Article
Chemistry, Multidisciplinary
Yifan Zhang, Yunyan Liao, Qinan Tang, Jing Lin, Peng Huang
Summary: A novel biomimetic nanoemulsion camouflaged with a PD-1-expressing cell membrane was developed for synergistic photodynamic-immunotherapy against hypoxic breast tumors, effectively inhibiting tumor growth by boosting dendritic cell maturation and cytotoxic T lymphocyte infiltration.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Nanoscience & Nanotechnology
Binlong Chen, Ye Yang, Yaoqi Wang, Yue Yan, Zenghui Wang, Qingqing Yin, Qiang Zhang, Yiguang Wang
Summary: The SPR-SOSG nanosensor has been developed to specifically illuminate singlet oxygen in endocytic organelles through encoding SOSG into pH-sensitive micelles, achieving more than 10-fold amplification of the singlet oxygen signal.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Minh Tuan Nguyen, Elizaveta V. Guseva, Aida N. Ataeva, Andrey L. Sigan, Anna V. Shibaeva, Maria V. Dmitrieva, Ivan D. Burtsev, Yulia L. Volodina, Alexandra S. Radchenko, Anton E. Egorov, Alexey A. Kostyukov, Pavel V. Melnikov, Nikolai D. Chkanikov, Vladimir A. Kuzmin, Alexander A. Shtil, Alina A. Markova
Summary: The efficacy of photodynamic therapy (PDT) relies on the availability of molecular oxygen and fluorocarbons have been used as oxygen carriers. In this study, fluorous derivatives of chlorin were synthesized and used to prepare nanoemulsions with perfluorodecalin as an oxygen depot. The modified emulsions showed strong photodamaging potency in hypoxic cells, making them efficient and biocompatible instruments for PDT-assisted eradication of hypoxic cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Environmental
Yanyan Zhu, Ying Yang, Ning Li, Chai Luo, Xiaohong Hou
Summary: This study has successfully developed a multifunctional nanoplatform integrating PDT effect, O2 self-sufficiency, and intracellular 1O2 self-monitoring to enhance the efficacy of PDT.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Chun Yang, Meihui Su, Pei Luo, Yanan Liu, Feng Yang, Changhua Li
Summary: The study presents a sophisticated photosensitive polymeric material (An-NP) that allows sustained generation of singlet oxygen (O-1(2)) and sufficient oxygen supply during phototherapy. Alternately controlled by two NIR laser beams, the material combines PDT and PTT to address the oxygen shortage issue in tumors, achieving sustained therapeutic effect.
Review
Medicine, Research & Experimental
Dorota Bartusik-Aebisher, Lukasz Ozog, David Aebisher
Summary: Photooxidation generates reactive oxygen species through interaction with light, useful in PDT therapy. However, limitations in the depth of light penetration through tissue restrict its use in deep tissue cancer treatment. More research is needed to improve delivery of singlet oxygen to deep tissue.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Physical
Zhen Zhang, Xiao-Lian Zhang, Bin Li
Summary: The study focused on an ordered core-shell structure encapsulated by mesoporous SiO2 with upconverting emission property, aiming to promote the effectiveness of photodynamic therapy. By employing near-infrared light irradiation, the nanomaterials demonstrated strong green upconverting luminescence, triggering the production of singlet oxygen by the photosensitizer. This core-shell structure effectively combines upconverting nanocrystals with a mesoporous SiO2 shell, facilitating the adsorption and excitation of the photosensitizer.
Review
Chemistry, Inorganic & Nuclear
Hande Gunduz, Safacan Kolemen, Engin U. Akkaya
Summary: The detection and imaging of singlet oxygen is a challenging task due to its short half-life and solvent sensitivity. Selective probes for singlet oxygen are crucial in the presence of other oxidizing species, and smart designs are already making progress in pushing signalling events towards longer wavelengths of the visible spectrum.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Nanoscience & Nanotechnology
Irene Villa, Chiara Villa, Roberta Crapanzano, Valeria Secchi, Massimo Tawfilas, Elena Trombetta, Laura Porretti, Andrea Brambilla, Marcello Campione, Yvan Torrente, Anna Vedda, Angelo Monguzzi
Summary: The multicomponent nanomaterial developed in this study shows remarkable ability to enhance singlet oxygen production, providing significant efficacy as an adjuvant for radiotherapy, especially at low doses.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Chemistry, Inorganic & Nuclear
Suman Joseph, S. K. Ashok Kumar
Summary: Singlet oxygen (1O2) plays an important role in chemistry, medicine, and human physiology, but its use in biological systems is limited due to a lack of efficient probes. This review discusses the current developments of probes and molecular carriers of 1O2, which typically consist of a 1O2-specific binding unit and a signaling unit. Based on the signaling mode, these probes can be categorized into absorption-based, colorimetric, photoluminescent, and chemiluminescent. The review also highlights the factors affecting their efficiency and identifies unexplored areas for potential future developments.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Li Wei, Zhishang Zhang, Ashish Kumar, Samya Banerjee, Huaiyi Huang
Summary: Photodynamic therapy (PDT) is a promising cancer treatment method due to its non-invasiveness, low side effects, and spatiotemporal selectivity. However, the hypoxic microenvironment in solid tumors can significantly reduce the effectiveness of PDT. Recent studies have shown that endoperoxides can enhance the therapeutic effects of PDT under hypoxia, making them valuable for treating hypoxic cancer cells.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Materials Science, Multidisciplinary
Jie Zhang, Zihuayuan Yang, Yan-Hong Li, Samran Durrani, Ai-Ping Pang, Yichen Gao, Fu-Gen Wu, Fengming Lin
Summary: This study presented super-stable carboxymethyl chitosanpolyethyleneimine-protoporphyrin IX nanoparticles (CMCS-PEI-PpIX NPs) for effective photodynamic inactivation of bacteria and fungi with excellent biocompatibility. The NPs exhibited exceptional photoinactivation toward a broad range of microbes with record low minimal bactericidal concentrations, showing high stability and negligible cytotoxicity. The development of CMCS-PEI-PpIX NPs provides a promising route for improving microbicidal PDT efficacy in clinic treatment of microbial infections.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Debabrata Dutta, Jingbo Wang, Xiang Li, Qinghao Zhou, Zhishen Ge
Summary: This study presents the use of covalent organic framework (COF) nanoparticles loaded with the near-infrared (NIR) dye cypate for oxygen-independent generation of singlet oxygen (O-1(2)), allowing for concurrent photothermal therapy (PTT) and photodynamic therapy (PDT) under NIR irradiation. The COF nanoparticles protect cypate from photodegradation and improve its photostability and photothermal conversion efficiency. Upon NIR irradiation, the COF nanoparticles release the stored O-1(2) and induce ablation of tumors through oxygen-independent concurrent PTT/PDT.
Article
Biochemistry & Molecular Biology
Ksenija Bozinovic, Davor Nestic, Evripidis Michail, Matthias Ferger, Marta Koscak, Christoph Lambert, Dragomira Majhen, Todd B. Marder, Ivo Piantanida
Summary: This study shows that specific compounds can increase cytotoxicity and antiviral activity through irradiation, possibly related to the generation of reactive oxygen species.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Alibasha Akbar, Syamantak Khan, Tanmay Chatterjee, Mihir Ghosh
Summary: This comprehensive review discusses the current trends and recent developments of porphyrin-based photosensitizers, highlighting their pivotal role in advancing photodynamic therapy (PDT) for cancer treatment. Integration of porphyrins with nanoparticles offers improved selectivity, reduced toxicity, and heightened biocompatibility. The article provides a panoramic snapshot of the field, addressing challenges and charting prospects for future research and clinical applications.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2023)
Article
Chemistry, Organic
Margeaux A. Miller, Rachael A. Day, Daniel A. Estabrook, Ellen M. Sletten
Article
Nanoscience & Nanotechnology
Rachael A. Day, Daniel A. Estabrook, Carolyn Wu, John O. Chapman, Alyssa J. Togle, Ellen M. Sletten
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Chemistry, Multidisciplinary
Irene Lim, Antoine Vian, Heidi L. van de Wouw, Rachael A. Day, Carlos Gomez, Yucen Liu, Arnold L. Rheingold, Otger Campas, Ellen M. Sletten
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Chemistry, Multidisciplinary
Daniel A. Estabrook, Rachael A. Day, Ellen M. Sletten
Summary: This study presents a method to create redox-responsive PFC nanoemulsions using cleavable poly(2-oxazoline) diblock copolymer surfactants, allowing for cargo release within cells. A noncovalent fluorous tagging strategy successfully solubilizes GFP plasmids inside the PFC nanoemulsions, enabling protein expression selectively with stimuli-responsive surfactants. This work offers a novel approach to non-viral gene delivery and demonstrates a general method for nanoemulsions that respond to endogenous stimuli.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Rachael A. Day, Ellen M. Sletten
Summary: The study discusses three methods to directly probe endosomal/lysosomal rupture, including calcein dye dilution, lysosome size quantification, and visualization of membrane integrity with a genetically engineered cell line. These methods can help understand the limiting factors in the therapeutic use of nanomaterials.
Article
Chemistry, Multidisciplinary
Daniel A. Estabrook, Amanda F. Ennis, Rachael A. Day, Ellen M. Sletten
Article
Chemistry, Multidisciplinary
Rachael A. Day, Daniel A. Estabrook, Jessica K. Logan, Ellen M. Sletten
CHEMICAL COMMUNICATIONS
(2017)
