Defending against smallpox: a focus on vaccines

Systems biology of immunity to MF59-adjuvanted versus nonadjuvanted trivalent seasonal influenza vaccines in early childhood

(2016) Helder I. Nakaya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Monkeypox in the Kivus, a Conflict Region of the Democratic Republic of the Congo

(2015) Andrea M. McCollum et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Freeze-dried live attenuated smallpox vaccine prepared in cell culture “LC16-KAKETSUKEN”: Post-marketing surveillance study on safety and efficacy compliant with Good Clinical Practice

(2015) Yasumasa Nishiyama et al.   VACCINE

Smallpox vaccine, ACAM2000: Sites and duration of viral shedding and effect of povidone iodine on scarification site shedding and immune response

(2015) Phillip R. Pittman et al.   VACCINE

Comparison of lyophilized versus liquid modified vaccinia Ankara (MVA) formulations and subcutaneous versus intradermal routes of administration in healthy vaccinia-naïve subjects

(2015) Sharon E. Frey et al.   VACCINE

Vaccinia virus strain LC16m8 defective in the B5R gene keeps strong protection comparable to its parental strain Lister in immunodeficient mice

(2015) Hiroyuki Yokote et al.   VACCINE

Systems vaccinology: Enabling rational vaccine design with systems biological approaches

(2015) Thomas Hagan et al.   VACCINE

Safety and Immunogenicity of Modified Vaccinia Ankara-Bavarian Nordic Smallpox Vaccine in Vaccinia-Naive and Experienced Human Immunodeficiency Virus-Infected Individuals: An Open-Label, Controlled Clinical Phase II Trial

(2015) E. T. Overton et al.   Open Forum Infectious Diseases

A Prospective Study of the Incidence of Myocarditis/Pericarditis and New Onset Cardiac Symptoms following Smallpox and Influenza Vaccination

(2015) Renata J. M. Engler et al.   PLoS One

Immunomodulator-Based Enhancement of Anti Smallpox Immune Responses

(2015) Osmarie Martínez et al.   PLoS One

A Multicenter, Open-Label, Controlled Phase II Study to Evaluate Safety and Immunogenicity of MVA Smallpox Vaccine (IMVAMUNE) in 18–40 Year Old Subjects with Diagnosed Atopic Dermatitis

(2015) Richard N Greenberg et al.   PLoS One

Generation of an attenuated Tiantan vaccinia virus by deletion of the ribonucleotide reductase large subunit

(2014) Shifu Kan et al.   ARCHIVES OF VIROLOGY

Global Analyses of Human Immune Variation Reveal Baseline Predictors of Postvaccination Responses

(2014) John S. Tsang et al.   CELL

Human Antibody Responses to the Polyclonal Dryvax Vaccine for Smallpox Prevention Can Be Distinguished from Responses to the Monoclonal Replacement Vaccine ACAM2000

(2014) Christine Pugh et al.   Clinical and Vaccine Immunology

Novel Poxvirus Infection in 2 Patients From the United States

(2014) L. U. Osadebe et al.   CLINICAL INFECTIOUS DISEASES

Discovery of forgotten variola specimens at the National Institutes of Health in the USA

(2014) Isao Arita   Expert Review of Anti-Infective Therapy

Smallpox vaccines: New formulations and revised strategies for vaccination

(2014) Nir Paran et al.   Human vaccines & immunotherapeutics

Cytokine production associated with smallpox vaccine responses

(2014) Whitney L Simon et al.   Immunotherapy

Infectious diseases: Smallpox watch

(2014) Sara Reardon   NATURE

Safety and immunogenicity of modified vaccinia Ankara as a smallpox vaccine in people with atopic dermatitis

(2014) Frank von Sonnenburg et al.   VACCINE

Transcriptomic profiles of high and low antibody responders to smallpox vaccine

(2013) R B Kennedy et al.   GENES AND IMMUNITY

Race and sex-based differences in cytokine immune responses to smallpox vaccine in healthy individuals

(2013) Iana H. Haralambieva et al.   HUMAN IMMUNOLOGY

Assessment of the Protective Effect of Imvamune and Acam2000 Vaccines against Aerosolized Monkeypox Virus in Cynomolgus Macaques

(2013) G. J. Hatch et al.   JOURNAL OF VIROLOGY

Vaccinomics, adversomics, and the immune response network theory: Individualized vaccinology in the 21st century

(2013) Gregory A. Poland et al.   SEMINARS IN IMMUNOLOGY

An open-label, single arm, phase III clinical study to evaluate the efficacy and safety of CJ smallpox vaccine in previously vaccinated healthy adults

(2013) Nak-Hyun Kim et al.   VACCINE

An Increasing Danger of Zoonotic Orthopoxvirus Infections

(2013) Sergei N. Shchelkunov   PLoS Pathogens

Impact of cytokine and cytokine receptor gene polymorphisms on cellular immunity after smallpox vaccination

(2012) Inna G. Ovsyannikova et al.   GENE

Unusual Features of Vaccinia Virus Extracellular Virion Form Neutralization Resistance Revealed in Human Antibody Responses to the Smallpox Vaccine

(2012) Mohammed Rafii-El-Idrissi Benhnia et al.   JOURNAL OF VIROLOGY

Variola Virus in a 300-Year-Old Siberian Mummy

(2012) Philippe Biagini et al.   NEW ENGLAND JOURNAL OF MEDICINE

Side-by-Side Comparison of Gene-Based Smallpox Vaccine with MVA in Nonhuman Primates

(2012) Joseph W. Golden et al.   PLoS One

Genome-wide association study of antibody response to smallpox vaccine

(2012) Inna G. Ovsyannikova et al.   VACCINE

A vaccinia virus renaissance

(2012) Paulo H. Verardi et al.   Human Vaccines & Immunotherapeutics

What was the primary mode of smallpox transmission? Implications for biodefense

(2012) Donald K. Milton   Frontiers in Cellular and Infection Microbiology

MVA and NYVAC as Vaccines against Emergent Infectious Diseases and Cancer

(2011) Carmen E. Gomez et al.   CURRENT GENE THERAPY

Vaccinia viruses: vaccines against smallpox and vectors against infectious diseases and tumors

(2011) Stephen R Walsh et al.   Expert Review of Vaccines

Early Patterns of Gene Expression Correlate With the Humoral Immune Response to Influenza Vaccination in Humans

(2011) Kristine L. Bucasas et al.   JOURNAL OF INFECTIOUS DISEASES

Safety and Immunogenicity of LC16m8, an Attenuated Smallpox Vaccine in Vaccinia-Naive Adults

(2011) J. S. Kennedy et al.   JOURNAL OF INFECTIOUS DISEASES

Smallpox Vaccine Safety Is Dependent on T Cells and Not B Cells

(2011) Shari N. Gordon et al.   JOURNAL OF INFECTIOUS DISEASES

Genomic Analysis of the Vaccinia Virus Strain Variants Found in Dryvax Vaccine

(2011) L. Qin et al.   JOURNAL OF VIROLOGY

Systems biology of vaccination for seasonal influenza in humans

(2011) Helder I Nakaya et al.   NATURE IMMUNOLOGY

Why not destroy the remaining smallpox virus stocks?

(2011) J. Michael Lane et al.   VACCINE

Emergence and reemergence of smallpox: The need for development of a new generation smallpox vaccine

(2011) Sergei N. Shchelkunov   VACCINE

The eradication of smallpox – An overview of the past, present, and future

(2011) Donald A. Henderson   VACCINE

Zoonotic cases of camelpox infection in India

(2011) B.C. Bera et al.   VETERINARY MICROBIOLOGY

Kinetics of Serum Cytokines after Primary or Repeat Vaccination with the Smallpox Vaccine

(2010) Jeffrey I. Cohen et al.   JOURNAL OF INFECTIOUS DISEASES

Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo

(2010) A. W. Rimoin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A randomized, double-blind, controlled clinical trial to evaluate the efficacy and safety of CJ-50300, a newly developed cell culture-derived smallpox vaccine, in healthy volunteers

(2010) Hee-Chang Jang et al.   VACCINE

A protein-based smallpox vaccine protects non-human primates from a lethal monkeypox virus challenge

(2010) George W. Buchman et al.   VACCINE

Impact of ST-246® on ACAM2000™ smallpox vaccine reactogenicity, immunogenicity, and protective efficacy in immunodeficient mice

(2010) Aklile Berhanu et al.   VACCINE

VennVax, a DNA-prime, peptide-boost multi-T-cell epitope poxvirus vaccine, induces protective immunity against vaccinia infection by T cell response alone

(2010) Leonard Moise et al.   VACCINE

ACAM2000™: The new smallpox vaccine for United States Strategic National Stockpile

(2010) Aysegul Nalca et al.   Drug Design Development and Therapy

How long ago did smallpox virus emerge?

(2009) Sergei N. Shchelkunov   ARCHIVES OF VIROLOGY

The immunology of smallpox vaccines

(2009) Richard B Kennedy et al.   CURRENT OPINION IN IMMUNOLOGY

Clinical and Immunological Response to Attenuated Tissue-Cultured Smallpox Vaccine LC16m8

(2009) Tomoya Saito   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Adversomics: The Emerging Field of Vaccine Adverse Event Immunogenetics

(2009) Gregory A. Poland et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Discovery of naturally processed and HLA-presented class I peptides from vaccinia virus infection using mass spectrometry for vaccine development

(2009) Kenneth L. Johnson et al.   VACCINE

Smallpox vaccines for biodefense

(2009) Richard B. Kennedy et al.   VACCINE

Molecular smallpox vaccine delivered by alphavirus replicons elicits protective immunity in mice and non-human primates

(2009) Jay W. Hooper et al.   VACCINE

The smallpox vaccine induces an early neutralizing IgM response

(2009) Juan E. Moyron-Quiroz et al.   VACCINE

Gender effects on humoral immune responses to smallpox vaccine

(2009) Richard B. Kennedy et al.   VACCINE

Zoonotic poxviruses

(2009) Sandra Essbauer et al.   VETERINARY MICROBIOLOGY

Zoonotic Infections of Buffalopox in India

(2009) V. Bhanuprakash et al.   Zoonoses and Public Health

Evaluation of preterm births and birth defects in liveborn infants of US military women who received smallpox vaccine

(2008) Margaret A. K. Ryan et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Severe Eczema Vaccinatum in a Household Contact of a Smallpox Vaccinee

(2008) Surabhi Vora et al.   CLINICAL INFECTIOUS DISEASES

Personalized vaccines: the emerging field of vaccinomics

(2008) Gregory A Poland et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Vaccinia virus strain NYVAC induces substantially lower and qualitatively different human antibody responses compared with strains Lister and Dryvax

(2008) C. M. Midgley et al.   JOURNAL OF GENERAL VIROLOGY

Genetic Basis for Adverse Events after Smallpox Vaccination

(2008) David M. Reif et al.   JOURNAL OF INFECTIOUS DISEASES

Vaccination of BALB/c Mice with Escherichia coli-Expressed Vaccinia Virus Proteins A27L, B5R, and D8L Protects Mice from Lethal Vaccinia Virus Challenge

(2008) A. Berhanu et al.   JOURNAL OF VIROLOGY

Differential CD4+ versus CD8+ T-Cell Responses Elicited by Different Poxvirus-Based Human Immunodeficiency Virus Type 1 Vaccine Candidates Provide Comparable Efficacies in Primates

(2008) P. Mooij et al.   JOURNAL OF VIROLOGY

Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans

(2008) Troy D Querec et al.   NATURE IMMUNOLOGY

US military service members vaccinated against smallpox in 2003 and 2004 experience a slightly higher risk of hospitalization postvaccination

(2008) Isabel G. Jacobson et al.   VACCINE

Immunogenic properties of plant-derived recombinant smallpox vaccine candidate pB5

(2008) Carla Portocarrero et al.   VACCINE

Comparison of the safety and immunogenicity of ACAM1000, ACAM2000 and Dryvax® in healthy vaccinia-naive adults

(2008) Sharon E. Frey et al.   VACCINE

Heterogeneity in the A33 protein impacts the cross-protective efficacy of a candidate smallpox DNA vaccine

(2008) Joseph W. Golden et al.   VIROLOGY

Immunogenicity and protection efficacy of subunit-based smallpox vaccines using variola major antigens

(2007) Pavlo Sakhatskyy et al.   VIROLOGY