Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 69, Issue -, Pages 78-85Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2021.03.010
Keywords
-
Categories
Funding
- Wellcome Trust Investigator Award [104633/Z/14/Z]
- Medical Research Council Program grant [MR/N020413/1]
- Wellcome Trust [104633/Z/14/Z] Funding Source: Wellcome Trust
- MRC [MR/N020413/1] Funding Source: UKRI
Ask authors/readers for more resources
Structure determination of membrane proteins has revealed the significant roles of lipids in influencing protein architecture. It is widely accepted that lipids surrounding membrane proteins play crucial roles by modulating their conformational, structural, and functional properties. Recent advances in mass spectrometry have provided insights into lipid interactions, shedding light on the dynamic nature of lipid-mediated interactions and their effects on conformation, interactions, and signaling.
Structure determination of membrane proteins has highlighted the many roles played by lipids in influencing overall protein architecture. It is now widely accepted that lipids surrounding membrane proteins play crucial roles by modulating their conformational, structural, and functional properties. Capturing often transient lipid interactions and defining their chemical identity, however, remains challenging. Recent advances in mass spectrometry have resolved questions concerning lipid interactions by providing the molecular composition of intact complexes in association with lipids. Together with other biophysical tools, a picture is emerging of the dynamic nature of lipid-mediated interactions and their effects on conformation, interactions, and signaling.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available