Article
Immunology
Geng Lu, Jiawei Zhou, Ting Yang, Jin Li, Xinrui Jiang, Wenjun Zhang, Shuangshuang Gu, Jun Wang
Summary: This study compared the metabolic features between sepsis and control groups and identified differentially expressed metabolites. Risk scores based on these metabolites were established to distinguish different stages of sepsis. The findings suggest that these metabolites can aid in personalized treatment and improve current therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Jong-Ho Kim, Young-Suk Kwon, Jae Jun Lee, Sang-Hwa Lee, Jong-Hee Sohn
Summary: Dietary triggers are often associated with migraines, but the connection between migraines and nutrition remains unclear. In this study, we investigated the relationship between nutritional status and migraines. The results showed that individuals with varying degrees of malnutrition were at a higher risk of migraines compared to those with optimal nutrition, indicating the potential of nutrition-oriented approaches in migraine treatment.
Article
Nutrition & Dietetics
Gang Li, Chen-Liang Zhou, Yuan-Ming Ba, Ye-Ming Wang, Bin Song, Xiao-Bin Cheng, Qiu-Fen Dong, Liu-Lin Wang, Sha-Sha You
Summary: The study found that severe and critical patients with COVID-19 have a high risk of malnutrition, with low BMI and plasma protein levels significantly associated with adverse events. Early nutritional risk screening and therapy are essential for these patients.
CLINICAL NUTRITION
(2021)
Review
Cardiac & Cardiovascular Systems
Nick S. Nurmohamed, Jordan M. Kraaijenhof, Manuel Mayr, Stephen J. Nicholls, Wolfgang Koenig, Alberico L. Catapano, Erik S. G. Stroes
Summary: Given the limited accuracy of clinically used risk scores, novel risk algorithms based on proteomics and lipidomics data could provide more reliable ASCVD risk prediction. Retrospective studies have consistently shown the additive prognostic value of these panels over traditional risk scores, and prospective studies are needed to determine their clinical utility.
EUROPEAN HEART JOURNAL
(2023)
Article
Medicine, Research & Experimental
Fei Fei, Tingting Ma, Xuan Zhou, Meihong Zheng, Bei Cao, Juan Li
Summary: This study identified distinct metabolic features between multiple myeloma patients and healthy volunteers, especially in bone marrow, with disruptions in glutamate metabolism and carnitine synthesis being unique in multiple myeloma patients. Aspartate in plasma was highlighted as a top candidate biomarker for diagnosis, while threonine was identified as a preferential biomarker for risk prediction, showing significant relations with various risk indexes of multiple myeloma in both bone marrow and plasma.
Article
Oncology
Boyoung Park, Sarah Yang, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
Summary: Risk prediction models for cancer incorporate established and genetic risk factors to accurately estimate individual risk. This study examined the performance of a gastric cancer risk assessment model combined with SNPs as a polygenic risk score (PRS) in consideration of H. pylori infection. The combination of PRS with the risk assessment model improved identification of a high-risk population with H. pylori infection for gastric cancer susceptibility.
Article
Nutrition & Dietetics
Ping Zhang, Zhigang He, Gang Yu, Dan Peng, Yikuan Feng, Jianmin Ling, Ye Wang, Shusheng Li, Yi Bian
Summary: In the context of the COVID-19 pandemic, a study found that a majority of critically ill COVID-19 patients had a high nutritional risk, as indicated by the mNUTRIC score. The score was found to be a useful tool in predicting prognosis, with patients in the high nutritional risk group showing significantly higher mortality rates.
CLINICAL NUTRITION
(2021)
Article
Oncology
Jie Ping, Yaohua Yang, Wanqing Wen, Sun-Seog Kweon, Koichi Matsuda, Wei-Hua Jia, Aesun Shin, Yu-Tang Gao, Keitaro Matsuo, Jeongseon Kim, Dong-Hyun Kim, Sun Ha Jee, Qiuyin Cai, Zhishan Chen, Ran Tao, Min-Ho Shin, Chizu Tanikawa, Zhi-Zhong Pan, Jae Hwan Oh, Isao Oze, Yoon-Ok Ahn, Keum Ji Jung, Zefang Ren, Xiao-Ou Shu, Jirong Long, Wei Zheng
Summary: PRS constructed using East Asian-specific data showed better performance in predicting colorectal cancer risk compared to PRS constructed using European descendants data. Individuals in the highest 5% risk group had a 2.52-fold elevated risk of colorectal cancer compared to the medium risk group.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Jun Xu, Guning Liu, Sheila M. Hegde, Priya Palta, Eric Boerwinkle, Kelley P. Gabriel, Bing Yu
Summary: Habitual physical activity is linked to reduced risk of premature death. A study identified a set of metabolites associated with physical activity and an MRS linked to lower mortality risk. This provides novel insights into potential mechanisms underlying the health impacts of physical activity.
Article
Oncology
Raza M. Alvi, Thiago Quinaglia, Aferdita Spahillari, Giselle A. Suero-Abreu, Malek Z. O. Hassan, Carlos Gongora, Hannah K. Gilman, Sofia Nikolaidou, Supraja Sama, Lori J. Wirth, Annie W. Chan, Daniel Addison, Tomas G. Neilan
Summary: Radiation therapy is associated with an increased risk for atherosclerotic cardiovascular disease (ASCVD), which is underestimated by current risk prediction models, especially among patients receiving radiation therapy for head and neck cancer.
Review
Oncology
Alix G. Sleight, Sylvia L. Crowder, Jacek Skarbinski, Paul Coen, Nathan H. Parker, Aasha Hoogland, Brian D. Gonzalez, Mary C. Playdon, Steven Cole, Jennifer Ose, Yuichi Murayama, Erin M. Siegel, Jane C. Figueiredo, Heather S. L. Jim
Summary: Fatigue presents a major challenge for cancer survivors, and our current understanding of its causes and treatment options is limited. This paper proposes a comprehensive model, the 3P factors model, which combines metabolomics, the microbiome, inflammation, and behavioral science to better understand the pathophysiology of cancer-related fatigue. The complex biological, clinical, demographic, and lifestyle mechanisms underlying fatigue hinder the development of new treatments. The application of the 3P model may provide a more in-depth analysis of the etiology of cancer-related fatigue and improve personalized approaches to its clinical treatment.
Article
Cardiac & Cardiovascular Systems
Xiao-Teng Ma, Qiao-Yu Shao, Qiu-Xuan Li, Zhi-Qiang Yang, Kang-Ning Han, Jing Liang, Hua Shen, Xiao-Li Liu, Yu-Jie Zhou, Zhi-Jian Wang
Summary: Malnutrition defined by NRI was independently associated with major adverse cardiovascular events in patients with acute coronary syndrome undergoing PCI, especially in those with diabetes, and NRI improved the predictive ability of GRACE score-based prognostic models.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemical Research Methods
Chengnan Fang, Benzhe Su, Tianyi Jiang, Chao Li, Yexiong Tan, Qingqing Wang, Liwei Dong, Xinyu Liu, Xiaohui Lin, Guowang Xu
Summary: The study aimed to build prognostic models for hepatocellular carcinoma (HCC) patients based on serum metabolomics data, which demonstrated favorable ability to predict prognosis when combined with clinical staging system. Identified metabolic features were associated with mortality, recurrence, and metastasis, showing the power of metabolomics in screening HCC prognosis risk.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Genetics & Heredity
Weang-Kee Ho, Mei-Chee Tai, Joe Dennis, Xiang Shu, Jingmei Li, Peh Joo Ho, Iona Y. Millwood, Kuang Lin, Yon-Ho Jee, Su-Hyun Lee, Nasim Mavaddat, Manjeet K. Bolla, Qin Wang, Kyriaki Michailidou, Jirong Long, Eldarina Azfar Wijaya, Tiara Hassan, Kartini Rahmat, Veronique Kiak Mien Tan, Benita Kiat Tee Tan, Su Ming Tan, Ern Yu Tan, Swee Ho Lim, Yu-Tang Gao, Ying Zheng, Daehee Kang, Ji-Yeob Choi, Wonshik Han, Han-Byoel Lee, Michiki Kubo, Yukinori Okada, Shinichi Namba, Sue K. Park, Sung-Won Kim, Chen-Yang Shen, Pei-Ei Wu, Boyoung Park, Kenneth R. Muir, Artitaya Lophatananon, Anna H. Wu, Chiu-Chen Tseng, Keitaro Matsuo, Hidemi Ito, Ava Kwong, Tsun L. Chan, Esther M. John, Allison W. Kurian, Motoki Iwasaki, Taiki Yamaji, Sun-Seog Kweon, Kristan J. Aronson, Rachel A. Murphy, Woon-Puay Koh, Chiea-Chuen Khor, Jian-Min Yuan, Rajkumar Dorajoo, Robin G. Walters, Zhengming Chen, Liming Li, Jun Lv, Keum-Ji Jung, Peter Kraft, Paul D. B. Pharoah, Alison M. Dunning, Jacques Simard, Xiao-Ou Shu, Cheng-Har Yip, Nur Aishah Mohd Taib, Antonis C. Antoniou, Wei Zheng, Mikael Hartman, Douglas F. Easton, Soo-Hwang Teo
Summary: This study developed breast cancer polygenic risk scores (PRSs) using data from Asian populations and evaluated their transferability across different ethnic subgroups. The results showed that the combined Asian and European PRSs had the best performance in stratifying the breast cancer risk for women of Asian ancestry.
GENETICS IN MEDICINE
(2022)
Review
Oncology
Jie Peng, Xiaoyu Li, Mingsheng Huang, Mincai Ma, Qin Huang, Ning Huang, Yuan Cheng
Summary: This meta-analysis evaluated the prognostic value of PNI and CONUT scores in patients with glioblastoma. The results showed that a high PNI score was associated with longer overall survival and progression-free survival, while a low CONUT score was associated with longer overall survival. Multivariate analyses confirmed that high PNI score and low CONUT score were independently associated with longer overall survival. Therefore, PNI and CONUT scores have prognostic value in patients with glioblastoma, but further large-scale studies are needed to confirm these findings.
FRONTIERS IN ONCOLOGY
(2023)
Review
Nutrition & Dietetics
Nina Kaegi-Braun, Sara Germann, Montserrat Faessli, Fiona Kilchoer, Saranda Dragusha, Pascal Tribolet, Filomena Gomes, Celine Bretscher, Nicolaas E. Deutz, Zeno Stanga, Beat Mueller, Philipp Schuetz
Summary: This secondary analysis of randomized controlled trials found that nutritional support interventions can reduce mortality in medical inpatients. However, there was no evidence to suggest that micronutrient supplementation in addition to nutritional therapy was superior in terms of outcomes.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Medical Laboratory Technology
Philipp Schuetz
Summary: PCT can help differentiate bacterial from non-bacterial infections and inflammation states, particularly in respiratory illness. PCT-guided antibiotic stewardship has been shown to reduce antibiotic exposure and associated side-effects in patients with respiratory infection and sepsis. Patient-specific decisions regarding antibiotic usage should consider clinical situation, pretest probability for bacterial infection, severity of presentation, and PCT test results.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Health Care Sciences & Services
Christoph Becker, Sebastian Gross, Martina Gamp, Katharina Beck, Simon A. Amacher, Jonas Mueller, Chantal Bohren, Rene Blatter, Rainer Schaefert, Philipp Schuetz, Joerg Leuppi, Stefano Bassetti, Sabina Hunziker
Summary: This study investigated the association between patients' decisional control preference (DCP) and their medical knowledge, ward round performance measures, and perceived quality of care measures. The findings demonstrate that patients with an active DCP have lower trust in physicians and nurses and are less satisfied with their hospital stay.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Letter
Nutrition & Dietetics
Carla Gressies, Nina Kaegi-Braun, Filomena Gomes, Philipp Schuetz
CLINICAL NUTRITION
(2023)
Article
Geriatrics & Gerontology
Umberto Spennato, Nathalie Lerjen, Jennifer Siegwart, Beat Mueller, Philipp Schuetz, Daniel Koch, Tristan Struja
Summary: This retrospective cohort study investigated the prevalence of physical restraints and their associated outcomes in medical wards of a tertiary care hospital. The results showed that sensor mats were the most frequently used restraint, followed by blanket restrictions, bedrails, and belts. Patients with restraints had longer hospital stays, higher rates of falls, and increased mortality.
Article
Endocrinology & Metabolism
Natasha Anouschka Mueller, Nina Kaegi-Braun, Mirsada Durmisi, Carla Gressies, Pascal Tribolet, Zeno Stanga, Beat Mueller, Philipp Schuetz
Summary: During illness, the conversion of thyroxine (T4) to triiodothyronine (T3) is reduced, known as low T3 syndrome. This study aimed to investigate the prognostic role of low T3 syndrome in patients at nutritional risk, including mortality, clinical outcomes, and response to nutritional support.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Nutrition & Dietetics
Carla Gressies, Pascal Tribolet, Philipp Schuetz
Summary: Disease-related malnutrition in patients in the general medical ward is a complex syndrome that affects recovery and increases morbidity and mortality. Recent advances in research have led to better understanding of diagnostic criteria and evidence-based treatment for malnutrition. More specific clinical parameters and blood biomarkers are needed to personalize treatments. There is also a need for improved education and screening for nutrition risk in hospitals.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Leonie Mueller, Nicole Mentil, Nathalie Staub, Stephanie Griot, Tobias Olpe, Felice Burn, Sebastian Schindera, Beat Mueller, Philipp Schuetz, Zeno Stanga, Annic Baumgartner
Summary: This study examined the association of skeletal muscle index (SMI) at the thoracic level with nutritional and clinical outcomes and response to nutritional intervention. The results showed that SMI at the thoracic vertebra provided limited prognostic information regarding clinical outcomes and nutritional treatment response.
Article
Geriatrics & Gerontology
Jennifer Siegwart, Umberto Spennato, Nathalie Lerjen, Beat Mueller, Philipp Schuetz, Daniel Koch, Tristan Struja
Summary: A retrospective cohort study in a Swiss tertiary care hospital assessed the predictive ability of different clinical scores for fall risk and developed a new fall risk score. The scores showed fair accuracy in predicting fall risk, which could help in establishing preventive strategies.
Article
Nutrition & Dietetics
Roxana Wimmer, Andrea Audetat, Julia Binggeli, Philipp Schuetz, Nina Kaegi-Braun
Summary: A study conducted in the Swiss population found that a significant proportion of individuals have low energy and protein intake. Factors such as high income, obesity, and living in households with children were associated with a reduced risk of low energy intake, while being in the age group of 65-75 years and being female were associated with a higher risk of low protein intake. Regular meat consumption was found to reduce the risk of low protein intake.
Review
Nutrition & Dietetics
Franziska Stumpf, Bettina Keller, Carla Gressies, Philipp Schuetz
Summary: The interplay between inflammation and nutrition has attracted significant attention recently. Inflammation has been identified as a critical factor in disease-related malnutrition, leading to anorexia, reduced food intake, muscle catabolism, and insulin resistance. Inflammation also affects the response to nutritional treatment, with patients with high inflammation showing no response and patients with lower inflammation levels showing a response. This may explain the conflicting results of nutritional trials.
Article
Biochemistry & Molecular Biology
Fabienne Jaun, Maria Boesing, Giorgia Luethi-Corridori, Kristin Abig, Nando Bloch, Stephanie Giezendanner, Victoria Grillmayr, Philippe Haas, Anne B. Leuppi-Taegtmeyer, Juergen Muser, Andrea Raess, Philipp Schuetz, Michael Brandle, Joerg D. Leuppi
Summary: The role of vitamin D in the COVID-19 pandemic has been controversial, and the effectiveness of vitamin D-3 supplementation in COVID-19 patients remains inconclusive. This study conducted a randomized, placebo-controlled double-blind trial on hospitalized COVID-19 patients to compare the effect of high-dose vitamin D-3 supplementation on length of hospital stay. The results showed that vitamin D-3 supplementation did not significantly shorten the hospital stay.
Editorial Material
Nutrition & Dietetics
Philipp Schuetz
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2023)
Article
Medicine, General & Internal
Giorgia Luethi-Corridori, Maria Boesing, Nicola Ottensarendt, Anne Barbara Leuppi-Taegtmeyer, Philipp Schuetz, Joerg Daniel Leuppi
Summary: This study aimed to identify predictors of length of hospital stay, mortality, and rehospitalization in patients admitted for acute exacerbation of COPD. The results showed that the need for oxygen supplementation was the only significant predictor of hospital stay, while older age, COPD severity, active cancer, and arrhythmias were associated with higher mortality.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Geriatrics & Gerontology
Marco Falcone, Michael Bauer, Ricard Ferrer, Gaetan Gavazzi, Juan Gonzalez del Castillo, Alberto Pilotto, Philipp Schuetz
Summary: The optimal treatment of infections in the elderly population is challenging due to less specific clinical symptoms and signs. Elderly patients have a weaker immune response to infection and may be at risk of both over- and undertreatment. The use of biomarkers, particularly procalcitonin (PCT), has shown potential in assessing the risk of septic complications and guiding antibiotic treatment decisions in elderly patients.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)