Advancement of chimeric hybrid drugs to cure malaria infection: An overview with special emphasis on endoperoxide pharmacophores

Exploration of artemisinin derivatives and synthetic peroxides in antimalarial drug discovery research

(2021) Om P.S. Patel et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, in vitro biological evaluation and in silico docking studies of new quinazolin‐2,4‐dione analogues as possible anticarcinoma agents

(2020) Aboubakr H. Abdelmonsef et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Are three drugs for malaria better than two?

(2020) Philip J Rosenthal   LANCET

Synthesis of Novel G Factor or Chloroquine-Artemisinin Hybrids and Conjugates with Potent Antiplasmodial Activity

(2020) Dionissia A. Pepe et al.   ACS Medicinal Chemistry Letters

Novel Quinazolin-2,4-Dione Hybrid Molecules as Possible Inhibitors Against Malaria: Synthesis and in silico Molecular Docking Studies

(2020) Aboubakr Haredi Abdelmonsef et al.   Frontiers in Molecular Biosciences

Synthesis and Antiplasmodial Activity of Novel Fosmidomycin Derivatives and Conjugates with Artemisinin and Aminochloroquinoline

(2020) Despina Palla et al.   MOLECULES

The past, present and future of anti-malarial medicines

(2019) Edwin G. Tse et al.   MALARIA JOURNAL

Artemisinin-(Iso)Quinoline Hybrids by C-H Activation and Click Chemistry: Combating Multidrug-Resistant Malaria

(2019) Aysun Çapcı et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

New dimensions in the field of antimalarial research against malaria resurgence

(2019) Anudeep K. Narula et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Malaria: The Past and the Present

(2019) Talapko et al.   Microorganisms

Triple artemisinin-containing combination anti-malarial treatments should be implemented now to delay the emergence of resistance

(2019) Nicholas J. White   MALARIA JOURNAL

Design and synthesis of novel ferrocene-quinoline conjugates and evaluation of their electrochemical and antiplasmodium properties

(2019) Aleksandra Minić et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability

(2018) Rita Capela et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of N' -(Quinazolin-4-yl)isonicotinohydrazides and their biological screening, docking and ADME studies

(2018) Kinjal D. Patel et al.   Arabian Journal of Chemistry

Oxidative stress and protein damage responses mediate artemisinin resistance in malaria parasites

(2018) Frances Rocamora et al.   PLoS Pathogens

Synthesis, antimalarial activities and cytotoxicities of amino-artemisinin-1,2-disubstituted ferrocene hybrids

(2018) Christo de Lange et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of Artemisinin–Estrogen Hybrids Highly Active against HCMV, P. falciparum, and Cervical and Breast Cancer

(2018) Tony Fröhlich et al.   ACS Medicinal Chemistry Letters

Quinoline hybrids and their antiplasmodial and antimalarial activities

(2017) Yuan-Qiang Hu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design of Drug Delivery Systems Containing Artemisinin and Its Derivatives

(2017) Blessing Aderibigbe   MOLECULES

Synthesis, Structural, and Theoretical Studies of Quinazoline-2,4-dione Derivatives

(2017) Hamdy S. El-Sheshtawy et al.   POLYCYCLIC AROMATIC COMPOUNDS

Transmission-Blocking Potential of MEFAS, a Hybrid Compound Derived from Artesunate and Mefloquine

(2016) Julia Penna-Coutinho et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

4-Aminoquinoline derivatives: Synthesis, in vitro and in vivo antiplasmodial activity against chloroquine-resistant parasites

(2016) Shailja Singh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, antimalarial activity evaluation and docking studies of some novel tetraoxaquines

(2016) Mukesh Kumar Kumawat et al.   MEDICINAL CHEMISTRY RESEARCH

Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies

(2016) M. Isabel Veiga et al.   Nature Communications

Quinoline-based antimalarial hybrid compounds

(2015) Stéphanie Vandekerckhove et al.   BIOORGANIC & MEDICINAL CHEMISTRY

New efficient artemisinin derived agents against human leukemia cells, human cytomegalovirus and Plasmodium falciparum: 2nd generation 1,2,4-trioxane-ferrocene hybrids

(2015) Christoph Reiter et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Characterisation of artemisinin–chloroquinoline hybrids for potential metabolic liabilities

(2015) Roslyn Thelingwani et al.   XENOBIOTICA

Synthesis and study of cytotoxic activity of 1,2,4-trioxane- and egonol-derived hybrid molecules against Plasmodium falciparum and multidrug-resistant human leukemia cells

(2014) Christoph Reiter et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and in vitro biological evaluation of aminoacridines and artemisinin–acridine hybrids

(2014) Juan P. Joubert et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Tetraoxane–Pyrimidine Nitrile Hybrids as Dual Stage Antimalarials

(2014) Rudi Oliveira et al.   JOURNAL OF MEDICINAL CHEMISTRY

Diversification in the synthesis of antimalarial trioxane and tetraoxane analogs

(2014) Neesha Yadav et al.   RSC Advances

Synthesis and Antimalarial Efficacy of Two-Carbon-Linked, Artemisinin-Derived Trioxane Dimers in Combination with Known Antimalarial Drugs

(2013) Bryan T. Mott et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular epidemiology of Plasmodium vivax in Latin America: polymorphism and evolutionary relationships of the circumsporozoite gene

(2013) Lilia González-Cerón et al.   MALARIA JOURNAL

Malaria and Quinine Resistance: A Medical and Scientific Issue between Brazil and Germany (1907–19).

(2013) André Felipe Cândido da Silva et al.   MEDICAL HISTORY

Quinolone-3-Diarylethers: A New Class of Antimalarial Drug

(2013) A. Nilsen et al.   Science Translational Medicine

Pharmacokinetics of Ferroquine, a Novel 4-Aminoquinoline, in Asymptomatic Carriers of Plasmodium falciparum Infections

(2012) Christian Supan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Novel 4-Aminoquinoline Analogs Highly Active against the Blood and Sexual Stages of PlasmodiumIn VivoandIn Vitro

(2012) Fabián E. Sáenz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis and evaluation of hybrid drugs for a potential HIV/AIDS-malaria combination therapy

(2012) Makoah N. Aminake et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Medicinal Chemistry Perspectives of Trioxanes and Tetraoxanes

(2012) N. Kumar et al.   CURRENT MEDICINAL CHEMISTRY

Development of artemisinin compounds for cancer treatment

(2012) Henry C. Lai et al.   INVESTIGATIONAL NEW DRUGS

From methylene blue to chloroquine: a brief review of the development of an antimalarial therapy

(2012) Kristine Krafts et al.   PARASITOLOGY RESEARCH

Unique trifurcated hydrogen bonding in a pseudopolymorph of tricyclohexane triperoxide (TCTP) and its thermal studies

(2012) Chiranjeev Sharma Neupane et al.   TETRAHEDRON LETTERS

Effects of highly active novel artemisinin–chloroquinoline hybrid compounds on β-hematin formation, parasite morphology and endocytosis in Plasmodium falciparum

(2011) Tzu-Shean Feng et al.   BIOCHEMICAL PHARMACOLOGY

Artemisinin: Discovery from the Chinese Herbal Garden

(2011) Louis H. Miller et al.   CELL

Synthesis of 4-aminoquinoline-1,2,3-triazole and 4-aminoquinoline-1,2,3-triazole-1,3,5-triazine Hybrids as Potential Antimalarial Agents

(2011) Sunny Manohar et al.   Chemical Biology & Drug Design

Road Towards New Antimalarials – Overview of the Strategies and their Chemical Progress

(2011) Tao Wu et al.   CURRENT MEDICINAL CHEMISTRY

Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug

(2011) Maria P. Crespo-Ortiz et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Phase I randomized dose-ascending placebo-controlled trials of ferroquine - a candidate anti-malarial drug - in adults with asymptomatic Plasmodium falciparum infection

(2011) Ghyslain Mombo-Ngoma et al.   MALARIA JOURNAL

Adherence to prescribed artemisinin-based combination therapy in Garissa and Bunyala districts, Kenya

(2011) Harriet Lawford et al.   MALARIA JOURNAL

A new world malaria map: Plasmodium falciparum endemicity in 2010

(2011) Peter W Gething et al.   MALARIA JOURNAL

Synthesis of hybrid 4-anilinoquinoline triazines as potent antimalarial agents, their in silico modeling and bioevaluation as Plasmodium falciparumtransketolase and β-hematin inhibitors

(2011) Moni Sharma et al.   MedChemComm

Antimalarial peroxides: advances in drug discovery and design

(2011) Rachel D. Slack et al.   MedChemComm

Heme as Trigger and Target for Trioxane-Containing Antimalarial Drugs†

(2010) Bernard Meunier et al.   ACCOUNTS OF CHEMICAL RESEARCH

Synthesis and in vitro evaluation of novel coumarin–chalcone hybrids as potential anticancer agents

(2010) Koneni V. Sashidhara et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Quinolines and structurally related heterocycles as antimalarials

(2010) Kirandeep Kaur et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Trioxaferroquines as New Hybrid Antimalarial Drugs

(2010) François Bellot et al.   JOURNAL OF MEDICINAL CHEMISTRY

Adult and child malaria mortality in India: a nationally representative mortality survey

(2010) Neeraj Dhingra et al.   LANCET

Combination therapy for visceral leishmaniasis

(2010) Johan van Griensven et al.   LANCET INFECTIOUS DISEASES

Artemisone effective against murine cerebral malaria

(2010) Judith H Waknine-Grinberg et al.   MALARIA JOURNAL

The Molecular Mechanism of Action of Artemisinin—The Debate Continues

(2010) Paul M. O’Neill et al.   MOLECULES

Exploiting Structural Analysis,in SilicoScreening, and Serendipity To Identify Novel Inhibitors of Drug-Resistant Falciparum Malaria

(2009) Tina Dasgupta et al.   ACS Chemical Biology

In Vitro Activities of Trioxaquines against Schistosoma mansoni

(2009) J. Boissier et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Redox-Directed Cancer Therapeutics: Molecular Mechanisms and Opportunities

(2009) Georg T. Wondrak   ANTIOXIDANTS & REDOX SIGNALING

Synthesis and in vitro antitubercular activity of a series of quinoline derivatives

(2009) Marcus V.N. de Souza et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Antitumour and antimalarial activity of artemisinin–acridine hybrids

(2009) Michael Jones et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Semi-synthetic and synthetic 1,2,4-trioxaquines and 1,2,4-trioxolaquines: synthesis, preliminary SAR and comparison with acridine endoperoxide conjugates

(2009) Nuna C.P. Araújo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of Novel Conjugates of Tetraoxane Endoperoxide with Bis(Quaternary Ammonium Salts)

(2009) Naokazu KUMURA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Pharmacokinetics and Pharmacodynamics of Endoperoxide Antimalarials

(2009) Anirudh Gautam et al.   CURRENT DRUG METABOLISM

Hybrid Drugs for Malaria

(2009) J. Walsh et al.   CURRENT PHARMACEUTICAL DESIGN

Recent developments in the design and synthesis of hybrid molecules basedon aminoquinoline ring and their antiplasmodial evaluation

(2009) Vladimir V. Kouznetsov et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Malaria-Infected Mice Are Cured by a Single Oral Dose of New Dimeric Trioxane Sulfones Which Are Also Selectively and Powerfully Cytotoxic to Cancer Cells

(2009) Andrew S. Rosenthal et al.   JOURNAL OF MEDICINAL CHEMISTRY

Malaria-Infected Mice Live until at Least Day 30 after a New Monomeric Trioxane Combined with Mefloquine Are Administered Together in a Single Low Oral Dose†

(2009) Lauren E. Woodard et al.   JOURNAL OF MEDICINAL CHEMISTRY

Modular Synthesis and in Vitro and in Vivo Antimalarial Assessment of C-10 Pyrrole Mannich Base Derivatives of Artemisinin

(2009) Bénédicte Pacorel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antimalarial peroxides

(2009) Dejan Opsenica et al.   JOURNAL OF THE SERBIAN CHEMICAL SOCIETY

Artemisinin resistance on the Thai–Cambodian border

(2009) Olaf Müller et al.   LANCET

Key gaps in the knowledge of Plasmodium vivax, a neglected human malaria parasite

(2009) Ivo Mueller et al.   LANCET INFECTIOUS DISEASES

The Antimalarial Trioxaquine DU1301 Alkylates Heme in Malaria-Infected Mice

(2008) F. Bousejra-El Garah et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis, Antimalarial Activity, and Intracellular Targets of MEFAS, a New Hybrid Compound Derived from Mefloquine and Artesunate

(2008) F. de Pilla Varotti et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Heme activates artemisinin more efficiently than hemin, inorganic iron, or hemoglobin

(2008) Shiming Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Chemical Stability of the Peroxide Bond Enables Diversified Synthesis of Potent Tetraoxane Antimalarials(1)

(2008) Igor Opsenica et al.   JOURNAL OF MEDICINAL CHEMISTRY

New Chimeric Antimalarials with 4-Aminoquinoline Moiety Linked to a Tetraoxane Skeleton(1)

(2008) Igor Opsenica et al.   JOURNAL OF MEDICINAL CHEMISTRY

Combining 4-Aminoquinoline- and Clotrimazole-Based Pharmacophores toward Innovative and Potent Hybrid Antimalarials

(2008) Sandra Gemma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure–activity relationships of 4-N-substituted ferroquine analogues: Time to re-evaluate the mechanism of action of ferroquine

(2008) Christophe Biot et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Maternal and child undernutrition: global and regional exposures and health consequences

(2008) Robert E Black et al.   LANCET

Selection of a trioxaquine as an antimalarial drug candidate

(2008) F. Cosledan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Qinghaosu (Artemisinin): The Price of Success

(2008) N. J. White   SCIENCE

Plasmodium vivax in India

(2008) Hema Joshi et al.   TRENDS IN PARASITOLOGY

Hybrid Molecules with a Dual Mode of Action: Dream or Reality?†

(2007) Bernard Meunier   ACCOUNTS OF CHEMICAL RESEARCH

Ferrocene Conjugates of Chloroquine and other Antimalarials: the Development of Ferroquine, a New Antimalarial

(2007) Daniel Dive et al.   ChemMedChem

Plasmodium knowlesi Malaria in Humans Is Widely Distributed and Potentially Life Threatening

(2007) J. Cox-Singh et al.   CLINICAL INFECTIOUS DISEASES