Article
Pharmacology & Pharmacy
Bruno Altran Costa, Marina Paiva Abucafy, Thulio Wliandon Lemos Barbosa, Bruna Lallo da Silva, Rafael Bianchini Fulindi, Guilherme Isquibola, Paulo Inacio da Costa, Leila Aparecida Chiavacci
Summary: Loading antibiotic drugs into zeolitic imidazolate frameworks (ZIFs), in combination with ZnO nanoparticles, can improve drug delivery efficiency and reduce side effects. This association allows for controlled release of active moieties and shows good antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa.
Article
Chemistry, Physical
Jungwon Kong, Sung Soo Park, Chang-Sik Ha
Summary: In this study, polyacrylic acid-functionalized MCM-41 nanoparticles were synthesized to achieve enhanced pH-responsive nanocarriers for sustained drug release. The modified nanoparticles showed calcium-carboxyl ionic bonds in the polymeric layer, which prevented the leakage of cargo in the mesopores. The release of guest molecules was controlled by different pH conditions, indicating the potential of these materials as pH-responsive nanocarriers in medical treatment.
Article
Polymer Science
Hassan Arkaban, Mahmood Barani, Majid Reza Akbarizadeh, Narendra Pal Singh Chauhan, Sapana Jadoun, Maryam Dehghani Soltani, Payam Zarrintaj
Summary: Polyacrylic acid (PAA) is a non-toxic, biocompatible, and biodegradable polymer that has attracted significant interest in recent years. By chemically modifying carboxyl groups, superior PAA nano-derivatives with enhanced stability and biocompatibility can be obtained, making them ideal for drug delivery and antimicrobial applications.
Article
Chemistry, Physical
Maryam Sadeghpour, Maryam Homayoonfal, Fatemeh Davar
Summary: In this research, pH sensitive bilayer membranes were used for separating a pH-sensitive drug. The presence of specific components in the membrane layers led to improved porosity, roughness reduction, and enhanced separation performance. The synergistic effect of pH-sensitive agents in both layers of the membrane resulted in significant enhancements in flux, separation, and flux recovery compared to membranes with only one pH-sensitive layer.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Biochemistry & Molecular Biology
Hessam Jafari, Hassan Namazi, Gholam Reza Mahdavinia
Summary: In this study, magnetite nanoparticles were immobilized on sepiolite needles via co-precipitation of iron ions. The resulting magnetic sepiolite nanoparticles were coated with chitosan biopolymer in the presence of citric acid to prepare core-shell drug nanocarriers. The synthesized nanocarriers showed promising properties for biomedical applications, such as sustained drug release, cytotoxicity against cancer cells, hemocompatibility, antioxidant activity, and antibacterial efficacy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nanoscience & Nanotechnology
Yingjian Ma, Rui Zhao, Hongyi Shang, Shuo Zhen, Linjie Li, Xinyu Guo, Meng Yu, Yong Xu, Jianguo Feng, Xuemin Wu
Summary: This study successfully prepared a pH-responsive delivery nanoparticle to control termites. The nanoparticle has precise controlled release modes, improving pesticide targeting and reducing toxic side effects. It showed longer duration of termite control compared to commercial pesticides and lower acute toxicity to earthworms, zebrafish, and human hepatocyte cells.
ACS APPLIED NANO MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Hamidreza Abdouss, Mehrab Pourmadadi, Payam Zahedi, Majid Abdouss, Fatemeh Yazdian, Abbas Rahdar, Ana M. Diez-Pascual
Summary: A novel pH-sensitive nanocarrier was designed using chitosan, polyacrylic acid, and graphitic carbon nitride via water/oil/water emulsification for curcumin drug delivery. The incorporation of g-C3N4 into CS/PAA hydrogel was achieved, providing a high drug loading capacity and pH-sensitive release profile. The nanocarrier showed excellent efficacy in eliminating cancer cells and has great potential for controlled drug release.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Multidisciplinary
Seyed Mohammad Reza Shoja, Majid Abdouss, Ali Akbar Miran Beigi, Raheleh Saeedirad
Summary: This study investigated the design and synthesis of a pH-responsive corrosion inhibitor hybrid based on zeolite rimidazolate framework-8 (ZIF-8) structure as nanocarrier and the ionic liquid. The hybrid structure showed long-term inhibition capability for carbon steel in 3.0 wt% NaCl solution, and the maximum release rate of anti-corrosion agent occurred in strongly acidic and basic conditions.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Zhangjie Wang, Xiaowen Ye, Yuting Fang, Hui Cheng, Yan Xu, Xiaoqin Wang
Summary: This study successfully synthesized a pH-sensitive and aptamer-modified drug-loading polymer micelles, demonstrating superior tumor targeting and pH-sensitive drug release abilities. In vitro experiments showed significant inhibitory effects and clear targeting of AP-(NAR@ZIF-8)/PMs on human lung cancer and breast cancer cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Physical
Eunbi Kim, Ahmad Umar, Sadia Ameen, Rajesh Kumar, Ahmed A. Ibrahim, Mohsen A. M. Alhamami, M. S. Akhtar, Sotirios Baskoutas
Summary: In this study, ZIF-8/GO and ZIF-8/rGO composites were synthesized and characterized for electrochemical sensing of Cu2+ ions. The composites were prepared by dispersing GO or rGO in a solution of Zn(NO3)2·6H2O and 2-methylimidazole in anhydrous methanol. Various techniques were used to investigate the structural, morphological, and chemical properties of the materials. The ZIF-8/GO composite-based Cu2+ ion sensor exhibited superior sensitivity and LOD compared to ZIF-8/rGO and ZIF-8 alone, demonstrating its potential in electrochemical sensing applications.
SURFACES AND INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Xiaohui Niu, Simeng Yan, Rui Zhao, Hongxia Li, Xiaoyu Liu, Kunjie Wang
Summary: In the pursuit of chiral materials with significant chiral recognition effects and stability, the integration of metal nanoparticles and chiral metal-organic frameworks (CMOFs) has shown promise. However, the combination of metal nanoparticles (MNPs)/CMOFs often suffer from inferior stabilities due to the detachment of MNPs under certain conditions. To overcome this, a novel sandwich chiral material (D-His-ZIF-8@ Au@ZIF-8) was synthesized, which demonstrated excellent chiral recognition capabilities. This experiment presents a new perspective for the fabrication of a chiral electrochemical sensing platform based on a solid sandwich chiral nanocomposite.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Wenxuan Chen, Suiping Wang, Minghui Yang
Summary: In this study, an electrochemical sensor was prepared to detect uric acid in serum. Platinum nanoparticles were synthesized within porous carbon material to enhance adhesion and stability. The sensor exhibited sensitive and selective detection of uric acid.
Article
Engineering, Environmental
Yingjian Ma, Yinmin Wang, Rui Zhao, Zhijie Wang, Shuang Li, Meng Yu, Sen Pang, Xinyu Guo, Yong Xu, Xuemin Wu
Summary: Using advanced functional materials and technologies to construct new, efficient, and controlled-release pesticide formulations can effectively improve the target utilization of pesticides and reduce their impact on nontarget organisms and the surrounding environment. The study presents a strategy for preparing pH-responsive nanodrug delivery systems that can release pesticides rapidly in acidic environments. The results show that the nanodrug delivery system has longer-lasting fungicidal activity and lower impact on non-target organisms and the environment. Moreover, it can provide trace elements required by plants to promote crop growth without disturbing normal growth.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Jie Liang, Weiwei Zhang, Jun Wang, Wanzhen Li, Fei Ge, Weihao Jin, Yugui Tao
Summary: A novel nanocatalytic platform CaO2@DOX@Cu/ZIF-8 was prepared, which enabled the combination of chemotherapy and chemodynamic therapy (CDT) in cancer cells. In the tumor microenvironment, CaO2@DOX@Cu/ZIF-8 NPs rapidly disintegrated to release CaO2, generating H2O2 and O-2. The combination of chemotherapy and CDT using CaO2@DOX@Cu/ZIF-8 NPs showed a more favorable tumor suppression effect compared to the nanomaterial precursors.
Article
Biochemical Research Methods
Haibao Jin, Evan S. Feura, Mark H. Schoenfisch
Summary: The study describes the synthesis of NO-releasing carbon quantum dots and their anticancer activity, showing that the efficacy against cancer cell lines depends on the NO payloads and surface functionalizations. The modified CQDs with adjustable NO payloads demonstrated promising dual NO-releasing and bioimaging capabilities.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Chemistry, Physical
Mehdi Arkaban, Leila Mahdavian, Hassan Arkaban
Article
Biochemical Research Methods
Hassan Arkaban, Mohammad Mirzaei, Mansoureh Behzadi
Summary: A novel polyphenol-coated CoFe2O4 system was synthesized as a magnetic sorbent for solid-phase extraction of lawsone. Under optimized conditions, the nanosorbent showed efficient extraction of lawsone from saline aqueous solution, with a linear calibration curve and high relative recovery percentages.
Article
Chemistry, Physical
Ahmad Khajeh Ebrahimi, Iran Sheikhshoaie, Saeideh Salimi, Hassan Arkaban
Summary: The threat of water pollution as a result of industrial development and population growth has garnered increasing attention worldwide. This study introduces a superparamagnetic Mn-MOF core-shell nanostructure as a significant magnetic adsorbent for removing organic dyes, showing promising potential for the treatment of contaminated water. Results demonstrate the effectiveness of the CoFe2O4@Mn-MOF core-shell in removing Malachite green from water medium, indicating a high adsorption capacity and porous structure which make it a promising candidate for dye removal applications.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Nanoscience & Nanotechnology
Hassan Arkaban, Ahmad Khajeh Ebrahimi, Ali Yarahmadi, Payam Zarrintaj, Mahmood Barani
Summary: In this study, a multifunctional theranostic nanocomposite was designed for cancer treatment, with high Dox encapsulation efficiency. Various techniques were used to investigate the physicochemical properties of the nanosystem, showing a more efficient therapeutic effect in vitro compared to free Dox.
Article
Chemistry, Inorganic & Nuclear
Hassan Arkaban, Reza Karimi Shervedani, Fatemeh Yaghoobi, Amirhosein Kefayat
Summary: A nanocomposite system containing targeted imaging and therapeutic agents with high doxorubicin delivery capability was designed and constructed. The system demonstrated effective capturing of 4T1 breast cancer cells, showcasing its potential for targeted therapy.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Hassan Arkaban, Fatemeh Yaghoobi, Amirhosein Kefayat, Fatemeh Ghahremani, Reza Karimi Shervedani
Summary: A targeted imaging and therapeutic nanocomposite system was developed in this study, using AuNPs double coated by MnCO3/Mn3O4 and polyacrylic acid as contrast agents, conjugated with folic acid as a targeting agent, and loaded with doxorubicin and propidium iodide as therapeutic and fluorescence agents. The system demonstrated high efficiency in MRI and pH sensitivity, as well as a synergistic effect in enhancing the contrast of CT images. It also showed promising results in intracellular delivery, anticancer activity, biodistribution, and biocompatibility.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Hassan Arkaban, Reza Karimi Shervedani, Mostafa Torabi, Leyla Norouzi-Barough
Summary: This study reports the synthesis and characterization of a biocompatible and biodegradable nanocomposite for tumor diagnosis and treatment. The nanocomposite showed promising diagnostic efficiency as an MRI contrast agent and pH-sensitive drug release capability. It exhibited effective inhibition of cancer cell proliferation while being non-toxic to normal cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Polymer Science
Hassan Arkaban, Mahmood Barani, Majid Reza Akbarizadeh, Narendra Pal Singh Chauhan, Sapana Jadoun, Maryam Dehghani Soltani, Payam Zarrintaj
Summary: Polyacrylic acid (PAA) is a non-toxic, biocompatible, and biodegradable polymer that has attracted significant interest in recent years. By chemically modifying carboxyl groups, superior PAA nano-derivatives with enhanced stability and biocompatibility can be obtained, making them ideal for drug delivery and antimicrobial applications.
Review
Biochemistry & Molecular Biology
Mehdi Bazi Alahri, Alhawarin Jibril Ibrahim, Mahmood Barani, Hassan Arkaban, Seyedeh Malahat Shadman, Soodeh Salarpour, Payam Zarrintaj, Javad Jaberi, Abduladheem Turki Jalil
Summary: The blood-brain barrier restricts drug entry into the brain and poses a challenge in CNS disease treatment. Nanotechnology-based delivery systems with polymer coatings, such as HSA, PLGA, PLA, PACA, gelatin, and chitosan, have been developed to overcome this barrier and deliver drugs to the brain. The review article discusses the application of polymer-coated nanoparticles as novel drug carriers to the brain.
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)