Mechanism of transcription initiation and primer generation at the mitochondrial replication origin OriL

Mammalian mitochondrial DNA replication and mechanisms of deletion formation

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Copy-choice recombination during mitochondrial L-strand synthesis causes DNA deletions

(2019) Örjan Persson et al.   Nature Communications

Single-Molecule Analysis of mtDNA Replication Uncovers the Basis of the Common Deletion

(2017) Aaron F. Phillips et al.   MOLECULAR CELL

A model for transcription initiation in human mitochondria

(2015) Yaroslav I. Morozov et al.   NUCLEIC ACIDS RESEARCH

Regulation of DNA replication at the end of the mitochondrial D-loop involves the helicase TWINKLE and a conserved sequence element

(2015) Elisabeth Jemt et al.   NUCLEIC ACIDS RESEARCH

Replication-transcription switch in human mitochondria

(2015) K. Agaronyan et al.   SCIENCE

In D-loop: 40years of mitochondrial 7S DNA

(2014) Thomas J. Nicholls et al.   EXPERIMENTAL GERONTOLOGY

A novel intermediate in transcription initiation by human mitochondrial RNA polymerase

(2014) Yaroslav I. Morozov et al.   NUCLEIC ACIDS RESEARCH

In Vivo Occupancy of Mitochondrial Single-Stranded DNA Binding Protein Supports the Strand Displacement Mode of DNA Replication

(2014) Javier Miralles Fusté et al.   PLoS Genetics

TWINKLE is an essential mitochondrial helicase required for synthesis of nascent D-loop strands and complete mtDNA replication

(2013) D. Milenkovic et al.   HUMAN MOLECULAR GENETICS

Structure of human mitochondrial RNA polymerase elongation complex

(2013) Kathrin Schwinghammer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

In vivo mutagenesis reveals that OriL is essential for mitochondrial DNA replication

(2012) Sjoerd Wanrooij et al.   EMBO REPORTS

Human Mitochondrial DNA Helicase TWINKLE Is Both an Unwinding and Annealing Helicase

(2012) Doyel Sen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A hybrid G-quadruplex structure formed between RNA and DNA explains the extraordinary stability of the mitochondrial R-loop

(2012) P. H. Wanrooij et al.   NUCLEIC ACIDS RESEARCH

Structure of human mitochondrial RNA polymerase

(2011) Rieke Ringel et al.   NATURE

The mitochondrial DNA helicase TWINKLE can assemble on a closed circular template and support initiation of DNA synthesis

(2011) Elisabeth Jemt et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial RNA Polymerase Is Needed for Activation of the Origin of Light-Strand DNA Replication

(2010) Javier Miralles Fusté et al.   MOLECULAR CELL

G-quadruplex structures in RNA stimulate mitochondrial transcription termination and primer formation

(2010) P. H. Wanrooij et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TFB2 Is a Transient Component of the Catalytic Site of the Human Mitochondrial RNA Polymerase

(2009) Marina Sologub et al.   CELL

Structural Insight into Processive Human Mitochondrial DNA Synthesis and Disease-Related Polymerase Mutations

(2009) Young-Sam Lee et al.   CELL

Maintenance of RNA-DNA Hybrid Length in Bacterial RNA Polymerases

(2009) Tatyana Kent et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple Functions of Yeast Mitochondrial Transcription Factor Mtf1p during Initiation

(2009) Maria Savkina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human mitochondrial RNA polymerase primes lagging-strand DNA synthesis in vitro

(2008) S. Wanrooij et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA