Article
Allergy
Thanisorn Sukakul, Magnus Bruze, Martin Mowitz, Annarita Antelmi, Ola Bergendorff, Jonas Bjork, Jakob Dahlin, Nils Hamnerius, Inese Hauksson, Marlene Isaksson, Tina Lejding, Ann Ponten, Cecilia Svedman
Summary: Contact allergy to oxidized linalool and limonene is on the rise, with symptoms usually appearing on Day 3/4 post-exposure. Patients with this allergy are typically younger and predominantly female. Stronger reactions are associated with older age and multiple fragrance allergies.
CONTACT DERMATITIS
(2022)
Article
Allergy
Aoife Hollywood, John F. Bourke
Summary: This is a case series of allergic contact dermatitis to F5 in pharmaceutical workers, confirmed by patch testing. With the globalized production of imatinib, more similar cases may arise.
CONTACT DERMATITIS
(2022)
Article
Allergy
Jojo B. Dietz, Torkil Menne, Harald W. Meyer, Sven Viskum, Mari-Ann Flyvholm, Ulrik Ahrensboll-Friis, Swen M. John, Jeanne D. Johansen
Summary: This study investigates the causes and consequences of occupational contact dermatitis (OCD) among workers younger than 35 years. The results show that healthcare workers, kitchen workers, nursery teachers, and hairdressers and beauticians are the most commonly affected occupations. The severity and long-term effects of eczema have significant implications for young workers.
CONTACT DERMATITIS
(2022)
Article
Dermatology
Nils Hamnerius, Jakob Dahlin, Magnus Bruze, Kristina Nilsson, Thanisorn Sukakul, Cecilia Svedman
Summary: This study investigated an outbreak of foot dermatitis in military conscripts following continuous use of medical adhesive tapes during a field exercise. The results showed that the subjects had contact allergy to the adhesive tapes and colophonium, a constituent of the tapes. The study highlights the importance of assessing possible side effects of medical devices before they are introduced to the market.
ACTA DERMATO-VENEREOLOGICA
(2023)
Article
Dermatology
Joel G. DeKoven, Benjamin M. DeKoven, Erin M. Warshaw, C. G. T. Mathias, James S. Taylor, Denis Sasseville, Donald Belsito, Joseph F. Fowler, Melanie D. Pratt, Kathryn A. Zug, Howard Maibach, Vincent A. DeLeo, Jonathan Silverberg, Amber R. Atwater, Margo J. Reeder, D. Linn Holness
Summary: This study provides an overview of occupational skin disease (OSD) and analyzes the cases of occupational allergic contact dermatitis (ACD) in North American patients undergoing patch testing. The study identified common occupational allergens, exposure sources, and occupations/industries at risk, which can help clinicians evaluate and manage patients with occupational contact dermatitis.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Review
Allergy
Andrew W. Liu, Jacob E. Gillis, Tina L. Sumpter, Daniel H. Kaplan
Summary: The skin is populated by various immune cells and sensory neurons, and the interaction between the nervous and immune systems plays a crucial role in inflammatory skin diseases. Neurotransmitters secreted by nerve terminals mediate immune cell function, while immune factors derived from immune cells interact with neurons to induce itching. This review explores the effector functions of neurons on skin immune cells in mouse models of atopic and contact dermatitis, and discusses the contribution of specific neuronal subsets and immune factors to itch induction and inflammation. The findings also shed light on treatment strategies and the relationship between scratching and dermatitis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Allergy
D. Linn Holness, Pilar Gomez, Irena Kudla, Sandy Skotnicki, Joel G. DeKoven
Summary: Occupational contact dermatitis often leads to work disruption, but successful return-to-work outcomes can be achieved with good communication, availability of modified work, and worker adherence to the plan. Barriers to successful return-to-work include lack of modified work, unresponsive employers, and ongoing skin problems.
CONTACT DERMATITIS
(2021)
Article
Allergy
Kate Dear, Amanda Palmer, Rosemary L. Nixon
Summary: The study investigated contact allergy to PFR2 in a single tertiary dermatology centre, and found that even in a selected population of patients, contact allergy to PFR2 is uncommon. The research recommends routine patch testing to a plastics and glues series containing PFR2 for patients exposed to plastics and glues, or who work with wood products.
CONTACT DERMATITIS
(2021)
Article
Allergy
Jojo B. Dietz, Torkil Menne, Harald W. Meyer, Sven Viskum, Mari-Ann Flyvholm, Ulrik Ahrensboll-Friis, Swen M. John, Jeanne D. Johansen
Summary: This study found a high prevalence of previously diagnosed AD among young workers with recognized OCD, and AD significantly impacts the severity and long-term consequences of OCD.
CONTACT DERMATITIS
(2023)
Article
Dermatology
Holly Neale, Anna Cristina Garza-Mayers, Idy Tam, JiaDe Yu
Summary: ACD is a delayed hypersensitivity skin reaction to environmental allergens that affects children and adults similarly. However, pediatric patch testing for ACD is less common due to challenges such as smaller surface area for testing and difficulty in cooperation, particularly with younger children. Clinical suspicion guided by patient presentation and history is key in diagnosing ACD in children.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Allergy
Morgan Nguyen, Slaton Case, Nina Botto, Walter Liszewski
Summary: This study identified discussions about allergic contact dermatitis (ACD) across various social media platforms, including content created by patients, physicians, professional organizations, and companies. Instagram had the most content, while Facebook had patient support groups. However, YouTube videos presented poor quality medical information.
CONTACT DERMATITIS
(2022)
Article
Allergy
Anne Birgitte Simonsen, Jojo Biel-Nielsen Dietz, Jeanne Duus Johansen
Summary: This study aimed to explore the epidemiology, aetiology and severity of hand eczema (HE) among Danish adolescents. The study found a high prevalence of HE among Danish adolescents, raising concerns about this significant clinical problem.
CONTACT DERMATITIS
(2023)
Article
Allergy
Taylor E. Gladys, Steven Maczuga, Alexandra Flamm
Summary: DE is a common form of eczema affecting the hands, feet, or both areas, with 34932 patients filing claims in 2018, 61% of whom are female. DE is mostly seen in employees from the service industry and the manufacturing of durable goods. The total annual direct cost was US $11,738,985.
CONTACT DERMATITIS
(2022)
Article
Dermatology
Dan Slodownik, Assi Levi, Moshe Lapidoth, Shlomo Moshe
Summary: This study describes and reviews the long-term use of dupilumab in the treatment of chronic recalcitrant occupational contact dermatitis in 6 patients, and found that all patients achieved positive treatment responses.
Review
Allergy
Sander Vandeweege, Britt Debaene, Hilde Lapeere, Hans Verstraelen
Summary: This study reviewed the literature on vulvar allergic contact dermatitis (vACD) and irritative contact dermatitis (vICD), providing a comprehensive reference list of potential vulvar allergens and irritants, and emphasizing the importance of patch testing for identifying causal allergens. Multiple allergens were identified, but not all positive reactions were relevant to the disease. Additional testing methods and late readings should be considered in standard practice. Limited information was found on irritants, highlighting the need for further research.
CONTACT DERMATITIS
(2023)
Article
Allergy
Francois-Marie Moussallieh, Eric Moss, Karim Elbayed, Guillaume Lereaux, Fleur Tourneix, Jean-Pierre Lepoittevin
CONTACT DERMATITIS
(2020)
Editorial Material
Allergy
Flore Kurihara, Angele Soria, Jean-Pierre Lepoittevin, Francois Chasset, Annick Barbaud, Catherine Pecquet
CONTACT DERMATITIS
(2020)
Review
Environmental Sciences
Wolfgang Uter, Thomas Werfel, Jean-Pierre Lepoittevin, Ian R. White
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Chemistry, Medicinal
Hassan Srour, Francois-Marie Moussallieh, Karim Elbayed, Elena Gimenez-Arnau, Jean-Pierre Lepoittevin
CHEMICAL RESEARCH IN TOXICOLOGY
(2020)
Article
Chemistry, Medicinal
Minh-Thuong Khong, Valerie Berl, Lauriane Kuhn, Philippe Hammann, Jean-Pierre Lepoittevin
Summary: The study found that the reaction of phthalic anhydride 1 (PA) in reconstructed human epidermis was fast, forming mainly phthalic acid. Proteomics analysis of RHE samples exposed to phthalic anhydride (C-13)-1 identified 135 proteins modified by PA, accounting for 14.2% of the extracted proteome.
CHEMICAL RESEARCH IN TOXICOLOGY
(2021)
Article
Chemistry, Medicinal
Hassan Srour, Alexis Gosset, Francois-Marie Moussallieh, Karim Elbayed, Elena Gimenez-Arnau, Jean-Pierre Lepoittevin
Summary: This study synthesized two 13C isotopomers of PPD and investigated their reactivity in reconstructed human epidermis using HRMAS NMR technique. The results showed that PPD underwent acetylation reaction catalyzed by N-acetyltransferase enzymes in reconstructed human epidermis, and under oxidative conditions, cysteine adducts were detected.
CHEMICAL RESEARCH IN TOXICOLOGY
(2022)
Article
Allergy
Isabelle Maniere, Alizee Aubert, Celine Dubois, Cecilia Solal, Jean-Pierre Lepoittevin, Christophe Rousselle
Summary: Twelve case reports from Europe and North America confirmed that acetophenone azine, found in sports equipment, is suspected to cause skin allergies. In vitro and in vivo tests based on the Adverse Outcome Pathway (AOP) built for skin sensitization by OECD in 2012 were conducted to confirm its skin sensitization properties. The results showed positive reactions in the in vitro tests and negative reactions in the in vivo test. As a result, acetophenone azine was classified as a skin sensitizer under the CLP regulation.
CONTACT DERMATITIS
(2023)