Article
Medicine, General & Internal
Li Lu, Gaocheng Zou, Li Chen, Qianyi Lu, Mian Wu, Chunxia Li
Summary: The study found that levels of NLRP3 inflammasome pathway and VEGF significantly increased in the vitreous of PDR patients, while vitamin D concentrations showed the opposite trend and were negatively correlated with NLRP3 expression. Additionally, serum and vitreous vitamin D concentrations were associated with DR and had discriminatory ability in PDR patients.
FRONTIERS IN MEDICINE
(2021)
Article
Cell Biology
Dean F. Loporchio, Emily K. Tam, Jane Cho, Jaeyoon Chung, Gyungah R. Jun, Weiming Xia, Marissa G. Fiorello, Nicole H. Siegel, Steven Ness, Thor D. Stein, Manju L. Subramanian
Summary: This study compared the vitreous cytokine profiles of patients with proliferative diabetic retinopathy (PDR) to those without PDR. Novel increases in IL-15 and IL-16, along with expected VEGF, were observed in the vitreous humor of patients with PDR. Additionally, elevations of ICAM-1, VCAM-1, SAA, IL-8, and CRP were confirmed in the vitreous of PDR patients, as previously described.
Article
Medicine, General & Internal
Guanrong Wu, Baoyi Liu, Qiaowei Wu, Changting Tang, Zijing Du, Ying Fang, Yijun Hu, Honghua Yu
Summary: The study found that the expression of various angiogenesis and inflammation mediators in the vitreous fluid of eyes with proliferative diabetic retinopathy (PDR) was significantly increased, and there were correlations between these mediators. The levels of these mediators were also correlated with kidney damage, indicating potential common pathways in diabetic retinopathy and nephropathy.
FRONTIERS IN MEDICINE
(2021)
Review
Medicine, General & Internal
Sarah R. Weber, Yuanjun Zhao, Christopher Gates, Jingqun Ma, Felipe da Veiga Leprevost, Venkatesha Basrur, Alexey I. Nesvizhskii, Thomas W. Gardner, Jeffrey M. Sundstrom
Summary: Vitreous fluid has emerged as a valuable medium for studying retinal diseases, with proteomic analysis providing insights into proliferative diabetic retinopathy. Despite the lack of standardized methodology, there have been numerous studies utilizing mass spectrometry for vitreous proteomic analysis. Moving forward, addressing common pitfalls and proposing next steps is crucial for advancing this field.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Irene Andres-Blasco, Alex Gallego-Martinez, Ximena Machado, Javier Cruz-Espinosa, Salvatore Di Lauro, Ricardo Casaroli-Marano, Victor Alegre-Ituarte, Jose Fernando Arevalo, Maria Dolores Pinazo-Duran
Summary: The study aimed to evaluate the molecules related to oxidative stress, inflammation, angiogenesis, and apoptosis in patients with proliferative diabetic retinopathy (PDR) and diabetic macular edema (DME). By investigating their correlation in the plasma and vitreous body, as well as examining ophthalmological examination data, the study found that oxidative stress and inflammation were increased in the plasma and vitreous samples from patients with PDR/DME, while antioxidant capacity was decreased. The study suggests that exploring the relationship between these potential biomarkers in the plasma and vitreous may help detect early molecular changes in PDR/DME and monitor therapeutic outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sara Rezzola, Jessica Guerra, Adwaid Manu Krishna Chandran, Alessandra Loda, Anna Cancarini, Piergiuseppe Sacristani, Francesco Semeraro, Marco Presta
Summary: Proliferative diabetic retinopathy (PDR) is a major complication of diabetes mellitus, resulting from inflammation among endothelial cells, neurons, and glia. While anti-vascular endothelial growth factor (VEGF) interventions are the current therapeutic option for PDR, their impact on Muller cell activation remains unclear. Additional modulators besides VEGF have been found to play a role in Muller cell activation, suggesting potential for novel therapeutic strategies in PDR.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Ophthalmology
Tantai Zhao, Yanbin Wang, Xiaojian Guo, Huiling Li, Wenmin Jiang, Yangyan Xiao, Bin Deng, Yun Sun
Summary: This study found that the levels of oxylipins in the vitreous humor of patients with proliferative diabetic retinopathy (PDR) were altered, indicating an imbalance in inflammation-resolution homeostasis in PDR.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Ophthalmology
Jesse M. Smith, Nikhil Mandava, Vanessa Tirado-Gonzalez, Rodrigo Garcia-Santisteban, Matthew D. Geiger, Jennifer L. Patnaik, Ashley Frazer-Abel, Anne M. Lynch, Naresh Mandava, V. Michael Holers, Brandie D. Wagner, Idaira Sanchez-Santos, Daniela Meizner, Hugo Quiroz-Mercado, Alan G. Palestine
Summary: This study found a strong correlation between complement levels in aqueous and vitreous samples in patients with diabetic eye disease. The results suggest that the analysis of aqueous specimens can accurately sample the intraocular complement, allowing for the rapid and safe measurement of experimental complement targets and treatment response.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Article
Biochemical Research Methods
Junwei Fang, Hanying Wang, Tian Niu, Xin Shi, Xindan Xing, Yuan Qu, Yujuan Liu, Xinyi Liu, Yu Xiao, Tianyu Dou, Yinchen Shen, Kun Liu
Summary: This study analyzed the vitreous cavity fluid of patients with proliferative diabetic retinopathy (PDR) and control subjects without diabetes to identify metabolic and lipid differences. The results revealed significant differences in metabolism and lipids between PDR and control groups. Pathway analysis identified 8 metabolic processes associated with PDR development and 14 altered lipid species in PDR patients. Additionally, fatty acid desaturase 2 (FADS2) was identified as a potential contributor to the pathogenesis of PDR.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Jinfeng Qu, Xiuju Chen, Qinghuai Liu, Fang Wang, Mingxin Li, Qiong Zhou, Jin Yao, Xiaoxin Li
Summary: This study aimed to evaluate the effects of preoperative intravitreal aflibercept (IVA) injection on the incidence of postoperative vitreous hemorrhage (VH) in patients with proliferative diabetic retinopathy (PDR). The results showed that the VH incidence was significantly lower in the IVA group compared to the control group, and it also improved visual acuity. Therefore, prophylactic use of aflibercept can reduce the risk of postoperative hemorrhage in patients with PDR.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Ophthalmology
San-Ni Chen, Shih-Jen Chen, Tsung-Tien Wu, Wei-Chi Wu, Chang-Hao Yang, Chung-May Yang
Summary: Pars plana vitrectomy (PPV) has been widely used in the treatment of severe diabetic retinopathy, and new technologies have expanded its applications. This article reviews the applications of new technologies for PPV in eyes with diabetic retinopathy, based on the experiences with Asian patients, and highlights important procedures and entities not commonly mentioned in the literature.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Medicine, General & Internal
Yusuke Kameda, Tadashiro Saeki, Ko Hanai, Yuta Suzuki, Yasuko Uchigata, Tetsuya Babazono, Shigehiko Kitano
Summary: Chronic kidney disease may increase the risk of post-vitrectomy vitreous hemorrhage and neovascular glaucoma in patients with proliferative diabetic retinopathy. A reduced estimated glomerular filtration rate is the significant variable associated with postoperative complications.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Chirag D. Jhaveri, Adam R. Glassman, Frederick L. Ferris, Danni Liu, Maureen G. Maguire, John B. Allen, Carl W. Baker, David Browning, Matthew A. Cunningham, Scott M. Friedman, Lee M. Jampol, Dennis M. Marcus, Daniel F. Martin, Carin M. Preston, Cynthia R. Stockdale, Jennifer K. Sun
Summary: The relative efficacy of administering aflibercept monotherapy compared with bevacizumab followed by aflibercept if there is insufficient improvement in eyes with diabetic macular edema is uncertain.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Siyan Li, Enzhong Jin, Xuan Shi, Yi Cai, Hui Zhang, Mingwei Zhao
Summary: This study identified a highly expressed proteome in vitreous humor of PDR patients, with majority of proteins involved in complement and coagulation cascades. Transcription factors PPAR-alpha, RXR, LXR were identified as possible upstream regulators of these proteins in disease progression. Further study is required to explore their role in PDR.
FRONTIERS IN MEDICINE
(2021)
Article
Endocrinology & Metabolism
Yohei Tomita, Gael Cagnone, Zhongjie Fu, Bertan Cakir, Yumi Kotoda, Masaki Asakage, Yoshihiro Wakabayashi, Ann Hellstrom, Jean-Sebastien Joyal, Saswata Talukdar, Lois E. H. Smith, Yoshihiko Usui
Summary: The study identified a set of metabolites altered in the vitreous humour of PDR patients compared with non-diabetic controls, including both previously identified changes and novel dysregulated metabolites. By investigating the association of creatine with retinal NV and conducting oral supplementation experiments in a mouse model, the study suggests that metabolites in vitreous humour may provide insights into pathways influencing retinopathy, and that creatine supplementation could potentially be beneficial in suppressing NV in PDR.
Article
Ophthalmology
Atul Arora, Aniruddha Agarwal, Reema Bansal, Deeksha Katoch, Alessandro Marchese, Kanika Aggarwal, Rupesh Agrawal, Vishali Gupta
Summary: This study aimed to analyze the structural features and therapeutic response in patients with clinical and subclinical inflammatory choroidal neovascularization (i-CNV) using swept-source optical coherence tomography (SS-OCT) and SS-OCT angiography (SS-OCTA). The results showed that subretinal hyperreflective material (SHRM) may serve as a useful biomarker for monitoring activity and response to therapy in eyes with iCNV.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Ophthalmology
Shrey Maheshwari, Shweta Parakh, Shrutanjoy M. Das, Alok Ahuja, Shashi Nath Jha, Rupesh Agrawal, Vishali Gupta, Saurabh Luthra
Summary: This case report highlights the occurrence of nontubercular choroiditis caused by Mycobacterium mageritense after laparoscopic hysterectomy in an immunocompetent patient. The use of MALDI-TOF MS for specific diagnosis and the importance of aseptic precautions perioperatively during major surgeries is emphasized.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Editorial Material
Ophthalmology
Atul Arora, Sabia Handa, Simar Rajan Singh, Aman Sharma, Reema Bansal, Rupesh Agrawal, Vishali Gupta
Summary: This study reports the recurrence of tubercular choroiditis in two patients with quiescent disease activity for more than a year following anti-SARS-CoV-2 vaccination. The findings suggest a potential role of vaccination as a trigger for disease reactivation.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Ophthalmology
Alessandro Marchese, Maria Vittoria Cicinelli, Alessia Amato, Francesco Bandello, Vishali Gupta, Elisabetta Miserocchi, Aniruddha Agarwal
Summary: This article describes the advances in ocular imaging in uveitis and highlights the potential future developments. The use of advanced imaging techniques has provided significant information for understanding disease pathogenesis and manifestations, as well as aiding diagnosis in challenging cases. Notable developments include wide-field and ultra-wide field imaging, optical coherence tomography (OCT), and intraoperative imaging.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Ophthalmology
Kusum Sharma, Megha Sharma, Nikitha Ayyadurai, Mohit Dogra, Aman Sharma, Vishali Gupta, Ramandeep Singh, Amod Gupta
Summary: This study evaluated the use of Xpert MTB/RIF Ultra on Ocular tuberculosis (OTB) samples and compared it with Xpert. The results showed that Ultra outperformed Xpert in diagnosing OTB, but the advantage of simultaneous RifR detection was lost due to the low bacterial loads in the samples.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Review
Ophthalmology
Andrea York Tiang Teo, Bjorn Kaijun Betzler, Keith Low Qie Hua, Elizabeth Jiahui Chen, Vishali Gupta, Rupesh Agrawal
Summary: This review provides an update on the clinical presentation, etiologies, complications, and treatment options in intermediate uveitis. It affects all age groups with no gender predominance and has varied etiologies. Various treatment options are currently used in practice.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Review
Ophthalmology
Mohammad Amin Salehi, Soheil Mohammadi, Mahdi Gouravani, Fateme Rezagholi, J. Fernando Arevalo
Summary: Optical coherence tomography is capable of detecting biomarkers of age-related macular degeneration (AMD) that cannot be similarly recognized in conventional imaging. A meta-analysis of relevant studies revealed significant differences in retinal layer thickness between AMD patients and healthy controls.
SURVEY OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Aniruddha Agarwal, Federico Corvi, Nitin Kumar Menia, Kanika Aggarwal, Roel J. Erckens, Tos T. J. M. Berendschot, Carroll A. B. Webers, Alessandro Invernizzi, Vishali Gupta, SriniVas Sadda
Summary: The aim of this study was to analyze the automated quantification of choriocapillaris flow deficit (CCFD) using SS-OCTA in patients with TBSLC. The results showed that SS-OCTA CCFD can serve as a useful biomarker of disease activity in eyes with TBSLC.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2022)
Review
Ophthalmology
Zheting Zhang, Sean Ng Ming Sheng, John H. Kempen, Claudia Fabiani, Atul Arora, Vishali Gupta, Edmund Tsui, Luca Cimino, Richard J. Symes, Jennifer Dell, Robert P. Finger, Carsten Heinz, Rupesh Agrawal
Summary: This review summarizes and compares current uveitis registries, emphasizing their importance in collecting patient data and improving understanding of uveitis.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Review
Ophthalmology
Cen Amy Xie, Jayanti Singh, Mudit Tyagi, Sofia Androudi, Vivek Pravin Dave, Atul Arora, Vishali Gupta, Rupesh Agrawal, Helen Mi, Alok Sen
Summary: Endogenous endophthalmitis is a rare but potentially serious ocular infection with various symptoms such as conjunctival injection, ocular pain, and reduced visual acuity. The diagnosis can be challenging and delayed, leading to poor prognosis. Blood cultures and ocular fluid samples are helpful in identifying the causative pathogen(s), and treatment involves systemic and intravitreal antibiotic therapy, with the use of steroids being controversial. Surgical options include pars plana vitrectomy. Prognosis depends on host and pathogen factors, emphasizing the importance of early diagnosis and treatment.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Editorial Material
Ophthalmology
Rupesh Agrawal, Zheng Xian Thng, Amod Gupta, Brian C. Toy, Andrew A. Dick, Justine R. Smith, Soon-Phaik Chee, Vishali Gupta, Narsing A. Rao
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Ophthalmology
Kusum Sharma, Megha Sharma, Nikitha Ayyadurai, Mohit Dogra, Aman Sharma, Vishali Gupta, Ramandeep Singh, Amod Gupta
Summary: The Truenat MTB Plus assay was found to be a rapid and reliable tool for diagnosing ocular tuberculosis and detecting drug resistance. It showed high sensitivity and performance compared to other methods.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Letter
Ophthalmology
Nitin Kumar Menia, Reema Bansal, Vishali Gupta
Summary: This article reports an atypical case of Vogt-Koyanagi-Harada (VKH) disease with retrolental bullous retinal detachment (RD). In this case, a 67-year-old Indian woman presented with bilateral visual loss, light perception in both eyes, keratic precipitates, 2+ cells and bullous RD in the right eye (RE). Systemic investigations were unremarkable, and the patient received systemic corticosteroids as well as pars plana vitrectomy (PPV) in the left eye (LE).
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Computer Science, Information Systems
Fernando Arevalo, Christian M. P. Alison, M. Tahasanul Ibrahim, Andreas Schwung
Summary: This paper introduces a novel approach for production assessment that formalizes tacit knowledge using a knowledge transfer framework and evidence theory, providing companies with a strategic advantage and steady operation.
Review
Multidisciplinary Sciences
Mohammad Amin Salehi, Amirali Karimi, Soheil Mohammadi, J. Fernando Arevalo
Summary: This study found that certain ocular layers are thinner in patients with higher BMI compared to normal weight individuals. These findings may be associated with adverse events related to increased body weight and have prognostic abilities.
