Article
Immunology
Yanxia Lu, Bao-Peng Liu, Crystal T. Y. Tan, Fang Pan, Anis Larbi, Tze Pin Ng
Summary: The link between pathogen exposure and mental health has been investigated in a study of over 800 participants in the Singapore Longitudinal Ageing Studies. The study found that high pathogen burden is associated with increased prevalence of depressive symptoms and impaired mental health. Certain infections and inflammatory markers were found to mediate this association. These findings highlight the potential impact of pathogens on mental health.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Immunology
Mauricio T. Caballero, Ashish Satav, Christopher J. Gill, Saad B. Omer, Rachel C. Pieciak, Abdul Momin Kazi, Eric Af Simoes, Fernando P. Polack
Summary: The study found that there are obstacles and challenges in conducting research in developing countries to determine the factors associated with community mortality due to RSV, including obtaining family consent for testing, sampling at the household level, supporting grieving parents, developing tailored strategies for challenging settings, and integrating data from different sources.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Jocelyn Moyes, Stefano Tempia, Sibongile Walaza, Meredith L. McMorrow, Florette Treurnicht, Nicole Wolter, Anne von Gottberg, Kathleen Kahn, Adam L. Cohen, Halima Dawood, Ebrahim Variava, Cheryl Cohen
Summary: Based on a study in South African children, the burden of RSV-associated illness was estimated, with newborns and infants being the most affected group. Implementing maternal vaccination and monoclonal antibody products for this group can help reduce the disease burden.
Article
Medicine, General & Internal
Jocelyn Moyes, Stefano Tempia, Sibongile Walaza, Meredith L. McMorrow, Florette Treurnicht, Nicole Wolter, Anne von Gottberg, Kathleen Kahn, Adam L. Cohen, Halima Dawood, Ebrahim Variava, Cheryl Cohen
Summary: Studying the economic burden of RSV-associated illness can help inform decisions on the implementation of maternal vaccines and monoclonal antibodies. A costing study conducted in South Africa estimated the cost of RSV-associated illness in infants and found that the highest cost burden was in the youngest infants.
Article
Pediatrics
Phanthila Sitthikarnkha, Rattapon Uppala, Sirapoom Niamsanit, Sumitr Sutra, Kaewjai Thepsuthammarat, Leelawadee Techasatian, Watit Niyomkarn, Jamaree Teeratakulpisarn
Summary: Among hospitalized children in Thailand, RSV LRTI was the leading cause of hospitalization, with the highest incidence occurring during the rainy season. The mortality rate of RSV LRTI was higher in infants under 1 year old and children with underlying illnesses; future preventive interventions should target these patient groups.
Article
Immunology
Koos Korsten, Niels Adriaenssens, Samuel Coenen, Chris C. Butler, Theo J. M. Verheij, Louis J. Bont, Joanne G. Wildenbeest
Summary: The accuracy of the influenza-like illness (ILI) case definition from the World Health Organization (WHO) in identifying acute respiratory tract infections (ARTI) caused by respiratory syncytial virus (RSV) in older adults is uncertain. The ILI definition, which includes fever, underestimates the occurrence of RSV-ARTI. There is a need for a better approach to measure RSV disease occurrence and the impact of future RSV vaccine introduction.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Bingbing Cong, Izzie Dighero, Tiantian Zhang, Alexandria Chung, Harish Nair, You Li
Summary: This study used statistical modelling to investigate the morbidity and mortality rates of RSV (Respiratory Syncytial Virus) and found that both rates showed a U-shaped distribution. Infants and older adults should be prioritized for RSV immunization programs.
Article
Medicine, General & Internal
B. Kampmann, S. A. Madhi, I. Munjal, E. A. F. Simoes, B. A. Pahud, C. Llapur, J. Baker, G. Perez Marc, D. Radley, E. Shittu, J. Glanternik, H. Snaggs, J. Baber, P. Zachariah, S. L. Barnabas, M. Fausett, T. Adam, N. Perreras, M. A. Van Houten, A. Kantele, L. -M Huang, L. J. Bont, T. Otsuki, S. L. Vargas, J. Gullam, B. Tapiero, R. T. Stein, F. P. Polack, H. J. Zar, N. B. Staerke, M. Duron Padilla, P. C. Richmond, K. Koury, K. Schneider, E. V. Kalinina, D. Cooper, K. U. Jansen, A. S. Anderson, K. A. Swanson, W. C. Gruber, A. Gurtman
Summary: Vaccination of pregnant women with RSVpreF vaccine was effective in reducing severe RSV-associated lower respiratory tract illness in infants. The vaccine showed 81.8% efficacy within 90 days and 69.4% efficacy within 180 days. The vaccine was found to be safe for both mothers and infants.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Immunology
Mauricio T. Caballero, Alejandra M. Bianchi, Sebastian Diaz Grigaites, Paola X. De la Iglesia Niveyro, Alejandra Nuno, Sandra Valle, Gabriela Afarian, Sebastian A. Esperante, Adrian J. P. Ferretti, Sofia Jares Baglivo, Julian De Luca, Damian Alvarez-Paggi, Adriana Diamanti, Quique Bassat, Fernando P. Polack
Summary: A study conducted in Argentina found that infant community mortality rates due to RSV are higher than those in industrialized countries, with the average age of death being 2.8 months and 75% of deaths involving co-infection with Streptococcus pneumoniae and/or Moraxella catarrhalis.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Ymir Oskarsson, Asgeir Haraldsson, Bryndis Hogna Oddsdottir, Tinna Laufey Asgeirsdottir, Valtyr Thors
Summary: The clinical and socioeconomic burden of respiratory syncytial virus (RSV) in Iceland is substantial, despite slightly lower hospital admission rates compared to other high-income countries. Prevention of RSV in young children has the potential to decrease both the clinical and financial impact of annual epidemics.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Immunology
Natalie Mazur, Yvette N. Lowensteyn, Joukje E. Willemsen, Christopher J. Gill, Leah Forman, Lawrence M. Mwananyanda, Dianna M. Blau, Robert F. Breiman, Shabir A. Madhi, Sana Mahtab, Emily S. Gurley, Shams El Arifeen, Nega Assefa, J. Anthony G. Scott, Dickens Onyango, Beth A. Tippet Barr, Karen L. Kotloff, Samba O. Sow, Inacio Mandomando, Ikechukwu Ogbuanu, Amara Jambai, Quique Bassat, Mauricio T. Caballero, Fernando P. Polack, Saad Omer, Abdul Momin Kazi, Eric A. F. Simoes, Ashish Satav, Louis J. Bont
Summary: The study investigated 829 RSV-related deaths in children under 1 year old from 38 developing countries, including 166 community deaths from 12 countries. It was found that infants who died in the community were younger at the time of death compared to those who died in the hospital. Neonatal deaths were also higher in the community than in hospitals.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Immunology
Ting Shi, Sophie Vennard, Francis Jasiewicz, Rory Brogden, Harish Nair
Summary: RSV-ARI in adults with comorbidities is a significant burden, with limited data available. This study estimated the incidence, hospitalization rate, and in-hospital case fatality ratio of RSV-ARI in this population, and found an association between the disease and any comorbidity.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Bryan O. Nyawanda, Nickson Murunga, Nancy A. Otieno, Godfrey Bigogo, Joyce U. Nyiro, Elisabeth Vodicka, Marc Bulterys, D. James Nokes, Patrick K. Munywoki, Gideon O. Emukule
Summary: Using data collected from 2010 to 2018, researchers estimated the incidence and mortality rates of respiratory syncytial virus (RSV) in Kenyan children and found a significant disease burden. Prioritizing the development and use of maternal vaccines and affordable long-lasting monoclonal antibodies could help reduce this burden.
Article
Infectious Diseases
Lise Beier Havdal, Hakon Boas, Terese Bekkevold, Anne-Marte Bakken Kran, Astrid Elisabeth Rojahn, Ketil Stordal, Sara Debes, Henrik Dollner, Svein Arne Nordbo, Bjorn Barstad, Elisebet Haarr, Liliana Vazquez Fernandez, Britt Nakstad, Christopher Inchley, Elmira Flem
Summary: This study estimated the age-specific incidence of medically attended RSV infections in hospitalised Norwegian children and provided insights into the epidemiology of the disease. The highest incidence rates were observed in 1-month-old children, while lower rates were found in children aged 24-59 months.
JOURNAL OF INFECTION
(2022)
Article
Infectious Diseases
Alaa Atamna, Tanya Babich, Dafi Froimovici, Dafna Yahav, Nadav Sorek, Haim Ben-Zvi, Leonard Leibovici, Jihad Bishara, Tomer Avni
Summary: This study compared the clinical outcomes of patients with laboratory-confirmed RSV and patients with influenza infection, finding that RSV patients had higher rates of complications and were more prone to pneumonia. Hypoalbuminemia, reduced room-air saturation, and RSV infection were identified as predictors of complications.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
