Review
Biochemistry & Molecular Biology
Hui Zhao, Tianqi Ming, Shun Tang, Shan Ren, Han Yang, Maolun Liu, Qiu Tao, Haibo Xu
Summary: The Wnt signaling pathway is a complex network involved in embryonic development and cancer, as well as normal physiological processes. It plays a crucial role in cell differentiation and the progression of colorectal cancer.
Article
Biochemistry & Molecular Biology
William C. C. Cho, Chi F. F. Wong, Kwan P. P. Li, Alvin H. H. Fong, King Y. Y. Fung, Joseph S. S. Au
Summary: Our previous study showed that miR-145 is downregulated in NSCLC tissues and inhibits cell proliferation. In this study, we found that miR-145 is also downregulated in NSCLC plasma samples and is associated with NSCLC in patients. Additionally, we discovered that transfection of miR-145 inhibits the proliferation, migration, and invasion of NSCLC cells and delays tumor growth in a mouse model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Michael Latour, Nam-Gu Her, Santosh Kesari, Elmar Nurmemmedov
Summary: The WNT signaling pathway plays a crucial role in glioblastoma genesis and therapy resistance, presenting a therapeutic challenge. Current targeted therapies under clinical investigation may offer new treatment options.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biology
Lorenzo Manfreda, Elena Rampazzo, Luca Persano
Summary: The involvement of Wnt signaling in normal tissue homeostasis and disease, particularly in neoplastic malignancies, has been summarized. The impact of aberrant Wnt pathway activation on brain tumorigenesis and tumor aggressiveness, as well as the interdependency between Wnt signaling components and the brain tumor microenvironment, has been emphasized. Furthermore, the latest therapeutic approaches targeting Wnt signaling in cancer treatment have been extensively reviewed and discussed. This review provides evidence that Wnt signaling could be a relevant target in brain tumors, but requires further investigation and overcoming potential concerns for clinical application.
Article
Immunology
Yumei Fan, Bing Liu, Fei Chen, Zhiyuan Song, Bihui Han, Yanxiu Meng, Jiajie Hou, Pengxiu Cao, Yanzhong Chang, Ke Tan
Summary: The study found that high expression of hepcidin in lung cancer patients is associated with unfavorable prognosis and immune cell infiltration levels. Hepcidin may affect prognosis in lung cancer patients by regulating immune cell infiltration.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, Research & Experimental
Wenqiang Zhang, Kexin Zhang, Yanhui Ma, Yixin Song, Tongbing Qi, Guoji Xiong, Yuanzhu Zhang, Chengxia Kan, Jingwen Zhang, Fang Han, Xiaodong Sun
Summary: This review examines the expression patterns of SFRPs in cancer and their potential as therapeutic targets, summarizing the current knowledge on SFRPs in cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Wei-Min Chung, Lumin Chen, Wei-Chun Chang, Sheng-Yuan Su, Yao-Ching Hung, Wen-Lung Ma
Summary: Ovarian cancer primarily originates from three cellular origins, with over 85% being epithelial ovarian carcinomas, and cancer stem/progenitor cells are considered cancer promoters. Activation of the androgen receptor is linked to the development and progression of ovarian cancer, with experimental studies showing positive effects of anti-androgen or anti-AR reagents in suppressing disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Fei Yue, Weiyu Jiang, Amy T. Ku, Adelaide I. J. Young, Weijie Zhang, Eric P. Souto, Yankun Gao, Zihan Yu, Yi Wang, Chad J. Creighton, Chandandeep Nagi, Tao Wang, Susan G. Hilsenbeck, Xin-Hua Feng, Shixia Huang, Cristian Coarfa, Xiang H-F Zhang, Qingyun Liu, Xia Lin, Yi Li
Summary: The mechanism by which LGR4 promotes cancer metastasis is independent of the Wnt signaling pathway and involves interaction with EGFR to block its degradation, leading to increased migration and invasion of cancer cells.
Article
Oncology
Elena Levantini, Giorgia Maroni, Marzia Del Re, Daniel G. Tenen
Summary: EGFR plays an important role in maintaining epithelial tissues, but when its signaling is altered, it becomes a major regulator of epithelial transformation and is one of the most studied tyrosine kinase receptors involved in neoplasia worldwide. EGFR-targeted therapies have revolutionized cancer treatment, but the dream of turning solid tumors into chronic diseases remains unfulfilled.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Ya-Qun Zhou, Xue-Bi Tian, Yu-Ke Tian, Wei Mei, Dai-Qiang Liu, Da-Wei Ye
Summary: Despite advancements in therapeutic pharmacological interventions, chronic pain remains a challenging healthcare concern. Aberrant activation of Wnt signaling pathways has been found in animal models of chronic pain and blocking them has shown potential in attenuating pain behaviors. This review summarizes the therapeutic potential of pharmacological inhibitors of Wnt signaling in preclinical studies for chronic pain.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Oncology
Samyuktha Suresh, Solene Huard, Amelie Brisson, Fariba Nemati, Rayan Dakroub, Coralie Poulard, Mengliang Ye, Elise Martel, Cecile Reyes, David C. Silvestre, Didier Meseure, Andre Nicolas, David Gentien, Hussein Fayyad-Kazan, Muriel Le Romancer, Didier Decaudin, Sergio Roman-Roman, Thierry Dubois
Summary: This study identified PRMT1 as a potential therapeutic target for TNBC patients, as it is highly expressed in TNBC tumor samples and essential for breast cancer cell survival. Targeting PRMT1 in combination with chemotherapies may improve the survival outcome of TNBC patients.
Article
Medicine, Research & Experimental
Meng Nie, Na Chen, Huanhuan Pang, Tao Jiang, Wei Jiang, Panwen Tian, LiAng Yao, Yangzi Chen, Ralph J. DeBerardinis, Weimin Li, Qitao Yu, Caicun Zhou, Zeping Hu
Summary: This study discovered that the neurotransmitter acetylcholine (ACh) specifically accumulates in drug-tolerant persister (DTP) cells in EGFR-mutant non-small cell lung cancer (NSCLC). Manipulating ACh biosynthesis or signaling can predictably regulate the formation of DTP cells. Pharmacologically targeting ACh/M3R signaling with darifenacin, an FDA-approved drug, can delay tumor relapse by activating the WNT signaling pathway. Aberrant ACh metabolism in NSCLC patients may play a role in predicting the response rate and progression-free survival of EGFR-TKI treatment.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Oncology
Ayumi Kanemaru, Yuki Ito, Michiko Yamaoka, Yuki Shirakawa, Kou Yonemaru, Shunsuke Miyake, Misaki Ando, Masako Ota, Takeshi Masuda, Akitake Mukasa, Jian-Dong Li, Hideyuki Saito, Takuichiro Hide, Hirofumi Jono
Summary: The downregulation of tumor suppressor CYLD is associated with poor prognosis in GBM patients. The Wnt/β-catenin signaling pathway is significantly activated in CYLD-downregulated GBM patients. Inhibiting this pathway can suppress the malignant characteristics induced by CYLD downregulation in GBM.
Review
Cell Biology
Andrea Favero, Ilenia Segatto, Tiziana Perin, Barbara Belletti
Summary: miR-223 has diverse functions in different cancer types, acting as either an oncogene or a tumor suppressor. Its expression may be associated with treatment response and prognosis in certain cancer types.
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2021)
Article
Cell Biology
Shaifali Singh, Nai Yang Yeat, Ya-Ting Wang, Shu-Yu Lin, I-Ying Kuo, Kuen-Phon Wu, Won-Jing Wang, Wen-Ching Wang, Wu-Chou Su, Yi-Ching Wang, Ruey-Hwa Chen
Summary: WDR4/PTPN23 axis plays a central role in the trafficking of EGFR and c-MET in non-small cell lung cancer (NSCLC). WDR4-mediated PTPN23 ubiquitination inhibits lysosome trafficking and degradation, sustaining EGFR and c-MET signaling and promoting NSCLC proliferation, migration, and metastasis. Clinical studies show that low expression of PTPN23 is associated with high expression of WDR4 and poor prognosis in lung cancer. Targeting WDR4-mediated PTPN23 ubiquitination may be a potential therapeutic strategy for EGFR TKI-resistant NSCLC.
CELL DEATH & DISEASE
(2023)
Article
Immunology
Jinrui Xu, Yanbing Zhou, Yi Yang, Cuiping Lv, Xiaoming Liu, Yujiong Wang
Article
Cell Biology
Binwei Hao, Ruiting Sun, Xiaotong Guo, Lili Zhang, Jieda Cui, Yumin Zhou, Wei Hong, Yanan Zhang, Jinxi He, Xiaoming Liu, Bing Li, Pixin Ran, Juan Chen
Summary: NOX4-mediated ROS production alters TGF-beta(1) induced cell differentiation and collagen I protein synthesis in HBSMCs through the p38MAPK/Akt signaling pathway in a Smad-dependent manner.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Biotechnology & Applied Microbiology
Qian Cai, Jia Ma, Jing Wang, Juying Wang, Jieda Cui, Shuang Wu, Zhaojun Wang, Na Wang, Jiaqi Wang, Dandan Yang, Jiali Yang, Jing Xue, Feng Li, Juan Chen, Xiaoming Liu
Summary: Silicosis is an occupational disease caused by inhalation of silica dust, and Wnt/beta-catenin signaling pathway is implicated in its pathogenesis. Adenovirus-mediated transduction of Dkk1 gene shows potential in preventing silicosis development, ameliorating lung fibrosis, and inhibiting TGF-beta/Smad signaling.
HUMAN GENE THERAPY
(2022)
Article
Immunology
Shuhong Chi, Jing Xue, Xiaodong Chen, Xiaoming Liu, Yanhong Ji
Summary: The study found that concentrations of Wnt5A in plasma and urine were significantly higher in SLE patients compared to healthy controls, particularly in those with active disease. Wnt5A could serve as a potential biomarker for assessing disease activity and severity in SLE patients.
IMMUNOLOGIC RESEARCH
(2022)
Article
Medicine, Research & Experimental
Nan He, Xiaoming Liu, Amber R. Vegter, T. Idil A. Evans, Jaimie S. Gray, Junfeng Guo, Shashanna R. Moll, Lydia J. Guo, Meihui Luo, Ningxia Ma, Xingshen Sun, Bo Liang, Ziying Yan, Zehua Feng, Lisi Qi, Arnav S. Joshi, Weam Shahin, Yaling Yi, Katherine N. Gibson-Corley, Eric A. Hoffman, Kai Wang, Christian Mueller, John F. Engelhardt, Bradley H. Rosen
Summary: Alpha-1 antitrypsin deficiency (AATD) is the most common genetic cause and risk factor for chronic obstructive pulmonary disease. This study used ferret models to demonstrate that complete loss of AAT and the most common mutation in AAT result in lung and hepatic diseases similar to those observed in AATD patients, making them a potential platform for preclinical testing of therapeutics including gene therapy.
Article
Multidisciplinary Sciences
Maria C. Basil, Fabian L. Cardenas-Diaz, Jaymin J. Kathiriya, Michael P. Morley, Justine Carl, Alexis N. Brumwell, Jeremy Katzen, Katherine J. Slovik, Apoorva Babu, Su Zhou, Madison M. Kremp, Katherine B. McCauley, Shanru Li, Joseph D. Planer, Shah S. Hussain, Xiaoming Liu, Rebecca Windmueller, Yun Ying, Kathleen M. Stewart, Michelle Oyster, Jason D. Christie, Joshua M. Diamond, John F. Engelhardt, Edward Cantu, Steven M. Rowe, Darrell N. Kotton, Harold A. Chapman, Edward E. Morrisey
Summary: This study reveals the existence of a unique population of secretory cells in the respiratory bronchioles of the human lung, which act as unidirectional progenitors for alveolar type 2 cells. The differentiation of these respiratory airway secretory cells into alveolar type 2 cells is regulated by Notch and Wnt signaling. These findings highlight the importance of this distinct progenitor cell population in maintaining the gas-exchange compartment and its potential role in chronic lung diseases.
Article
Immunology
Jing Xue, Wenfeng Hu, Shuang Wu, Jing Wang, Shuhong Chi, Xiaoming Liu
Summary: The aim of this study was to construct a nomogram for identifying interstitial lung disease (ILD) in rheumatoid arthritis (RA) patients. Plasma matrix metalloproteinase-3 (MMP-3) levels were found to be elevated in RA-ILD patients. Several risk factors were identified through regression analysis for the construction of the nomogram. The accuracy of the nomogram was validated and it can serve as a non-invasive tool to assist physicians in treatment decisions for RA patients with ILD.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Chenjie Ma, Xiaoling Wu, Xu Zhang, Xiaoming Liu, Guangcun Deng
Summary: The study revealed that HO-1 is a crucial regulator of Mtb-induced ferroptosis in macrophages, controlling ROS production and iron accumulation to alter macrophage death against Mtb infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wenfeng Hu, Jiali Yang, Jing Xue, Jia Ma, Shuang Wu, Jing Wang, Ranran Xu, Jun Wei, Yujiong Wang, Shuyan Wang, Xiaoming Liu
Summary: This study investigated the antioxidative and anti-inflammatory properties of the secretome of human embryonic stem cell-derived mesenchymal stem cell-like immune and matrix regulatory cells (IMRCs) and its therapeutic effect on pulmonary fibrosis. The results showed that the IMRC secretome could reduce oxidative stress, extracellular matrix deposition, and epithelial-mesenchymal transition in lung cells. Administering the concentrated IMRC secretome effectively alleviated pulmonary fibrosis in mice, likely through inhibiting oxidative stress and inflammation. This study provides evidence for the development of cell-free IMRC secretome therapy for pulmonary fibrosis in clinical settings.
Article
Biochemistry & Molecular Biology
Qian Cai, Meihui Luo, Yinghua Tang, Miao Yu, Feng Yuan, Grace N. Gasser, Xiaoming Liu, John F. Engelhardt
Summary: This study found that the Sonic Hedgehog (SHH) pathway is directly involved in the specification of CFTR-expressing pulmonary ionocytes in the airway basal cells, and is likely responsible for the increased abundance of ionocytes in the cystic fibrosis (CF) airway epithelium. Pharmacologic approaches to enhance ionocyte specification and reduce secretory cell specification after CFTR gene editing of basal cells may have potential utility in the treatment of CF.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Environmental Sciences
Jiali Yang, Jing Xue, Wenfeng Hu, Lifan Zhang, Ranran Xu, Shuang Wu, Jing Wang, Jia Ma, Jun Wei, Yujiong Wang, Shuyan Wang, Xiaoming Liu
Summary: This study found that human embryonic stem cell-derived immune and matrix regulatory cells have potential therapeutic effects for silicosis. These cells can alleviate silica-induced silicosis by activating Bmi1 signaling and restoring airway epithelial cell proliferation and differentiation.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jia Ma, Jiaqi Wang, Chenjie Ma, Qian Cai, Shuang Wu, Wenfeng Hu, Jiali Yang, Jing Xue, Juan Chen, Xiaoming Liu
Summary: This study found that silica induces ferroptosis in mouse macrophages, accompanied by increased inflammatory responses, Wnt5a/Ca2+ signaling activation, and elevated endoplasmic reticulum (ER) stress and mitochondrial redox imbalance. Mechanistically, Wnt5a/Ca2+ signaling plays a key role in silica-induced macrophage ferroptosis by modulating ER stress and mitochondrial redox balance. Inhibition of Wnt5a signaling or blockade of calcium flow has the opposite effect, reducing ferroptosis and the expression of Bip-Chop signaling molecules.
Article
Pharmacology & Pharmacy
Jiali Yang, Shuang Wu, Wenfeng Hu, Dandan Yang, Jia Ma, Qian Cai, Jing Xue, Juan Chen, Feng Li, Jing Zeng, Xiaoming Liu
Summary: This study investigated the role of Bmi1 in the proliferation and differentiation of airway basal cells during the development of silicosis. The results showed that the expression of Bmi1 decreased in silicosis lungs and with prolonged exposure to SiO2, leading to reduced cell proliferation and differentiation capacity.
Article
Immunology
Jiali Yang, Ying Wang, Dandan Yang, Jia Ma, Shuang Wu, Qian Cai, Jing Xue, Chao Yuan, Jing Wang, Xiaoming Liu
Summary: The Wnt/beta-catenin signaling pathway modulates macrophage polarization in an inflammatory state by regulating the Stat signaling pathway.
EUROPEAN JOURNAL OF INFLAMMATION
(2021)
Letter
Medicine, General & Internal
Jing Xue, Yu-Jiao Wang, He-Chun Xia, Xue-Yun Liang, Jie-Da Cui, Min Yu, Xiao-Ming Liu, Shu-Hong Chi, Juan Chen
CHINESE MEDICAL JOURNAL
(2021)
