Design, synthesis and bioevaluation of 6-aryl-1-(3,4,5-trimethoxyphenyl)-1H-benzo[d]imidazoles as tubulin polymerization inhibitors

A facile synthesis of diaryl pyrroles led to the discovery of potent colchicine site antimitotic agents

(2021) Romeo Romagnoli et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of highly potent tubulin polymerization inhibitors: Design, synthesis, and structure-activity relationships of novel 2,7-diaryl-[1,2,4]triazolo[1,5-a]pyrimidines

(2021) Xian-Sen Huo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Developments of isoCombretastatin A-4 derivatives as highly cytotoxic agents

(2020) Abdallah Hamze et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Potent and Selective Non-Nucleotide Small Molecule Inhibitors of CD73

(2020) Joel W. Beatty et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and anticancer properties of isocombretapyridines as potent colchicine binding site inhibitors

(2020) Wen Shuai et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, and biological evaluation of 3,6-diaryl-[1,2,4]triazolo[4,3-a]pyridine analogues as new potent tubulin polymerization inhibitors

(2020) Fang Yang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, antitumor activities and biological studies of novel diaryl substituted fused heterocycles as dual ligands targeting tubulin and katanin

(2019) Feng Gao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, and biological evaluation of 1-substituted -2-aryl imidazoles targeting tubulin polymerization as potential anticancer agents

(2019) Ling Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors

(2019) Romeo Romagnoli et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent advances in trimethoxyphenyl (TMP) based tubulin inhibitors targeting the colchicine binding site

(2018) Ling Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy

(2018) Souvik Banerjee et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site

(2018) Wenlong Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure-activity relationship (SAR) study and design strategies of nitrogen-containing heterocyclic moieties for their anticancer activities

(2017) Jawaid Akhtar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent Development of Benzimidazole-Containing Antibacterial Agents

(2016) Di Song et al.   ChemMedChem

Current Advances of Tubulin Inhibitors in Nanoparticle Drug Delivery and Vascular Disruption/Angiogenesis

(2016) Souvik Banerjee et al.   MOLECULES

3-(3-Hydroxy-4-methoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-1,2,5-selenadiazole (G-1103), a novel combretastatin A-4 analog, induces G2/M arrest and apoptosis by disrupting tubulin polymerization in human cervical HeLa cells and fibrosarcoma HT-1080 cells

(2015) Daiying Zuo et al.   CHEMICO-BIOLOGICAL INTERACTIONS

A Phase I/II Trial of BNC105P with Everolimus in Metastatic Renal Cell Carcinoma

(2015) S. Pal et al.   CLINICAL CANCER RESEARCH

Synthesis and biological evaluation of novel 4,5-disubstituted 2H-1,2,3-triazoles as cis-constrained analogues of combretastatin A-4

(2015) Nikhil R. Madadi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

3-(3,4,5-Trimethoxyphenylselenyl)-1H-indoles and their selenoxides as combretastatin A-4 analogs: Microwave-assisted synthesis and biological evaluation

(2015) Zhiyong Wen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Control of microtubule organization and dynamics: two ends in the limelight

(2015) Anna Akhmanova et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Recent developments in tubulin polymerization inhibitors: An overview

(2014) Ramandeep Kaur et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and evaluation of benzimidazole carbamates bearing indole moieties for antiproliferative and antitubulin activities

(2014) Qi Guan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Benzimidazole: An emerging scaffold for analgesic and anti-inflammatory agents

(2014) Monika Gaba et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel Tubulin Polymerization Inhibitors Overcome Multidrug Resistance and Reduce Melanoma Lung Metastasis

(2012) Zhao Wang et al.   PHARMACEUTICAL RESEARCH

An Overview of Tubulin Inhibitors That Interact with the Colchicine Binding Site

(2012) Yan Lu et al.   PHARMACEUTICAL RESEARCH

Discovery of 7-Hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a Tubulin Polymerization Inhibitor with Potent Antiproliferative and Tumor Vascular Disrupting Properties

(2011) Bernard L. Flynn et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Phase Ib trial of CA4P (combretastatin A-4 phosphate), carboplatin and paclitaxel in patients with advanced cancer

(2010) G J Rustin et al.   BRITISH JOURNAL OF CANCER

Identification of CKD-516: A Potent Tubulin Polymerization Inhibitor with Marked Antitumor Activity against Murine and Human Solid Tumors

(2010) Jaekwang Lee et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery ofN-(4-Methoxyphenyl)-N,2-dimethylquinazolin-4-amine, a Potent Apoptosis Inducer and Efficacious Anticancer Agent with High Blood Brain Barrier Penetration

(2009) Nilantha Sirisoma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Indibulin, a Novel Microtubule Inhibitor, Discriminates between Mature Neuronal and Nonneuronal Tubulin

(2008) A. Wienecke et al.   CANCER RESEARCH