Structure-dynamic basis of splicing-dependent regulation in tissue-specific variants of the sodium-calcium exchanger

Structure-dynamic determinants governing a mode of regulatory response and propagation of allosteric signal in splice variants of Na+/Ca2+exchange (NCX) proteins

(2015) Moshe Giladi et al.   BIOCHEMICAL JOURNAL

How do disordered regions achieve comparable functions to structured domains?

(2015) Natasha S. Latysheva et al.   PROTEIN SCIENCE

The role of reorganization energy in rational enzyme design

(2014) Monika Fuxreiter et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Controlling entropy to tune the functions of intrinsically disordered regions

(2014) Tilman Flock et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

A Unified View of “How Allostery Works”

(2014) Chung-Jung Tsai et al.   PLoS Computational Biology

Alternative splicing of intrinsically disordered regions and rewiring of protein interactions

(2013) Marija Buljan et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Population Shift Underlies Ca2+-induced Regulatory Transitions in the Sodium-Calcium Exchanger (NCX)

(2013) Moshe Giladi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The SLC8 gene family of sodium–calcium exchangers (NCX) – Structure, function, and regulation in health and disease

(2013) Daniel Khananshvili   MOLECULAR ASPECTS OF MEDICINE

Sodium-calcium exchangers (NCX): molecular hallmarks underlying the tissue-specific and systemic functions

(2013) Daniel Khananshvili   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Expansion of the mutually exclusive spliced exome in Drosophila

(2013) Klas Hatje et al.   Nature Communications

G503 Is Obligatory for Coupling of Regulatory Domains in NCX Proteins

(2012) Moshe Giladi et al.   BIOCHEMISTRY

Dynamic features of allosteric Ca2+ sensor in tissue-specific NCX variants

(2012) Moshe Giladi et al.   CELL CALCIUM

Structural mass spectrometry in biologics discovery: advances and future trends

(2012) Jingjie Mo et al.   DRUG DISCOVERY TODAY

Structural Arrangement of the Intracellular Ca2+Binding Domains of the Cardiac Na+/Ca2+Exchanger (NCX1.1)

(2012) Mrinalini Dixit et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Common Ca2+-Driven Interdomain Module Governs Eukaryotic NCX Regulation

(2012) Moshe Giladi et al.   PLoS One

Versatility from Protein Disorder

(2012) M. M. Babu et al.   SCIENCE

Proton-sensing Ca2+Binding Domains Regulate the Cardiac Na+/Ca2+Exchanger

(2011) Liron Boyman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ca2+Binding Alters the Interdomain Flexibility between the Two Cytoplasmic Calcium-binding Domains in the Na+/Ca2+Exchanger

(2011) Roberto K. Salinas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ca2+-dependent structural rearrangements within Na+-Ca2+ exchanger dimers

(2011) S. A. John et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interactions between Ca2+binding domains of the Na+-Ca2+exchanger and secondary regulation

(2010) Michela Ottolia et al.   Channels

Hydrogen exchange mass spectrometry for studying protein structure and dynamics

(2010) Lars Konermann et al.   CHEMICAL SOCIETY REVIEWS

Essential Role of the CBD1-CBD2 Linker in Slow Dissociation of Ca2+from the Regulatory Two-domain Tandem of NCX1

(2010) Moshe Giladi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding of calcium is sensed structurally and dynamically throughout the second calcium-binding domain of the sodium/calcium exchanger

(2010) Vincent Breukels et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Roles of Two Ca2+-binding Domains in Regulation of the Cardiac Na+-Ca2+Exchanger

(2009) Michela Ottolia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetic and Equilibrium Properties of Regulatory Calcium Sensors of NCX1 Protein

(2009) Liron Boyman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of CBD2 from the Drosophila Na+/Ca2+ Exchanger: Diversity of Ca2+ Regulation and Its Alternative Splicing Modification

(2009) Mousheng Wu et al.   JOURNAL OF MOLECULAR BIOLOGY

Ca2+ regulation in the Na+/Ca2+ exchanger features a dual electrostatic switch mechanism

(2009) M. Hilge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

What regulates Na+/Ca2+ exchange? Focus on “Sodium-dependent inactivation of sodium/calcium exchange in transfected Chinese hamster ovary cells”

(2008) Larry Hryshko   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY