DevS/DosS sensor is bifunctional and its phosphatase activity precludes aerobic DevR/DosR regulon expression inMycobacterium tuberculosis

DosS Is Required for the Complete Virulence ofMycobacterium tuberculosisin Mice with Classical Granulomatous Lesions

(2015) Uma S. Gautam et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

DevR (DosR) mimetic peptides impair transcriptional regulation and survival of Mycobacterium tuberculosis under hypoxia by inhibiting the autokinase activity of DevS sensor kinase

(2014) Kohinoor Kaur et al.   BMC MICROBIOLOGY

Essentiality of DevR/DosR Interaction with SigA for the Dormancy Survival Program in Mycobacterium tuberculosis

(2013) U. S. Gautam et al.   JOURNAL OF BACTERIOLOGY

DevR (DosR) binding peptide inhibits adaptation of Mycobacterium tuberculosis under hypoxia

(2012) Sakshi Dhingra et al.   FEMS MICROBIOLOGY LETTERS

Appropriate DevR (DosR)-Mediated Signaling Determines Transcriptional Response, Hypoxic Viability and Virulence of Mycobacterium tuberculosis

(2012) Shyamasree De Majumdar et al.   PLoS One

K182G substitution in DevR or C8G mutation in the Dev box impairs protein-DNA interaction and abrogates DevR-mediated gene induction in Mycobacterium tuberculosis

(2011) Rajesh Kumar Gupta et al.   FEBS Journal

The Residue Threonine 82 of DevR (DosR) Is Essential for DevR Activation and Function in Mycobacterium tuberculosis Despite Its Atypical Location

(2011) U. S. Gautam et al.   JOURNAL OF BACTERIOLOGY

Adaptation to Environmental Stimuli within the Host: Two-Component Signal Transduction Systems of Mycobacterium tuberculosis

(2011) D. J. Bretl et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Negative control in two-component signal transduction by transmitter phosphatase activity

(2011) TuAnh Ngoc Huynh et al.   MOLECULAR MICROBIOLOGY

Comprehensive insights into Mycobacterium tuberculosis DevR (DosR) regulon activation switch

(2011) Santosh Chauhan et al.   NUCLEIC ACIDS RESEARCH

Determinants Outside the DevR C-Terminal Domain Are Essential for Cooperativity and Robust Activation of Dormancy Genes in Mycobacterium tuberculosis

(2011) Uma Shankar Gautam et al.   PLoS One

Structural and Enzymatic Insights into the ATP Binding and Autophosphorylation Mechanism of a Sensor Histidine Kinase

(2010) Felipe Trajtenberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Is Mycobacterium tuberculosis stressed out? A critical assessment of the genetic evidence

(2010) Christina L. Stallings et al.   MICROBES AND INFECTION

Mycobacterium tuberculosis Transcriptional Adaptation, Growth Arrest and Dormancy Phenotype Development Is Triggered by Vitamin C

(2010) Neetu Kumra Taneja et al.   PLoS One

Conserved mechanism for sensor phosphatase control of two-component signaling revealed in the nitrate sensor NarX

(2010) T. N. Huynh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Insight into Partner Specificity and Phosphoryl Transfer in Two-Component Signal Transduction

(2009) Patricia Casino et al.   CELL

Structure-Based Design of DevR Inhibitor Active against NonreplicatingMycobacterium tuberculosis

(2009) Rajesh Kumar Gupta et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tuberculous Granulomas Are Hypoxic in Guinea Pigs, Rabbits, and Nonhuman Primates

(2008) L. E. Via et al.   INFECTION AND IMMUNITY

Cooperative Binding of Phosphorylated DevR to Upstream Sites Is Necessary and Sufficient for Activation of the Rv3134c-devRS Operon in Mycobacterium tuberculosis: Implication in the Induction of DevR Target Genes

(2008) S. Chauhan et al.   JOURNAL OF BACTERIOLOGY