Remestemcel-L for the treatment of graft versus host disease

Effect of Human Mesenchymal Stem Cells (Remestemcel-L) on Clinical Response and Survival Confirmed in a Large Cohort of Pediatric Patients with Severe High-Risk Steroid-Refractory Acute Graft Versus Host Disease

(2016) Joanne Kurtzberg et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Advances in understanding the pathogenesis of graft-versus-host disease

(2016) John Magenau et al.   BRITISH JOURNAL OF HAEMATOLOGY

International Society for Cellular Therapy perspective on immune functional assays for mesenchymal stromal cells as potency release criterion for advanced phase clinical trials

(2016) Jacques Galipeau et al.   CYTOTHERAPY

Insurance approval of mesenchymal stem cell for acute GVHD in Japan: need of follow up for some remaining concerns

(2016) Koichi Miyamura   INTERNATIONAL JOURNAL OF HEMATOLOGY

Survival after mesenchymal stromal cell therapy in steroid-refractory acute graft-versus-host disease: systematic review and meta-analysis

(2016) Shahrukh Hashmi et al.   Lancet Haematology

Unraveling mechanisms of mesenchymal stromal cell-mediated immunomodulation through patient monitoring and product characterization

(2015) Koen Schepers et al.   Annals of the New York Academy of Sciences

Immunomodulation Effects of Mesenchymal Stromal Cells on Acute Graft-versus-Host Disease after Hematopoietic Stem Cell Transplantation

(2015) Ke Zhao et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Standardization of Good Manufacturing Practice–compliant production of bone marrow–derived human mesenchymal stromal cells for immunotherapeutic applications

(2015) Patrick Wuchter et al.   CYTOTHERAPY

The challenge of defining mesenchymal stromal cell potency assays and their potential use as release criteria

(2015) Jacques Galipeau et al.   CYTOTHERAPY

Mesenchymal stromal cells and chronic inflammatory bowel disease

(2015) M. Algeri et al.   IMMUNOLOGY LETTERS

The secretome of mesenchymal stromal cells: Role of extracellular vesicles in immunomodulation

(2015) Stefania Bruno et al.   IMMUNOLOGY LETTERS

Bone marrow-derived mesenchymal stem cells (JR-031) for steroid-refractory grade III or IV acute graft-versus-host disease: a phase II/III study

(2015) Kazuo Muroi et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Biomarker profiling of steroid-resistant acute GVHD in patients after infusion of mesenchymal stromal cells

(2015) L C J te Boome et al.   LEUKEMIA

Human Mesenchymal Stromal Cells Attenuate Graft-Versus-Host Disease and Maintain Graft-Versus-Leukemia Activity Following Experimental Allogeneic Bone Marrow Transplantation

(2015) Jeffery J. Auletta et al.   STEM CELLS

Mesenchymal Stromal Cells for Treatment of Acute Steroid-Refractory Graft Versus Host Disease: Clinical Responses and Long-Term Outcome

(2015) Felix von Dalowski et al.   STEM CELLS

Inhibition of B-Cell Proliferation and Antibody Production by Mesenchymal Stromal Cells Is Mediated by T Cells

(2015) Maria Manuela Rosado et al.   STEM CELLS AND DEVELOPMENT

Sequential Third-Party Mesenchymal Stromal Cell Therapy for Refractory Acute Graft-versus-Host Disease

(2014) Fermín Sánchez-Guijo et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

IDO-Independent Suppression of T Cell Effector Function by IFN- -Licensed Human Mesenchymal Stromal Cells

(2014) R. Chinnadurai et al.   JOURNAL OF IMMUNOLOGY

Mesenchymal stromal cells inhibit proliferation of virus-specific CD8+ T cells

(2014) G Malcherek et al.   LEUKEMIA

Mesenchymal stromal cells in the antimicrobial host response of hematopoietic stem cell recipients with graft-versus-host disease—friends or foes?

(2014) A Balan et al.   LEUKEMIA

Mesenchymal stem cells: immune evasive, not immune privileged

(2014) James A Ankrum et al.   NATURE BIOTECHNOLOGY

Bone Marrow Mesenchymal Stromal Cells to Treat Tissue Damage in Allogeneic Stem Cell Transplant Recipients: Correlation of Biological Markers with Clinical Responses

(2014) Fang Yin et al.   STEM CELLS

Mesenchymal Stromal Cell Therapy Is Associated With Increased Adenovirus-Associated but Not Cytomegalovirus-Associated Mortality in Children With Severe Acute Graft-Versus-Host Disease

(2014) Friso G.J. Calkoen et al.   Stem Cells Translational Medicine

Gastrointestinal Acute Graft-versus-Host Disease in Children: Histology for Diagnosis, Mesenchymal Stromal Cells for Treatment, and Biomarkers for Prediction of Response

(2013) Friso G.J. Calkoen et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Treatment of Graft versus Host Disease with Mesenchymal Stromal Cells: A Phase I Study on 40 Adult and Pediatric Patients

(2013) Martino Introna et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Allogeneic Human Mesenchymal Stem Cell Therapy (Remestemcel-L, Prochymal) as a Rescue Agent for Severe Refractory Acute Graft-versus-Host Disease in Pediatric Patients

(2013) Joanne Kurtzberg et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Multiple infusions of mesenchymal stromal cells induce sustained remission in children with steroid-refractory, grade III-IV acute graft-versus-host disease

(2013) Lynne M. Ball et al.   BRITISH JOURNAL OF HAEMATOLOGY

Mesenchymal Stromal Cells: Sensors and Switchers of Inflammation

(2013) Maria Ester Bernardo et al.   Cell Stem Cell

The mesenchymal stromal cells dilemma—does a negative phase III trial of random donor mesenchymal stromal cells in steroid-resistant graft-versus-host disease represent a death knell or a bump in the road?

(2013) Jacques Galipeau   CYTOTHERAPY

Unrelated allogeneic bone marrow-derived mesenchymal stem cells for steroid-refractory acute graft-versus-host disease: a phase I/II study

(2013) Kazuo Muroi et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Alterations in the Cellular Immune Compartment of Patients Treated with Third-Party Mesenchymal Stromal Cells Following Allogeneic Hematopoietic Stem Cell Transplantation

(2013) Regina Jitschin et al.   STEM CELLS

Multipotent stromal cells induce human regulatory T cells through a novel pathway involving skewing of monocytes toward anti-inflammatory macrophages

(2013) Sara M. Melief et al.   STEM CELLS

Concise Review: Two negative feedback loops place mesenchymal stem/stromal cells at the center of early regulators of inflammation

(2013) Darwin J. Prockop   STEM CELLS

First- and Second-Line Systemic Treatment of Acute Graft-versus-Host Disease: Recommendations of the American Society of Blood and Marrow Transplantation

(2012) Paul J. Martin et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Diagnosis and management of acute graft-versus-host disease

(2012) Fiona L. Dignan et al.   BRITISH JOURNAL OF HAEMATOLOGY

Mesenchymal-Stem-Cell-Induced Immunoregulation Involves FAS-Ligand-/FAS-Mediated T Cell Apoptosis

(2012) Kentaro Akiyama et al.   Cell Stem Cell

Mesenchymal stromal cells for the treatment of graft-versus-host disease: understanding the in vivo biological effect through patient immune monitoring

(2012) E Dander et al.   LEUKEMIA

Relearning the Lessons of Genomic Stability of Human Cells During Expansion in Culture: Implications for Clinical Research

(2012) Darwin J. Prockop et al.   STEM CELLS

Mesenchymal Stromal Cells Do Not Increase the Risk of Viral Reactivation Nor the Severity of Viral Events in Recipients of Allogeneic Stem Cell Transplantation

(2012) Giovanna Lucchini et al.   Stem Cells International

Long-Term Complications, Immunologic Effects, and Role of Passage for Outcome in Mesenchymal Stromal Cell Therapy

(2011) Lena von Bahr et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Autologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulising Crohn's disease

(2011) R. Ciccocioppo et al.   GUT

Mesenchymal stem cells expanded in vitro with human serum for the treatment of acute and chronic graft-versus-host disease: results of a phase I/II clinical trial

(2011) J. A. Perez-Simon et al.   HAEMATOLOGICA

Mesenchymal stromal cell therapy for steroid-refractory acute and chronic graft versus host disease: a phase 1 study

(2011) Richard Herrmann et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Human MSC Suppression Correlates With Cytokine Induction of Indoleamine 2,3-Dioxygenase and Bystander M2 Macrophage Differentiation

(2011) Moïra François et al.   MOLECULAR THERAPY

Treatment Of Steroid-Refractory Acute GVHD With Mesenchymal Stem Cells Improves Outcomes In Pediatric Patients; Results Of The Pediatric Subset In A Phase III Randomized, Placebo-Controlled Study

(2010) P. Szabolcs et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Prochymal Improves Response Rates In Patients With Steroid-Refractory Acute Graft Versus Host Disease (SR-GVHD) Involving The Liver And Gut: Results Of A Randomized, Placebo-Controlled, Multicenter Phase III Trial In GVHD

(2010) P.J. Martin et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Platelet-lysate-Expanded Mesenchymal Stromal Cells as a Salvage Therapy for Severe Resistant Graft-versus-Host Disease in a Pediatric Population

(2010) Giovanna Lucchini et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Efficacy and Safety of Ex Vivo Cultured Adult Human Mesenchymal Stem Cells (Prochymal™) in Pediatric Patients with Severe Refractory Acute Graft-Versus-Host Disease in a Compassionate Use Study

(2010) Vinod K. Prasad et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

One-Antigen Mismatched Related versus HLA-Matched Unrelated Donor Hematopoietic Stem Cell Transplantation in Adults with Acute Leukemia: Center for International Blood and Marrow Transplant Research Results in the Era of Molecular HLA Typing

(2010) David Valcárcel et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Spontaneous Malignant Transformation of Human Mesenchymal Stem Cells Reflects Cross-Contamination: Putting the Research Field on Track - Letter

(2010) A. Torsvik et al.   CANCER RESEARCH

Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: results of a phase I study

(2010) Marjolijn Duijvestein et al.   GUT

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

(2010) Simón Méndez-Ferrer et al.   NATURE

Adult Human Mesenchymal Stem Cells Added to Corticosteroid Therapy for the Treatment of Acute Graft-versus-Host Disease

(2009) Partow Kebriaei et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2

(2009) G. M. Spaggiari et al.   BLOOD

Clinical-grade production of human mesenchymal stromal cells: occurrence of aneuploidy without transformation

(2009) K. Tarte et al.   BLOOD

Cytokine Modulation of TLR Expression and Activation in Mesenchymal Stromal Cells Leads to a Proinflammatory Phenotype

(2009) R. Romieu-Mourez et al.   JOURNAL OF IMMUNOLOGY

Graft-versus-host disease

(2009) James LM Ferrara et al.   LANCET

Third-party mesenchymal stem cells as part of the management of graft-failure after haploidentical stem cell transplantation

(2009) Malte von Bonin et al.   LEUKEMIA RESEARCH

The Negative Co-Signaling Molecule B7-H4 Is Expressed by Human Bone Marrow–Derived Mesenchymal Stem Cells and Mediates its T-Cell Modulatory Activity

(2009) Qun Xue et al.   STEM CELLS AND DEVELOPMENT

Acute GvHD: pathogenesis and classification

(2008) L M Ball et al.   BONE MARROW TRANSPLANTATION

Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study

(2008) Katarina Le Blanc et al.   LANCET

Application of multipotent mesenchymal stromal cells in pediatric patients following allogeneic stem cell transplantation

(2007) Ingo Müller et al.   BLOOD CELLS MOLECULES AND DISEASES

Bone Marrow-Derived Mesenchymal Stem Cells Induce Both Polyclonal Expansion and Differentiation of B Cells Isolated from Healthy Donors and Systemic Lupus Erythematosus Patients

(2007) Elisabetta Traggiai et al.   STEM CELLS