Article
Oncology
Yaning He, Yingbo Shao, Qi Chen, Chaojun Liu, Fangyuan Zhu, Hui Liu
Summary: This study retrospectively analyzed the clinical and survival information of de novo stage IV breast cancer patients with brain metastasis (BM) using the SEER database. The incidence and prognosis of BM were found to be closely associated with subtype and metastatic burden, which may help in developing diagnostic strategies.
Article
Oncology
J. C. Chen, Yaming Li, James L. Fisher, Oindrila Bhattacharyya, Allan Tsung, Jose G. Bazan, Samilia Obeng-Gyasi
Summary: This study suggests that MRM may improve DSS in patients with de novo metastatic IBC. Patients undergoing MRM have longer survival time and higher survival rates compared to those not undergoing surgery.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Natalia Partain, Lauren M. Postlewait, Mediget Teshome, Kelly Rosso, Carolyn Hall, Juhee Song, Salyna Meas, Sarah M. DeSnyder, Bora Lim, Vicente Valero, Wendy Woodward, Naoto T. Ueno, Henry Kuerer, Anthony Lucci
Summary: In this retrospective study, MRM in de novo stage IV IBC patients is an independent factor associated with improved OS. Our findings strongly support the need for prospective randomized trials evaluating possible survival benefits of MRM in de novo stage IV IBC patients.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Oncology
Filippo Merloni, Michela Palleschi, Caterina Gianni, Chiara Casadei, Annalisa Curcio, Antonino Romeo, Maddalena Rocchi, Simona Cima, Marianna Sirico, Samanta Sarti, Lorenzo Cecconetto, Marita Mariotti, Giandomenico Di Menna, Ugo De Giorgi
Summary: Approximately 6% of metastatic breast cancers are de novo. The role of locoregional treatment (LRT) for the primary tumor remains controversial, with retrospective evidence suggesting a survival benefit, while most randomized evidence suggests avoiding LRT. Both retrospective and prospective studies have limitations, and this review aims to identify subgroups of patients who may benefit from LRT to guide clinical practice and future research.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Chloe C. Su, Julie T. Wu, Eunji Choi, Nathaniel J. Myall, Joel W. Neal, Allison W. Kurian, Henning Stehr, Douglas Wood, Solomon M. Henry, Leah M. Backhus, Ann N. Leung, Heather A. Wakelee, Summer S. Han
Summary: This study aimed to evaluate the impact of metastatic disease type on overall survival (OS) among patients with non-small cell lung cancer (NSCLC) and identify potential mechanisms underlying any survival difference.
Article
Oncology
Yunfang Yu, Huangming Hong, Ying Wang, Tuping Fu, Yongjian Chen, Jianli Zhao, Peixian Chen, Ruizhao Cai, Yujie Tan, Zifan He, Wei Ren, Lihuan Zhou, Junhao Huang, Jun Tang, Guolin Ye, Herui Yao
Summary: This study found that locoregional surgery did not improve overall survival compared to no surgery in de novo stage IV breast cancer patients, but it did result in longer locoregional progression-free survival. Patients with bone-only metastasis tended to benefit from surgery in terms of overall survival.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Ang Zheng, Bao-Liang Guo, Jian-Guo Zhang, Feng Jin
Summary: This study found that age, hormone receptor status, and HER2 status are correlated with metastasis in de novo stage IV breast cancer. The majority of patients received chemotherapy and systemic therapy, with over half of them undergoing surgical treatment for the primary lesion.
CHINESE MEDICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Zhijun Zhang, Jiahui Zhang, Qizhang Chen, Jianyun He, Xiaowei Li, Yunsheng Wang, Yaobin Lu
Summary: In this study, a complete genome assembly of Wolbachia strain wFI in Thysanopteran insects was successfully obtained using Nanopore long reads and Illumina short reads. The assembled genome consisted of 1838 protein-coding genes and various other functional genes. The research revealed the nutritional mutualism between Wolbachia and flower thrips and provided a valuable resource for further studies on the interactions between Wolbachia and its host.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Seema A. Khan, Fengmin Zhao, Lori J. Goldstein, David Cella, Mark Basik, Mehra Golshan, Thomas B. Julian, Barbara A. Pockaj, Christine A. Lee, Wajeeha Razaq, Joseph A. Sparano, Gildy Babiera, Irene A. Dy, Sarika Jain, Paula Silverman, Carla S. Fisher, Amye J. Tevaarwerk, Lynne Wagner, George W. Sledge
Summary: Early locoregional therapy for the primary site did not improve survival in patients with metastatic breast cancer, but it was associated with improved locoregional control without impacting overall quality of life.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Zhen Huang, Qixing Tan, Qinghong Qin, Qinguo Mo, Changyuan Wei
Summary: Surgical resection of the primary site can improve survival in selected de novo stage IV breast cancer patients, especially those with bone metastasis or <= 3 metastases. However, surgery does not provide survival benefits for patients with visceral metastasis.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Oncology
Catalina Malinowski, Xiudong Lei, Hui Zhao, Sharon H. Giordano, Mariana Chavez-MacGregor
Summary: This study examined the association between Medicaid expansion and mortality disparity among patients with de novo stage IV breast cancer. The results showed that after Medicaid expansion, the survival disparity between racial and ethnic minority groups and White patients significantly decreased, and the mortality rate also decreased.
Article
Surgery
Wei-Yu Lin, Meng-Hung Lin, Yao-Hsu Yang, Wen-Cheng Chen, Cih-En Huang, Miao-Fen Chen, Chun-Te Wu
Summary: The study demonstrates that NU + CT provides significant survival benefits for patients with stage IV UTUC compared to CT alone, particularly for patients with nmUTUC and mUTUC.
FRONTIERS IN SURGERY
(2022)
Review
Oncology
Gary M. Freedman, Joshua A. Jones, Neil K. Taunk
Summary: For decades, the treatment of distant metastases in breast cancer has mainly focused on systemic therapy or low to moderate-dose radiation therapy for symptom relief. However, there have been anecdotes suggesting that more aggressive local treatment of metastases could lead to long-term disease-free survival. The hypothesis of oligometastases proposes that treating a limited number of distant metastases can change the natural history of stage IV breast cancer. Stereotactic body radiation (SBRT) technology has advanced, allowing for non-invasive, potentially disease-modifying ablative treatment for metastases. While phase I/II trials show promising local control and survival outcomes, there is still a lack of phase III evidence for ablative SBRT's impact on the natural history of metastatic breast cancer. This review discusses the data from key clinical trials to inform decision-making for potentially ablative SBRT in cases of oligometastases or oligoprogression.
Article
Oncology
Xiaojuan Wang, Ning Liang, Tiantian Tian, Jiandong Zhang, Pingping Hu
Summary: This study demonstrates that postmastectomy radiotherapy (PMRT) can improve the survival outcomes in patients with metastatic breast cancer who underwent modified radical mastectomy. The survival benefit is particularly pronounced in patients with T3-4 or N+ stage and Her2-/HR+ breast subtype.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2022)
Article
Oncology
Jun Wang, Shi-Ping Yang, Ping Zhou, Chen-Lu Lian, Jian Lei, Li Hua, Zhen-Yu He, San-Gang Wu
Summary: The study evaluated the value of locoregional treatment in patients with de novo stage IV breast cancer, and found that postoperative radiotherapy can improve breast cancer-specific survival in these patients.