Journal
FEBS LETTERS
Volume 590, Issue 2, Pages 224-231Publisher
WILEY
DOI: 10.1002/1873-3468.12050
Keywords
colistin resistance; hydrophobic channel; iron homeostasis
Funding
- Centre National de la Recherche Scientifique [UMR 6270]
- Spanish Ministry of Health [FIS 05/0068, FIS PI 12/00552]
- Spanish Network for the Research in Infectious Diseases [REIPI RE06/0008]
- European Community [HEALTH-F3-2008-223031]
- Ministere de l'Enseignement Superieur et de la Recherche
- ANR (Agence Nationale de Recherche) [IronPath ANR-12-BSV8-0007-01]
- Ministerio de Sanidad y Consumo
- Instituto de Salud Carlos II
Ask authors/readers for more resources
This study was undertaken to characterize functions of the outer membrane protein OmpW, which potentially contributes to the development of colistin- and imipenem-resistance in Acinetobacter baumannii. Reconstitution of OmpW in artificial lipid bilayers showed that it forms small channels (23 pS in 1 m KCl) and markedly interacts with iron and colistin, but not with imipenem. In vivo,Fe-55 uptake assays comparing the behaviours of ompW mutant and wild-type strains confirmed a role for OmpW in A. baumannii iron homeostasis. However, the loss of OmpW expression did not have an impact on A. baumannii susceptibilities to colistin or imipenem.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available