Review
Biochemistry & Molecular Biology
Manizha Shekibi, Sophea Heng, Guiying Nie
Summary: The development of endometrial receptivity is crucial for successful embryo implantation and pregnancy initiation. Recent studies have focused on the role of microRNAs (miRNAs) in the regulation of endometrial receptivity. This review provides an up-to-date knowledge of the miRNAs identified in humans and mice that may play a functional role in the establishment of receptivity. The findings suggest that miRNAs could be potential biomarkers and therapeutic targets for improving endometrial receptivity in human fertility treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Irem Gulfem Albayrak, Fatemeh Azhari, Ezgi Nur Colak, Burcin Karamustafaoglu Balci, Ege Ulgen, Ugur Sezerman, Ercan Bastu, Tuba Gunel
Summary: Recurrent implantation failure (RIF) is diagnosed when good-quality embryos repeatedly fail to implant after transfer, potentially due to dysregulated gene expression. This study focused on identifying significantly dysregulated genes related to implantation between healthy fertile women and RIF patients. The study found up-regulated expression of MME and WWC1 genes, and down-regulated expression of TNC gene in RIF samples compared to controls, suggesting potential mechanisms underlying RIF.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Obstetrics & Gynecology
Henrieta Papuchova, Malene Hviid Saxtorph, Trine Hallager, Ida E. Jepsen, Jens O. Eriksen, Gry Persson, Tina Funck, Iben Weisdorf, Nicholas S. Macklon, Lise Grupe Larsen, Thomas Vauvert F. Hviid
Summary: The study found that HLA-F protein is expressed in mid-secretory endometrium and its expression levels are influenced by HLA-F gene polymorphisms. HLA-F is correlated with immune cell infiltration and plasma progesterone concentrations. However, women with recurrent implantation failure show differences in HLA-F protein levels compared to women undergoing their first IVF treatment.
HUMAN REPRODUCTION
(2022)
Review
Biochemistry & Molecular Biology
Adam Maciejewski, Katarzyna Lacka
Summary: Vitamin D plays a crucial role in immunity and differentiation/proliferation processes, and it is potentially associated with thyroid cancer. This study systematically reviewed publications on the association between vitamin D-related gene variants and thyroid cancer. Results were inconclusive, and further validation is required.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Claire Stenhouse, Makenzie G. Newton, Katherine M. Halloran, Robyn M. Moses, Nirvay Sah, Larry J. Suva, Fuller W. Bazer
Summary: Recent evidence shows the important roles of progesterone and interferon tau in the regulation of calcium, phosphate, and vitamin D signaling in the uteri of pregnant sheep. However, the effects of progesterone and estradiol, and their respective receptors, on mineral signaling during the estrous cycle have not been investigated. This study found that the expression of certain genes and proteins related to mineral signaling was different at different stages of the estrous cycle. Overall, these results suggest that progesterone and its receptor play important roles in regulating mineral signaling during the estrous cycle in ewes.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Obstetrics & Gynecology
Greta Chiara Cermisoni, Marco Reschini, Marie-Pierre Piccinni, Letizia Lombardelli, Federica Logiodice, Veronica Sarais, Elisa Giacomini, Simona Signorelli, Anna Cecchele, Paola Vigano
Summary: Oral Vitamin D supplementation does not significantly modify cytokine and chemokine levels in the intrauterine milieu. Vitamin D may act on the uterine environment through a different mechanism.
HUMAN REPRODUCTION OPEN
(2022)
Article
Immunology
Rumiana Ganeva, Dimitar Parvanov, Nina Vidolova, Margarita Ruseva, Maria Handzhiyska, Katarina Arsov, Ivon Decheva, Dimitar Metodiev, Veselina Moskova-Doumanova, Georgi Stamenov
Summary: The objective of this study was to compare the quantities and ratios of immune cells in the endometrium during the mid-luteal phase between women with recurrent implantation failure (RIF) with successful and unsuccessful embryo implantation. Endometrial biopsies from 116 women undergoing Assisted Reproductive Technology (ART) were stained for different immune cells, and the quantities and ratios were compared based on the outcome of embryo implantation in the subsequent cycle. The results showed that certain ratios of immune cells were significantly different between the successful and unsuccessful implantation groups, and could be predictive factors for successful implantation in RIF patients.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Review
Immunology
Nupur Mukherjee, Richa Sharma, Deepak Modi
Summary: Recurrent implantation failure (RIF) can be caused by uterine factors, male factors, or embryo factors. It is associated with disrupted endometrial receptivity, altered gene expression, immunologic disturbances, and epigenetic alterations. RIF is a heterogeneous condition with varied immune responses, and personalized therapies based on the patient's immune status are being tested.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
S. S. Ersahin, A. Ersahin
Summary: This study investigated the relationship between serum vitamin D level and homeobox 10 mRNA expression in women with polycystic ovary syndrome (PCOS). The results showed that women with sufficient serum vitamin D levels had significantly higher HOXA10 mRNA expression in the endometrium compared to patients with low serum vitamin D levels.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Reproductive Biology
Claire Stenhouse, Katherine M. Halloran, Makenzie G. Newton, Dana Gaddy, Larry J. Suva, Fuller W. Bazer
Summary: The study identified that the calcium and vitamin D signaling pathways in ovine endometria and placentae are influenced by gestational day, suggesting a potential role in the establishment of pregnancy and regulation of fetal and placental growth. The expression of various genes involved in calcium binding, transport, and vitamin D metabolism were quantified, providing a platform for further mechanistic investigation in this area. The spatiotemporal profile of VDR protein expression indicates its involvement in calcium and vitamin D regulation throughout gestation.
BIOLOGY OF REPRODUCTION
(2021)
Article
Endocrinology & Metabolism
Rong Luo, Jiahui Wang, Yu Yang, Cen Xu, Minyan Yang, Dandan Zhu, Jia Wang, Ping Zhang, Hongshan Ge
Summary: This study aimed to assess the impact of vitamin D levels on embryo quality and pregnancy outcomes in patients with normal ovarian reserve undergoing the first IVF/ICSI cycle. The findings suggest that serum vitamin D level is not associated with embryo quality and pregnancy outcomes for these patients. Further studies are needed to elucidate the relationships between vitamin D levels and IVF outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Ling Guo, Xiyao Wang, Yufeng Wang, Fengxuan Sun, Yifei Song, Caiyi Chen, Junhao Yan, Yan Li
Summary: This study investigated the effect of thyroid autoimmunity on pregnancy outcomes in euthyroid patients with recurrent implantation failure after IVF/ICSI. The results showed that thyroid autoimmunity had no impact on pregnancy outcomes, except for a lower biochemical pregnancy rate in the TAI-positive group.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Review
Nutrition & Dietetics
Ana Palanca, Francisco Javier Ampudia-Blasco, Jose T. Real
Summary: Thyroid cancer is increasing in incidence and vitamin D may have a role in its prevention. However, the exact role of vitamin D in thyroid cancer development is controversial. Some studies suggest elevated serum vitamin D levels have a protective role, while others show no inverse relationship with the occurrence of thyroid cancer. Circulating vitamin D concentration is inversely correlated with disease aggressiveness and poor prognosis.
Article
Endocrinology & Metabolism
Federica Cariati, Consolata Carotenuto, Francesca Bagnulo, Daniela Pacella, Vincenzo Marrone, Rossella Paolillo, Maria Rosaria Catania, Raffaella Di Girolamo, Alessandro Conforti, Ida Strina, Carlo Alviggi
Summary: The study aimed to use a culturomics-based method to analyze the endometrial microbiota and correlate the results with ongoing pregnancy rates. It was found that detection of bacteria by culturomics from catheter tips used for embryo transfer could offer a reliable method to detect pathogen growth. The study highlights the importance of endometrial microbiota testing in improving diagnosis and treatment strategies in IVF patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biophysics
Victor Ruiz-Valdepenas Montiel, Juliane R. Sempionatto, Eva Vargas, Eileen Bailey, Jennifer May, Andrea Bulbarello, Andre Duesterloh, Nathan Matusheski, Joseph Wang
Summary: This study introduces a new bioelectronic chip that can selectively and cross-talk free detect vitamin C and D in a 10-mu L saliva sample within 25 minutes, showing potential for personalized nutrition guidance.
BIOSENSORS & BIOELECTRONICS
(2021)
Review
Obstetrics & Gynecology
Chelsea Fox, Kacey Eichelberger
FERTILITY AND STERILITY
(2015)
Article
Obstetrics & Gynecology
Soo Hyun Ahn, Kasra Khalaj, Steven L. Young, Bruce A. Lessey, Madhuri Koti, Chandrakant Tayade
FERTILITY AND STERILITY
(2016)
Article
Obstetrics & Gynecology
Chelsea Fox, Denise Azores-Gococo, Linda Swart, Kristin Holoch, Ricardo F. Savaris, Creighton E. Likes, Paul B. Miller, David A. Forstein, Bruce A. Lessey
REPRODUCTIVE BIOMEDICINE ONLINE
(2017)
Article
Genetics & Heredity
Creighton E. Likes, Leah J. Cooper, Jessica Efird, David A. Forstein, Paul B. Miller, Ricardo Savaris, Bruce A. Lessey
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2019)
Article
Genetics & Heredity
Yasmin M. Vasquez, Xiaoqiu Wang, Margeaux Wetendorf, Heather L. Franco, Qianxing Mo, Tianyuan Wang, Rainer B. Lanz, Steven L. Young, Bruce A. Lessey, Thomas E. Spencer, John P. Lydon, Francesco J. DeMayo
Article
Endocrinology & Metabolism
Tae Hoon Kim, Steven L. Young, Tsutomu Sasaki, Jeffrey L. Deaton, David P. Schammel, Wilder Alberto Palomino, Jae-Wook Jeong, Bruce A. Lessey
Summary: The study revealed that SIRT1 expression in the endometrium is associated with progesterone resistance and normal endometrial function, while aberrant SIRT1 expression may contribute to progesterone resistance and the pathophysiology of endometriosis. SIRT1 serves as a novel and targetable protein for the diagnosis and treatment of endometriosis and infertility associated with this disease.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, Research & Experimental
Jessica E. Miller, Harshavardhan Lingegowda, Lindsey K. Symons, Olga Bougie, Steven L. Young, Bruce A. Lessey, Madhuri Koti, Chandrakant Tayade
Summary: The study found that IL-33 contributes to the expansion of ILC2s in both humans and murine models, regulating the microenvironment of endometriosis lesions, and driving severe endometriosis symptoms such as inflammation, lesion proliferation, and fibrosis. IL-33 neutralization shows promise as a potential novel therapeutic avenue for treating the debilitating symptoms of endometriosis.
Letter
Obstetrics & Gynecology
Ricardo F. Savaris, Bruce A. Lessey
FERTILITY AND STERILITY
(2022)
Article
Obstetrics & Gynecology
Chelsea W. Fox, Ricardo F. Savaris, Jae-Wook Jeong, Tae Hoon Kim, Paul B. Miller, Creighton E. Likes, David P. Schammel, Steven L. Young, Bruce A. Lessey
HUMAN REPRODUCTION OPEN
(2020)
Article
Endocrinology & Metabolism
Chelsea W. Fox, Lingzhi Zhang, Abhishek Sohni, Manuel Doblado, Miles F. Wilkinson, R. Jeffrey Chang, Antoni J. Duleba
Article
Medicine, Research & Experimental
Kasra Khalaj, Jessica E. Miller, Harshavardhan Lingegowda, Asgerally T. Fazleabas, Steven L. Young, Bruce A. Lessey, Madhuri Koti, Chandrakant Tayade