Up-regulation of the mammalian target of rapamycin complex 1 subunit Raptor by aldosterone induces abnormal pulmonary artery smooth muscle cell survival patterns to promote pulmonary arterial hypertension

Estradiol improves right ventricular function in rats with severe angioproliferative pulmonary hypertension: effects of endogenous and exogenous sex hormones

(2015) Andrea L. Frump et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

A Sex-Specific MicroRNA-96/5-Hydroxytryptamine 1B Axis Influences Development of Pulmonary Hypertension

(2015) Emma Wallace et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Key mediators of intracellular amino acids signaling to mTORC1 activation

(2015) Yehui Duan et al.   AMINO ACIDS

Rapamycin Attenuates Aldosterone-Induced Tubulointerstitial Inflammation and Fibrosis

(2015) Bin Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Emerging Concepts in the Molecular Basis of Pulmonary Arterial Hypertension: Part II: Neurohormonal Signaling Contributes to the Pulmonary Vascular and Right Ventricular Pathophenotype of Pulmonary Arterial Hypertension

(2015) B. A. Maron et al.   CIRCULATION

Endothelial-to-Mesenchymal Transition in Pulmonary Hypertension

(2015) B. Ranchoux et al.   CIRCULATION

Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension

(2015) K. White et al.   EMBO Molecular Medicine

Mammalian target of rapamycin overexpression antagonizes chronic hypoxia-triggered pulmonary arterial hypertension via the autophagic pathway

(2015) LINGXIA LI et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Lipid nanoparticle delivery of a microRNA-145 inhibitor improves experimental pulmonary hypertension

(2015) Jared M. McLendon et al.   JOURNAL OF CONTROLLED RELEASE

High Mobility Group Box 1 Induced Human Lung Myofibroblasts Differentiation and Enhanced Migration by Activation of MMP-9

(2015) Chen-Chen Lee et al.   PLoS One

Overnutrition, mTOR signaling, and cardiovascular diseases

(2014) Guanghong Jia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Wnt5a-Induced Wnt1-Inducible Secreted Protein-1 Suppresses Vascular Smooth Muscle Cell Apoptosis Induced by Oxidative Stress

(2014) Carina Mill et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Upregulation of Steroidogenic Acute Regulatory Protein by Hypoxia Stimulates Aldosterone Synthesis in Pulmonary Artery Endothelial Cells to Promote Pulmonary Vascular Fibrosis

(2014) Bradley A. Maron et al.   CIRCULATION

Resveratrol Induces Vascular Smooth Muscle Cell Differentiation through Stimulation of SirT1 and AMPK

(2014) Anne Marie Thompson et al.   PLoS One

MicroRNA Expression Profile of Pulmonary Artery Smooth Muscle Cells and the Effect of Let-7d in Chronic Thromboembolic Pulmonary Hypertension

(2014) Lei Wang et al.   Pulmonary Circulation

Everolimus in Patients with Severe Pulmonary Hypertension: A Safety and Efficacy Pilot Trial

(2014) Hans-Jürgen Seyfarth et al.   Pulmonary Circulation

Mineralocorticoid receptor antagonism attenuates experimental pulmonary hypertension

(2013) Ioana R. Preston et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Mammalian Target of Rapamycin Complex 2 (mTORC2) Coordinates Pulmonary Artery Smooth Muscle Cell Metabolism, Proliferation, and Survival in Pulmonary Arterial Hypertension

(2013) Dmitry A. Goncharov et al.   CIRCULATION

Amino Acids Activate Mammalian Target of Rapamycin (mTOR) Complex 1 without Changing Rag GTPase Guanyl Nucleotide Charging

(2013) Noriko Oshiro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The PI3K/AKT/mTOR Signaling Pathway Is Overactivated in Primary Aldosteronism

(2013) Hengchuan Su et al.   PLoS One

Aldosterone Inactivates the Endothelin-B Receptor via a Cysteinyl Thiol Redox Switch to Decrease Pulmonary Endothelial Nitric Oxide Levels and Modulate Pulmonary Arterial Hypertension

(2012) Bradley A. Maron et al.   CIRCULATION

Dynamin-Related Protein 1–Mediated Mitochondrial Mitotic Fission Permits Hyperproliferation of Vascular Smooth Muscle Cells and Offers a Novel Therapeutic Target in Pulmonary Hypertension

(2012) Glenn Marsboom et al.   CIRCULATION RESEARCH

Plasma aldosterone levels are elevated in patients with pulmonary arterial hypertension in the absence of left ventricular heart failure: a pilot study

(2012) Bradley A. Maron et al.   EUROPEAN JOURNAL OF HEART FAILURE

Aldosterone Modulates Endothelial Permeability and Endothelial Nitric Oxide Synthase Activity by Rearrangement of the Actin Cytoskeleton

(2012) Torsten Kirsch et al.   HYPERTENSION

Plexiform vasculopathy of severe pulmonary arterial hypertension and microRNA expression

(2012) Clemens L. Bockmeyer et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Aldosterone Induces Vascular Insulin Resistance by Increasing Insulin-Like Growth Factor-1 Receptor and Hybrid Receptor

(2011) Shamshad J. Sherajee et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Formation of Plexiform Lesions in Experimental Severe Pulmonary Arterial Hypertension

(2010) Kohtaro Abe et al.   CIRCULATION

Mammalian Target of Rapamycin (mTOR): Conducting the Cellular Signaling Symphony

(2010) Kathryn G. Foster et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

(2010) Shomit Sengupta et al.   MOLECULAR CELL

The Association of AMPK with ULK1 Regulates Autophagy

(2010) Jong Woo Lee et al.   PLoS One

Aldosterone blockade by Spironolactone improves the hypertensive vascular hypertrophy and remodeling in angiotensin II overproducing transgenic mice

(2009) Sachiko Sakurabayashi-Kitade et al.   ATHEROSCLEROSIS

Ambrisentan for the Treatment of Pulmonary Arterial Hypertension

(2008) Nazzareno Galiè et al.   CIRCULATION

The magnitude and temporal dependence of apoptosis early after myocardial ischemia with or without reperfusion

(2008) Christopher J. French et al.   FASEB JOURNAL

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE