Article
Urology & Nephrology
Masoud Barah, Vikram Kilambi, John J. Friedewald, Sanjay Mehrotra
Summary: Reducing discard is crucial for the US transplantation system, and shorter cold ischemia time and closer proximity to the donor increase the acceptability of marginal organs.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sarah A. Hosgood, Christopher J. Callaghan, Colin H. Wilson, Laura Smith, Joanne Mullings, Jennifer Mehew, Gabriel C. Oniscu, Benedict L. Phillips, Lucy Bates, Michael L. Nicholson
Summary: Kidney transplantation is the optimal treatment for end-stage renal disease, but the lack of suitable organ donors remains a severe limitation. Normothermic machine perfusion (NMP) is an emerging technique that maintains near-physiological conditions in donated kidneys, but its effectiveness in reducing delayed graft function (DGF) in donation after circulatory death (DCD) kidneys is still unclear. In a randomized controlled trial comparing NMP and conventional static cold storage (SCS), we found that a 1-hour NMP at the end of SCS did not reduce the rate of DGF in DCD kidneys. However, NMP was demonstrated to be feasible, safe, and suitable for clinical application without increasing any adverse events.
Article
Medicine, General & Internal
S. Dhanani, L. Hornby, A. van Beinum, N. B. Scales, M. Hogue, A. Baker, S. Beed, J. G. Boyd, J. A. Chandler, M. Chasse, F. D'Aragon, C. Dezfulian, C. J. Doig, F. Duska, J. O. Friedrich, D. Gardiner, T. Gofton, D. Harvey, C. Herry, G. Isac, A. H. Kramer, D. J. Kutsogiannis, D. M. Maslove, M. Meade, S. Mehta, L. Munshi, L. Norton, G. Pagliarello, T. Ramsay, K. Rusinova, D. Scales, M. Schmidt, A. Seely, J. Shahin, M. Slessarev, D. So, H. Talbot, W. N. K. A. van Mook, P. Waldauf, M. Weiss, J. T. Wind, S. D. Shemie
Summary: This study investigated the timing of resumption of cardiac activity in patients after planned withdrawal of life-sustaining measures. It found that 14% of patients experienced transient resumption of cardiac activity after pulselessness, with only 1% of resumptions being identified at the bedside. These events occurred within 4 minutes 20 seconds after a period of pulselessness.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Shivank Madan, Omar Saeed, Stephen J. Forest, Daniel J. Goldstein, Ulrich P. Jorde, Snehal R. Patel
Summary: This study provides a preliminary analysis of adult donation after circulatory death heart transplantations (DCD-HTs) in the United States, showing favorable early outcomes and suggesting the potential for a substantial increase in adult heart transplant volumes with the use of DCD donors.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Robert Qaqish, Yui Watanabe, Konrad Hoetzenecker, Jon Yeung, Manyin Chen, Andrew Pierre, Kazuhiro Yasufuku, Laura Donahoe, Marc de Perrot, Tom Waddell, Shaf Keshavjee, Marcelo Cypel
Summary: Short- and long-term outcomes are similar between recipients of lungs from donation after neurologic determination of death and donation after circulatory determination of death. Different intervals between withdrawal of life-sustaining therapies and cardiac arrest did not impact recipient outcomes, and the maximum acceptable duration of this interval remains to be established.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Surgery
Elsaline Rijkse, Sebastiaan Ceuppens, Hongchao Qi, Jan N. M. IJzermans, Dennis A. Hesselink, Robert C. Minnee
Summary: Despite a higher risk of graft loss in the first year after transplantation, long-term outcomes of DCD kidney transplants are similar to DBD, encouraging the implementation of DCD programs.
INTERNATIONAL JOURNAL OF SURGERY
(2021)
Article
Urology & Nephrology
Argiris Asderakis, Tarique K. Sabah, William J. Watkins, Usman Khalid, Laszlo Szabo, Michael R. Stephens, Sian Griffin, Rafael Chavez
Summary: This study evaluated the effects of different induction immunosuppression agents on the outcome of kidney transplants from donors after circulatory death (DCD). The results suggest that thymoglobulin induction may provide better patient survival compared to alemtuzumab, while having similar advantage in terms of acute rejection.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Surgery
Anji Wall, Matthew Rosenzweig, Gregory J. McKenna, Tsung-Wei Ma, Sumeet K. Asrani, Giuliano Testa
Summary: Super-rapid recovery (SRR) is the standard US practice for donation after circulatory death (DCD) abdominal organ procurement. However, a newer approach called thoracoabdominal normothermic regional perfusion (TA-NRP) shows promise for better recipient outcomes. In this study, TA-NRP kidney recipients had significantly lower rates of delayed graft function (DGF) compared to SRR kidney recipients. No biliary complications were observed in either group of liver recipients. These early results suggest that TA-NRP is an effective approach to expand the use of DCD organs.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Surgery
Yan K. Gernhofer, Quan M. Bui, Jenna J. Powell, Priscilla M. Perez, John Jones, Andriy I. Batchinsky, Ian C. Glenn, Eric Adler, Mark J. Kearns, Victor Pretorius
Summary: A retrospective analysis showed that using donation after circulatory death (DCD) hearts can reduce waitlist time and increase transplant rate, with comparable short-term posttransplant outcomes to conventional transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Katrien Vandendriessche, Vincent Tchana-Sato, Didier Ledoux, Karlien Degezelle, Steffen Rex, Arne Neyrinck, Ina Jochmans, Diethard Monbaliu, Christophe Vandenbriele, Johan Van Cleemput, Bart Meyns, Filip Rega
Summary: This study investigates the safety and feasibility of heart transplantation after circulatory death using thoraco-abdominal normothermic regional perfusion and subsequent cold storage. The results show a 100% survival rate and good cardiac function in four procedures.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Henry Aceros, Shant Der Sarkissian, Melanie Borie, Roberto Vanin Pinto Ribeiro, Simon Maltais, Louis-Mathieu Stevens, Nicolas Noiseux
Summary: This study investigates the use of a HSP90 inhibitor as a cardioprotective agent in DCD hearts, showing promising results in preserving ventricular function and reducing ischemic injury. These findings suggest that HSP90i could potentially expand the use of DCD hearts and improve organ availability for transplantation.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
David A. D 'Alessandro, Stanley B. Wolfe, Asishana A. Osho, Kamila Drezek, Monica N. Prario, S. Alireza Rabi, Eriberto Michel, Lana Tsao, Erin Coglianese, Meaghan Doucette, Daniel A. Zlotoff, Christopher Newton-Cheh, Sunu S. Thomas, Van-Khue Ton, Nilay Sutaria, Mark W. Schoenike, Anastasia M. Christ, Dane C. Paneitz, Joren C. Madsen, Richard Pierson, Gregory D. Lewis
Summary: Utilization of DCD hearts could increase heart donor availability, and the short-term clinical outcomes are similar to transplantation using DBD hearts, but there is transient right heart dysfunction post-transplantation.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rene Ferrera, Marie Vedere, Megane Lo-Grasso, Lionel Augeul, Christophe Chouabe, Gabriel Bidaux, Delphine Baetz
Summary: This study aimed to evaluate the protective effects of postconditioning on DCD hearts. The results showed that CsA and POST could reduce necrosis and improve heart function. However, the efficacy of POST was lost if delayed beyond 3 minutes of reperfusion, while CsA treatment remained effective even if applied after a delay. Delayed CsA application correlated with better functional recovery and higher mitochondrial respiratory index, suggesting the crucial role of MPTP in delayed protection of DCD hearts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Dane C. Paneitz, Ameen M. Basha, Antonia Van Kampen, Duc Giao, Jason Thomas, S. Alireza Rabi, Eriberto Michel, David A. D'Alessandro, Asishana A. Osho
Summary: This study analyzed the data of 237 DCD heart transplant recipients and found that a warm ischemia time of more than 36 minutes and donor left ventricular ejection fraction less than 60% were associated with higher 30-day mortality. Therefore, it is not recommended to proceed with DCD heart transplantation in patients with warm ischemia time longer than 36 minutes, particularly in donors with LVEF less than 60%.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Maria Arnold, Natalia Mendez-Carmona, Rahel K. Wyss, Anna Joachimbauer, Daniela Casoni, Thierry Carrel, Sarah Longnus
Summary: The study investigated the impact of different ischemia models on post-ischemic cardiac recovery in a rat model of heart donation. Results showed that hearts in the in-situ ischemia model had significantly lower contractile recovery compared to the ex-situ model, although the use of cardioplegic storage improved this outcome.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Taihei Ito, Takashi Kenmochi, Shinichiro Ono, Minoru Oshima, Naohiro Aida, Atsushi Suzuki, Midori Hasegawa, Mamoru Kusaka, Kiyotaka Hoshinaga
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2016)
Article
Gastroenterology & Hepatology
Naohiro Aida, Takashi Kenmochi, Taihei Ito, Toru Nishikawa, Izumi Hiratsuka, Megumi Shibata, Atsushi Suzuki, Midori Hasegawa, Akihiro Kawai, Mamoru Kusaka, Kiyotaka Hoshinaga, Hisahiro Matsubara
Meeting Abstract
Immunology
Taihei Ito, Takashi Kenmochi, Kei Kurihara, Naohiro Aida
Article
Medicine, General & Internal
Taihei Ito, Takashi Kenmochi, Kei Kurihara, Akihiro Kawai, Naohiro Aida, Yumi Akashi, Sakurako Kato
JOURNAL OF CLINICAL MEDICINE
(2019)
Article
Medicine, General & Internal
Taihei Ito, Takashi Kenmochi, Naohiro Aida, Kei Kurihara, Akihiro Kawai, Atsushi Suzuki, Megumi Shibata, Izumi Hiratsuka, Midori Hasegawa
JOURNAL OF CLINICAL MEDICINE
(2019)
Article
Surgery
Taihei Ito, Takashi Kenmochi, Naohiro Aida, Kei Kurihara, Tadafumi Asaoka, Toshinori Ito
TRANSPLANT INTERNATIONAL
(2020)
Article
Medicine, General & Internal
Taihei Ito, Takashi Kenmochi, Naohiro Aida, Hajime Matsushima, Kei Kurihara, Takuma Ishihara, Ayumi Shintani, Tadafumi Asaoka, Toshinori Ito
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Gastroenterology & Hepatology
Taihei Ito, Takashi Kenmochi, Naohiro Aida, Kei Kurihara, Yoshito Tomimaru, Toshinori Ito
Summary: The revision of the law on donating brain-dead organs in Japan has significantly increased the number of pancreatic transplantations. Improvements in surgical techniques due to increased experience from performing pancreas transplants may have contributed to better pancreatic graft survival rates in the post-revision era.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2021)
Article
Surgery
Hajime Matsushima, Taihei Ito, Naohiro Aida, Kei Kurihara, Yoshito Tomimaru, Toshinori Ito, Takashi Kenmochi
Summary: The feasibility of pancreas transplantation (PT) in older recipients remains controversial, as studies have shown that older recipients have significantly lower patient survival rates and are more prone to death from infection, multiple organ failure, and cardiac/cerebrovascular events compared to younger recipients. A longer duration of diabetes was identified as an independent risk factor for 1-year mortality in older recipients. Therefore, caution should be exercised when considering PT for older recipients with a long history of diabetes.
Article
Medicine, General & Internal
Taihei Ito, Takashi Kenmochi, Kei Kurihara, Naohiro Aida
Summary: Islet transplantation has shown promise in relieving glucose instability and improving quality of life for patients with type 1 diabetes. After several trials and studies in Japan, clinical islet transplantation is now covered by health insurance in the country.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Naohiro Aida, Taihei Ito, Kei Kurihara, Izumi Hiratsuka, Megumi Shibata, Atsushi Suzuki, Takashi Kenmochi
Summary: The reconstruction of the common hepatic artery in pancreas transplantation does not significantly impact patient and graft survival rates and endocrine functions. Common hepatic artery reconstruction is not essential unless there is a risk of ischemia.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Naohiro Aida, Taihei Ito, Kei Kurihara, Izumi Hiratsuka, Megumi Shibata, Atsushi Suzuki, Takashi Kenmochi
Summary: Charcot neuroarthropathy (CN) is a progressive complication of diabetes mellitus that can occur in patients who have undergone pancreatic transplantation. In this study, factors associated with CN in pancreatic transplant patients were investigated. Analysis of data from 61 patients revealed that six developed CN, with cumulative incidence rates increasing over time. Severe sensory neuropathy and absence of sural nerve waveforms were observed in patients with CN. The administration of high-dose corticosteroids significantly increased the incidence of CN in patients without sural nerve waveforms. Appropriate therapeutic intervention is necessary due to the association between corticosteroid administration and bone metabolism.
APPLIED SCIENCES-BASEL
(2023)
Article
Medicine, General & Internal
Naohiro Aida, Taihei Ito, Michihiro Maruyama, Kenichi Saigo, Naotake Akutsu, Hiromichi Aoyama, Hiroshi Kitamura, Takashi Kenmochi
CLINICAL MEDICINE INSIGHTS-CASE REPORTS
(2019)
Article
Transplantation
Shinichiro Ono, Takashi Kenmochi, Taihei Ito, Naohiro Aida, Kazunori Otsuki, Naotake Akutsu, Michihiro Maruyama, Mamoru Kusaka, Ryoichi Shiroki, Kiyotaka Hoshinaga
TRANSPLANTATION DIRECT
(2017)