Clusterin as a therapeutic target

A phase II randomized study of custirsen (OGX-011) combination therapy in patients with poor-risk hormone refractory prostate cancer (HRPC) who relapsed on or within six months of 1st-line docetaxel therapy

(2017) F. Saad et al.   JOURNAL OF CLINICAL ONCOLOGY

RNA Interference (RNAi)-Based Therapeutics: Delivering on the Promise?

(2016) Maggie L. Bobbin et al.   Annual Review of Pharmacology and Toxicology

Clusterin levels are increased in Alzheimer's disease and influence the regional distribution of Aβ

(2016) J. Scott Miners et al.   BRAIN PATHOLOGY

Clusterin knockdown sensitizes prostate cancer cells to taxane by modulating mitosis

(2016) Nader Al Nakouzi et al.   EMBO Molecular Medicine

Clusterin in the eye: An old dog with new tricks at the ocular surface

(2016) M. Elizabeth Fini et al.   EXPERIMENTAL EYE RESEARCH

Clusterin facilitates metastasis by EIF3I/Akt/MMP13 signaling in hepatocellular carcinoma

(2015) Cun Wang et al.   Oncotarget

Clusterin Seals the Ocular Surface Barrier in Mouse Dry Eye

(2015) Aditi Bauskar et al.   PLoS One

The Chaperone Activity of Clusterin is Dependent on Glycosylation and Redox Environment

(2014) Philipp Rohne et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Clusterin Is a Ligand for Apolipoprotein E Receptor 2 (ApoER2) and Very Low Density Lipoprotein Receptor (VLDLR) and Signals via the Reelin-signaling Pathway

(2014) Christian Leeb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Intracellular Clusterin Attenuates Cell Death in Nephropathic Cystinosis

(2014) P. Sansanwal et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Expression and Purification of Chaperone-Active Recombinant Clusterin

(2014) Rebecca A. Dabbs et al.   PLoS One

Clusterin facilitates stress-induced lipidation of LC3 and autophagosome biogenesis to enhance cancer cell survival

(2014) Fan Zhang et al.   Nature Communications

Extracellular Chaperones and Proteostasis

(2013) Amy R. Wyatt et al.   Annual Review of Biochemistry

Extracellular chaperones prevent Aβ42-induced toxicity in rat brains

(2013) Roberta Cascella et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cotargeting Androgen Receptor and Clusterin Delays Castrate-Resistant Prostate Cancer Progression by Inhibiting Adaptive Stress Response and AR Stability

(2013) H. Matsumoto et al.   CANCER RESEARCH

The cellular mechanisms of dry eye: From pathogenesis to treatment

(2013) Flavio Mantelli et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Single Molecule Characterization of the Interactions between Amyloid-β Peptides and the Membranes of Hippocampal Cells

(2013) Priyanka Narayan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Non-Secreted Clusterin Isoforms Are Translated in Rare Amounts from Distinct Human mRNA Variants and Do Not Affect Bax-Mediated Apoptosis or the NF-κB Signaling Pathway

(2013) Hans Prochnow et al.   PLoS One

ApoE influences amyloid-  (A ) clearance despite minimal apoE/A  association in physiological conditions

(2013) P. B. Verghese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interaction of Clusterin and Matrix Metalloproteinase-9 and Its Implication for Epithelial Homeostasis and Inflammation

(2012) Shinwu Jeong et al.   AMERICAN JOURNAL OF PATHOLOGY

Clusterin Mediates TGF- -Induced Epithelial-Mesenchymal Transition and Metastasis via Twist1 in Prostate Cancer Cells

(2012) M. Shiota et al.   CANCER RESEARCH

Clinical significance of serum clusterin as a biomarker for evaluating diagnosis and metastasis potential of viral‐related hepatocellular carcinoma

(2012) Abeer M. Nafee et al.   CLINICAL BIOCHEMISTRY

Small heat shock proteins in cancer therapy and prognosis

(2012) Amina Zoubeidi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Tumor-derived secretory clusterin induces epithelial–mesenchymal transition and facilitates hepatocellular carcinoma metastasis

(2012) Cun Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk

(2012) Karolien Bettens et al.   Molecular Neurodegeneration

The mutational landscape of lethal castration-resistant prostate cancer

(2012) Catherine S. Grasso et al.   NATURE

Increased Survival with Enzalutamide in Prostate Cancer after Chemotherapy

(2012) Howard I. Scher et al.   NEW ENGLAND JOURNAL OF MEDICINE

GRP78 regulates clusterin stability, retrotranslocation and mitochondrial localization under ER stress in prostate cancer

(2012) N Li et al.   ONCOGENE

Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer

(2011) Brett S. Carver et al.   CANCER CELL

EZH2 Mediates Epigenetic Silencing of Neuroblastoma Suppressor Genes CASZ1, CLU, RUNX3, and NGFR

(2011) C. Wang et al.   CANCER RESEARCH

Clusterin Inhibition Using OGX-011 Synergistically Enhances Hsp90 Inhibitor Activity by Suppressing the Heat Shock Response in Castrate-Resistant Prostate Cancer

(2011) F. Lamoureux et al.   CANCER RESEARCH

Clusterin facilitates in vivo clearance of extracellular misfolded proteins

(2011) Amy R. Wyatt et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Randomized Phase II Trial of Custirsen (OGX-011) in Combination with Docetaxel or Mitoxantrone as Second-line Therapy in Patients with Metastatic Castrate-Resistant Prostate Cancer Progressing after First-line Docetaxel: CUOG Trial P-06c

(2011) F. Saad et al.   CLINICAL CANCER RESEARCH

Clusterin and COMMD1 Independently Regulate Degradation of the Mammalian Copper ATPases ATP7A and ATP7B

(2011) Stephanie Materia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clusterin (Apolipoprotein J), a Molecular Chaperone That Facilitates Degradation of the Copper-ATPases ATP7A and ATP7B

(2011) Stephanie Materia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phase I/II Trial of Custirsen (OGX-011), an Inhibitor of Clusterin, in Combination with a Gemcitabine and Platinum Regimen in Patients with Previously Untreated Advanced Non-small Cell Lung Cancer

(2011) Janessa J. Laskin et al.   Journal of Thoracic Oncology

Clusterin Is a Critical Downstream Mediator of Stress-Induced YB-1 Transactivation in Prostate Cancer

(2011) M. Shiota et al.   MOLECULAR CANCER RESEARCH

The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β1−40 peptide

(2011) Priyanka Narayan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Abiraterone and Increased Survival in Metastatic Prostate Cancer

(2011) Johann S. de Bono et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting the Cytoprotective Chaperone, Clusterin, for Treatment of Advanced Cancer

(2010) A. Zoubeidi et al.   CLINICAL CANCER RESEARCH

Randomized Phase II Study of Docetaxel and Prednisone With or Without OGX-011 in Patients With Metastatic Castration-Resistant Prostate Cancer

(2010) Kim N. Chi et al.   JOURNAL OF CLINICAL ONCOLOGY

Clusterin Facilitates COMMD1 and I- B Degradation to Enhance NF- B Activity in Prostate Cancer Cells

(2010) A. Zoubeidi et al.   MOLECULAR CANCER RESEARCH

Detecting soluble Clusterin in in-vitro and in-vivo models of prostate cancer

(2010) F. Girard et al.   NEOPLASMA

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Clusterin silencing in human lung adenocarcinoma cells induces a mesenchymal-to-epithelial transition through modulating the ERK/Slug pathway

(2009) Teh-Ying Chou et al.   CELLULAR SIGNALLING

Over-expression of clusterin is a resistance factor to the anti-cancer effect of histone deacetylase inhibitors

(2009) Tao Liu et al.   EUROPEAN JOURNAL OF CANCER

Transcriptional and posttranslational regulation of clusterin by the two main cellular proteolytic pathways

(2009) Eirini Balantinou et al.   FREE RADICAL BIOLOGY AND MEDICINE

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

Loss of Nkx3.1 leads to the activation of discrete downstream target genes during prostate tumorigenesis

(2009) H Song et al.   ONCOGENE

Identification and characterization of glycosylation sites in human serum clusterin

(2009) James T. Kapron et al.   PROTEIN SCIENCE

Serum Level of Clusterin and Its Density in Men with Prostate Cancer as Novel Biomarkers Reflecting Disease Extension

(2009) Hideaki Miyake et al.   UROLOGY

Clusterin knockdown using the antisense oligonucleotide OGX-011 re-sensitizes docetaxel-refractory prostate cancer PC-3 cells to chemotherapy

(2008) Richard D. Sowery et al.   BJU INTERNATIONAL

A Phase I Study of OGX-011, a 2'-Methoxyethyl Phosphorothioate Antisense to Clusterin, in Combination with Docetaxel in Patients with Advanced Cancer

(2008) K. N. Chi et al.   CLINICAL CANCER RESEARCH

Intracellular Clusterin Inhibits Mitochondrial Apoptosis by Suppressing p53-Activating Stress Signals and Stabilizing the Cytosolic Ku70-Bax Protein Complex

(2008) I. P. Trougakos et al.   CLINICAL CANCER RESEARCH

Clusterin is epigenetically regulated in prostate cancer

(2008) Hanna E. Rauhala et al.   INTERNATIONAL JOURNAL OF CANCER

Clusterin Activates Survival through the Phosphatidylinositol 3-Kinase/Akt Pathway

(2008) Hayet Ammar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clusterin, a novel modulator of TGF-β signaling, is involved in Smad2/3 stability

(2007) Kwan-Bok Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lack of Causal Relationship Between Clusterin Expression and Photoreceptor Apoptosis in Light-Induced Retinal Degeneration

(2003) Catherine Jomary et al.   JOURNAL OF NEUROCHEMISTRY