Article
Cardiac & Cardiovascular Systems
Sehoon Park, Soojin Lee, Yaerim Kim, Yeonhee Lee, Min Woo Kang, Kwangsoo Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim
Summary: This study suggests that atrial fibrillation may lead to decreased kidney function and increased risk of chronic kidney disease.
EUROPEAN HEART JOURNAL
(2021)
Article
Nutrition & Dietetics
Shafqat Ahmad, Johan Arnlov, Susanna C. Larsson
Summary: This study suggests that elevated circulating copper levels may contribute to the development of chronic kidney disease. Using a genetic prediction approach, it was found that higher copper levels were associated with higher prevalence of CKD and decline in kidney function.
Article
Nutrition & Dietetics
Yang Xiong, Yangchang Zhang, Fuxun Zhang, Changjing Wu, Peiyi Luo, Feng Qin, Jiuhong Yuan
Summary: This study found a causal relationship between increased levels of Hcy and renal function injury as well as CKD using genetic data.
FRONTIERS IN NUTRITION
(2022)
Article
Genetics & Heredity
Ruicheng Wu, Peiyi Luo, Min Luo, Xiaoyu Li, Xin Zhong, Qiang He, Jie Zhang, Yangchang Zhang, Yang Xiong, Ping Han
Summary: This study provides novel causal evidence using genetic data that adiponectin can protect kidney function and further reduce the risk of chronic kidney disease (CKD).
FRONTIERS IN GENETICS
(2022)
Article
Immunology
Chang Hu, Yiming Li, Yaoyao Qian, Zhenying Wu, Bo Hu, Zhiyong Peng
Summary: This study aims to examine the causal relationship between kidney function and cardiovascular diseases (CVDs) through observational analysis and two-sample bidirectional Mendelian randomization analysis. The results show that CVDs have a causal effect on kidney function, but the evidence to support the causal effects of kidney function on CVDs is currently insufficient, further studies are needed to determine the causality.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Urology & Nephrology
Belen Ponte, Marie C. Sadler, Eric Olinger, Peter Vollenweider, Murielle Bochud, Sandosh Padmanabhan, Caroline Hayward, Zoltan Kutalik, Olivier Devuyst
Summary: UMOD variants associated with higher levels of urinary uromodulin increase the risk of chronic kidney disease (CKD) and hypertension. Mendelian randomization studies showed that higher uUMOD levels have a direct adverse effect on kidney function outcome, not mediated by blood pressure.
KIDNEY INTERNATIONAL
(2021)
Editorial Material
Urology & Nephrology
Sho Hasegawa, Masaomi Nangaku
Summary: This study suggests that SGLT2 inhibitors, such as dapagliflozin, may reduce the risk of abrupt declines in kidney function in patients with chronic kidney disease.
KIDNEY INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Min Kyoung Kang, Hee-Jung Ha, Raon Jung, Yunseo Oh, Dong-Hyeok Kim, Tae-Jin Song
Summary: This study found an association between elevated estimated glomerular filtration rate (eGFR) and a reduced risk of atrial fibrillation (AF) based on a nationwide longitudinal study in Korea. Individuals with eGFR>120 mL/min/1.73 m2 or falling within the highest 10% of eGFR levels (>113.41 mL/min/1.73 m2) were found to have a lower risk of developing AF.
FRONTIERS IN MEDICINE
(2023)
Article
Urology & Nephrology
Yulan Bai, Zefeng Chen, Zheng Wen, Xinyang Long, Zengnan Mo, Jianfeng Xu
Summary: This study found that adiponectin has a causal effect on estimated glomerular filtration rate (eGFR), but eGFR has no causal effect on adiponectin. This suggests that adiponectin may be a potential clinical target for improving kidney function and treating chronic kidney disease.
Article
Endocrinology & Metabolism
Baiyu Feng, Yu Lu, Lin Ye, Lijun Yin, Yingjun Zhou, Anqun Chen
Summary: This study used Mendelian randomization analysis to determine the causal relationship between cystatin C and diabetic nephropathy. The study found that cystatin C is an independent risk factor for diabetic nephropathy in patients with diabetes, regardless of BMI and SBP.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Sehoon Park, Soojin Lee, Yaerim Kim, Yeonhee Lee, Min Woo Kang, Kwangsoo Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim
Summary: Higher vegetable intake is associated with higher eGFR and lower odds of CKD in a cross-sectional investigation, and genetically predicted vegetable intake is causally associated with higher eGFR in European populations. However, the association with CKD remains inconclusive.
JOURNAL OF NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Jeong Min Cho, Jung Hun Koh, Seong Geun Kim, Soojin Lee, Yaerim Kim, Semin Cho, Kwangsoo Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim, Sehoon Park
Summary: The study identified significant causal associations between genetically predicted primary sclerosing cholangitis and kidney function impairment. Genetically predicted PSC was linked to decreased glomerular filtration rate, accelerated yearly decline in eGFR, and increased risk of chronic kidney disease. Further research is needed to investigate the underlying mechanisms behind these associations.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Marie Klevjer, Humaira Rasheed, Pal R. Romundstad, Erik Madssen, Ben M. Brumpton, Anja Bye
Summary: This study used Mendelian randomization to explore the causal association between resting heart rate (RHR) and atrial fibrillation (AF), and found an inverse causal relationship between them, especially when RHR was below 90 beats per minute. The results challenge the current observational knowledge on RHR and AF.
Review
Food Science & Technology
Lajos Zsom, Marianna Zsom, Sohail Abdul Salim, Tibor Fulop
Summary: Estimated GFR (eGFR) is widely used to predict the progression of chronic kidney disease (CKD) and the need for dialysis, but it has several limitations, including only reflecting one physiological function of the kidney, depending on non-renal factors, being influenced by dietary intake and cardiovascular status, and not correlating with GFR in certain conditions. Many clinicians rely too heavily on eGFR as a valid reflection of renal function and a reliable diagnostic tool for CKD.
Article
Public, Environmental & Occupational Health
Alisa D. Kjaergaard, Christina Ellervik, Daniel R. Witte, Borge G. Nordestgaard, Ruth Frikke-Schmidt, Stig E. Bojesen
Summary: This study investigated the association between impaired kidney function and the risk of developing dementia. The results showed a modestly increased risk of dementia in individuals with impaired kidney function, but genetic analysis did not support a causal relationship. However, further research is needed to re-evaluate the causal hypothesis.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Cell Biology
Sehoon Park, Hajeong Lee, Jeongha Lee, Sangmoon Lee, Semin Cho, Hyeok Huh, Joo Young Kim, Minkyoung Park, Soojin Lee, Yaerim Kim, Murim Choi, Kwon Wook Joo, Yon Su Kim, Seung Hee Yang, Dong Ki Kim
Summary: Transcriptome profiling of tubulointerstitial tissue in glomerulonephritis identified DUSP1 as a potential biomarker for tubulointerstitial injury. Overexpression of DUSP1 alleviated inflammation, while its inhibition increased inflammatory markers. Combination of DUSP1 overexpression with low-concentration corticosteroid treatment showed more potent suppression of inflammation.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Transplantation
Ji Eun Kim, Jina Park, Sehoon Park, Mi-Yeon Yu, Seon Ha Baek, Sang Hyun Park, Kyungdo Han, Yong Chul Kim, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Yon Su Kim, Hajeong Lee
Summary: The risk of de novo major adverse cardiovascular events (MACEs) in kidney transplant recipients (KTRs) is lower compared to dialysis patients and similar to the general population (GP). However, once such events occur, they increase the risk of mortality in KTRs.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Geriatrics & Gerontology
Sehoon Park, Seong Geun Kim, Soojin Lee, Yaerim Kim, Semin Cho, Kwangsoo Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim
Summary: Through genetic analysis, it has been found that smoking is causally related to various aging traits, and smoking is associated with poor aging and frailty. This finding is important for further understanding the impact of smoking on human health.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Critical Care Medicine
Seong Geun Kim, Donghwan Yun, Jinwoo Lee, Yong Chul Kim, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Yon Su Kim, Seung Seok Han
Summary: This study aimed to investigate the incidence of intradialytic hypotension (IDH) following the transition from continuous renal replacement therapy (CRRT) to intermittent hemodialysis (iHD), and its association with mortality risk. The results showed that IDH occurred in 36% of patients, with a higher mortality rate compared to those without IDH. Patients with IDH also experienced delayed weaning from renal replacement therapy. Therefore, IDH following the transition from CRRT to iHD is associated with increased mortality and delayed recovery.
ACUTE AND CRITICAL CARE
(2023)
Article
Endocrinology & Metabolism
Byungwook Kim, Dha Woon Im, Heejae Won, Jung Sunwoo, Seung Seok Han, Hajeong Lee, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Yon Su Kim, Joo-Youn Cho, SeungHwan Lee, Jaeseong Oh, In-Jin Jang, Yong Chul Kim
Summary: The aim of this study was to investigate the potential effect of haemodialysis on the pharmacokinetic and pharmacodynamic characteristics of evogliptin, a dipeptidyl peptidase-4 inhibitor. The results showed that haemodialysis had no clinically significant effect on the pharmacokinetic and pharmacodynamic characteristics of evogliptin, indicating that dose adjustment is not necessary according to the haemodialysis status.
DIABETES OBESITY & METABOLISM
(2023)
Article
Nutrition & Dietetics
Jinwoo Lee, Hyunjin Ryu, Yong-Chul Kim, Hayne Cho Park, Curie Ahn, Kyu-Beck Lee, Yeong Hoon Kim, Yaerim Kim, Seungyeop Han, Eun Hui Bae, Kook-Hwan Oh, Yun Kyu Oh
Summary: The study examined the association between nutritional status and the preservation of kidney function in ADPKD patients. The results showed that good nutritional status is associated with better-preserved kidney function.
JOURNAL OF RENAL NUTRITION
(2023)
Article
Urology & Nephrology
Seong Geun Kim, Chung Hee Han, Sung Bong Yu, Hyeseung Lee, Soie Kwon, Yerim Kim, Jeonghwan Lee, Dong Ki Kim, Yun Kyu Oh, Chun Soo Lim, Yon Su Kim, Byung Gun Kim, Jung Pyo Lee
Summary: AKI in COVID-19 patients is associated with poor prognosis. Characterization of AKI by timing and trajectory and early prediction of AKI progression is required for better preventive management and the prediction of patient outcomes.
Article
Multidisciplinary Sciences
Tae Hyun Ban, Bum Soon Choi, Sun Ae Yoon, Yaerim Kim, Kyubok Jin, Gheun-Ho Kim, Young-Ki Lee, Kook-Hwan Oh, Sang-Ho Lee, Ji Yong Jung, Hyeong Cheon Park, Shin Young Ahn, Gang-Jee Ko, Young Joo Kwon, Yu Ah Hong, ORCHESTRA Study Investigators
Summary: This study investigated the relationship between neutrophil-to-lymphocyte ratio (NLR) and abdominal aortic calcification (AAC) and bone mineral density (BMD) in dialysis patients. The results showed a significant correlation between NLR and AAC, but no association with osteoporosis.
Article
Nutrition & Dietetics
Jeong-Min Cho, Jung-Hun Koh, Seong-Geun Kim, Soojin Lee, Yaerim Kim, Semin Cho, Kwangsoo Kim, Yong-Chul Kim, Seung-Seok Han, Hajeong Lee, Jung-Pyo Lee, Kwon-Wook Joo, Chun-Soo Lim, Yon-Su Kim, Dong-Ki Kim, Sehoon Park
Summary: This study conducted a summary-level Mendelian randomization analysis to investigate the causal effects of chondroitin, glucosamine, and vitamin/mineral supplement intake on kidney function. The results suggest a potential causal effect of chondroitin and glucosamine intake on a lower estimated glomerular filtration rate, while vitamin/mineral supplement intake may be associated with a higher eGFR.
Article
Medicine, General & Internal
Jin Ho Hwang, Sohee Oh, Ho Jun Chin, Sejoong Kim, Dong Ki Kim, Suhnggwon Kim, Jung Hwan Park, Sung Joon Shin, Sang-Ho Lee, Bum Soon Choi, Chun Soo Lim
Summary: This study compared various equations for estimating glomerular filtration rate with the results of 24-hour urine creatinine clearance. The IDMS-MDRD equation showed the best correlation with 24-hour urine creatinine clearance, while the CKD-EPI (2021) equation had the highest accuracy in CKD stage 1 and the KOR-IDMS-MDRD equation had the highest accuracy in CKD stages 2-3.
Article
Urology & Nephrology
Yaerim Kim, Jueun Lee, Mi Sun Kang, Jeongin Song, Seong Geun Kim, Semin Cho, Hyuk Huh, Soojin Lee, Sehoon Park, Hyung Ah Jo, Seung Hee Yang, Jin Hyuk Paek, Woo Yeong Park, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Geum-Sook Hwang, Dong Ki Kim
Summary: Metabolomic analysis can identify urinary metabolites that are significant predictors of CKD progression, with better predictive ability than traditional biomarkers.
Article
Urology & Nephrology
Seong Geun Kim, Donghwan Yun, Jayoun Kim, Jinwoo Lee, Min Woo Kang, Yong Chul Kim, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Hoseok Koo, Yon Su Kim, Seung Seok Han
Summary: This study found that the occurrence of ventricular tachycardia (VT) during continuous renal replacement therapy (CRRT) is associated with increased patient mortality, especially sustained VT.
KIDNEY RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Urology & Nephrology
Min Woo Kang, Navdeep Tangri, Soie Kwon, Lilin Li, Hyeseung Lee, Seung Seok Han, Jung Nam An, Jeonghwan Lee, Dong Ki Kim, Chun Soo Lim, Yon Su Kim, Sejoong Kim, Jung Pyo Lee
Summary: This study developed equations for predicting the mortality risk of patients on CRRT, which showed superior performance to previous scoring systems and can assist physicians in patient management.
Article
Urology & Nephrology
Hyuk Huh, Ejin Kim, Una Amelia Yoon, Mun Jeong Choi, Hyewon Lee, Soie Kwon, Clara Tammy Kim, Dong Ki Kim, Yon Su Kim, Chun Soo Lim, Jung Pyo Lee, Ho Kim, Yong Chul Kim
Summary: This study in the Korean ESRD cohort found a significant association between carbon monoxide concentration and mortality in hemodialysis patients, especially in older patients and those with diabetes.
KIDNEY RESEARCH AND CLINICAL PRACTICE
(2022)