Article
Immunology
Vanessa de Carvalho Oliveira, Olga Tatsiy, Patrick. P. P. McDonald
Summary: Neutrophil extracellular traps (NETs) can immobilize and kill pathogens, but also contribute to inflammatory and autoimmune diseases as well as cancer. The PI3K signaling pathway is crucial for NET formation, but the specific components involved are not well understood. This study identified the PI3K isoforms and signaling partners activated in response to different physiological NET inducers. The data revealed complexity and redundancy in the PI3K pathway controlling NET formation and suggest therapeutic targets for diseases involving NETs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Samo Pirnat, Mico Bozic, Dorian Dolanc, Anemari Horvat, Petra Tavcar, Nina Vardjan, Alexei Verkhratsky, Robert Zorec, Matjaz Stenovec
Summary: The plasticity of astrocytes is crucial for maintaining homeostasis in the central nervous system and varies under different environmental conditions, affecting vesicle dynamics and intracellular calcium signaling. Astrocytes in arborized morphology show altered vesicle dynamics with increased [Ca2+] and subcellular heterogeneity, while cAMP signaling remains stable.
Article
Food Science & Technology
Jing Wang, Meiling Fan, Shuhe Yin, Xiaohao Xu, Baoyu Fu, Rui Jiang, Liwei Sun
Summary: The research shows that ginseng oligosaccharide extract (GSO) has the potential for clinical treatment in alleviating allergies by inhibiting multiple immune response pathways.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Agriculture, Multidisciplinary
Nguyen Minh Trang, Eun-Nam Kim, Thi Hoa Pham, Gil-Saeng Jeong
Summary: Osteoporosis and Alzheimer's disease are common types of dementia in seniors, and they share common risk factors. Previous studies have shown that individuals with osteoporosis are more susceptible to Alzheimer's disease. Citropten, a compound found in Citrus aurantifolia, has various pharmacological activities, and this study reveals its potential in suppressing osteoclastogenesis through Aβ regulation. The findings suggest that citropten is a potential candidate for treating osteoclastogenesis-related diseases.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Reproductive Biology
Dong-Dong Gao, Chong-Feng Lan, Xiao-Nian Cao, Lei Chen, Tian-Lun Lei, Lei Peng, Jia-Wen Xu, Zhuo-Er Qiu, Long-Long Wang, Qing Sun, Zi-Yang Huang, Yun-Xin Zhu, Wen-Liang Zhou, Yi-Lin Zhang
Summary: In this study, it was found that GPER is expressed at the acrosome and mid-flagellum of mouse sperm. Activation of GPER triggers an increase in intracellular Ca2+ concentration in mouse sperm through PLC-dependent Ca2+ mobilization and CatSper-mediated Ca2+ influx, which promotes the acrosome reaction of mouse sperm.
BIOLOGY OF REPRODUCTION
(2022)
Article
Food Science & Technology
Yan-qi Yang, Rui-fang Sun, Pan Ge, Wen-Xing Li, Xiang Zhang, Jian Zhang, Lu Ye, Nan Zhang, Si-yu Wang, Mo-qi Lv, Dang-xia Zhou
Summary: This study reveals that formaldehyde exposure reduces sperm quality and inhibits spermatogenesis in rats. The down-regulation of GRPR and suppression of Ca2+ concentration in spermatogenic cells contribute to the mechanisms behind formaldehyde-induced male infertility.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Multidisciplinary Sciences
Ya-nan Deng, Hamdy Kashtoh, Quan Wang, Guang-xiao Zhen, Qi-yu Li, Ling-hui Tang, Hai-long Gao, Chun-rui Zhang, Li Qin, Min Su, Fei Li, Xia-he Huang, Ying-chun Wang, Qi Xie, Oliver B. Clarke, Wayne A. Hendrickson, Yu-hang Chen
Summary: Stomata in leaves regulate gas exchange between the plant and its atmosphere. Phosphorylation of SLAC1 fine-tunes an equilibrium between basal and activated states, controlling the degree of stomatal opening. Cryo-EM analysis revealed structural features of SLAC1 that help understand its functional mechanism.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Miguel Angel Sarabia-Sanchez, Angela Patricia Moreno-Londono, Maria Cristina Castaneda-Patlan, Eduardo Alvarado-Ortiz, Juan Carlos Martinez-Morales, Martha Robles-Flores
Summary: Cancer stem cells (CSCs) play a crucial role in tumor growth, chemoresistance, and metastasis. The non-canonical Wnt signaling pathway is found to be important for the functions of CSCs in colon cancer. Activation of the Wnt/Ca2+ signaling axis by Wnt3a and Wnt5a promotes sphere formation and proliferation of CSCs, independent of β-catenin-dependent transcription.
FRONTIERS IN ONCOLOGY
(2023)
Article
Neurosciences
Silas E. Busch, Dana H. Simmons, Eric Gama, Xiaofei Du, Francesco Longo, Christopher M. Gomez, Eric Klann, Christian Hansel
Summary: Cyfip1 is a candidate gene for autism and is located on chromosome 15q11-13, which is associated with copy number variations in autism. It interacts with the FMRP protein and plays a role in translation regulation. Overexpression of Cyfip1 in mice increases the localization of the NRXN1 protein at synaptic sites and enhances synaptic transmission. This study demonstrates that Cyfip1 overexpression shares similar phenotypes with an increased number of non-overlapping genes on chromosome 15q11-13.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Editorial Material
Microbiology
R. Gary Sawers
Summary: Current evidence suggests a clear link between Ca2+ signaling in bacteria and membrane potential as well as mechanosensation. A recent study identified genes associated with Ca2+ signaling, outer membrane biogenesis, proton motive force, and DNA damage, revealing implications for electrophysiological communication between bacteria and their environment.
JOURNAL OF BACTERIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Veronica Costiniti, Guilherme H. S. Bomfim, Maria Neginskaya, Ga-Yeon Son, Erna Mitaishvili, Marta Giacomello, Evgeny Pavlov, Rodrigo S. Lacruz
Summary: This study analyzed the functional features of mitochondria in rat ameloblasts and found an increased mitochondrial Ca2+ handling in the maturation stage, particularly in response to Ca2+ influx via store-operated Ca2+ entry (SOCE). These findings provide insights into the role of mitochondria in enamel and suggest that SOCE and mitochondrial Ca2+ uptake are complementary processes in biological mineralization.
Article
Pharmacology & Pharmacy
Zhenni Liu, Xue Wu, Qi Wang, Zixuan Li, Xueqi Liu, Xiaodong Sheng, Hong Zhu, Mengda Zhang, Junrui Xu, Xiaowen Feng, Baoming Wu, Xiongwen Lv
Summary: The CD73-A(1)R axis can regulate the activation and apoptosis of HSCs through the PLC-IP3-Ca2+/DAG-PKC signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Michael S. Schappe, Marta E. Stremska, Gregory W. Busey, Taylor K. Downs, Philip Seegren, Suresh K. Mendu, Zachary Flegal, Catherine A. Doyle, Eric J. Stipes, Bimal N. Desai
Summary: Efficient clearance of apoptotic cells is crucial for various fields, but the signaling pathways involved are not well understood. A siRNA screen identified TRPM7 as an essential calcium ion channel in the process of efferocytosis. TRPM7-mediated cationic current is necessary for maintaining phagosomal acidification.
NATURE COMMUNICATIONS
(2022)
Article
Reproductive Biology
Li-Ming Yuan, Yun-Lei Chen, Xin-Huai Shi, Xiao-Xue Wu, Xin-Jie Liu, Su-Ping Liu, Ning Chen, Wu-Jia-Fu Sai
Summary: Phospholipase C zeta (PLC) is an important inducer of Ca2+ oscillations in mammalian sperm. This study constructed an early embryonic Ca2+ fluctuation model using PLC from sheep sperm. The results showed that both the PLC and ionomycin combined with 6-DMAP activation methods induced sheep oocyte parthenogenetic activation and early embryonic development. However, the cleavage rate and blastocyst rate were higher in the ionomycin combined with 6-DMAP group compared to the PLC group.
Article
Biology
Salah A. Baker, Wesley A. Leigh, Guillermo Del Valle, Inigo F. De Yturriaga, Sean M. Ward, Caroline A. Cobine, Bernard T. Drumm, Kenton M. Sanders
Summary: Interstitial cells of Cajal (ICC) produce pacemaker activity that is responsible for rhythmic contractions in colon, while ICC along the submucosal border (ICC-SM) contribute to more complex patterns of colonic motility. Our study demonstrates how ICC-SM exhibit rhythmic firing of Ca2+ transients, which play a crucial role in driving smooth muscle activity and overall colonic contractions. This intricate process is organized and dependent on specific Ca2+ channels, highlighting the complexity of colonic pacemaker ICC-SM function.
Article
Pharmacology & Pharmacy
Harry Z. E. Greenberg, Kazi S. Jahan, Jian Shi, W. -S. Vanessa Ho, Anthony P. Albert
EUROPEAN JOURNAL OF PHARMACOLOGY
(2016)
Article
Neurosciences
Jian Shi, Francesc Miralles, Lutz Birnbaumer, William A. Large, Anthony P. Albert
JOURNAL OF PHYSIOLOGY-LONDON
(2017)
Article
Pharmacology & Pharmacy
Harry Z. E. Greenberg, Simonette R. E. Carlton-Carew, Dhanak M. Khan, Alexander K. Zargaran, Kazi S. Jahan, W-S. Vanessa Ho, Anthony P. Albert
VASCULAR PHARMACOLOGY
(2017)
Review
Cell Biology
Miguel A. S. Martin-Aragon Baudel, Jian Shi, William A. Large, Anthony P. Albert
Article
Neurosciences
Miguel A. S. Martin-Aragon Baudel, Jian Shi, William A. Large, Anthony P. Albert
JOURNAL OF PHYSIOLOGY-LONDON
(2020)
Article
Pharmacology & Pharmacy
Kazi S. Jahan, Jian Shi, Harry Z. E. Greenberg, Sam Khavandi, Miguel Martin-Aragon Baudel, Vincenzo Barrese, Iain A. Greenwood, Anthony P. Albert
VASCULAR PHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Elif Damla Arisan, Ozge Rencuzogullari, Clara Cieza-Borrella, Francesc Miralles Arenas, Miriam Dwek, Sigrun Lange, Pinar Uysal-Onganer
Summary: miR-21 plays a critical role in the mesenchymal transition in metastatic breast cancer cells, with its knockout leading to a decrease in mesenchymal markers and alterations in the Wnt-11 related signaling axis. Its expression is associated with an increase in mesenchymal markers and influences the release of extracellular vesicles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Maria Mortoglou, Francesc Miralles, Elif Damla Arisan, Alwyn Dart, Stipo Jurcevic, Sigrun Lange, Pinar Uysal-Onganer
Summary: This study investigated the role of miR-21 in cancer stem cells (CSCs) and its association with the aggressiveness of PDAC. Knockout of miR-21 resulted in reversed expressions of CSC markers and suppressed cellular invasion and proliferation. These findings suggest that miR-21 is involved in the stemness of PDAC cells, may play roles in mesenchymal transition, and serves as a novel functional biomarker for PDAC aggressiveness.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ella Rimmer, Sadaf Rashid, Igor Kraev, Francesc Miralles, Androulla Elia
Summary: Pancreatic cancer cells release extracellular vesicles that confer resistance to gemcitabine and TRAIL treatment. Removal of these vesicles during treatment may improve the response of pancreatic cancer cells to gemcitabine and TRAIL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Hong Doan, Alexander Parsons, Shruthi Devkumar, Jogitha Selvarajah, Francesc Miralles, Veronica A. Carroll
Article
Biochemistry & Molecular Biology
Jian Shi, Francesc Miralles, Jean-Pierre Kinet, Lutz Birnbaumer, William A. Large, Anthony P. Albert
Article
Biochemistry & Molecular Biology
Yeon-Joo Kim, Daniel P. S. Osborn, Ji-Young Lee, Masatake Araki, Kimi Araki, Timothy Mohun, Johanna Kansakoski, Nina Brandstack, Hyun-Taek Kim, Francesc Miralles, Cheol-Hee Kim, Nigel A. Brow, Hyung-Goo Kim, Juan Pedro Martinez-Barbera, Paris Ataliotis, Taneli Raivio, Lawrence C. Layman, Soo-Hyun Kim