Fuzzy regions in an intrinsically disordered protein impair protein-protein interactions

Insights into the Hendra virus N TAIL –XD complex: Evidence for a parallel organization of the helical MoRE at the XD surface stabilized by a combination of hydrophobic and polar interactions

(2015) Jenny Erales et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Relating sequence encoded information to form and function of intrinsically disordered proteins

(2015) Rahul K Das et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structural disorder within paramyxoviral nucleoproteins

(2015) Sonia Longhi   FEBS LETTERS

Structural Disorder within Paramyxoviral Nucleoproteins and Phosphoproteins in Their Free and Bound Forms: From Predictions to Experimental Assessment

(2015) Johnny Habchi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Demonstration of a Folding after Binding Mechanism in the Recognition between the Measles Virus NTAIL and X Domains

(2014) Marion Dosnon et al.   ACS Chemical Biology

Dynamics of the Intrinsically Disordered C-Terminal Domain of the Nipah Virus Nucleoprotein and Interaction with the X Domain of the Phosphoprotein as Unveiled by NMR Spectroscopy

(2014) Lorenzo Baronti et al.   CHEMBIOCHEM

Introducing Protein Intrinsic Disorder

(2014) Johnny Habchi et al.   CHEMICAL REVIEWS

Molecular Basis for Structural Heterogeneity of an Intrinsically Disordered Protein Bound to a Partner by Combined ESI-IM-MS and Modeling

(2014) Annalisa D’Urzo et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

The Measles Virus Nucleocapsid Protein Tail Domain Is Dispensable for Viral Polymerase Recruitment and Activity

(2013) Stefanie A. Krumm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dissecting Partner Recognition by an Intrinsically Disordered Protein Using Descriptive Random Mutagenesis

(2013) Antoine Gruet et al.   JOURNAL OF MOLECULAR BIOLOGY

Remarkably Fast Coupled Folding and Binding of the Intrinsically Disordered Transactivation Domain of cMyb to CBP KIX

(2013) Sarah L. Shammas et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Folding and Binding of an Intrinsically Disordered Protein: Fast, but Not ‘Diffusion-Limited’

(2013) Joseph M. Rogers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP

(2013) Ruifeng Qi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Conformations of intrinsically disordered proteins are influenced by linear sequence distributions of oppositely charged residues

(2013) R. K. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiscaled exploration of coupled folding and binding of an intrinsically disordered molecular recognition element in measles virus nucleoprotein

(2013) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atomic Resolution Description of the Interaction between the Nucleoprotein and Phosphoprotein of Hendra Virus

(2013) Guillaume Communie et al.   PLoS Pathogens

Flexible-meccano: a tool for the generation of explicit ensemble descriptions of intrinsically disordered proteins and their associated experimental observables

(2012) V. Ozenne et al.   BIOINFORMATICS

Coupled Folding-Binding in a Hydrophobic/Polar Protein Model: Impact of Synergistic Folding and Disordered Flanks

(2012) Arnab Bhattacherjee et al.   BIOPHYSICAL JOURNAL

Assessing induced folding within the intrinsically disordered C-terminal domain of theHenipavirusnucleoproteins by site-directed spin labeling EPR spectroscopy

(2012) Marlène Martinho et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Electrostatically Accelerated Coupled Binding and Folding of Intrinsically Disordered Proteins

(2012) Debabani Ganguly et al.   JOURNAL OF MOLECULAR BIOLOGY

One-step generation of error-prone PCR libraries using Gateway® technology

(2012) Antoine Gruet et al.   Microbial Cell Factories

Fractional factorial approach combining 4 Escherichia coli strains, 3 culture media, 3 expression temperatures and 5 N-terminal fusion tags for screening the soluble expression of recombinant proteins

(2012) Christophe Noguère et al.   PROTEIN EXPRESSION AND PURIFICATION

Interaction between the C-terminal domains of measles virus nucleoprotein and phosphoprotein: A tight complex implying one binding site

(2012) David Blocquel et al.   PROTEIN SCIENCE

Characterization of the Interactions between the Nucleoprotein and the Phosphoprotein ofHenipavirus

(2011) Johnny Habchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetic Recognition of the Retinoblastoma Tumor Suppressor by a Specific Protein Target

(2011) Lucía B. Chemes et al.   JOURNAL OF MOLECULAR BIOLOGY

Compaction and binding properties of the intrinsically disordered C-terminal domain of Henipavirus nucleoprotein as unveiled by deletion studies

(2011) David Blocquel et al.   Molecular BioSystems

Fuzziness: linking regulation to protein dynamics

(2011) Monika Fuxreiter   Molecular BioSystems

Structural disorder within paramyxovirus nucleoproteins and phosphoproteins

(2011) Johnny Habchi et al.   Molecular BioSystems

Benchmarking a luciferase complementation assay for detecting protein complexes

(2011) Patricia Cassonnet et al.   NATURE METHODS

Intrinsic disorder in measles virus nucleocapsids

(2011) M. R. Jensen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic protein–DNA recognition: beyond what can be seen

(2011) Monika Fuxreiter et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Basic Helix−Loop−Helix Region of Human Neurogenin 1 Is a Monomeric Natively Unfolded Protein Which Forms a “Fuzzy” Complex upon DNA Binding

(2010) David Aguado-Llera et al.   BIOCHEMISTRY

Probing Structural Transitions in the Intrinsically Disordered C-Terminal Domain of the Measles Virus Nucleoprotein by Vibrational Spectroscopy of Cyanylated Cysteines

(2010) Connor G. Bischak et al.   BIOPHYSICAL JOURNAL

Conformational Analysis of the Partially Disordered Measles Virus NTAIL-XD Complex by SDSL EPR Spectroscopy

(2010) Aleh Kavalenka et al.   BIOPHYSICAL JOURNAL

Solution structure of the C-terminal X domain of the measles virus phosphoprotein and interaction with the intrinsically disordered C-terminal domain of the nucleoprotein

(2010) Stéphane Gely et al.   JOURNAL OF MOLECULAR RECOGNITION

Structural Disorder within Henipavirus Nucleoprotein and Phosphoprotein: From Predictions to Experimental Assessment

(2010) Johnny Habchi et al.   PLoS One

Net charge per residue modulates conformational ensembles of intrinsically disordered proteins

(2010) A. H. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Charge interactions can dominate the dimensions of intrinsically disordered proteins

(2010) S. Muller-Spath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interaction between the C-terminal domains of N and P proteins of measles virus investigated by NMR

(2009) Cedric Bernard et al.   FEBS LETTERS

Phosphorylated Intrinsically Disordered Region of FACT Masks Its Nucleosomal DNA Binding Elements

(2009) Yasuo Tsunaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High Local Concentration: A Fundamental Strategy of Life

(2009) Stefan Oehler et al.   JOURNAL OF MOLECULAR BIOLOGY

The Thymine−DNA Glycosylase Regulatory Domain: Residual Structure and DNA Binding†

(2008) Caroline Smet-Nocca et al.   BIOCHEMISTRY

Chromatin Condensing Functions of the Linker Histone C-Terminal Domain Are Mediated by Specific Amino Acid Composition and Intrinsic Protein Disorder†

(2008) Xu Lu et al.   BIOCHEMISTRY

Structure of the BH3 Domains from the p53-Inducible BH3-Only Proteins Noxa and Puma in Complex with Mcl-1

(2008) Catherine L. Day et al.   JOURNAL OF MOLECULAR BIOLOGY

Rapid one-step recombinational cloning

(2008) C. Fu et al.   NUCLEIC ACIDS RESEARCH

Mapping α-helical induced folding within the intrinsically disordered C-terminal domain of the measles virus nucleoprotein by site-directed spin-labeling EPR spectroscopy

(2008) Valérie Belle et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Fuzzy interactome: the limitations of models in molecular biology

(2008) Monika Fuxreiter et al.   TRENDS IN BIOCHEMICAL SCIENCES

Fuzzy complexes: polymorphism and structural disorder in protein–protein interactions

(2007) Peter Tompa et al.   TRENDS IN BIOCHEMICAL SCIENCES