Journal
EXPERT REVIEW OF ANTICANCER THERAPY
Volume 16, Issue 7, Pages 767-774Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14737140.2016.1191950
Keywords
Tumor invasion; metastasis; microRNA; non-small cell lung cancer; radiation oncology
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Introduction: MicroRNAs (miRs), small sequences of RNA regulating various cellular processes, are implicated to play cancer (NSCLC), specifically relating to tumor invasion and metastasis to lymphatics and/or distant organs, which can often be correlated with overall prognosis. Areas covered: There exists strong evidence that presence of several miR combinations correlates with prognosis in both early-and advanced-stage NSCLCs. Principally, miR alterations could be useful in enhancing current imaging-based methods to more accurately estimate the extent of invasion/metastases. Expert Commentary: Despite the immature nature of this subject, its large ramifications on clinical oncology are clearly evident. Based on miR signature-related stratification, radiotherapy could be potentially personalized beyond current treatment standards.
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