Article
Immunology
Adam H. Dyer, Isabella Batten, Conor Reddy, Liam Townsend, Conor P. Woods, Desmond O'Neill, James Gibney, Sean P. Kennelly, Nollaig M. Bourke
Summary: Midlife type 2 diabetes mellitus is associated with an increased risk of Alzheimer's disease, with altered inflammatory responses being a possible mechanism. However, peripheral NLRP3 inflammasome responses may not be altered during the early stages of cognitive dysfunction in midlife type 2 diabetes.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Yao Xie, Le Xie, Fuliang Kang, Junlin Jiang, Ting Yao, Yingchen Li, Guo Mao, Dahua Wu
Summary: This study aims to investigate the association between diffusion tensor imaging (DTI) data and cognitive impairment in cerebral small vessel disease (CSVD) to identify potential biomarkers for early diagnosis or treatment evaluation. The systematic review will analyze published studies to provide relevant information on the relationship between DTI metrics and cognitive disorders.
Article
Clinical Neurology
Rodrigo B. Mansur, Mehala Subramaniapillai, Yena Lee, Zihang Pan, Nicole E. Carmona, Margarita Shekotikhina, Michelle Iacobucci, Nelson Rodrigues, Flora Nasri, Joshua D. Rosenblat, Elisa Brietzke, Victoria E. Cosgrove, Nicole E. Kramer, Trisha Suppes, Jason Newport, Tomas Hajek, Roger S. McIntyre
Summary: The study found that treatment with infliximab did not significantly affect prefrontal NAA concentration in adults with BD. However, there was a significant effect on Glx levels, with an interaction between treatment and time indicating a decrease in Glx levels in infliximab-treated patients. Furthermore, the reduction in Glx levels in infliximab-treated participants was associated with cognitive improvement, as measured by neurocognitive tests.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Cardiac & Cardiovascular Systems
Katharine E. Thomas, Anastasia Fotaki, Rene M. Botnar, Vanessa M. Ferreira
Summary: Myocardial inflammation leads to changes in the myocardial tissue, which can be detected using cardiovascular magnetic resonance imaging. Various techniques, such as T2-weighted imaging, parametric T1- and T2-mapping, and contrast-enhanced imaging, have been used to identify myocardial inflammation and its effects. Emerging techniques aim to simultaneously image multiple parameters to better characterize myocardial tissue and detect subtle immune-mediated changes. This review outlines the principles of current and emerging cardiovascular magnetic resonance methods for imaging myocardial inflammation.
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Review
Neurosciences
Shuhui Wu, Yuxin Wang, Yaqin Song, Hongjie Hu, Liang Jing, Wei Zhu
Summary: Sepsis-associated encephalopathy (SAE) is a brain dysfunction caused by systemic infection, without infection in the central nervous system. Early diagnosis is challenging and currently exclusionary. Magnetic resonance imaging (MRI) related techniques, such as magnetic resonance spectroscopy, molecular MRI, arterial spin-labeling, fluid-attenuated inversion recovery, and diffusion-weighted imaging, offer new options for early identification of SAE. This review summarizes the principles and applications of MRI technology in diagnosing SAE and provides a basis for diagnosing SAE using MRI-related techniques.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Isabelle De Kock, Simon Bos, Louke Delrue, Sophie Van Welden, Peter Bunyard, Pieter Hindryckx, Martine De Vos, Geert Villeirs, Debby Laukens
Summary: This study investigated the value of MT MRI and TA of T2WI in the assessment of intestinal fibrosis. The results showed that TA is especially useful for the quantification of fibrosis in mixed inflammatory-fibrotic tissue and for evaluating antifibrotic treatment response. Therefore, further validation of this post-processing technique is warranted due to its potential benefits in clinical practice and antifibrotic trial design.
EUROPEAN RADIOLOGY
(2023)
Article
Clinical Neurology
Saima Hilal, Arwin Doolabi, Henri Vrooman, M. Kamran Ikram, M. Arfan Ikram, Meike W. Vernooij
Summary: Cortical cerebral microinfarcts (CMIs) are associated with cardiovascular disease, cognitive decline, and increased risk of stroke and mortality in a population-based setting. Main risk factors for CMIs include male sex, smoking history, heart disease, and stroke. People with CMIs experience cognitive decline and have a higher risk of stroke and mortality.
Article
Clinical Neurology
Hugo P. Aben, Leonie De Munter, Yael D. Reijmer, Jacoba M. Spikman, Johanna M. A. Visser-Meily, Geert Jan Biessels, Paul L. M. De Kort
Summary: The prediction of long-term recovery of poststroke cognitive disorder (PSCD) is currently inaccurate. However, diffusion-weighted imaging (DWI)-based measures of brain connectivity appear to predict recovery of PSCD, although they do not have added value over conventional predictors at present.
Review
Biophysics
Stephanie Anderson, James T. Grist, Andrew Lewis, Damian J. Tyler
Summary: Inflammation plays a central role in numerous diseases and the emerging technique of hyperpolarized MRI shows potential in assessing immune cell responses by exploiting characteristic metabolic reprogramming. This method has the potential to improve understanding of inflammatory processes in different diseases and preclinical models.
NMR IN BIOMEDICINE
(2021)
Article
Geriatrics & Gerontology
Rui Zhou, Hao-Wen Chen, Fu-Rong Li, Qi Zhong, Yi-Ning Huang, Xian-Bo Wu
Summary: The Life's Essential 8 (LE8) score is associated with the risk of dementia, cognitive abilities, and neuroimaging outcomes, and this association differs based on the APOE-ε4 genotype.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Article
Neurosciences
Liangqi Wang, Huandong Lin, Yifeng Peng, Zehua Zhao, Lingyan Chen, Li Wu, Ting Liu, Jing Li, Anna Liu, Chun-Yi Zac Lo, Xin Gao
Summary: The study found that incidental findings in the brain are common in the elderly population and are related to cardiovascular health and brain function. Interventions targeting cardiovascular risk factors may help slow down cognitive decline. The study also suggests that incidental findings should be considered as potential confounding factors in neuroimaging research on aging or diseases.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Jinyu Lu, Cheng Zhou, Jiali Pu, Jun Tian, Xinzhen Yin, Dayao Lv, Xiaojun Guan, Tao Guo, Minming Zhang, Baorong Zhang, Yaping Yan, Guohua Zhao
Summary: This study aimed to investigate the microstructural degeneration of gray matter (GM) and white matter (WM) in essential tremor (ET) patients and its correlation with cognition and tremor. The results showed that the ET group had significantly lower mean kurtosis in several brain regions and lower radial kurtosis in multiple tracts compared to the control group. These microstructural changes were correlated with tremor severity and cognitive scores. However, there was no significant volume difference between the two groups. In conclusion, our findings suggest extensive microstructural alterations in GM and WM in ET patients, supporting the neurodegenerative hypothesis of ET. This study contributes to a better understanding of the mechanisms underlying tremor and cognitive impairment in ET.
JOURNAL OF NEUROLOGY
(2023)
Article
Medicine, General & Internal
Bojana Stamenkovic, Sonja Stojanovic, Valentina Zivkovic, Dragan Djordjevic, Mila Bojanovic, Aleksandra Stankovic, Natasa Rancic, Nemanja Damjanov, Marco Matucci Cerinic
Summary: The study aimed to investigate hand joint inflammation in systemic sclerosis (SSc) patients and examine the relationship between these subclinical inflammatory changes and clinical manifestations, disease activity, and functional capacity. The results showed that MRI can detect significant subclinical joint inflammation in SSc patients, which is associated with systemic inflammation, vascular complications, and more severe forms of the disease.
Article
Clinical Neurology
Qichang Fu, Yuting Wang, Yi Zhang, Yong Zhang, Xinbin Guo, Haowen Xu, Zhiqiang Yao, Meng Wang, Michael R. Levitt, Mahmud Mossa-Basha, Jinxia Zhu, Jingliang Cheng, Sheng Guan, Chengcheng Zhu
Summary: The study shows that AWE pattern and WEI are independently associated with aneurysm-related symptoms, with circumferential AWE and high WEI being more significantly associated with symptomatic UIAs. This provides an effective method for identifying unstable intracranial aneurysms.
Article
Cardiac & Cardiovascular Systems
Aylina Glasenapp, Katja Derlin, Marcel Gutberlet, Annika Hess, Tobias L. Ross, Hans-Juergen Wester, Frank M. Bengel, James T. Thackeray
Summary: The study focused on investigating the interplay between ventricle loading conditions, tissue inflammation, and progressive fibrosis in pressure overload heart failure using noninvasive multimodality molecular imaging. Inflammation and fibrosis play crucial roles in the early response to pressure overload and can be sensitively monitored by multimodality imaging, which may guide novel treatment strategies in nonischemic heart failure.
CIRCULATION RESEARCH
(2021)
Article
Immunology
Annemieke M. Peters van Ton, Guus P. Leijte, Gerben M. Franssen, Niklas Bruse, Jan Booij, Janine Doorduin, Mark Rijpkema, Matthijs Kox, Wilson F. Abdo, Peter Pickkers
Summary: This study investigated the trajectory of the immune response systemically and within the brain following repeated LPS challenges in healthy volunteers. The results showed that while the first LPS challenge induced systemic and cerebral inflammation, the second challenge led to a decrease in cerebral inflammation below baseline levels, indicating a neuroprotective mechanism of in vivo immunological reprogramming in the brain. These findings suggest further studies on immunotolerance in patients with systemic inflammation-induced cerebral dysfunction.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Cardiac & Cardiovascular Systems
Shokoufeh CheheiliSobbi, Annemieke M. Peters van Ton, Esther M. Wesselink, Marjolein F. Looije, Jelle Gerretsen, Wim J. Morshuis, Arjen J. C. Slooter, Wilson F. Abdo, Peter Pickkers, Mark van den Boogaard
Summary: The study found that there was no significant difference in immunoparalysis between patients with delirium and those without delirium following cardiothoracic surgery.
JOURNAL OF CARDIOTHORACIC SURGERY
(2021)
Article
Critical Care Medicine
Remi Beunders, Ilse H. van de Wijgert, Maarten van den Berg, Johannes G. van der Hoeven, Wilson F. Abdo, Peter Pickkers
JOURNAL OF CRITICAL CARE
(2021)
Article
Anesthesiology
Abhijit V. Lele, Sarah Wahlster, Bhunyawee Alunpipachathai, Meron Awraris Gebrewold, Sherry H. -Y. Chou, Gretchen Crabtree, Shane English, Caroline Der-Nigoghossian, David J. Gagnon, May Kim-Tenser, Navaz Karanjia, Matthew A. Kirkman, Massimo Lamperti, Sarah L. Livesay, Jorge Mejia-Mantilla, Kara Melmed, Hemanshu Prabhakar, Leandro Tumino, Chethan P. Venkatasubba Rao, Andrew A. Udy, Walter Videtta, Asma M. Moheet
Summary: This study explores the impact of the COVID-19 pandemic on neurocritical care delivery. The results show that regardless of country income level, presence of a dedicated neurocritical care unit, or experiencing a surge in COVID-19 patients, participants reported reductions in admissions, drug shortages, reduction in services, diagnostic testing, and temporary cancellation of teaching and research. Respondents from low/middle income countries were more likely to report lack of surge preparedness and struggles to return to pre-pandemic standards of care. Respondents experiencing a surge were more likely to report conversions in neurocritical care units and ICU beds, as well as deviations in critical care and pharmaceutical practices.
JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY
(2022)
Article
Clinical Neurology
Marc Vervuurt, Xiaoyue Zhu, Joseph Schrader, Anna M. Kort, Taina M. Marques, Iris Kersten, Annemieke M. Peters van Ton, Wilson F. Abdo, Floris H. B. M. Schreuder, Ingeborg Rasing, Gisela M. Terwindt, Marieke J. H. Wermer, Steven M. Greenberg, Catharina J. M. Klijn, H. Bea Kuiperij, William E. Van Nostrand, Marcel M. Verbeek
Summary: The aim of this study was to investigate the relationship between urokinase plasminogen activator (uPA) and cerebral amyloid angiopathy (CAA). The results showed that increased cerebrovascular expression of uPA in CAA is associated with elevated levels of uPA in cerebrospinal fluid (CSF), suggesting that uPA could serve as a biomarker for CAA.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2022)
Article
Clinical Neurology
Mengfei Cai, Mina A. Jacob, Mark R. van Loenen, Mayra Bergkamp, Jose Marques, David G. Norris, Marco Duering, Anil M. Tuladhar, Frank-Erik De Leeuw
Summary: This study investigated the temporal dynamics of small vessel disease (SVD) and the impact of vascular risk factors and baseline SVD burden on its progression. The findings showed that SVD progresses significantly over time, but mild white matter hyperintensities (WMH) rarely progress to severe WMH. Older age, baseline SVD burden, and vascular risk factors were associated with faster WMH progression and incident lacunes.
Article
Clinical Neurology
Marc Vervuurt, Anna M. M. de Kort, Lieke Jakel, Iris Kersten, Wilson F. F. Abdo, Floris H. B. M. Schreuder, Ingeborg Rasing, Gisela M. M. Terwindt, Marieke J. H. Wermer, Steven M. M. Greenberg, Catharina J. M. Klijn, H. Bea Kuiperij, Marcel M. M. Verbeek
Summary: This study investigates the potential of cerebrospinal fluid (CSF) levels of matrix metalloproteinases and tissue-type inhibitors (MMP; TIMP) as biomarkers for cerebral amyloid angiopathy (CAA). The results suggest that CSF MMP-2/TIMP-2 and MMP-14/TIMP-2 ratios are consistently decreased in sporadic CAA patients, compared to controls. Additionally, MMP-14/TIMP-2 levels are also decreased in symptomatic hereditary CAA patients, compared to pre-symptomatic patients and controls, and can be considered a biomarker for late-stage forms of CAA.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Critical Care Medicine
Sanne P. C. van Oosterhout, Anneke G. van der Niet, W. Farid Abdo, Marianne Boenink, Thomas G. V. Cherpanath, Jelle L. L. Epker, Angela M. M. Kotsopoulos, Walther N. K. A. van Mook, Hans P. C. Sonneveld, Meint Volbeda, Gert Olthuis, Jelle L. P. van Gurp
Summary: The study examines how clinicians discuss patients' donor registrations in donor conversations in the first years of the opt-out system in the Netherlands. It highlights the complex interplay between donor registrations and clinician-family interactions, and suggests incorporating different routes in clinical training and promoting public conversations about donation.
Article
Immunology
Harmke B. Duindam, Roy P. C. Kessels, Bram van den Borst, Peter Pickkers, Wilson F. Abdo
Summary: A relevant proportion of critically ill COVID-19 patients exhibit deficits in long-term cognitive functioning. Anti-inflammatory therapy does not seem to affect long-term cognitive performance, except for more pronounced executive dysfunction. Additionally, subjective cognitive complaints are associated with patient gender and ICU stay duration.
BRAIN, BEHAVIOR, & IMMUNITY - HEALTH
(2022)
Letter
Anesthesiology
Mark L. Van Zuylen, Annemieke M. Peters Van Ton, Harmke B. Duindam, Erik Scholten, Eric P. A. Van Dongen, Werner Ten Hoope, Mark P. Plummer, J. Hans DeVries, Benedikt Preckel, Gert-Jan Scheffer, Wilson F. Abdo, Jeroen Hermanides
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Gastroenterology & Hepatology
Adriaan G. Volkers, Laura Appleton, Richard B. Gearry, Christopher M. Frampton, Floris A. E. de Voogd, Annemieke M. Peters van Ton, Steven T. Leach, Daniel A. Lemberg, Andrew S. Day
Summary: This study evaluated the performance of fecal biomarkers FC, CHI3L1, S100A12, and OPG in children with Crohn's disease and compared them with other measures of disease activity. The results showed that FC correlated with both endoscopic and clinical disease activity and was the only biomarker that differentiated between active and inactive ileal CD. CHI3L1 also predicted clinical disease activity and correlated highly with FC.
GASTROINTESTINAL DISORDERS
(2022)
