Improvement of renal and non-renal SLE outcome measures on sirolimus therapy – A 21-year follow-up study of 73 patients

Two-Year, Randomized, Controlled Trial of Belimumab in Lupus Nephritis

(2020) Richard Furie et al.   NEW ENGLAND JOURNAL OF MEDICINE

A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects

(2018) Ellen Kraig et al.   EXPERIMENTAL GERONTOLOGY

Sirolimus in patients with clinically active systemic lupus erythematosus resistant to, or intolerant of, conventional medications: a single-arm, open-label, phase 1/2 trial

(2018) Zhi-Wei Lai et al.   LANCET

Longterm Data on Sirolimus Treatment in Patients with Lupus Nephritis

(2018) Desmond Y.H. Yap et al.   JOURNAL OF RHEUMATOLOGY

The PI3K/Akt/mTOR pathway is activated in murine lupus nephritis and downregulated by rapamycin

(2010) Kostas Stylianou et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Rapamycin prevents the development of nephritis in lupus-prone NZB/W F1 mice

(2008) SL Lui et al.   LUPUS

Rapamycin attenuates the severity of established nephritis in lupus-prone NZB/W F1 mice

(2008) S. L. Lui et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION