Ebola virus disease candidate vaccines under evaluation in clinical trials

A Recombinant Vesicular Stomatitis Virus Ebola Vaccine

(2017) Jason A. Regules et al.   NEW ENGLAND JOURNAL OF MEDICINE

Implementation of an Ebola virus disease vaccine clinical trial during the Ebola epidemic in Liberia: Design, procedures, and challenges

(2016) Stephen B Kennedy et al.   Clinical Trials

Safety and Immunogenicity of Novel Adenovirus Type 26– and Modified Vaccinia Ankara–Vectored Ebola Vaccines

(2016) Iain D. Milligan et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Duration of immune responses after Ebola virus vaccination

(2016) Steven B Bradfute   LANCET INFECTIOUS DISEASES

Use of ChAd3-EBO-Z Ebola virus vaccine in Malian and US adults, and boosting of Malian adults with MVA-BN-Filo: a phase 1, single-blind, randomised trial, a phase 1b, open-label and double-blind, dose-escalation trial, and a nested, randomised, double-blind, placebo-controlled trial

(2016) Milagritos D Tapia et al.   LANCET INFECTIOUS DISEASES

Safety and immunogenicity of a chimpanzee adenovirus-vectored Ebola vaccine in healthy adults: a randomised, double-blind, placebo-controlled, dose-finding, phase 1/2a study

(2016) Olga De Santis et al.   LANCET INFECTIOUS DISEASES

Adjuvant-enhanced CD4 T Cell Responses are Critical to Durable Vaccine Immunity

(2016) Karen A.O. Martins et al.   EBioMedicine

Aerosolized Ebola vaccine protects primates and elicits lung-resident T cell responses

(2015) Michelle Meyer et al.   JOURNAL OF CLINICAL INVESTIGATION

Safety and immunogenicity of Ebola virus and Marburg virus glycoprotein DNA vaccines assessed separately and concomitantly in healthy Ugandan adults: a phase 1b, randomised, double-blind, placebo-controlled clinical trial

(2015) Hannah Kibuuka et al.   LANCET

Safety and immunogenicity of a novel recombinant adenovirus type-5 vector-based Ebola vaccine in healthy adults in China: preliminary report of a randomised, double-blind, placebo-controlled, phase 1 trial

(2015) Feng-Cai Zhu et al.   LANCET

Efficacy and effectiveness of an rVSV-vectored vaccine expressing Ebola surface glycoprotein: interim results from the Guinea ring vaccination cluster-randomised trial

(2015) Ana Maria Henao-Restrepo et al.   LANCET

The effect of dose on the safety and immunogenicity of the VSV Ebola candidate vaccine: a randomised double-blind, placebo-controlled phase 1/2 trial

(2015) Angela Huttner et al.   LANCET INFECTIOUS DISEASES

Ebola vaccine R&D: Filling the knowledge gaps

(2015) Donata Medaglini et al.   Science Translational Medicine

Analysis of T cell responses to chimpanzee adenovirus vectors encoding HIV gag–pol–nef antigen

(2015) S. Herath et al.   VACCINE

Cross-Protection Conferred by Filovirus Virus-Like Particles Containing Trimeric Hybrid Glycoprotein

(2015) Karen Martins et al.   VIRAL IMMUNOLOGY

Skin Transfection Patterns and Expression Kinetics of Electroporation-Enhanced Plasmid Delivery Using the CELLECTRA-3P, a Portable Next-Generation Dermal Electroporation Device

(2015) Dinah H. Amante et al.   Human Gene Therapy Methods

Safety and Immunogenicity of DNA Vaccines Encoding Ebolavirus and Marburgvirus Wild-Type Glycoproteins in a Phase I Clinical Trial

(2014) U. N. Sarwar et al.   JOURNAL OF INFECTIOUS DISEASES

Recombinant Modified Vaccinia Virus Ankara Generating Excess Early Double-Stranded RNA Transiently Activates Protein Kinase R and Triggers Enhanced Innate Immune Responses

(2014) M. Wolferstatter et al.   JOURNAL OF VIROLOGY

A Single Dose Respiratory Recombinant Adenovirus-Based Vaccine Provides Long-Term Protection for Non-Human Primates from Lethal Ebola Infection

(2014) Jin Huk Choi et al.   MOLECULAR PHARMACEUTICS

Chimpanzee adenovirus vaccine generates acute and durable protective immunity against ebolavirus challenge

(2014) Daphne A Stanley et al.   NATURE MEDICINE

Toll-Like Receptor Agonist Augments Virus-Like Particle-Mediated Protection from Ebola Virus with Transient Immune Activation

(2014) Karen A. O. Martins et al.   PLoS One

A highly immunogenic fragment derived from Zaire Ebola virus glycoprotein elicits effective neutralizing antibody

(2014) Yu Wang et al.   VIRUS RESEARCH

The influence of delivery vectors on HIV vaccine efficacy

(2014) Beatrice O. Ondondo   Frontiers in Microbiology

Airway Delivery of an Adenovirus-Based Ebola Virus Vaccine Bypasses Existing Immunity to Homologous Adenovirus in Nonhuman Primates

(2013) J. S. Richardson et al.   JOURNAL OF VIROLOGY

Antibodies are necessary for rVSV/ZEBOV-GP-mediated protection against lethal Ebola virus challenge in nonhuman primates

(2013) A. Marzi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recombinant MVA vaccines: dispelling the myths

(2013) Matthew G. Cottingham et al.   VACCINE

Oral administration of an adenovirus vector encoding both an avian influenza A hemagglutinin and a TLR3 ligand induces antigen specific granzyme B and IFN-γ T cell responses in humans

(2013) Wendy Peters et al.   VACCINE

Clinical development of Modified Vaccinia virus Ankara vaccines

(2013) Sarah C. Gilbert   VACCINE

Prospects for oral replicating adenovirus-vectored vaccines

(2013) Cailin Deal et al.   VACCINE

Characterization of a putative filovirus vaccine: Virus-like particles

(2013) Karen A. O. Martins et al.   VIROLOGICA SINICA

An Adenovirus-Based Vaccine with a Double-Stranded RNA Adjuvant Protects Mice and Ferrets against H5N1 Avian Influenza in Oral Delivery Models

(2012) Ciaran D. Scallan et al.   Clinical and Vaccine Immunology

Clinical Assessment of a Recombinant Simian Adenovirus ChAd63: A Potent New Vaccine Vector

(2012) Geraldine A. O’Hara et al.   JOURNAL OF INFECTIOUS DISEASES

Ad35 and Ad26 Vaccine Vectors Induce Potent and Cross-Reactive Antibody and T-Cell Responses to Multiple Filovirus Species

(2012) Roland Zahn et al.   PLoS One

Respiratory Syncytial Virus Fusion Glycoprotein Expressed in Insect Cells Form Protein Nanoparticles That Induce Protective Immunity in Cotton Rats

(2012) Gale Smith et al.   PLoS One

Novel Adenovirus-Based Vaccines Induce Broad and Sustained T Cell Responses to HCV in Man

(2012) E. Barnes et al.   Science Translational Medicine

Immune responses and protection in children in developing countries induced by oral vaccines

(2012) Firdausi Qadri et al.   VACCINE

An Interagency Collaboration to Facilitate Development of Filovirus Medical Countermeasures

(2012) Nicole Kilgore et al.   Viruses-Basel

Viral vectors as vaccine platforms: deployment in sight

(2011) Christine S Rollier et al.   CURRENT OPINION IN IMMUNOLOGY

ISCOM technology-based Matrix M™ adjuvant: success in future vaccines relies on formulation

(2011) Karin Lövgren Bengtsson et al.   Expert Review of Vaccines

Recombinant Vesicular Stomatitis Virus–Based Vaccines Against Ebola and Marburg Virus Infections

(2011) Thomas W. Geisbert et al.   JOURNAL OF INFECTIOUS DISEASES

Recombinant Adenovirus Serotype 26 (Ad26) and Ad35 Vaccine Vectors Bypass Immunity to Ad5 and Protect Nonhuman Primates against Ebolavirus Challenge

(2011) T. W. Geisbert et al.   JOURNAL OF VIROLOGY

CD8+ cellular immunity mediates rAd5 vaccine protection against Ebola virus infection of nonhuman primates

(2011) Nancy J Sullivan et al.   NATURE MEDICINE

Immunogenicity and efficacy of oral vaccines in developing countries: lessons from a live cholera vaccine

(2010) Myron M Levine   BMC BIOLOGY

The Th1 Immune Response to Plasmodium falciparum Circumsporozoite Protein Is Boosted by Adenovirus Vectors 35 and 26 with a Homologous Insert

(2010) K. Radosevic et al.   Clinical and Vaccine Immunology

Protection of Nonhuman Primates against Two Species of Ebola Virus Infection with a Single Complex Adenovirus Vector

(2010) W. D. Pratt et al.   Clinical and Vaccine Immunology

Potent CD8+ T-Cell Immunogenicity in Humans of a Novel Heterosubtypic Influenza A Vaccine, MVA-NP+M1

(2010) T. K. Berthoud et al.   CLINICAL INFECTIOUS DISEASES

Adenovirus-Based Vaccines: Comparison of Vectors from Three Species ofAdenoviridae

(2010) H. Chen et al.   JOURNAL OF VIROLOGY

A replication defective recombinant Ad5 vaccine expressing Ebola virus GP is safe and immunogenic in healthy adults

(2010) J.E. Ledgerwood et al.   VACCINE

Respiratory tract immunization of non-human primates with a Newcastle disease virus-vectored vaccine candidate against Ebola virus elicits a neutralizing antibody response

(2010) Joshua M. DiNapoli et al.   VACCINE

Mucosal parainfluenza virus-vectored vaccine against Ebola virus replicates in the respiratory tract of vector-immune monkeys and is immunogenic

(2010) Alexander A. Bukreyev et al.   VIROLOGY

Oral Rotavirus Vaccines: How Well Will They Work Where They Are Needed Most?

(2009) Manish Patel et al.   JOURNAL OF INFECTIOUS DISEASES

New Insights on Adenovirus as Vaccine Vectors

(2009) Marcio O Lasaro et al.   MOLECULAR THERAPY

Correlates of protective immunity for Ebola vaccines: implications for regulatory approval by the animal rule

(2009) Nancy J. Sullivan et al.   NATURE REVIEWS MICROBIOLOGY

Mucosal Immunization of Cynomolgus Macaques with the VSVΔG/ZEBOVGP Vaccine Stimulates Strong Ebola GP-Specific Immune Responses

(2009) Xiangguo Qiu et al.   PLoS One

Evaluation of a prime-boost vaccine schedule with distinct adenovirus vectors against malaria in rhesus monkeys

(2009) Ariane Rodríguez et al.   VACCINE

International epidemiology of human pre-existing adenovirus (Ad) type-5, type-6, type-26 and type-36 neutralizing antibodies: Correlates of high Ad5 titers and implications for potential HIV vaccine trials

(2009) T. Christopher Mast et al.   VACCINE

Monovalent virus-like particle vaccine protects guinea pigs and nonhuman primates against infection with multiple Marburg viruses

(2008) Dana L Swenson et al.   Expert Review of Vaccines

Oral adenoviral-based vaccines: historical perspective and future opportunity

(2008) Sean N Tucker et al.   Expert Review of Vaccines

Impact of Recombinant Adenovirus Serotype 35 Priming versus Boosting of a Plasmodium falciparum Protein: Characterization of T- and B-Cell Responses to Liver-Stage Antigen 1

(2008) A. Rodriguez et al.   INFECTION AND IMMUNITY

Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial

(2008) Susan P Buchbinder et al.   LANCET

Nasal Delivery of an Adenovirus-Based Vaccine Bypasses Pre-Existing Immunity to the Vaccine Carrier and Improves the Immune Response in Mice

(2008) Maria A. Croyle et al.   PLoS One

Vesicular stomatitis virus-based vaccines protect nonhuman primates against aerosol challenge with Ebola and Marburg viruses

(2008) Thomas W. Geisbert et al.   VACCINE

A paramyxovirus-vectored intranasal vaccine against Ebola virus is immunogenic in vector-immune animals

(2008) Lijuan Yang et al.   VIROLOGY

Chimeric human parainfluenza virus bearing the Ebola virus glycoprotein as the sole surface protein is immunogenic and highly protective against Ebola virus challenge

(2008) Alexander Bukreyev et al.   VIROLOGY

Vesicular Stomatitis Virus-Based Ebola Vaccine Is Well-Tolerated and Protects Immunocompromised Nonhuman Primates

(2008) Thomas W. Geisbert et al.   PLoS Pathogens