Intestinal Flora is a Key Factor in Insulin Resistance and Contributes to the Development of Polycystic Ovary Syndrome

Obese adolescents with PCOS have altered biodiversity and relative abundance in gastrointestinal microbiota

(2020) Beza Jobira et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Letrozole treatment of adult female mice results in a similar reproductive phenotype but distinct changes in metabolism and the gut microbiome compared to pubertal mice

(2019) Pedro J. Torres et al.   BMC MICROBIOLOGY

Probiotic Bifidobacterium lactis V9 Regulates the Secretion of Sex Hormones in Polycystic Ovary Syndrome Patients through the Gut-Brain Axis

(2019) Jiachao Zhang et al.   mSystems

Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome

(2019) Xinyu Qi et al.   NATURE MEDICINE

Gut Microbiota and the Polycystic Ovary Syndrome: Influence of Sex, Sex Hormones, and Obesity

(2018) María Insenser et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment

(2018) Héctor F. Escobar-Morreale   Nature Reviews Endocrinology

Polycystic ovary syndrome, androgen excess, and the risk of nonalcoholic fatty liver disease in women: A longitudinal study based on a United Kingdom primary care database

(2018) Balachandran Kumarendran et al.   PLOS MEDICINE

An update of genetic basis of PCOS pathogenesis

(2018) Raiane P. Crespo et al.   Archives of Endocrinology Metabolism

Polycystic ovary syndrome and the risk of cardiometabolic complications in longitudinal studies

(2018) Małgorzata Jacewicz-Święcka et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Regional variation limits applications of healthy gut microbiome reference ranges and disease models

(2018) Yan He et al.   NATURE MEDICINE

The Polycystic Ovary Syndrome and the Metabolic Syndrome: A Possible Chronobiotic-Cytoprotective Adjuvant Therapy

(2018) Eduardo Spinedi et al.   International Journal of Endocrinology

Bile Acids Activated Receptors Regulate Innate Immunity

(2018) Stefano Fiorucci et al.   Frontiers in Immunology

Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

(2018) Lulu Sun et al.   NATURE MEDICINE

Hyperandrogenemia Induced by Letrozole Treatment of Pubertal Female Mice Results in Hyperinsulinemia Prior to Weight Gain and Insulin Resistance

(2017) Danalea V Skarra et al.   ENDOCRINOLOGY

The Pathogenesis of Polycystic Ovary Syndrome (PCOS): The Hypothesis of PCOS as Functional Ovarian Hyperandrogenism Revisited

(2016) Robert L. Rosenfield et al.   ENDOCRINE REVIEWS

The effect of heritability and host genetics on the gut microbiota and metabolic syndrome

(2016) Mi Young Lim et al.   GUT

Human gut microbes impact host serum metabolome and insulin sensitivity

(2016) Helle Krogh Pedersen et al.   NATURE

Diet–microbiota interactions as moderators of human metabolism

(2016) Justin L. Sonnenburg et al.   NATURE

The role of AMH in the pathophysiology of polycystic ovarian syndrome

(2016) Deepika Garg et al.   REPRODUCTIVE BIOMEDICINE ONLINE

A Novel Letrozole Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice1

(2015) Alexander S. Kauffman et al.   BIOLOGY OF REPRODUCTION

Alteration of gut microbiota by vancomycin and bacitracin improves insulin resistance via glucagon-like peptide 1 in diet-induced obesity

(2015) Injae Hwang et al.   FASEB JOURNAL

DHEA, DHEAS and PCOS

(2015) Mark O. Goodarzi et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

The post-translational regulation of 17,20 lyase activity

(2015) Walter L. Miller et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Stability of operational taxonomic units: an important but neglected property for analyzing microbial diversity

(2015) Yan He et al.   Microbiome

Microbial Modulation of Insulin Sensitivity

(2014) Muhammad Tanweer Khan et al.   Cell Metabolism

Microbiota Modification with Probiotics Induces Hepatic Bile Acid Synthesis via Downregulation of the Fxr-Fgf15 Axis in Mice

(2014) Chiara Degirolamo et al.   Cell Reports

The Role and Influence of Gut Microbiota in Pathogenesis and Management of Obesity and Metabolic Syndrome

(2014) Parth J. Parekh et al.   Frontiers in Endocrinology

Obesity-Induced Infertility and Hyperandrogenism Are Corrected by Deletion of the Insulin Receptor in the Ovarian Theca Cell

(2013) S. Wu et al.   DIABETES

Cancer risk and PCOS

(2013) Daniel A. Dumesic et al.   STEROIDS

Insulin Resistance and the Polycystic Ovary Syndrome Revisited: An Update on Mechanisms and Implications

(2012) Evanthia Diamanti-Kandarakis et al.   ENDOCRINE REVIEWS

FXR signaling in the enterohepatic system

(2012) Tsutomu Matsubara et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease

(2011) R. M. Gadaleta et al.   GUT

An improved Greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of bacteria and archaea

(2011) Daniel McDonald et al.   ISME Journal

FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis

(2011) S. Kir et al.   SCIENCE

Search and clustering orders of magnitude faster than BLAST

(2010) Robert C. Edgar   BIOINFORMATICS

QIIME allows analysis of high-throughput community sequencing data

(2010) J Gregory Caporaso et al.   NATURE METHODS

FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats

(2009) Sabrina Cipriani et al.   JOURNAL OF LIPID RESEARCH

Retinol-Binding Protein 4 and Insulin Resistance in Polycystic Ovary Syndrome

(2008) S. K. Hutchison et al.   DIABETES CARE