque Pranatasari, Lily Aina, Lailatul Maghfiroh, Fernanda Septi Ikhriandanti, Wa Ode Endiaverni, Krisna Wahyu Nugraha, Ory Wiranudirja, Sally Edinov, Ujang Hamdani, Lathifatul Rosyidah, Hanny Lubaba, Rinto Ariwibowo, Riska Andistyani, Ria Fitriani, Miftahul Hasanah, Fardha Ad Durrun Nafis, Fredo Tamara, Fitri Olga Latamu, Hendrix Indra Kusuma, Ali A. Rabaan, Saad Alhumaid, Abbas Al Mutair, Mohammed Garout, Muhammad A. Halwani, Mubarak Alfaresi, Reyouf Al Azmi, Nada A. Alasiri, Abeer N. Alshukairi, Kuldeep Dhama, Harapan Harapan
Summary: This study aimed to assess the global prevalence of COVID-19 vaccination hesitancy and determine the potential factors associated with such hesitancy. The study found that the global prevalence of COVID-19 vaccination hesitancy was 25%. Factors such as being a woman, being younger than 50 years old, being single, being unemployed, having a large household, having a lower educational attainment, having a non-healthcare-related job, and considering COVID-19 vaccines to be unsafe were associated with a higher risk of vaccination hesitancy. Conversely, factors such as living with children at home, maintaining physical distancing norms, having ever tested for COVID-19, and having a history of influenza vaccination in the past few years were associated with a lower risk of hesitancy to COVID-19 vaccination. The study provides valuable information on COVID-19 vaccination hesitancy and suggests targeted interventions for high-risk populations to reduce hesitancy.
Article
Dermatology
Jingmin Li, Weijing Wen, Zhenzhen Mu, Xuefei Du, Xiuping Han
Summary: This study conducted a meta-analysis on 33 studies and found that the overall prevalence of cutaneous manifestations in COVID-19 was 5.6%. The prevalence rates of different types of skin manifestations varied, and it was also found that children and patients with moderate to severe COVID-19 were more likely to have skin manifestations.
JOURNAL OF DERMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Erika Melendez-Oliva, Oliver Martinez-Pozas, Juan Nicolas Cuenca-Zaldivar, Jorge Hugo Villafane, Laura Jimenez-Ortega, Eleuterio A. Sanchez-Romero
Summary: This systematic review and meta-analysis examines the impact of pulmonary rehabilitation on subacute and long COVID-19 patients, evaluating improvements in dyspnea, physical function, quality of life, psychological state, and fatigue. The study included 34 studies involving 1970 patients and found moderate to large effects on dyspnea, physical function, quality of life, and depressive symptoms. However, caution should be taken due to the high risk of bias in the included studies.
Article
Public, Environmental & Occupational Health
Niu Yuan, Zhang-Hong Lv, Chun-Rong Sun, Yuan-Yuan Wen, Ting-Yu Tao, Dan Qian, Fang-Ping Tao, Jia-Hui Yu
Summary: This study compared the long-term effects of COVID-19 in hospitalized and non-hospitalized survivors and found that hospitalized patients had higher risks of long-term symptoms such as dyspnea, anxiety, myalgia, and hair loss. On the other hand, the risk of persisting ageusia was reduced in hospitalized patients compared to non-hospitalized patients. It is important to provide special attention and patient-centered rehabilitation services for hospitalized COVID-19 survivors.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
Giuseppe Maglietta, Francesca Diodati, Matteo Puntoni, Silvia Lazzarelli, Barbara Marcomini, Laura Patrizi, Caterina Caminiti
Summary: This study investigates the association between factors present during COVID-19 hospitalization and long-term sequelae. The findings suggest that female sex and acute disease severity may serve as independent prognostic factors. Further longitudinal studies with longer follow-up are needed to confirm these results and develop targeted prevention and management strategies for individuals at higher risk for PCS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Infectious Diseases
Cesar Fernandez-de-las-Penas, Jose D. Martin-Guerrero, Lidiane L. Florencio, Esperanza Navarro-Pardo, Jorge Rodriguez-Jimenez, Juan Torres-Macho, Oscar J. Pellicer-Valero
Summary: By using cluster analysis on clinical data of COVID-19 survivors, three different subgroups were identified with distinct post-COVID symptoms and clinical characteristics. The study found that some patients experienced more long-term symptoms post-recovery, with greater limitations in daily activities, higher levels of anxiety and depression, and poorer sleep quality.
Article
Anesthesiology
Cesar Fernandez-de-las-Penas, Ignacio Cancela-Cilleruelo, Paloma Moro-Lopez-Menchero, Jorge Rodriguez-Jimenez, Oscar J. Pellicer-Valero, Jose D. Martin-Guerrero, Lars Arendt-Nielsen
Summary: This multicenter cohort study investigated the prevalence and risk factors of musculoskeletal post-COVID pain. The study found that musculoskeletal pain remains highly prevalent one year after hospitalization, with female sex, previous history of pain symptoms, pain symptoms at onset, and days at hospital being associated factors.
Article
Education, Scientific Disciplines
Juan Antonio Valera-Calero, Marcos Jose Navarro-Santana, Cesar Fernandez-de-las-Penas, Umut Varol, Ibai Lopez-de-Uralde-Villanueva, Elena Sonsoles Rodriguez-Lopez, Gustavo Plaza-Manzano
Summary: This study aimed to analyze students' opinion and performance regarding the inclusion of cross-sectional and radiological images in traditional anatomy teaching. The results showed that most students found these additional resources helpful in improving their ability to identify structures in radiological images and their understanding of high-risk structures related to specific muscles during invasive procedures.
ANATOMICAL SCIENCES EDUCATION
(2023)
Article
Dermatology
Giulia Erica Aliotta, Silvia Lo Vecchio, Jesper Elberling, Lars Arendt-Nielsen
Summary: This study aims to evaluate the antipruritic effects of topical doxepin on histaminergic and nonhistaminergic itch induced by histamine, BAM8-22, and cowhage. The results showed that doxepin cream almost eliminated histamine-induced itch and slightly reduced BAM8-22- and cowhage-induced itch.
DERMATOLOGIC THERAPY
(2023)
Article
Chemistry, Analytical
Umut J. Varol, Marcos Navarro-Santana, Juan Antonio Valera-Calero, Sergio Anton-Ramirez, Javier Alvaro-Martinez, Maria Jose Diaz-Arribas, Cesar Fernandez-de-las-Penas, Gustavo Plaza-Manzano
Summary: This study aimed to assess the convergent validity between surface electromyography (EMG), ultrasound imaging (US), and dynamometry in evaluating muscle fatigue during a manual prehension maximal voluntary isometric contraction (MVIC). A diagnostic accuracy study was conducted, enrolling 50 healthy participants, and the results showed fair convergent associations between these methods, providing synergistic muscle fatigue information.
Review
Medicine, General & Internal
David Fernandez-Hernando, Cesar Fernandez-de-las-Penas, Ana Machado-Martin, Santiago Angulo-Diaz-Parreno, Francisco J. Garcia-Esteo, Juan A. Mesa-Jimenez
Summary: In this study, a systematic review and meta-analysis were conducted to evaluate the effectiveness of non-invasive neuromodulation of the vagus nerve in patients with tinnitus. The results showed that the treatment had a positive effect on related disability in patients with tinnitus, although its clinical relevance was low. More research is needed to draw firm conclusions about the effect of non-invasive neuromodulation of the vagus nerve on tinnitus.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Tamara del Corral, Raul Fabero-Garrido, Gustavo Plaza-Manzano, Cesar Fernandez-de-las-Penas, Marcos Jose Navarro-Santana, Ibai Lopez-de-Uralde-Villanueva
Summary: The study aimed to establish the minimal clinically important difference (MCID) for inspiratory muscle strength (MIP) and endurance (IME) in individuals with long-term post-COVID-19 symptoms. Results showed that a change of at least 18 cmH(2)O and 22.1% of that predicted for MIP, and 328.5s for IME represented the MCID. All variables showed acceptable discrimination, with MIP being the variable with the best discriminative ability when expressed as a percentage of prediction. Participants classified as improved had significantly greater improvements in quality of life and lung function.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Cesar Fernandez-de-las-Penas, Jo Nijs, Barbara Cagnie, Robert D. Gerwin, Gustavo Plaza-Manzano, Juan A. Valera-Calero, Lars Arendt-Nielsen
Summary: Myofascial pain syndrome involves the presence of myofascial trigger points (TrPs), which can cause referred pain. The classification of TrPs as primary or secondary phenomena and their relationship to central or peripheral nervous system disorders is controversial. The International Association for the Study of Pain (IASP) proposed a clinical criteria and grading system in 2021 to classify patients based on nociceptive, neuropathic, or nociplastic pain phenotypes. While myofascial TrP pain is traditionally categorized as nociceptive, evidence suggests it may also be present in patients with predominantly nociplastic pain. Successful clinical treatment outcomes may be achieved by accurately classifying myofascial TrP pain into these phenotypes.
Article
Biology
Daniel Ulman-Macon, Cesar Fernandez-de-las-Penas, Santiago Angulo-Diaz-Parreno, Jose L. Arias-Buria, Juan A. Mesa-Jimenez
Summary: This study compared the morphology of the suboccipital muscles between women with temporomandibular disorder (TMD) and healthy controls. The results showed that women with myofascial TMD pain had reduced thickness, cross-sectional area, and perimeter in the suboccipital muscles compared to healthy women, while there were no significant differences in width and depth. These morphological changes may be related to muscle atrophy and are similar to those found in women with headaches. Further research is needed to investigate the clinical relevance and potential treatment options for myofascial TMD patients.
Article
Clinical Neurology
Cristina Garcia-Iglesias, Ana Gonzalez-Celestino, Alvaro Sierra Mencia, Yesica Gonzalez Osorio, Andrea Recio Garcia, Cristina Martinez-Badillo, Ana Echavarria Iniguez, Berta Varona-Galan, David Garcia-Azorin, Angel Luis Guerrero-Peral
Summary: The long-term outcomes of nummular headache (NH) are generally positive, with a substantial number of patients experiencing inactive NH after a median follow-up period of 6.7 years. Preventive treatment is required by the majority of patients, but most of them respond well to the treatment. For patients with persistent symptoms, the frequency of headaches is lower.
Article
Anesthesiology
J. Vela, L. Dreyer, K. K. Petersen, L. Arendt-Nielsen, K. Skjaerbaek Duch, K. Amris, S. Kristensen
Summary: This study compared the differences in quantitative sensory testing between patients with Psoriatic Arthritis (PsA) and Hand Osteoarthritis (hand-OA) and a pain-free control group, as well as the differences between patients with and without concomitant Fibromyalgia (cFM). The results showed that patients with PsA and hand-OA exhibited higher pain sensitization, greater psychological distress, and disability. Patients with cFM had even higher levels of pain sensitization, psychological burden, and disability when compared to patients without cFM.
EUROPEAN JOURNAL OF PAIN
(2023)
Article
Genetics & Heredity
Cesar Fernandez-de-las-Penas, Lars Arendt-Nielsen, Gema Diaz-Gil, Francisco Gomez-Esquer, Antonio Gil-Crujera, Stella M. Gomez-Sanchez, Silvia Ambite-Quesada, Maria A. Palomar-Gallego, Oscar J. Pellicer-Valero, Rocco Giordano
Summary: The study aimed to investigate the association between the Apolipoprotein E (ApoE) gene and long COVID symptoms. The results showed no significant relationship between different genotypes of the ApoE gene (ApoE ε2, ApoE ε3, ApoE ε4) and the presence of long COVID symptoms.
Article
Biology
Juan Antonio Valera-Calero, Dario Lopez-Zanoni, Sandra Sanchez-Jorge, Cesar Fernandez-de-las-Penas, Marcos Jose Navarro-Santana, Sofia Olivia Calvo-Moreno, Gustavo Plaza-Manzano
Summary: This study developed an easy-to-use application for assessing the diagnostic accuracy of digital pain drawings (PDs) compared to the classic paper-and-pencil method. The results demonstrated that digital PDs have higher reliability and accuracy compared to paper-and-pencil PDs, and there were no significant differences in assessing pain extent between the two methods. The PAIN EXTENT app showed good convergent validity.
COMPUTERS IN BIOLOGY AND MEDICINE
(2024)
Review
Clinical Neurology
Lars Arendt-Nielsen, Henrik Klitgaard, Stine N. Hansen
Summary: Adenosine modulation demonstrates predictive validity across preclinical, human experimental, and clinical investigations. The most compelling evidence is in the field of neuropathic pain, where adenosine has been found to alleviate hyperexcitability and has the potential to be disease-modifying.
SCANDINAVIAN JOURNAL OF PAIN
(2023)
Article
Clinical Neurology
Svetlana Solgaard Nielsen, Soren T. Skou, Anette Enemark Larsen, Romanas Polianskis, Lars Arendt-Nielsen, Anne Skov Ostergaard, Kristian Kjaer-Staal Petersen, Henrik Bjarke Vaegter, Jens Sondergaard, Jeanette Reffstrup Christensen
Summary: This study investigated the impact of an occupational therapy lifestyle intervention on pain-related parameters, occupational function, occupational balance, lifestyle factors, and self-perceived health status in adults with chronic high-impact pain. The study found that the intervention appeared to improve motor skills but did not have clear effects on other outcomes. Further research, such as a randomized trial, is needed to confirm these findings.
SCANDINAVIAN JOURNAL OF PAIN
(2023)
