Synthesis and in vivo screening of isosteviol derivatives as new cardioprotective agents

Molecular avenues in targeted doxorubicin cancer therapy

(2020) Sayantani Roychoudhury et al.   Future Oncology

Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety

(2020) Abdullah Shaito et al.   Frontiers in Pharmacology

Cardioprotection by isosteviol derivate JC105: A unique drug property to activate ERK1/2 only when cells are exposed to hypoxia‐reoxygenation

(2020) Khaja Shameem Mohammed Abdul et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Ferroptosis as a target for protection against cardiomyopathy

(2019) Xuexian Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Streamlining drug discovery assays for cardiovascular disease using zebrafish

(2019) Alexander Pott et al.   Expert Opinion on Drug Discovery

Molecular mechanism of doxorubicin-induced cardiomyopathy – An update

(2018) Kaviyarasi Renu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A novel compound DT-010 protects against doxorubicin-induced cardiotoxicity in zebrafish and H9c2 cells by inhibiting reactive oxygen species-mediated apoptotic and autophagic pathways

(2018) Fan Tang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

What prevents cardioprotective drugs from reaching the market?

(2018) Fedor Simko et al.   Expert Review of Clinical Pharmacology

Diterpenoid lead stevioside and its hydrolysis products steviol and isosteviol: Biological activity and structural modification

(2018) Mingying Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Mitochondriotropic and Cardioprotective Effects of Triphenylphosphonium-Conjugated Derivatives of the Diterpenoid Isosteviol

(2017) Lara Testai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Basic Biology of Oxidative Stress and the Cardiovascular System

(2017) Michael N. Sack et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Syntheses, cytotoxic activity evaluation and HQSAR study of 1,2,3-triazole-linked isosteviol derivatives as potential anticancer agents

(2016) Cong-Jun Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, cytotoxic activity evaluation and HQSAR study of novel isosteviol derivatives as potential anticancer agents

(2016) Cong-Jun Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Mitochondria as Key Targets of Cardioprotection in Cardiac Ischemic Disease: Role of Thyroid Hormone Triiodothyronine

(2015) Francesca Forini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Zebrafish as tools for drug discovery

(2015) Calum A. MacRae et al.   NATURE REVIEWS DRUG DISCOVERY

Synthesis and cytotoxic activity of nitric oxide-releasing isosteviol derivatives

(2014) Ting-ting Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and cytotoxic activity of MOM-ether analogs of isosteviol

(2014) Ahmed Malki et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The zebrafish as a tool to identify novel therapies for human cardiovascular disease

(2014) A. Asnani et al.   Disease Models & Mechanisms

Design and Synthesis of Isosteviol Triazole Conjugates for Cancer Therapy

(2014) Ravil Khaybullin et al.   MOLECULES

Zebrafish Heart Failure Models for the Evaluation of Chemical Probes and Drugs

(2013) Cheng-Chen Huang et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Cytotoxic and Apoptosis-Inducing Activities of Steviol and Isosteviol Derivatives against Human Cancer Cell Lines

(2013) Motohiko Ukiya et al.   CHEMISTRY & BIODIVERSITY

Design and stereoselective synthesis of novel isosteviol-fused pyrazolines and pyrazoles as potential anticancer agents

(2013) Song-Lin Zhu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pharmacology of levosimendan: inotropic, vasodilatory and cardioprotective effects

(2013) A. Pathak et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

D-ring modified novel isosteviol derivatives: Design, synthesis and cytotoxic activity evaluation

(2012) Tao Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Stevioside and Steviol as Starting Materials in Organic Synthesis

(2012) Nico Moons et al.   CURRENT ORGANIC CHEMISTRY

Stevioside and Related Compounds - Molecules of Pharmaceutical Promise: A Critical Overview

(2010) Goutam Brahmachari et al.   ARCHIV DER PHARMAZIE

Stereoselective synthesis of bioactive isosteviol derivatives as α-glucosidase inhibitors

(2009) Ya Wu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Stereoselective synthesis of 15- and 16-substituted isosteviol derivatives and their cytotoxic activities

(2009) Ya Wu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS