Genetic impairments in folate enzymes increase dependence on dietary choline for phosphatidylcholine production at the expense of betaine synthesis

Methionine synthase A2756G variation is associated with the risk of retinoblastoma in Iranian children

(2015) Mohammad Taghi Akbari et al.   Cancer Epidemiology

Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort

(2015) Matt J. Silver et al.   FASEB JOURNAL

Choline intakes exceeding recommendations during human lactation improve breast milk choline content by increasing PEMT pathway metabolites

(2015) Crystal Davenport et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Identification of new genetic polymorphisms that alter the dietary requirement for choline and vary in their distribution across ethnic and racial groups

(2014) Kerry-Ann da Costa et al.   FASEB JOURNAL

Maternal choline supplementation: a nutritional approach for improving offspring health?

(2014) Xinyin Jiang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Choline intake influences phosphatidylcholine DHA enrichment in nonpregnant women but not in pregnant women in the third trimester

(2013) Allyson A West et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Pregnancy alters choline dynamics: results of a randomized trial using stable isotope methodology in pregnant and nonpregnant women

(2013) Jian Yan et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Choline Inadequacy Impairs Trophoblast Function and Vascularization in Cultured Human Placental Trophoblasts

(2013) Xinyin Jiang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans

(2012) Jian Yan et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Maternal choline intake alters the epigenetic state of fetal cortisol-regulating genes in humans

(2012) Xinyin Jiang et al.   FASEB JOURNAL

Folate Intake, Mthfr Genotype, and Sex Modulate Choline Metabolism in Mice

(2011) Tina W. Chew et al.   JOURNAL OF NUTRITION

MTHFR C677T genotype influences the isotopic enrichment of one-carbon metabolites in folate-compromised men consuming d9-choline

(2010) Jian Yan et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Molecular genetic analysis of the gene encoding the trifunctional enzyme MTHFD (methylenetetrahydrofolate-dehydrogenase, methenyltetrahydrofolate-cyclohydrolase, formyltetrahydrofolate synthetase) in patients with neural tube defects

(2010) Frans A Hol et al.   CLINICAL GENETICS

Specificity and rate of human and mouse liver and plasma phosphatidylcholine synthesis analyzed in vivo

(2010) Christopher J. Pynn et al.   JOURNAL OF LIPID RESEARCH

118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects

(2009) Gary M Shaw et al.   BMC Medical Genetics

Dietary omega 3 fatty acids and the developing brain

(2008) Sheila M. Innis   BRAIN RESEARCH

The MTHFD1 p.Arg653Gln variant alters enzyme function and increases risk for congenital heart defects

(2008) Karen E. Christensen et al.   HUMAN MUTATION