Long‐term safety of adjunctive cenobamate in patients with uncontrolled focal seizures: Open‐label extension of a randomized clinical study

Cenobamate: First Approval

(2020) Susan J. Keam   DRUGS

Cenobamate (YKP3089) as adjunctive treatment for uncontrolled focal seizures in a large, phase 3, multicenter, open‐label safety study

(2020) Michael R. Sperling et al.   EPILEPSIA

Understanding the challenge of comparative effectiveness research in focal epilepsy: A review of network meta‐analyses and real‐world evidence on antiepileptic drugs

(2020) Solène Thieffry et al.   EPILEPSIA

Randomized phase 2 study of adjunctive cenobamate in patients with uncontrolled focal seizures

(2020) Steve S. Chung et al.   NEUROLOGY

Assessment of the long‐term efficacy and safety of adjunctive perampanel in tonic‐clonic seizures: Analysis of four open‐label extension studies

(2020) Ivan Rektor et al.   EPILEPSIA

Positive allosteric modulation of GABAA receptors by a novel antiepileptic drug cenobamate

(2020) Ramesh Sharma et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cenobamate (XCOPRI): Can preclinical and clinical evidence provide insight into its mechanism of action?

(2020) Michelle Guignet et al.   EPILEPSIA

Safety, tolerability, and efficacy of brivaracetam as adjunctive therapy in patients with focal seizures, generalized onset seizures, or Unverricht–Lundborg disease: An open-label, long-term follow-up trial

(2020) Elinor Ben-Menachem et al.   EPILEPSY RESEARCH

Effects of cenobamate (YKP3089), a newly developed anti-epileptic drug, on voltage-gated sodium channels in rat hippocampal CA3 neurons

(2019) Michiko Nakamura et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Safety and efficacy of adjunctive cenobamate (YKP3089) in patients with uncontrolled focal seizures: a multicentre, double-blind, randomised, placebo-controlled, dose-response trial

(2019) Gregory L Krauss et al.   LANCET NEUROLOGY

Final safety, tolerability, and seizure outcomes in patients with focal epilepsy treated with adjunctive perampanel for up to 4 years in an open-label extension of phase III randomized trials: Study 307

(2018) Gregory L. Krauss et al.   EPILEPSIA

Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology

(2017) Robert S. Fisher et al.   EPILEPSIA

ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology

(2017) Ingrid E. Scheffer et al.   EPILEPSIA

Retention of perampanel in adults with pharmacoresistant epilepsy at a single tertiary care center

(2017) Tim Wehner et al.   EPILEPSY & BEHAVIOR

Long-term retention rates for antiepileptic drugs: A review of long-term extension studies and comparison with brivaracetam

(2017) Manuel Toledo et al.   EPILEPSY RESEARCH

Safety, tolerability, and seizure control during long-term treatment with adjunctive brivaracetam for partial-onset seizures

(2016) Manuel Toledo et al.   EPILEPSIA

Long-term safety and sustained efficacy of USL255 (topiramate extended-release capsules) in patients with refractory partial-onset seizures

(2016) Steve S. Chung et al.   EPILEPSY & BEHAVIOR

Long-term adjunctive lacosamide treatment in patients with partial-onset seizures

(2015) F. Rosenow et al.   ACTA NEUROLOGICA SCANDINAVICA

Long-term efficacy and safety of adjunctive extended-release oxcarbazepine (Oxtellar XR®) in adults with partial-onset seizures

(2015) S. S. Chung et al.   ACTA NEUROLOGICA SCANDINAVICA

Safety and efficacy of adjunctive lacosamide among patients with partial-onset seizures in a long-term open-label extension trial of up to 8years

(2014) William Rosenfeld et al.   EPILEPSY & BEHAVIOR

Long-term retention of lacosamide in a large cohort of people with medically refractory epilepsy: A single centre evaluation

(2013) Jan Novy et al.   EPILEPSY RESEARCH

Early predictors of outcome in newly diagnosed epilepsy

(2013) Rajiv Mohanraj et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Perampanel Study 207: long-term open-label evaluation in patients with epilepsy

(2012) I. Rektor et al.   ACTA NEUROLOGICA SCANDINAVICA

Measuring outcomes of treatment with antiepileptic drugs in clinical trials

(2010) Elinor Ben-Menachem et al.   EPILEPSY & BEHAVIOR

Eslicarbazepine acetate as adjunctive therapy in adult patients with partial epilepsy

(2010) E. Ben-Menachem et al.   EPILEPSY RESEARCH

The impact of side effects on long-term retention in three new antiepileptic drugs

(2008) Hans P. Bootsma et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY