Article
Endocrinology & Metabolism
M. S. A. M. Bevers, A. M. Daniels, B. van Rietbergen, P. P. M. M. Geusens, S. M. J. van Kuijk, S. Sassen, S. Kaarsemaker, P. F. W. Hannemann, M. Poeze, H. M. J. Janzing, J. P. van den Bergh, C. E. Wyers
Summary: By utilizing high-resolution peripheral quantitative computed tomography, this study examined changes in bone density, microstructure, and strength during the healing of conservatively-treated scaphoid fractures. The findings indicated a substantial decrease in bone density, trabecular thickness, and failure load during the initial 6 weeks of healing, followed by stabilization or increase in these parameters. However, at 26 weeks, these parameters had not returned to baseline levels.
Article
Biology
Dominik Saul, David G. Monroe, Jennifer L. Rowsey, Robyn Laura Kosinsky, Stephanie J. Vos, Madison L. Doolittle, Joshua N. Farr, Sundeep Khosla
Summary: Senescent cells and senescence-related secretory phenotype markers increase during fracture healing. Intermittent treatment with senolytics reduces senescence markers in the fracture callus and accelerates the time course of fracture healing.
Article
Biophysics
Manuela Ernst, Heiko Baumgartner, Stefan Doebele, Dankward Hoentzsch, Tim Pohlemann, Markus Windolf
Summary: This study aimed to investigate the feasibility of continuous implant load monitoring system in a clinical context. By monitoring ten patients treated with Taylor-Spatial-Frame external fixators, it was found that continuous measurement of implant load was indicative for the bone healing status.
JOURNAL OF BIOMECHANICS
(2021)
Article
Materials Science, Multidisciplinary
Yan Peng, Huaizhi Liu, Hao Peng, Jiuyang Zhang
Summary: Self-healing materials have long struggled to achieve both high mechanical strength and self-healing ability. This work successfully achieves self-repair in mechanically robust materials, inspired by biological self-healing. The mechanical performance and self-healing behavior of these materials can be precisely controlled through temperature and composition. An artificial bone-tissue system is created with bionic structure, effective self-healing, and high modulus.
Review
Biology
Elena Ortona, Maria Teresa Pagano, Lavinia Capossela, Walter Malorni
Summary: Fracture healing is a complex and long-term process influenced by various factors, including sex/gender disparity. Differences in bone healing between males and females are observed, and the role of sex hormones, inflammation, and estrogen-induced cellular processes are suggested to contribute to the delayed fracture repair in women. A better understanding of these factors could improve bone healing outcomes and mitigate sex/gender disparity.
Review
Endocrinology & Metabolism
Dominik Saul, Sundeep Khosla
Summary: More than 2.1 million age-related fractures occur in the United States annually, resulting in a significant socioeconomic burden. Age-related deterioration of bone structure is associated with impaired bone healing, which occurs in four stages: inflammation, angiogenesis and cartilage formation, soft callus development, and remodeling. Impaired fracture healing due to aging is related to detrimental changes at the cellular level, and recent studies show that clearing senescent cells enhances fracture repair.
Article
Biochemistry & Molecular Biology
Silvia Concetta Colucci, Cinzia Buccoliero, Lorenzo Sanesi, Mariella Errede, Graziana Colaianni, Tiziana Annese, Mohd Parvez Khan, Roberta Zerlotin, Manuela Dicarlo, Ernestina Schipani, Kenneth M. Kozloff, Maria Grano
Summary: The study found that irisin promotes bone formation and accelerates the fracture healing process, suggesting its potential use as a novel pharmacologic modulator.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Analytical
Angela Sorriento, Marcello Chiurazzi, Luca Fabbri, Michelangelo Scaglione, Paolo Dario, Gastone Ciuti
Summary: This study introduces a new system based on capacitive sensor technology to quantitatively measure relative pin displacements in bone fractures treated with external fixators, providing an objective and repeatable method. By utilizing smart arrangements of sensor units, it can detect movements of external pins in 3D space, giving valuable information about implant stability and bone callus stiffness.
Article
Critical Care Medicine
Davide Bizzoca, Giovanni Vicenti, Vincenzo Caiaffa, Antonella Abate, Oronzo De Carolis, Massimiliano Carrozzo, Giuseppe Solarino, Biagio Moretti
Summary: Fracture healing is a complex physiological process that relies on the interplay between biological and mechanical factors. Traditional imaging techniques are routinely used in orthopedic clinical practice but do not provide information on the biomechanical status of the fracture site. Recent advancements in non-invasive techniques and smart orthopedic implants have the potential to improve the assessment of fracture healing process and reduce patients' exposure to X-rays.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Article
Chemistry, Analytical
Benjamin Steven Vien, Wing Kong Chiu, Matthias Russ, Mark Fitzgerald
Summary: This study presents a clinical investigation on the associations between modal frequencies and musculoskeletal components of human legs using a prototype device based on vibration analysis. The findings suggest that specific frequencies are associated with femur length and are suitable for bone evaluation, while higher-order modes are associated with muscle and fat mass of the leg. Mathematical models are formulated to determine modal frequencies using measured leg components as variables.
Article
Medicine, General & Internal
Chul-Ho Kim, Dong Hwan Kim, Han-Vit Kang, Won Jun Kim, Minkyu Shin, Ji Wan Kim
Summary: Percutaneous intramedullary nailing is an effective technique for metacarpal fractures, but the fracture site and number of K-wires used can affect the time to achieve bone union.
Article
Medicine, General & Internal
Markus Windolf, Viktor Varjas, Dominic Gehweiler, Ronald Schwyn, Daniel Arens, Caroline Constant, Stephan Zeiter, Robert Geoff Richards, Manuela Ernst
Summary: The study aims to investigate the safety and performance of the Fracture Monitor device in animal models and explore the application of continuous implant load monitoring in assessing fracture healing. The results show that the sensor system can autonomously function for a certain period of time without any adverse effects. The relative implant loads at 4 and 8 weeks post-operation are significantly correlated with radiographic scores and normalized bone volume metrics.
MEDICINA-LITHUANIA
(2022)
Article
Biology
Kai Sun, Chun Wang, Jianqiu Xiao, Michael D. Brodt, Luorongxin Yuan, Tong Yang, Yael Alippe, Huimin Hu, Dingjun Hao, Yousef Abu-Amer, Matthew J. Silva, Jie Shen, Gabriel Mbalaviele
Summary: Amino-terminal fragments of proteolytically cleaved GSDMs form plasma membrane pores, leading to pyroptosis. GSDMD and GSDME play roles in bone microenvironment and contribute to fracture healing. Both GSDMD and GSDME regulate inflammatory responses through the GSDM-IL-1 axis, promoting bone healing after fracture.
Review
Chemistry, Analytical
Sahar Hassani, Mohsen Mousavi, Amir H. Gandomi
Summary: This study provides a comprehensive review of the history and development of damage-detection methods in composite structures. It emphasizes the importance of early damage detection to prevent catastrophic events and discusses various testing techniques and vibration-based methods. The study also highlights the use of advanced signal processing, machine learning, and deep learning in solving damage-detection problems. Additionally, it focuses on the application of smart composites and concludes with suggestions for future work.
Article
Engineering, Multidisciplinary
Clarisse Aujoux, Olivier Mesnil
Summary: This paper focuses on the environmental assessment of guided wave-based structural health monitoring (GW-SHM). Two prospective applications, railroad monitoring and wind turbine monitoring, are studied, and a complete GW-SHM system prototype is defined to quantify its environmental impact. The study finds that the system is either carbon neutral or carbon negative for the considered functional units.
STRUCTURAL HEALTH MONITORING-AN INTERNATIONAL JOURNAL
(2023)
Article
Clinical Neurology
Zelia K. Chiu, Iwan E. Bennett, Patrick Chan, Jeffrey V. Rosenfeld
JOURNAL OF CLINICAL NEUROSCIENCE
(2016)
Article
Construction & Building Technology
W. H. Ong, W. K. Chiu, M. Russ, Z. K. Chiu
STRUCTURAL CONTROL & HEALTH MONITORING
(2016)
Proceedings Paper
Engineering, Multidisciplinary
Wern Hann Ong, Wing Kong Chiu, Matthias Russ, Zelia Karmen Chiu
STRUCTURAL HEALTH MONITORING 2015: SYSTEM RELIABILITY FOR VERIFICATION AND IMPLEMENTATION, VOLS. 1 AND 2
(2015)
