Article
Plant Sciences
Runqiang Liu, Jingchong Li, Lei Zhang, Ta Feng, Zhiyong Zhang, Baohong Zhang
Summary: Difenoconazole exposure inhibits plant growth by reducing root and shoot development, decreasing chlorophyll biosynthesis, and inducing oxidative stress, ultimately leading to impaired wheat plant growth and development.
Article
Marine & Freshwater Biology
Xin Chen, Tiantong Qiu, Peng Xiao, Wenhua Li
Summary: Isoflucypram has been found to have teratogenic effects on retinogenesis in zebrafish, causing abnormalities in retinal development and increased retinal cell apoptosis. This SDHI fungicide also demonstrates toxic effects on non-target aquatic organisms, highlighting the need for further investigation.
AQUATIC TOXICOLOGY
(2022)
Article
Environmental Sciences
Shanshan Guo, Yaqing Wu, Wenhua Li, Peng Xiao
Summary: This study aimed to investigate the toxicity of tralomethrin in zebrafish. Results showed that tralomethrin exposure caused cardiovascular dysplasia and dysfunction, as well as developmental abnormalities and oxidative stress in embryos. The dysregulation of crucial genes responsible for cardiovascular development was also observed. These findings highlight the cardiovascular and developmental toxicity of tralomethrin in zebrafish, and their significance for assessing the environmental risk of tralomethrin in aquatic ecosystems.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zhong-Shang Xia, Er-Wei Hao, Yan-ting Wei, Xiao-Tao Hou, Zhang-mei Chen, Man Wei, Zheng-Cai Du, Jia-Gang Deng
Summary: The study demonstrated that genipin treatment inhibited hatching rates and body length, induced pericardial edema, cardiotoxicity, hepatotoxicity, and nephrotoxicity in zebrafish embryos/larvae. Genipin also increased oxidative stress and apoptosis in zebrafish, indicating a potential developmental toxicity mechanism associated with oxidative stress and apoptosis increase.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Garam An, Miji Kim, Junho Park, Hahyun Park, Taeyeon Hong, Whasun Lim, Gwonhwa Song
Summary: Chloroxylenol is a widely used anti-microbial compound, and recent studies have emphasized the need to assess its potential for ecotoxicity due to increased usage during the coronavirus pandemic and ban on other antimicrobial ingredients. Although the detrimental effect of chloroxylenol on zebrafish viability has been reported, the mechanisms underlying its toxicity are not well understood. This study used the zebrafish model to investigate the responses to chloroxylenol and predict its toxicity to human health and ecology. The findings suggest the risks of chloroxylenol exposure and highlight the importance of further ecotoxicological studies.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Garam An, Junho Park, Whasun Lim, Gwonhwa Song
Summary: Thiobencarb, a widely used herbicide on rice paddies, has been found to have toxic effects on aquatic organisms. This study investigated the mechanism of toxicity in zebrafish embryos and found that thiobencarb caused decreased viability, phenotypic abnormalities, and defects in the cardiovascular system. The toxicity was mediated by pro-inflammatory cytokines and excessive reactive oxygen species generation due to the downregulation of antioxidant enzyme genes.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuxin Shi, Lei Li, Chuansen Wang, Jing Huang, Lixin Feng, Xiqiang Chen, Attila Gabor Sik, Kechun Liu, Meng Jin, Rongchun Wang
Summary: This study investigates the developmental toxicity of Chelerythrine in zebrafish and finds that it leads to a significant increase in mortality and malformation rate, as well as a reduction in hatching rate and body length. Chelerythrine also affects the normal development processes of the heart, liver, and phagocytes in zebrafish, and increases levels of reactive oxygen species (ROS) and apoptosis.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Environmental Sciences
Fei Liu, Ying Zhang, Fan Wang
Summary: This study exposed zebrafish embryos to TCS and evaluated its developmental toxicity. The results showed that TCS can induce oxidative stress and apoptosis, potentially through the ROS-p53-caspase dependent pathway.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Shukai Zheng, Qiong Zhang, Xiaoling Shi, Congying Luo, Jiasheng Chen, Wancong Zhang, Kusheng Wu, Shijie Tang
Summary: Polybrominated diphenyl ether flame retardants, specifically 2,2',4,4'-tetrabromodiphenyl ether (BDE-47), have been found to have adverse effects on the development of zebrafish. This study investigated the molecular mechanisms behind these developmental hazards, with a focus on endoplasmic reticulum stress (ERS), oxidative stress, and apoptosis, as well as the behavioral and morphological alterations observed. The findings suggest that exposure to BDE-47 induces ERS, oxidative stress, and apoptosis in zebrafish, leading to behavioral abnormalities and craniofacial malformations. Understanding these mechanisms is crucial for understanding the toxicological effects of environmental contaminants and developing strategies to mitigate their adverse effects.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Feixue Liu, Xueqing Li, Babatunde Kazeem Bello, Tianmeng Zhang, Haitao Yang, Kun Wang, Jingquan Dong
Summary: With the increasing use of pesticides, there is a growing concern about the levels of residual pesticides in the aquatic environment and their impact on non-target organisms. This study focused on the acute toxic effects of difenoconazole (DFZ), a class of long-lasting fungicides, on the spleen tissue of carp. The results showed that DFZ caused severe histopathology, apoptosis, oxidative stress, and inflammation in the spleen tissue of carp, leading to tissue damage. These findings highlight the importance of ensuring the safety of aquatic organisms in pesticide usage.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Pharmacology & Pharmacy
Qing Xia, Shuo Gao, Samuel Rajendran Rapael Gnanamuthu, Kaiyan Zhuang, Zhenzhen Song, Yun Zhang, Xue Wang, Pengfei Tu, Jianheng Li, Kechun Liu
Summary: Aconitine (AC) exerts severe toxic effects on zebrafish embryo development, including cardiac, liver, and neurodevelopment impairment, as well as ROS-mediated mitochondrial apoptosis. High-concentration AC exposure results in deficient cardiovascular system and cell apoptosis in the heart and brain regions.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Mengqi Wan, Ling Huang, Jieping Liu, Fasheng Liu, Guilan Chen, Huiwen Ni, Guanghua Xiong, Xinjun Liao, Huiqiang Lu, Juhua Xiao, Qiang Tao, Zigang Cao
Summary: This study assessed the toxicity of Cyclosporine A on embryonic development using zebrafish as a model organism, revealing its potential to induce cardiac developmental abnormalities by upregulating oxidative stress and Wnt signaling pathway. Treatment with Astaxanthin and an inhibitor of Wnt signaling pathway showed promising results in alleviating the toxic effects caused by CsA.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Huimiao Feng, Huizhen Chen, Jingchao Qiang, Baoshi Xu, Xinyu Wu, Enzhuang Pan, Haitao Yang, Xueqing Li, Jian Zhang, Jingquan Dong
Summary: In this study, the respiratory toxicity of difenoconazole to carp was investigated. Exposure to difenoconazole caused severe damage to carp gill tissue and induced an inflammatory response. Additionally, difenoconazole exposure led to oxidative stress, apoptosis, and disrupted autophagy. These findings enhance our understanding of the toxic effects of difenoconazole on organisms and its potential threat to the aquatic environment.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Review
Food Science & Technology
Zahra Jamshidi, Ali Roohbakhsh, Gholamreza Karimi
Summary: Ellagic acid is a polyphenol extracted from many plants. It modulates inflammatory mediators via antioxidant mechanisms and has remarkable protective properties. These protective effects are mainly mediated by normalizing lipid metabolism, oxidative stress, and inflammatory mediators.
FOOD SCIENCE & NUTRITION
(2023)
Article
Environmental Sciences
Haoming Ma, Zihui Meng, Li Zhou, Huimiao Feng, Xinyu Wu, Yue Xin, Jingquan Dong, Yanan Li
Summary: It was discovered that difenoconazole (DFZ), a triazole fungicide, causes immunosuppression in non-target organisms. However, ferulic acid (FA), a polyphenolic molecule, was found to prevent DFZ-induced immunosuppression by upregulating immune system markers and reducing oxidative damage. Furthermore, FA inhibited inflammation and apoptosis by modulating specific signaling pathways.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)