Design, synthesis of new magenta dyestuffs based on thiazole azomethine disperse reactive dyes with antibacterial potential on both dyes and gamma-irradiated dyed fabric

A series of new magenta azomethine reactive disperse dyes were synthesized and applied into polyester/cotton blend fabrics. Various spectroscopic and analytical techniques characterized all the synthesized dyes. The obtained data and theoretical values of all the synthesized molecules were in good agreement with the proposed molecular structure. These dyes have proven their efficiency in dyeing blend fabrics, as they give satisfactory results in fastness properties, colorimetric data and exhaustion, fixation study. Moreover, the dyed fabrics were tested for ultraviolet protection factor and offered high ultraviolet protection. The advantage of synthesizing these dyes is quite facile, and scale-up is feasible, preferring industrial dyeing applications. The designed thiazole azomethine dyes exhibited broad-spectrum antibacterial agents against MDR Gram-positive and Gram-negative bacterial isolates, which will facilitate their rational usage in multiple therapeutic applications. Our findings also demonstrate the possibility of using gamma radiation for sterilization of dyed fabrics and the ability of radiation to intensify their antibacterial activities, thereby inhibiting any bacterial growth on the surface of textiles. The molecular docking study showed good binding as a preferred mode between the dyes and DNA gyrase's active site (2XCT).

Automated summary

The new magenta azomethine reactive disperse dyes show high efficiency and good color fastness in dyeing polyester/cotton blend fabrics, and also demonstrate high UV protection. Additionally, they exhibit broad-spectrum antibacterial properties, with potential for rational use in various therapeutic applications.