Design of the naphthyl-diarylpyrimidines as potent non-nucleoside reverse transcriptase inhibitors (NNRTIs) via structure-based extension into the entrance channel

FDA-approved pyrimidine-fused bicyclic heterocycles for cancer therapy: synthesis and clinical application

(2021) Shuai Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Druggability modification strategies of the diarylpyrimidine‐type non‐nucleoside reverse transcriptase inhibitors

(2021) Li Ding et al.   MEDICINAL RESEARCH REVIEWS

A sequestered fusion peptide in the structure of an HIV-1 transmitted founder envelope trimer

(2019) Neeti Ananthaswamy et al.   Nature Communications

Molecular Hybridization-Inspired Optimization of Diarylbenzopyrimidines as HIV-1 Nonnucleoside Reverse Transcriptase Inhibitors with Improved Activity against K103N and E138K Mutants and Pharmacokinetic Profiles

(2019) Sheng Han et al.   ACS Infectious Diseases

Improving the positional adaptability: structure-based design of biphenyl-substituted diaryltriazines as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

(2019) Kaijun Jin et al.   Acta Pharmaceutica Sinica B

Development of non-nucleoside reverse transcriptase inhibitors (NNRTIs): Our past twenty years

(2019) Chunlin Zhuang et al.   Acta Pharmaceutica Sinica B

Ligand-Based Design of Nondimethylphenyl-Diarylpyrimidines with Improved Metabolic Stability, Safety, and Oral Pharmacokinetic Profiles

(2019) Yali Sang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus

(2018) Ye Tian et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Advances in diarylpyrimidines and related analogues as HIV-1 nonnucleoside reverse transcriptase inhibitors

(2018) Shuang-Xi Gu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors

(2018) Yang Yang et al.   eLife

The Journey of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) from Lab to Clinic

(2018) Vigneshwaran Namasivayam et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of uracil-bearing DAPYs derivatives as novel HIV-1 NNRTIs via crystallographic overlay-based molecular hybridization

(2017) Heng Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure-Based Optimization of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated Variants

(2017) Dongwei Kang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Evaluation of Thiophene[3,2-d]pyrimidine Derivatives as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Drug Resistance Profiles

(2016) Dongwei Kang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of DAPY–DPEs hybrids as non-nucleoside inhibitors of HIV-1 reverse transcriptase

(2015) Hai-Qiu Wu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 4: Design, synthesis and biological evaluation of novel imidazo[1,2-a]pyrazines

(2015) Boshi Huang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

An Odyssey in antiviral drug development—50 years at the Rega Institute: 1964–2014

(2015) Erik De Clercq   Acta Pharmaceutica Sinica B

Design, Synthesis, and Anti-HIV Evaluation of Novel Triazine Derivatives Targeting the Entrance Channel of the NNRTI Binding Pocket

(2014) Xuwang Chen et al.   Chemical Biology & Drug Design

Towards new C6-rigid S-DABO HIV-1 reverse transcriptase inhibitors: Synthesis, biological investigation and molecular modeling studies

(2013) Hai-Qiu Wu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Extension into the entrance channel of HIV-1 reverse transcriptase—Crystallography and enhanced solubility

(2013) Mariela Bollini et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Optimization of 2,4-diarylanilines as non-nucleoside HIV-1 reverse transcriptase inhibitors

(2012) Lian-Qi Sun et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of dimeric inhibitors by extension into the entrance channel of HIV-1 reverse transcriptase

(2012) Anil R. Ekkati et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Diverse combinatorial design, synthesis and in vitro evaluation of new HEPT analogues as potential non-nucleoside HIV-1 reverse transcription inhibitors

(2012) Raimon Puig-de-la-Bellacasa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and anti-HIV activity of 2-naphthyl substituted DAPY analogues as non-nucleoside reverse transcriptase inhibitors

(2010) Yong-Hong Liang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Diarylaniline Derivatives as a Distinct Class of HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors

(2010) Bingjie Qin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Evaluation of Diarylpyridines and Diarylanilines as Potent Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors

(2010) Xingtao Tian et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal Structures of HIV-1 Reverse Transcriptase with Etravirine (TMC125) and Rilpivirine (TMC278): Implications for Drug Design

(2010) Eric B. Lansdon et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and SAR of Naphthyl-Substituted Diarylpyrimidines as Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase

(2009) Yong-Hong Liang et al.   ChemMedChem

Structural Modifications of DAPY Analogues with Potent Anti-HIV-1 Activity

(2008) Xiao-Qing Feng et al.   ChemMedChem

Tetrazolium-based colorimetric assay for the detection of HIV replication inhibitors: revisited 20 years later

(2008) Christophe Pannecouque et al.   Nature Protocols

Non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 11: Structural modulations of diaryltriazines with potent anti-HIV activity

(2007) Yuan-Zhen Xiong et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY