Article
Pediatrics
Phanthila Sitthikarnkha, Rattapon Uppala, Sirapoom Niamsanit, Sumitr Sutra, Kaewjai Thepsuthammarat, Leelawadee Techasatian, Watit Niyomkarn, Jamaree Teeratakulpisarn
Summary: Among hospitalized children in Thailand, RSV LRTI was the leading cause of hospitalization, with the highest incidence occurring during the rainy season. The mortality rate of RSV LRTI was higher in infants under 1 year old and children with underlying illnesses; future preventive interventions should target these patient groups.
Article
Virology
Ana B. Gorini da Veiga, Leticia G. Martins, Irina Riediger, Alix Mazetto, Maria do Carmo Debur, Tatiana S. Gregianini
Summary: Respiratory viral infections can be severe, especially for children, elderly, and patients with comorbidities. In Brazil, the official surveillance system investigates various viruses, but some cases with no identified pathogens remain. This study analyzed viruses in patients without underlying diseases, revealing the potential for coronaviruses to cause severe disease in healthy adults.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Respiratory System
Shuk Yu Leung, Steven Yuk Fai Lau, Ka Li Kwok, Kirran N. Mohammad, Paul Kay Sheung Chan, Ka Chun Chong
Summary: The study found that acute bronchiolitis-related hospitalisation in children was associated with high temperature, humidity, and exposure to NO2 and PM10, indicating the need for sustainable clean air policies to protect children's health.
Article
Public, Environmental & Occupational Health
Rodrigo C. Menezes, Isabella B. B. Ferreira, Luciana Sobral, Stefania L. Garcia, Hugo N. Pustilnik, Mariana Araujo-Pereira, Bruno B. Andrade
Summary: This study aimed to identify the clinical features associated with viral pathogens responsible for severe lower respiratory tract infections (LRTI) in children. The study found that different viral agents have distinct associations with clinical features in children.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2024)
Article
Medicine, Research & Experimental
Xingang Zhang, Jishan Zheng, Lihua Zhu, Huiqing Xu
Summary: This study investigated the prevalence and clinical characteristics of human bocavirus (HBoV) infection in infants with acute lower respiratory tract infection in China. The results showed that HBoV was frequently detected in infants, with the highest prevalence in winter. Co-infection was common, especially in infants requiring intensive care unit admission. Clinical symptoms included cough, fever, and respiratory distress.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Infectious Diseases
Phanthila Sitthikarnkha, Rattapon Uppala, Sirapoom Niamsanit, Sumitr Sutra, Kaewjai Thepsuthammarat, Leelawadee Techasatian, Jamaree Teeratakulpisarn
Summary: This study evaluated the epidemiology of lower respiratory tract infections in pediatric patients in Thailand from 2015 to 2019, revealing pneumonia as the most common LRTI in hospitalized children, with respiratory syncytial virus identified as the main etiologic pathogen of bronchiolitis. Mortality rate was highest in pneumonia in children under 1 year old, and children under 5 years old had a high mortality rate from pneumonia.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2022)
Article
Virology
Jun Tachikawa, Yuta Aizawa, Tetsuya Kobayashi, Tatsuki Ikuse, Kazuhiro Kamata, Su Mon Kyaw Win, Lasham Di Ja, Khin Nyo Thein, Nay Chi Win, Aye Thida, Aye Tun, Yuko Suzuki, Ai Ito, Hidekazu Osada, Irina Chon, Wint Wint Phyu, Tomomi Ota, Yadanar Kyaw, Htay Htay Tin, Kanako Watanabe, Yugo Shobugawa, Hisami Watanabe, Reiko Saito, Akihiko Saitoh
Summary: This study examined the presence of PeV-A virus in children in Myanmar and found positive samples. The virus was classified into four genotypes, and further evaluation of its clinical impact on children is needed.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Virology
Gregory J. Walker, Sacha Stelzer-Braid, Caroline Shorter, Claire Honeywill, Matthew Wynn, Christiana Willenborg, Phillipa Barnes, Janice Kang, Nevil Pierse, Julian Crane, Philippa Howden-Chapman, William D. Rawlinson
Summary: Acute respiratory infections are a common illness among children, with respiratory viruses being detected even in asymptomatic periods. This study aimed to define the rates of infection and community epidemiology of respiratory viruses in healthy children to help interpret molecular diagnostic assays. The results showed that respiratory viruses were more likely to be detected during symptomatic periods, and human rhinovirus was the most common virus identified.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Infectious Diseases
Kathryn Hacker, Guillermina Kuan, Nivea Vydiswaran, Gerardo Chowell-Puente, Mayuri Patel, Nery Sanchez, Roger Lopez, Sergio Ojeda, Brenda Lopez, Jarrod Mousa, Hannah E. Maier, Angel Balmaseda, Aubree Gordon
Summary: Symptomatic hMPV infection is burdensome among children, especially those under the age of one, in Nicaragua. The incidence of symptomatic hMPV follows a biennial seasonal pattern.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2022)
Review
Virology
Manika Suryadevara, Joseph B. Domachowske
Summary: RSV infections in young children are a major global health concern, with seasonal patterns of activity playing a crucial role in guiding resource allocation for treatment and prevention strategies. Surveillance data from developed countries have been instrumental in advancing public health initiatives, while surveillance in tropical regions still needs improvement.
Article
Public, Environmental & Occupational Health
Wancheng Zhang, Jianglong Ling, Runping Zhang, Jiyuan Dong, Li Zhang, Rentong Chen, Ye Ruan
Summary: Short-term exposure to air pollutants such as PM2.5, PM10, SO2, and NO2 is significantly associated with hospitalization for acute lower respiratory infections (ALRI), pneumonia, and bronchiolitis in children aged 0-14 years in Lanzhou, China. Local governments should take actions to improve urban air quality and reduce hospitalization rates for childhood respiratory diseases.
Article
Infectious Diseases
Felix Cheysson, Christian Brun-Buisson, Lulla Opatowski, Lenaig Le Fouler, Celine Caserio-Schonemann, Isabelle Pontais, Didier Guillemot, Laurence Watier
Summary: This study estimated that 40% of outpatient antibiotic prescriptions during the cold season in France were attributable to acute lower respiratory tract infections (LRTIs), with viral LRTIs playing a significant role, especially in young children. The results highlight the need to address antibiotic overuse driven by viral infections, particularly in specific age groups.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Article
Pediatrics
Aparna Mukherjee, K. R. Jat, Rakesh Lodha, Jagdish Prasad Goyal, Javeed Iqbal Bhatt, Rashmi Ranjan Das, Vinod Ratageri, Bhadresh Vyas, S. K. Kabra
Summary: This multi-site study conducted in India's medical colleges confirms the feasibility of establishing Acute Respiratory Infection Treatment Units (ATUs) for the management of acute respiratory infections in children. The observed case fatality and rate of unnecessary antibiotic usage were lower than reported in literature.
Article
Virology
Xiangpeng Chen, Yun Zhu, Wei Wang, Changchong Li, Shuhua An, Gen Lu, Rong Jin, Baoping Xu, Yunlian Zhou, Aihuan Chen, Lei Li, Meng Zhang, Zhengde Xie
Summary: During 2015-2019, ON1 and BA9 were the predominant genotypes of RSV in China. The G gene of these genotypes showed relatively high diversity and continued evolution.
Article
Medicine, General & Internal
Catherine Hyams, Elizabeth Begier, Maria Garcia Gonzalez, Jo Southern, James Campling, Sharon Gray, Jennifer Oliver, Bradford D. Gessner, Adam Finn
Summary: The disease burden of acute lower respiratory tract disease (aLRTD) and its subsets in hospitalised adults in Bristol, UK is high, increasing sharply with age.
Letter
Infectious Diseases
Pragya D. Yadav, Gajanan N. Sapkal, Rima R. Sahay, Varsha A. Potdar, Gururaj R. Deshpande, Deepak Y. Patil, Dimpal A. Nyayanit, Anita M. Shete, Jayanthi Shastri, Pradip Awate, Bharti Malhotra, Priya Abraham
JOURNAL OF INFECTION
(2022)
Letter
Public, Environmental & Occupational Health
Gururaj Rao Deshpande, Prudhvi Lal Bhukya, Pragya D. Yadav, Asha Salunke, Chetan Patil, Bipin N. Tilekar, Aparna Rakhe, Rashi Srivastava, Yogesh K. Gurav, Varsha Potdar, Priya Abraham, Gajanan N. Sapkal
JOURNAL OF TRAVEL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Harmanmeet Kaur, Labanya Mukhopadhyay, Nivedita Gupta, Neeraj Aggarwal, Lucky Sangal, Varsha Potdar, Francis Yesuraj Inbanathan, Jitendra Narayan, Swati Gupta, Salaj Rana, Neetu Vijay, Harpreet Singh, Jasmine Kaur, Vinit Kumar, Nirmal Kaundal, Priya Abraham, Vasanthapuram Ravi
Summary: The sudden emergence and rapid spread of COVID-19 led to the rapid expansion of testing laboratories in India. The implementation of quality control systems through the External Quality Assurance Program has ensured satisfactory performance of testing laboratories, boosting public and policy maker confidence.
Article
Public, Environmental & Occupational Health
Yadav Pragya, Mohandas Sreelekshmy, Prasad Sarkale, Dimpal Nyayanit, Anita Shete, Rima Sahay, Varsha Potdar, Shrikant Baradkar, Nivedita Gupta, Gajanan Sapkal, Priya Abraham, Samiran Panda, Balram Bhargava
Summary: A variant known as B.1.1.28.2 has been identified from international travelers returning to India from the United Kingdom and Brazil. In a hamster model, the B.1.1.28.2 variant caused weight loss, viral replication in the respiratory tract, and severe lung pathology compared to the B.1 variant. Furthermore, sera from hamsters infected with B.1.1.28.2 efficiently neutralized the D614G variant virus, while a 6-fold reduction in neutralization was observed in sera from hamsters infected with the D614G variant against the B.1.1.28.2 variant.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Pragya D. Yadav, Prasad Sarkale, Alpana Razdan, Nivedita Gupta, Dimpal A. Nyayanit, Rima R. Sahay, Varsha Potdar, Deepak Y. Patil, Shreekant Baradkar, Abhinendra Kumar, Neeraj Aggarwal, Anita M. Shete, Harmanmeet Kaur, Sreelekshmy Mohandas
Summary: This study collected samples from travelers and found that SARS-CoV-2 variants are more easily transmitted through international travel. The researchers successfully isolated two strains with high viral RNA loads, which is important for evaluating the protective efficacy of current and upcoming COVID-19 vaccines in India.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Parvaiz A. Koul, Siddhartha Saha, Kaisar A. Kaul, Hyder Mir, Varsha Potdar, Mandeep Chadha, Danielle Iuliano, Kathryn E. Lafond, Renu B. Lal, Anand Krishnan
Summary: Among children aged <5 years hospitalized with severe acute respiratory infections in Kashmir, India, respiratory viruses, especially RSV, were found to be prevalent. The most commonly detected viruses were RSV, HRV/enteroviruses, and PIVs.
JOURNAL OF GLOBAL HEALTH
(2022)
Article
Medicine, General & Internal
Ravi P. Sharma, Swati Gautam, Pratibha Sharma, Ruchi Singh, Himanshu Sharma, Dinesh Parsoya, Farah Deeba, Neha Bhomia, Nita Pal, Varsha Potdar, Pragya D. Yadav, Nivedita Gupta, Sudhir Bhandari, Abhinendra Kumar, Yash Joshi, Priyanka Pandit, Bharti Malhotra
Summary: The Omicron variant quickly spread in the community and became the dominant circulating variant. Most Omicron cases were asymptomatic or had mild disease, with a very low mortality rate compared to Delta and other lineages.
FRONTIERS IN MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Sumit Bhardwaj, Manohar Lal Choudhary, Sheetal Jadhav, Veena Vipat, Rohan Ghuge, Sonali Salvi, Rajesh Kulkarni, Aarti Kinikar, Vikram Padbidri, Sanjay Bafna, Ashish Bavdekare, Pradeep D'costa, Nilesh Gujar, Varsha Potdar
Summary: The study found that during the COVID-19 pandemic, the positivity for influenza A and B, metapneumovirus, parainfluenza virus, respiratory syncytial virus, and human coronavirus declined significantly.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Rajesh P. Karyakarte, Rashmita Das, Mansi V. Rajmane, Sonali Dudhate, Jeanne Agarasen, Praveena Pillai, Priyanka M. Chandankhede, Rutika S. Labhshetwar, Yogita Gadiyal, Preeti P. Kulkarni, Safanah Nizarudeen, Suvarna Joshi, Krishanpal Karmodiya, Varsha Potdar
Summary: The study found that the XBB.1.16* lineage has become the most predominant SARS-CoV-2 lineage in India. The clinical features and outcomes of XBB.1.16* cases were similar to those of other co-circulating Omicron lineage infected cases in Maharashtra, India.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Rajesh P. Karyakarte, Rashmita Das, Sonali Dudhate, Jeanne Agarasen, Praveena Pillai, Priyanka M. Chandankhede, Rutika S. Labhshetwar, Yogita Gadiyal, Mansi V. Rajmane, Preeti P. Kulkarni, Safanah Nizarudeen, Suvarna Joshi, Varsha Potdar, Krishanpal Karmodiya
Summary: The study indicates that the XBB* variant is causing mild disease in India. However, as XBB* possesses both immune-escape and infectivity-enhancing mutations, it has the potential to spread to other parts of the world rapidly. Furthermore, anti-SARS-CoV-2 vaccination improves survival rates in COVID-19.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Letter
Immunology
Mallika Lavania, Varsha A. Potdar, Sujata Ranshing, Veena Vipat, Ujjayni Saha, Santosh M. Jadhav, Pradeep M. Sawant, Vikram Padbidri, Piyush A. Chaudhari, Sampada Patwardhan
INDIAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Immunology
Shailesh D. Pawar, Sadhana S. Kode, Sachin S. Keng, Deeksha S. Tare, Ousmane M. Diop, Priya Abraham, Deepa K. Sharma, Lucky Sangal, Pragya D. Yadav, Varsha A. Potdar
Summary: This study evaluated the susceptibility of different cell lines to SARS-CoV-2, finding that unintended isolation of the virus may occur during surveillance procedures aiming to isolate measles, rubella, and rotavirus, potentially leading to laboratory-acquired infections and community risks.
INDIAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Immunology
Anuradha S. Tripathy, Diptee Trimbake, Poonam Suryawanshi, Srikanth P. Tripathy, Yogesh K. Gurav, Varsha A. Potdar, Manohar L. Chaudhary, Prachi Athavale, Nitin D. Mokashi, Sudhir D. Patsute, Arjun L. Kakrani, Priya Abraham
Summary: This study aimed to assess the peripheral lymphocyte phenotype and subset distribution in patients with COVID-19 disease from India. The study found that changes in lymphocyte compartment were correlated with disease course and clinical outcome. The percentages of CD4+Th cells were significantly higher in patients with different clinical manifestations compared to controls. Higher Th memory, Tc memory, and B memory cells were observed in the recovered group compared to mild symptomatic patients.
INDIAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Immunology
Varsha Potdar, Megha Brijwal, Rakesh Lodha, Pragya Yadav, Santosh Jadhav, Manohar Lal Choudhary, Aashish Choudhary, Veena Vipat, Nivedita Gupta, Ashok Kumar Deorari, Lalit Dar, Priya Abraham
Summary: An 11-year-old boy with acute myeloid leukemia in New Delhi, India, was treated for severe acute respiratory infection caused by avian influenza A(H5N1). The strain belonged to hemagglutinin gene clade 2.3.2.1a and was found to be susceptible to amantadine and neuraminidase inhibitors.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Aarti A. Kinikar, Sagar Vartak, Rahul Dawre, Chhaya Valvi, Pragathi Kamath, Naresh Sonkawade, Sameer Pawar, Vaishnavi Bhagat, A. Kiruthiga, Komal Nawale, Isha Deshmukh, Rashmita Das, Rajesh K. Kulkarni, Varsha Potdar, Rajesh Karyakarte
Summary: The Omicron variant of SARS-CoV-2 infection was found to be more contagious but less severe in children compared to adults. This study focused on hospitalized children with confirmed Omicron variant and highlighted the importance of ICU care for those with underlying comorbidities.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)