Calreticulin, a therapeutic target?

Antitumor Immunity Triggered by Melphalan Is Potentiated by Melanoma Cell Surface-Associated Calreticulin

(2015) A. M. Dudek-Peri  et al.   CANCER RESEARCH

Calreticulin Translocation Aggravates Endoplasmic Reticulum Stress-associated Apoptosis during Cardiomyocyte Hypoxia/Reoxygenation

(2015) Xiu-Hua Liu et al.   CHINESE MEDICAL JOURNAL

Capsaicin-mediated apoptosis of human bladder cancer cells activates dendritic cells via CD91

(2015) Maria Saveria Gilardini Montani et al.   NUTRITION

A long non-coding RNA links calreticulin-mediated immunogenic cell removal to RB1 transcription

(2015) A-S Musahl et al.   ONCOGENE

A sequence-specific DNA binding small molecule triggers the release of immunogenic signals and phagocytosis in a model of B-cell lymphoma

(2015) JeenJoo S. Kang et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Amblyomma americanum tick calreticulin binds C1q but does not inhibit activation of the classical complement cascade

(2015) Tae Kwon Kim et al.   Ticks and Tick-Borne Diseases

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

(2015) Abhishek D. Garg et al.   Frontiers in Immunology

Prognostic and Predictive Value of DAMPs and DAMP-Associated Processes in Cancer

(2015) Jitka Fucikova et al.   Frontiers in Immunology

Calreticulin as Cancer Treatment Adjuvant: Combination with Photodynamic Therapy and Photodynamic Therapy-Generated Vaccines

(2015) Mladen Korbelik et al.   Frontiers in Oncology

The Ever-Expanding Immunomodulatory Role of Calreticulin in Cancer Immunity

(2015) Marco de Bruyn et al.   Frontiers in Oncology

Mechanisms of Translocation of ER Chaperones to the Cell Surface and Immunomodulatory Roles in Cancer and Autoimmunity

(2015) Valerie R. Wiersma et al.   Frontiers in Oncology

Nanoelectroablation of Murine Tumors Triggers a CD8-Dependent Inhibition of Secondary Tumor Growth

(2015) Richard Nuccitelli et al.   PLoS One

Radiation-induced immunogenic modulation of tumor enhances antigen processing and calreticulin exposure, resulting in enhanced T-cell killing

(2015) Sofia R. Gameiro et al.   Oncotarget

Classification of current anticancer immunotherapies

(2015) Lorenzo Galluzzi et al.   Oncotarget

Relative Contribution of C1q and Apoptotic Cell-Surface Calreticulin to Macrophage Phagocytosis

(2014) Mélanie Verneret et al.   Journal of Innate Immunity

Trypanosoma cruzi calreticulin inhibits the complement lectin pathway activation by direct interaction with L-Ficolin

(2014) Eduardo Sosoniuk et al.   MOLECULAR IMMUNOLOGY

Human Survivin and Trypanosoma cruzi Calreticulin Act in Synergy against a Murine Melanoma In Vivo

(2014) Lorena Aguilar-Guzmán et al.   PLoS One

Immunological Activity Difference between Native Calreticulin Monomers and Oligomers

(2014) Mi-chun He et al.   PLoS One

Establishment of Tumor-Associated Immunity Requires Interaction of Heat Shock Proteins with CD91

(2014) Y. J. Zhou et al.   Cancer Immunology Research

Attacking malignant cells that survive therapy

(2014) James W Hodge et al.   OncoImmunology

Radiation-induced survival responses promote immunogenic modulation to enhance immunotherapy in combinatorial regimens

(2014) Sofia R Gameiro et al.   OncoImmunology

Consensus guidelines for the detection of immunogenic cell death

(2014) Oliver Kepp et al.   OncoImmunology

A comparative proteomic study identified calreticulin and prohibitin up-regulated in adrenocortical carcinomas

(2013) Ming-shan Yang et al.   Diagnostic Pathology

Calreticulin expression is reduced in high-grade ovarian serous carcinoma effusions compared with primary tumors and solid metastases

(2013) Olga Vaksman et al.   HUMAN PATHOLOGY

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

(2013) Agnieszka Kaczmarek et al.   IMMUNITY

Chemotherapy-induced immunogenic modulation of tumor cells enhances killing by cytotoxic T lymphocytes and is distinct from immunogenic cell death

(2013) James W. Hodge et al.   INTERNATIONAL JOURNAL OF CANCER

Overexpression of Calreticulin Contributes to the Development and Progression of Pancreatic Cancer

(2013) Weiwei Sheng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Recombinant murine calreticulin fragment 39-272 expands CD1dhiCD5+ IL-10-secreting B cells that modulate experimental autoimmune encephalomyelitis in C57BL/6 mice

(2013) Chao Hong et al.   MOLECULAR IMMUNOLOGY

Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2

(2013) J. Nangalia et al.   NEW ENGLAND JOURNAL OF MEDICINE

Somatic Mutations of Calreticulin in Myeloproliferative Neoplasms

(2013) Thorsten Klampfl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Self-Oligomerization Is Essential for Enhanced Immunological Activities of Soluble Recombinant Calreticulin

(2013) Shang-Hui Huang et al.   PLoS One

Calreticulin expression in infiltrating ductal breast carcinomas: relationships with disease progression and humoral immune responses

(2013) Maria Kabbage et al.   TUMOR BIOLOGY

A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death

(2012) Abhishek D Garg et al.   EMBO JOURNAL

Arginylated Calreticulin at Plasma Membrane Increases Susceptibility of Cells to Apoptosis

(2012) Cecilia López Sambrooks et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Correlation of expression levels of ANXA2, PGAM1, and CALR with glioma grade and prognosis

(2012) Huasong Gao et al.   JOURNAL OF NEUROSURGERY

Comparative effect of human andTrypanosoma cruzicalreticulin in wound healing

(2012) J. Ignacio Arias et al.   Journal of Tissue Engineering and Regenerative Medicine

Exogenous calreticulin improves diabetic wound healing

(2012) Matthew R. Greives et al.   WOUND REPAIR AND REGENERATION

The n3-polyunsaturated fatty acid docosahexaenoic acid induces immunogenic cell death in human cancer cell lines via pre-apoptotic calreticulin exposure

(2011) Romina Molinari et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Hypericin-based photodynamic therapy induces surface exposure of damage-associated molecular patterns like HSP70 and calreticulin

(2011) Abhishek D. Garg et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Involvement of damage-associated molecular patterns in tumor response to photodynamic therapy: surface expression of calreticulin and high-mobility group box-1 release

(2011) Mladen Korbelik et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Calreticulin as a potential diagnostic biomarker for lung cancer

(2011) Rongrong Liu et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Modulatory role of calreticulin as chaperokine for dendritic cell-based immunotherapy

(2011) A. Bajor et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Investigations on the C1q–Calreticulin–Phosphatidylserine Interactions Yield New Insights into Apoptotic Cell Recognition

(2011) Helena Païdassi et al.   JOURNAL OF MOLECULAR BIOLOGY

Surface-exposed calreticulin in the interaction between dying cells and phagocytes

(2010) Isabelle Martins et al.   Annals of the New York Academy of Sciences

Extracellular calreticulin is present in the joints of patients with rheumatoid arthritis and inhibits FasL (CD95L)-mediated apoptosis of T cells

(2010) Joanna M. Tarr et al.   ARTHRITIS AND RHEUMATISM

Lysyl tRNA synthetase is required for the translocation of calreticulin to the cell surface in immunogenic death

(2010) Oliver Kepp et al.   CELL CYCLE

Immunogenic Tumor Cell Death for Optimal Anticancer Therapy: The Calreticulin Exposure Pathway

(2010) L. Zitvogel et al.   CLINICAL CANCER RESEARCH

Taenia solium: Immune response against oral or systemic immunization with purified recombinant calreticulin in mice

(2010) Salvador Fonseca-Coronado et al.   EXPERIMENTAL PARASITOLOGY

Trypanosoma cruzi calreticulin: A novel virulence factor that binds complement C1 on the parasite surface and promotes infectivity

(2010) Galia Ramírez et al.   IMMUNOBIOLOGY

Calreticulin Is a Thermostable Protein with Distinct Structural Responses to Different Divalent Cation Environments

(2010) Sanjeeva J. Wijeyesakere et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Polypeptide Binding Conformation of Calreticulin Facilitates Its Cell-surface Expression under Conditions of Endoplasmic Reticulum Stress

(2010) Elise Jeffery et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Analysis of Recombinant Calreticulin Fragment 39-272: Implications for Immunobiological Activities of Calreticulin in Health and Disease

(2010) C. Hong et al.   JOURNAL OF IMMUNOLOGY

A Mechanism of Release of Calreticulin from Cells During Apoptosis

(2010) Joanna M. Tarr et al.   JOURNAL OF MOLECULAR BIOLOGY

Clinicopathological significance of calreticulin in breast invasive ductal carcinoma

(2010) Zin-Mar Lwin et al.   MODERN PATHOLOGY

Molecular mechanisms involved in the inactivation of the first component of human complement by Trypanosoma cruzi calreticulin

(2010) Carolina Valck et al.   MOLECULAR IMMUNOLOGY

Restoration of the immunogenicity of cisplatin-induced cancer cell death by endoplasmic reticulum stress

(2010) I Martins et al.   ONCOGENE

Calreticulin Is the Dominant Pro-Phagocytic Signal on Multiple Human Cancers and Is Counterbalanced by CD47

(2010) M. P. Chao et al.   Science Translational Medicine

Expression of calreticulin is associated with infiltration of T-cells in stage IIIB colon cancer

(2010) Rui-Qing Peng   WORLD JOURNAL OF GASTROENTEROLOGY

Calreticulin exposure on malignant blasts predicts a cellular anticancer immune response in patients with acute myeloid leukemia

(2010) M Wemeau et al.   Cell Death & Disease

Calreticulin, a multi-process calcium-buffering chaperone of the endoplasmic reticulum

(2009) Marek Michalak et al.   BIOCHEMICAL JOURNAL

Calreticulin: non-endoplasmic reticulum functions in physiology and disease

(2009) Leslie I. Gold et al.   FASEB JOURNAL

Calreticulin Enhances Porcine Wound Repair by Diverse Biological Effects

(2008) Lillian B. Nanney et al.   AMERICAN JOURNAL OF PATHOLOGY

Identification of Calreticulin as a Prognosis Marker and Angiogenic Regulator in Human Gastric Cancer

(2008) Chiung-Nien Chen et al.   ANNALS OF SURGICAL ONCOLOGY

Regulation of MHC Class I Assembly and Peptide Binding

(2008) David R. Peaper et al.   Annual Review of Cell and Developmental Biology

The co-translocation of ERp57 and calreticulin determines the immunogenicity of cell death

(2008) T Panaretakis et al.   CELL DEATH AND DIFFERENTIATION

Calreticulin requires an ancillary adjuvant for the induction of efficient cytotoxic T cell responses

(2007) S. Peter Bak et al.   MOLECULAR IMMUNOLOGY