Article
Medicine, General & Internal
Mani Maheshwari, Hemanthkumar Athiraman
Summary: This case report highlights the severe neurologic symptoms caused by vitamin B12 deficiency in a young adult who used nitrous oxide recreationally. It emphasizes the importance of recognizing the harmful effects of recreational nitrous oxide use.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Toxicology
Courtney Temple, B. Zane Horowitz
Summary: This study reported four cases of subacute combined degeneration induced by recreational nitrous oxide abuse despite self-administered vitamin B12 supplementation.
CLINICAL TOXICOLOGY
(2022)
Article
Emergency Medicine
Brian Lewis, Gilbert Nelson, Thomas Vu, Bryan Judge
Summary: Chronic nitrous oxide abuse can lead to myeloneuropathy, with similar clinical manifestations as vitamin B12 deficiency. Physicians in emergency medicine should consider nitrous oxide myeloneuropathy in the differential diagnosis when evaluating patients with bilateral neurological deficits and ataxia.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Clinical Neurology
Ulf Wike Ljungblad, Henriette Astrup, Lars Morkrid, Helle Borgstrom Hager, Morten Lindberg, Erik A. Eklund, Anne-Lise Bjorke-Monsen, Terje Rootwelt, Trine Tangeraas
Summary: This study aimed to identify risk factors and describe presenting symptoms and biochemical profiles in infants diagnosed with vitamin B12 deficiency. The results showed that spells, tremor, and irritability were common findings in early infant vitamin B12 deficiency. The administration of nitrous oxide during labor was proposed as a contributing risk factor to the development of early infant vitamin B12 deficiency.
PEDIATRIC NEUROLOGY
(2022)
Article
Medicine, General & Internal
Bahadar S. Srichawla
Summary: The abuse of nitrous oxide, commonly through inhalation of whipped cream canisters, can lead to irreversible neurological deficits. The sale of these canisters, known as whippits, is unregulated in the United States, contributing to the increasing prevalence of abuse. The mechanism of injury is related to severe depletion of vitamin B-12.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Pediatrics
Ulf Wike Ljungblad, Morten Lindberg, Erik A. Eklund, Ingjerd Saeves, Anne-Lise Bjorke-Monsen, Trine Tangeraas
Summary: This study aimed to investigate the risk factors for vitamin B12 deficiency in infants. The results indicated that the dose of nitrous oxide during labor was the strongest predictor for total homocysteine level in newborn screening dried blood spots.
Article
Toxicology
Etienne Mondesert, Celine Eiden, Helene Peyriere, Aude Formoso, Lucas Corti, Jean-Paul Cristol, Stephanie Badiou
Summary: Misuse of inhaled nitrous oxide is a growing concern in France, as it affects the concentration of vitamin B-12 and leads to a range of clinical issues. Measurement of vitamin B-12, homocysteine, and methylmalonic acid concentrations can assist in diagnosing complex cases.
CLINICAL TOXICOLOGY
(2023)
Review
Pharmacology & Pharmacy
Darmiga Thayabaran, Daniel Burrage
Summary: Research has shown that the use of nitrous oxide can lead to toxicity associated with vitamin B12 deficiency, primarily affecting the haematological and neurological systems. Health warnings have been issued by experts due to its legal status as a recreational drug, making it crucial for clinicians to have an awareness and understanding of the pathophysiology and management of nitrous oxide toxicity.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Clinical Neurology
Sunjeev K. Kamboj, Hannah Zhao, Luzia Troebinger, Giulia Piazza, Emma Cawley, Vanessa Hennessy, Georges Iskandar, Ravi K. Das
Summary: The study explored the subjective rewarding effects of N2O in comparison to ketamine, finding similar effects; it also highlighted the moderating roles of impulsivity and depressive symptoms on the subjective effects of N2O.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Clinical Neurology
B. J. Ruijter, M. J. de Mooij, J. E. Bruijnes, W. P. J. van Oosterhout, V. I. H. Kwa
Summary: This study reports a case series of excessive N2O users with neurological complications, including polyneuropathy, myelopathy, and encephalopathy. Testing for serum levels of vitamin B12, homocysteine, and methylmalonic acid may support the clinical diagnosis. Treatment should incorporate vitamin B12 supplementation and strategies to prevent relapses in N2O use.
JOURNAL OF NEUROLOGY
(2023)
Article
Medicine, General & Internal
Aicha H. Moussa, Walid Mohamed, Saad Zidouh
Summary: Nitrous oxide, commonly known as laughing gas, is being misused recreationally despite its intended industrial and medical uses. This article highlights the serious health consequences of excessive and prolonged recreational use of nitrous oxide. A distressing case of a young user developing severe myelitis is discussed to shed light on the abuse potential of this substance.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Clinical Neurology
Berenger Largeau, Arnaud Karam, Camille Potey, Anne-Sylvie Caous, Celine Tard, Louise Carton, Gregory Kuchcinski, Sophie Gautier, Sylvie Deheul, Regis Bordet
Summary: This study investigated the onset patterns of neurological disorders caused by nitrous oxide abuse and found that even low intermittent exposure could lead to neurological damage. There is no safe level of exposure to nitrous oxide in recreational settings.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Chemistry, Multidisciplinary
JoAnna Milam-Guerrero, Bingxin Yang, Dung T. To, Nosang V. Myung
Summary: Nitrous oxide, also known as laughing gas, is a highly detrimental greenhouse gas that is often overlooked. This review focuses on low-cost gas-sensing technologies, such as metal oxide semiconductors, chemiresistive sensors, and electrochemical sensors, for monitoring and detecting nitrous oxide emissions. The use of metal-organic frameworks for compositional modifications is also discussed to improve sensing performance.
Article
Psychiatry
Mark A. Gillman
Summary: This paper compares the safety and practical applicability of fixed concentrations of nitrous oxide with variable titrated concentrations of Psychotropic Analgesic N2O. The study shows that fixed concentrations may cause adverse effects in sensitive patients, while variable concentrations can be adjusted based on individual responses, making them safer and more scientific.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Environmental Sciences
Wangshou Zhang, Hengpeng Li, Steven G. Pueppke, Jiaping Pang
Summary: This study investigated the concentrations of N2O and CH4 in a headwater stream in the Taihu Lake basin of China, revealing that the saturation levels of CH4 in wetland reaches were seven times higher than those in non-wetland reaches, with peaks in July coinciding with a decrease in N2O saturation. Diurnal measurements showed that CH4 saturation in water passing through wetlands can surge to levels 10 times higher than at other times, while N2O saturation decreases by 75%. These findings highlight the potential hotspots of CH4 production and N2O consumption in riverine wetlands.
ENVIRONMENTAL POLLUTION
(2021)
Article
Cardiac & Cardiovascular Systems
Hiroki Takanari, Vincent J. A. Bourgonje, Magda S. C. Fontes, Antonia J. A. Raaijmakers, Helen Driessen, John A. Jansen, Roel van der Nagel, Bart Kok, Leonie van Stuijvenberg, Mohamed Boulaksil, Yoshio Takemoto, Masatoshi Yamazaki, Yukiomi Tsuji, Haruo Honjo, Kaichiro Kamiya, Itsuo Kodama, Mark E. Anderson, Marcel A. G. van der Heyden, Harold V. M. van Rijen, Toon A. B. van Veen, Marc A. Vos
CARDIOVASCULAR RESEARCH
(2016)
Article
Cell Biology
Yuan Ji, Hiroki Takanari, Muge Qile, Lukas Nalos, Marien J. C. Houtman, Fee L. Romunde, Raimond Heukers, Paul M. P. van Bergen En Henegouwen, Marc A. Vos, Marcel A. G. van der Heyden
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2017)
Review
Nutrition & Dietetics
Rogier P. M. te Dorsthorst, Jytte Hendrikse, Mats T. Vervoorn, Valerie Y. H. van Weperen, Marcel A. G. van der Heyden
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2019)
Article
Veterinary Sciences
Viktor Szatmari, Yuan Ji, Bianca van Herwijnen, Mei Feng, Michael Zhou Wang, Alexandre Bossu, Marcel A. G. van der Heyden
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2018)
Editorial Material
Cardiac & Cardiovascular Systems
Marcel A. G. van der Heyden, Marc A. Vos
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2019)
Article
Cell Biology
Marien J. C. Houtman, Xingyu Chen, Muge Qile, Karen Duran, Gijs van Haaften, Anna Stary-Weinzinger, Marcel A. G. van der Heyden
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2019)
Review
Biochemistry & Molecular Biology
Eva-Maria Zangerl-Plessl, Muge Qile, Meye Bloothooft, Anna Stary-Weinzinger, Marcel A. G. van der Heyden
Review
Biochemistry & Molecular Biology
Laura van der Schoor, Emma J. van Hattum, Sophie M. de Wilde, Netanja Harlianto, Aart-Jan Van Weert, Meye Bloothooft, Marcel A. G. van der Heyden
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Pharmacology & Pharmacy
Vera Loen, Marc A. Vos, Marcel A. G. van der Heyden
Summary: The article highlights the importance of ventricular cardiac arrhythmia and animal models in predicting drug effects, focusing on the chronic atrioventricular block (CAVB) model in dogs and summarizing its role and development in cardiovascular research. Data obtained from CAVB dogs are crucial for understanding the mechanisms of arrhythmias and drug efficacy.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ana Da Silva Costa, Peter Mortensen, Maria P. Hortigon-Vinagre, Marcel A. G. van der Heyden, Francis L. Burton, Hao Gao, Radostin D. Simitev, Godfrey L. Smith
Summary: Co-culturing hiCMs with HEK cells expressing Kir2.1 at a 1:1 ratio can incorporate I-K1, reduce spontaneous rate and action potential duration, and lead to changes in electrical activity in the syncytium.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Marcel A. G. van der Heyden
Summary: Falsified and fabricated images are frequently seen in publications, with industrialized image forgery from paper mills worsening the situation. Good education and awareness within the scientific society are crucial for establishing an environment where honesty and trust are key values in experimental research.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Joanne J. A. van Bavel, Henriette D. M. Beekman, Valerie Y. H. van Weperen, Henk J. van der Linde, Marcel A. G. van der Heyden, Marc A. Vos
Summary: In CAVB dogs, mimicking LQT1 using the IKs inhibitor JNJ303 prolongs the QTc interval and triggers arrhythmias. The induction of more severe arrhythmic events (TdP) requires a combination of IKs inhibition with enhanced contractility or the termination of the anesthetic regime.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Joanne J. A. van Bavel, Henriette D. M. Beekman, Agnieszka Smoczynska, Marcel A. G. van der Heyden, Marc A. Vos
Summary: Long QT syndrome type 1 with affected I-Ks carries a high risk of Torsade de Pointes (TdP) arrhythmias and sudden cardiac death. This study explored the antiarrhythmic effect of I-Ks channel activator ML277 in the chronic atrioventricular block (CAVB) dog model. ML277 temporarily prevented repolarization prolongation induced by dofetilide, delayed the first arrhythmic event, and reduced the overall arrhythmic outcome in the CAVB dog model.
Article
Cardiac & Cardiovascular Systems
Vera Loen, Agnieszka Smoczynska, Alfonso Aranda Hernandez, Coert O. S. Scheerder, Britt H. R. van der Linde, Henriette D. M. Beekman, Aina Cervera-Barea, Gerard J. J. Boink, Joost P. G. Sluijter, Marcel A. G. van der Heyden, Mathias Meine, Marc A. Vos
Summary: This study investigated the relationship between automated determination of short-term variability (STV-ARIauto) of repolarization on intracardiac electrograms and arrhythmias. The results showed that STV-ARIauto was able to predict the occurrence of arrhythmias in a porcine model of acute myocardial infarction. Additionally, the study found that high-rate pacing did not improve arrhythmic outcomes. The findings highlight the potential of using STV-ARIauto for monitoring arrhythmic risk and initiating preventive strategies.