Article
Engineering, Biomedical
Wan-Hang Zhou, Yan-Fei Li
Summary: The DPP bilayer membranes prepared in this study exhibited notable biological safety and osteogenic activity in vitro, and have the potential to be a prospective candidate for guided bone regeneration (GBR) approach in the future.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Biotechnology & Applied Microbiology
Jiaxin Li, Weichang Li, Mengjie Kong, Zongtai Li, Tao Yang, Qinmei Wang, Wei Teng
Summary: A bi-layered scaffold for guided bone regeneration (GBR) composed of a fiber barrier layer and a self-healing hydrogel repair layer has been successfully fabricated. This system can provide an osteogenic microenvironment, maintain the stability of the osteogenic space, and regulate the release of bioactive substances. The study shows that the hybrid scaffold has good biocompatibility, cell barrier function, and can enhance bone regeneration activity.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Matthias Schumacher, Pamela Habibovic, Sabine van Rijt
Summary: The slow and disorganized formation of a functional vascular network in large bone defect regeneration can cause delayed healing or implant failure. This study introduces a promising strategy by immobilizing the pro-angiogenic growth factor VEGF on nanosized bioactive glass particles using a binding peptide, which can induce angiogenesis and overcome the problem of insufficient neovascularization.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Biotechnology & Applied Microbiology
Ze Yang, Chang Wu, Huixin Shi, Xinyu Luo, Hui Sun, Qiang Wang, Dan Zhang
Summary: Guided bone regeneration (GBR) is a widely used technique for alveolar bone augmentation. The success of GBR relies on the barrier membrane, which should have satisfactory biological and mechanical properties. Currently, the bone augmentation effect of barrier membranes used in clinical practice depends on the body's own growth potential, and the osteogenic effect is difficult to predict. Therefore, researchers have been exploring new barrier membranes to improve the success rate of bone enhancement.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Chemistry, Medicinal
Gamal A. Atia, Hany K. Shalaby, Ali B. Roomi, Mohamed M. Ghobashy, Hager A. Attia, Sara Z. Mohamed, Ahmed Abdeen, Mohamed Abdo, Liana Fericean, Ioan Banatean Dunea, Ahmed M. Atwa, Tabinda Hasan, Wessam Mady, Afaf Abdelkader, Susan A. Ali, Ola A. Habotta, Rehab A. Azouz, Farag Malhat, Mustafa Shukry, Tarek Foda, Stefania Dinu
Summary: The introduction of dental polymers has greatly contributed to the advancement of biotechnological research in tissue engineering, biomaterials development, and drug delivery. They have been effectively used in dentistry for building dentures, orthodontic equipment, and various restorative materials. Dental polymers also have the potential to be utilized for medication administration and tissue regeneration.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Materials Science, Biomaterials
Hongyan Tang, Chengkai Qi, Yanjie Bai, Xufeng Niu, Xuenan Gu, Yubo Fan
Summary: In this study, a bi-layered membrane with dense and porous structure was prepared using poly(lactic acid-glycolic acid) (PLGA) as the matrix for guided bone regeneration (GBR). The dense layer was incorporated with zinc (Zn) particles to block soft tissues, while the porous layer was co-incorporated with magnesium (Mg) and Zn particles to promote bone regeneration. The Mg/Zn-embedded PLGA membranes showed higher mechanical strength and suitable degradation properties, as well as excellent antibacterial activity and good cytocompatibility. Therefore, the bi-layered PLGA membranes embedded with Mg and Zn particles have the potential to be a promising candidate for GBR therapy.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Review
Polymer Science
Manuel Toledano-Osorio, Cristina Vallecillo, Marta Vallecillo-Rivas, Francisco-Javier Manzano-Moreno, Raquel Osorio
Summary: Polymeric membranes are commonly utilized in bone regeneration for oral and periodontal surgeries by providing mechanical support and enhancing cell proliferation. Local antibiotic therapy using polymeric membranes has shown promising antibacterial effects, although further research and clinical studies are needed for validation.
Article
Materials Science, Ceramics
Tang Jieyin, Wang Gang, Liu Cong, Zou Xuenong, Chen Xiaofeng
Summary: Micro-nano bioactive glass pastes can effectively treat dentin hypersensitivity by inducing dentin remineralization and occluding dentin tubules.
JOURNAL OF INORGANIC MATERIALS
(2022)
Article
Chemistry, Applied
Yue Wang, Kei Kanie, Toshiaki Takezawa, Miki Horikawa, Kyoshiro Kaneko, Ayako Sugimoto, Aika Yamawaki-Ogata, Yuji Narita, Ryuji Kato
Summary: During wound regeneration, a membrane with dual surfaces, combining the properties of carboxymethyl cellulose (CMC) and collagen, was developed using vitrification. This membrane provides strong cell adhesion-inhibition and cell adhesion simultaneously.
CARBOHYDRATE POLYMERS
(2022)
Article
Materials Science, Multidisciplinary
Se-Chang Kim, Seong-Yeong Heo, Gun-Woo Oh, Pathum Chandika, Won Sun Park, Il- Whan Choi, Won-Kyo Jung
Summary: This study evaluated the effects of Spirulina maxima-derived phycocyanin (PC) on bone cells and developed a hierarchically structured fibrous membrane loaded with PC. The results showed that the fibrous membrane exhibited excellent biocompatibility and enhanced bone tissue regeneration.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Polymer Science
Zakaria Tabia, Sihame Akhtach, Meriame Bricha, Khalil El Mabrouk
Summary: Fibrous membranes composed of PCL and BGn were prepared using a green electrospinning method for potential use in GBR. The introduction of BGn improved fiber uniformity, alignment, and reduced hydrophobicity of PCL. In vitro studies demonstrated that biodegradability and bioactivity could be tailored by adjusting the BGn content, with higher concentrations leading to better biomineralization and matching degradation rates.
EUROPEAN POLYMER JOURNAL
(2021)
Review
Engineering, Biomedical
Soo-Ling Bee, Zuratul Ain Abdul Hamid
Summary: This article reviews the latest developments and applications of asymmetric barrier membranes used in periodontal regeneration. It first presents the requirements for constructing barrier membranes and the principles behind the asymmetric design, then discusses various innovative methods, and finally summarizes the application and evaluation of different types of asymmetric barrier membranes.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Yuwei Zhu, Bingyang Dai, Xu Li, Wei Liu, Jiangpeng Wang, Jiankun Xu, Shunxiang Xu, Xuan He, Shian Zhang, Quan Li, Ling Qin, To Ngai
Summary: The developed biphasic GBR membrane in this study can accelerate calvarial defect repair and has a favorable effect on bone regeneration.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Huijun Zhang, Jingjing Wu, Ying Wan, Stefan Romeis, Julian D. Esper, Wolfgang Peukert, Kai Zheng, Aldo R. Boccaccini
Summary: Novel bioactive glass flakes combined with chitosan in composite membranes show superior bioactivity and the ability to modulate swelling behavior, making them a promising material for guided bone regeneration.
ADVANCED ENGINEERING MATERIALS
(2022)
Review
Materials Science, Biomaterials
Kakyung Kim, Yingchao Su, Allan J. Kucine, Ke Cheng, Donghui Zhu
Summary: Guided bone regeneration (GBR) is a widely used technique for promoting bone regeneration and preventing soft tissue migration. It can be classified into resorbable and non-resorbable membranes, each with their advantages and drawbacks. GBR can be enhanced through modifications and understanding the role of osteoimmunology. Further research in this field has the potential to advance bone healing and treatment of bone diseases and injuries.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)