Article
Medicine, General & Internal
Luis Garcia de Guadiana-Romualdo, Daniel Morell-Garcia, Olaia Rodriguez-Fraga, Cristian Morales-Indiano, Ana Maria Lourdes Padilla Jimenez, Jose Ignacio Gutierrez Revilla, Eloisa Urrechaga, Jose Maria alamo, Ana Maria Hernando Holgado, Maria del Carmen Lorenzo-Lozano, Silvia Sanchez Fdez-Pacheco, Patricia de la Hera Cagigal, Maria angeles Juncos Tobarra, Juan A. Vilchez, Isabel I. Virseda Chamorro, Irene Gutierrez Garcia, Yolanda Pastor Murcia, Laura Sahuquillo Frias, Laura Altimira Queral, Elisa Nuez-Zaragoza, Juan Adell Ruiz de Leon, Alicia Ruiz Ripa, Paloma Salas Gomez-Pablos, Iria Cebreiros Lopez, Amaia Fernandez Uriarte, Alex Larruzea, Maria Luisa Lopez Yepes, Natalia Sancho-Rodriguez, Maria Consuelo Zamorano Andres, Jose Pedregosa Diaz, Cristina Acevedo Alcaraz, Alfonso-L Blazquez Manzanera, Sonia Perez Sanmartin, Maria del Carmen Baamonde Calzada, Marina Vera, Elena Valera Nunez, Magdalena Canalda Campas, Sara Garcia Munoz, Josep Miquel Bauca, Luis Vicente Gutierrez, Laura Jimenez Anon, Alfonso Perez Martinez, Aurelio Pons Castillo, Ruth Gonzalez Tamayo, Jorge Ferriz Vivancos, Maria Jose Alcaide Martin, Vicente Ferrer Diaz de Brito Fernandez, Vicente Aguadero, Maria Gloria Garcia Arevalo, Maria Arnaldos Carrillo, Mercedes Gonzalez Morales, Maria Nunez Garate, Cristina Ruiz Iruela, Patricia Esteban Torrella, Marti Vila Perez, Jose Manuel Egea-Caparros, Luis Saenz, Amparo Galan Ortega, Luciano Consuegra-Sanchez
Summary: Myocardial injury is common in COVID-19 patients and elevated troponin levels, especially when measured using sex-specific cut-offs and troponin T, are associated with increased prevalence and 30-day mortality, making it an important predictor for risk stratification in COVID-19.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cardiac & Cardiovascular Systems
Leo Poelzl, Clemens Engler, Philipp Sterzinger, Ronja Lohmann, Felix Naegele, Jakob Hirsch, Michael Graber, Jonas Eder, Sebastian Reinstadler, Nikolay Sappler, Juliane Kilo, Ivan Tancevski, Sebastian Bachmann, Hannes Abfalterer, Elfriede Ruttmann-Ulmer, Hanno Ulmer, Andrea Griesmacher, Samuel Heuts, Matthias Thielmann, Axel Bauer, Michael Grimm, Nikolaos Bonaros, Johannes Holfeld, Can Gollmann-Tepekoeylue
Summary: This study found that high postoperative levels of hs-cTnT are associated with increased 30-day mortality, but not with 5-year mortality. The hs-cTnT thresholds for mortality-associated PMI in different cardiac surgeries were higher than currently suggested.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Immunology
Tingting Chen, Haixin Chen, Ping Chen, Linchao Zhu, Wei Mao, Yimin Yao
Summary: The study identified key regulatory genes and pathways associated with myocardial injury in COVID-19 patients using gene enrichment analysis and protein-protein interaction network. The findings provide potential therapeutic targets and strategies for myocardial injury and were validated using clinical samples.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Thomas E. Kaier, Bashir Alaour, Michael Marber
Summary: The 4th Universal Definition of Myocardial Infarction has sparked debates aiming to define types of myocardial injury from a pathophysiological perspective, with necessary adjustments in clinical guidelines for real-world patient triage.
CARDIOVASCULAR RESEARCH
(2021)
Article
Medical Laboratory Technology
Laura De Michieli, Luciano Babuin, Stefania Vigolo, Giulia Berti De Marinis, Alessandro Lunardon, Francesco Favretto, Ronstan Lobo, Yader Sandoval, Sandra C. Bryant, Daniele Donato, Mario Plebani, Roberto Vettor, Sabino Iliceto, Vito Cianci, Allan S. Jaffe
Summary: A retrospective study in Italy found that high-sensitivity cardiac troponin I (hs-cTnI) can be used as a significant predictor of myocardial injury and mortality in COVID-19 patients. Patients with myocardial injury had higher mortality during hospitalization, and an initial hs-cTnI < 5 ng/L identified low-risk patients with high sensitivity.
CLINICAL BIOCHEMISTRY
(2021)
Review
Cardiac & Cardiovascular Systems
Thomas E. Kaier, Bashir Alaour, Michael Marber
Summary: The 4th Universal Definition of Myocardial Infarction aims to define types of myocardial injury based on their pathophysiology, sparking debates and leading to necessary pragmatic adjustments in clinical guidelines to improve triage of real-world patients.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Olatunde Ola, Ashok Akula, Laura De Michieli, Marshall Dworak, Erika Crockford, Ronstan Lobo, Nicholas Rastas, Jonathan D. Knott, Ramila A. Mehta, David O. Hodge, Eric Grube, Swetha Karturi, Scott Wohlrab, Tahir Tak, Charles Cagin, Rajiv Gulati, Allan S. Jaffe, Yader Sandoval
Summary: This study evaluated the impact of high-sensitivity cardiac troponin T (cTnT) implementation in U.S. emergency department patients, showing a marked increase in myocardial injury and MI post-implementation, particularly in women and patients with type 2 MI.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Martina Patone, Xue W. Mei, Lahiru Handunnetthi, Sharon Dixon, Francesco Zaccardi, Manu Shankar-Hari, Peter Watkinson, Kamlesh Khunti, Anthony Harnden, Carol A. C. Coupland, Keith M. Channon, Nicholas L. Mills, Aziz Sheikh, Julia Hippisley-Cox
Summary: The study found that there is an increased risk of myocarditis associated with the first dose of ChAdOx1 and BNT162b2 vaccines, as well as the first and second doses of the mRNA-1273 vaccine in the 1-28 days post-vaccination period. Additionally, individuals with SARS-CoV-2 infection also face a greater risk of myocarditis, pericarditis, and cardiac arrhythmia.
Article
Medicine, General & Internal
Peter A. Kavsak, Lorna Clark, Janet Martin, Ching-Tong Mark, Guillaume Pare, Shawn Mondoux, V. Tony Chetty, Craig Ainsworth, Andrew Worster
Summary: High-sensitivity cardiac troponin testing allows for earlier diagnostic and prognostic decisions in the hospital setting. However, caution is needed when interpreting results, as different assays may have varying accuracy, especially in patients with acute phase response.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medical Laboratory Technology
Nils A. Soerensen, Alina Gossling, Johannes T. Neumann, Tau S. Hartikainen, Paul M. Haller, Lea Scharlemann, Jonas Lehmacher, Andreas Ziegler, Stefan Blankenberg, Tanja Zeller, Gerhard Nordholt, Thomas Renne, Dirk Westermann
Summary: This study assessed the diagnostic accuracy of a high-sensitivity cardiac troponin I assay in patients with suspected acute MI, developing and validating a 0/1 hour diagnostic algorithm. The algorithm showed high negative predictive value and sensitivity, making it suitable for rapid diagnostic stratification of patients with suspected MI.
CLINICAL CHEMISTRY
(2021)
Review
Cell Biology
Christoph C. Kaufmann, Amro Ahmed, Achim Leo Burger, Marie Muthspiel, Bernhard Jager, Johann Wojta, Kurt Huber
Summary: COVID-19 is a complex multi-system disease that can affect various organs, including the cardiovascular system. Early reports have shown excessive myocardial injury in COVID-19 patients, making cardiovascular involvement an important topic of discussion. Cardiac biomarkers, such as high-sensitive cardiac troponin and N-terminal pro-B-type natriuretic peptide, can provide valuable prognostic information and aid in the management of patients with atypical presentations.
Article
Cardiac & Cardiovascular Systems
Laura De Michieli, Allan S. Jaffe, Yader Sandoval
Summary: Myocardial injury is common in COVID-19 patients and is associated with adverse events and short-term mortality. Most cases are related to chronic cardiovascular conditions and acute nonischemic myocardial injury. However, some studies suggest that myocardial injury may be linked to long-term structural abnormalities and poorer cardiac function. The appropriate treatment for COVID-19 patients with myocardial injury remains case-specific, and further research is needed to improve outcomes in this population.
HEART FAILURE CLINICS
(2023)
Article
Multidisciplinary Sciences
Alexander Liu, Robert Hammond, Kenneth Chan, Chukwugozie Chukwuenweniwe, Rebecca Johnson, Duaa Khair, Eleanor Duck, Oluwaseun Olubodun, Kristian Barwick, Winston Banya, James Stirrup, Peter D. D. Donnelly, Juan Carlos Kaski, Anthony R. M. Coates
Summary: Assessing the risk of inpatient mortality in COVID-19 patients is crucial for clinical decision-making. High sensitivity cardiac troponin T (hs-cTnT) is a biomarker associated with cardiac injury and a worse prognosis in COVID-19. This study examined the diagnostic value of hs-cTnT in COVID-19 patients and found that it could be used to rule out mortality and facilitate admission-avoidance and early safe discharge.
Article
Medical Laboratory Technology
Aldo Clerico, Daniela Maria Cardinale, Martina Zaninotto, Nadia Aspromonte, Maria Teresa Sandri, Claudio Passino, Marco Migliardi, Marco Perrone, Antonio Fortunato, Andrea Padoan, Tommaso Trenti, Sergio Bernardini, Laura Sciacovelli, Furio Colivicchi, Domenico Gabrielli, Mario Plebani
Summary: Significant progress in pharmacological cancer treatment has increased survival rates, but at a cost of potential cardiotoxicity and other side effects. Studies have shown that high-sensitivity methods can detect myocardial injury early, potentially benefiting cancer patients by enabling early cardioprotective therapy. Large randomized clinical trials are needed to evaluate the cost/benefit ratio of using these methods for early detection of cardiotoxicity in chemotherapy patients.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Bhurint Siripanthong, Babken Asatryan, Thomas C. Hanff, Salman R. Chatha, Mohammed Y. Khanji, Fabrizio Ricci, Daniele Muser, Victor A. Ferrari, Saman Nazarian, Pasquale Santangeli, Rajat Deo, Leslie T. Cooper, Saidi A. Mohiddin, C. Anwar A. Chahal
Summary: The mechanisms of myocardial injury related to COVID-19 include direct viral invasion and indirect cellular injuries. Some patients experience long-term structural and functional changes in the heart, such as myocardial fibrosis, edema, intraventricular thrombi, and reduced cardiac function.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2022)
Letter
Cardiac & Cardiovascular Systems
Anda Bularga, Kuan Ken Lee, Anoop S. V. Shah, Atul Anand, Andrew R. Chapman, Chris Tuck, David E. Newby, Sarah Jenks, Nicholas L. Mills, Dorien M. Kimenai
Article
Cardiac & Cardiovascular Systems
Mohammed N. Meah, Ryan Wereski, Anda Bularga, Edwin J. R. van Beek, Marc R. Dweck, Nicholas L. Mills, David E. Newby, Damini Dey, Michelle Claire Williams, Kuan Ken Lee
Summary: In patients with acute chest pain, plasma cardiac troponin I concentrations >= 5 ng/L, even without myocardial infarction, are associated with a higher burden of low-attenuation coronary plaque. This suggests that cardiac troponin may be indicative of future adverse cardiovascular events in these patients.
Article
Emergency Medicine
Jamie G. Cooper, James Ferguson, Lorna A. Donaldson, Kim M. M. Black, Kate J. Livock, Judith L. Horrill, Elaine M. Davidson, Neil W. Scott, Amanda J. Lee, Takeshi Fujisawa, Kuan Ken Lee, Atul Anand, Anoop S. Shah, Nicholas L. Mills
Summary: The study aimed to investigate whether the HEART score can be used by paramedics in a prehospital setting with high-sensitivity cardiac troponin testing available. The results showed that a HEART score derived by paramedics in the prehospital setting, even when modified to harness the precision of a high-sensitivity assay, does not allow safe rule-out of myocardial infarction or enhanced rule-in compared with cardiac troponin testing alone.
EMERGENCY MEDICINE JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Muhammad Shahzeb Khan, Muhammad Shariq Usman, Khawaja M. Talha, Harriette G. C. Van Spall, Stephen J. Greene, Muthiah Vaduganathan, Sadiya S. Khan, Nicholas L. Mills, Ziad A. Ali, Robert J. Mentz, Gregg C. Fonarow, Sunil Rao, John A. Spertus, Matthew T. Roe, Stefan D. Anker, Stefan K. James, Javed Butler, Darren K. McGuire
Summary: Embedding RCTs into electronic health records or wearable sensors can simplify trial processes. The use of web-enabled devices and internet connectivity enables data collection on cardiovascular health. Robust mechanisms and standardized data definitions are needed to capture data from different databases. Clinical research guidelines, ethics oversight, and regulatory requirements need to adapt. This review discusses the potential of routinely generated data for RCTs.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Matthew T. H. Lowry, Dimitrios Doudesis, Jasper Boeddinghaus, Dorien M. Kimenai, Anda Bularga, Caelan Taggart, Ryan Wereski, Amy Ferry, Stacey D. Stewart, Christopher Tuck, Luca Koechlin, Thomas Nestelberger, Pedro Lopez-Ayala, Gabrielle Hure, Kuan Ken Lee, Andrew R. Chapman, David E. Newby, Atul Anand, Paul O. Collinson, Christian Mueller, Nicholas L. Mills, High-STEACS Investigators
Summary: This study aimed to assess the diagnostic performance of cardiac troponin in early presenters. The sensitivity and negative predictive value of a single measurement of high-sensitivity cardiac troponin were compared using different thresholds. The results showed that in early presenters, a cardiac troponin level below the limit of detection can safely rule out myocardial infarction.
EUROPEAN HEART JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Dimitrios M. Doudesis, Kuan Ken Lee, Jasper Boeddinghaus, Anda Bularga, Amy E. Ferry, Chris D. Tuck, Matthew T. H. Lowry, Pedro Lopez-Ayala, Thomas Nestelberger, Luca E. Koechlin, Miguel Bernabeu, Lis Neubeck, Atul Anand, Karen Schulz, Fred Apple, William J. Parsonage, Jaimi Greenslade, Louise Cullen, John Pickering, Martin O. Than, Alasdair Gray, Christian W. Mueller, Nicholas Mills, CoDE-ACS Investigators
Summary: A clinical decision support system using machine learning models and high-sensitivity troponin measurements outperforms clinical guidelines that use fixed cardiac troponin thresholds for myocardial infarction diagnosis. The system integrates cardiac troponin concentrations and clinical features to calculate CoDE-ACS score, which corresponds to an individual's probability of myocardial infarction. It has excellent discrimination for myocardial infarction, identifies more low probability cases and reduces cardiac death rate.
Article
Medicine, General & Internal
Hamish J. C. McAuley, Rachael A. Evans, Charlotte E. Bolton, Christopher E. Brightling, James D. Chalmers, Annemarie B. Docherty, Omer Elneima, Paul L. Greenhaff, Ayushman Gupta, Victoria C. Harris, Ewen M. Harrison, Ling-Pei Ho, Alex Horsley, Linzy Houchen-Wolloff, Caroline J. Jolley, Olivia C. Leavy, Nazir I. Lone, William D. C. Man, Michael Marks, Dhruv Parekh, Krisnah Poinasamy, Jennifer K. Quint, Betty Raman, Matthew Richardson, Ruth M. Saunders, Marco Sereno, Aarti Shikotra, Amisha Singapuri, Sally J. Singh, Michael Steiner, Ai Lyn Tan, Louise Wain, Carly Welch, Julie Whitney, Miles D. Witham, Janet Lord, Neil J. Greening, HOSP-COVID Study Collaborat Grp
Summary: This study recruited COVID-19 survivors in the UK and objectively measured frailty using FFP. The results showed that frailty and pre-frailty are common after hospitalization with COVID-19, and comprehensive assessment and interventions targeting frailty are needed beyond the initial illness.
Article
Hematology
Beth Whittington, Evangelos Tzolos, Rong Bing, Jack Andrews, Christophe Lucatelli, Mark G. Macaskill, Adriana A. S. Tavares, Tim Clark, Nicholas L. Mills, Jennifer Nash, Damini Dey, Piotr J. Slomka, Norman Koglin, Andrew W. Stephens, Edwin J. R. van Beek, Colin Smith, Marc R. Dweck, Michelle C. Williams, William Whiteley, Joanna M. Wardlaw, David E. Newby
Summary: Using F-18-GP1 positron emission tomography and computed tomography angiography, it is possible to identify activated platelets and thrombus noninvasively, which has potential clinical application in establishing the role and origin of thrombus in ischemic stroke.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Ziwen Li, Mairi Brittan, Nicholas L. Mills
Summary: Ischaemic heart disease is a global healthcare challenge with high morbidity and mortality. Early revascularisation in acute myocardial infarction has improved survival; however, limited regenerative capacity and microvascular dysfunction often lead to impaired function and the development of heart failure. New mechanistic insights are required to identify robust targets for the development of novel strategies to promote regeneration.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Bertil Lindahl, Nicholas L. Mills
Summary: Proposed an alternative clinical classification for myocardial infarction and called for international consensus to reduce diagnostic uncertainty in practice and research.
Letter
Medicine, General & Internal
Dorien M. Kimenai, Nicholas L. Mills
Review
Medical Laboratory Technology
Kristin M. Aakre, Fred S. Apple, Nicolas L. Mills, Steven J. R. Meex, Paul O. Collinson
Summary: Cardiac troponin measurements are crucial for the diagnosis of myocardial infarction and long-term risk prediction of cardiovascular disease. However, the accuracy of these measurements at low concentrations and the potential misclassification of patients are still debated.
CLINICAL CHEMISTRY
(2023)
Letter
Cardiac & Cardiovascular Systems
Marie de Bakker, Atul Anand, Nicholas L. Mills, Dorien M. Kimenai
