Structures of androgen receptor bound with ligands: advancing understanding of biological functions and drug discovery

Estrogenic Activity Data Extraction and in Silico Prediction Show the Endocrine Disruption Potential of Bisphenol A Replacement Compounds

(2015) Hui Wen Ng et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Development and Validation of Decision Forest Model for Estrogen Receptor Binding Prediction of Chemicals Using Large Data Sets

(2015) Hui Wen Ng et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Androgen receptor: structure, role in prostate cancer and drug discovery

(2014) MH Eileen Tan et al.   ACTA PHARMACOLOGICA SINICA

Competitive molecular docking approach for predicting estrogen receptor subtype α agonists and antagonists

(2014) Hui Wen Ng et al.   BMC BIOINFORMATICS

Androgen receptor and its splice variant, AR-V7, differentially regulate FOXA1 sensitive genes in LNCaP prostate cancer cells

(2014) William C. Krause et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Human Sex Hormone-Binding Globulin Binding Affinities of 125 Structurally Diverse Chemicals and Comparison with Their Binding to Androgen Receptor, Estrogen Receptor, and α-Fetoprotein

(2014) Huixiao Hong et al.   TOXICOLOGICAL SCIENCES

Versatility or Promiscuity: The Estrogen Receptors, Control of Ligand Selectivity and an Update on Subtype Selective Ligands

(2014) Hui Ng et al.   International Journal of Environmental Research and Public Health

Discovery of non-LBD inhibitor for androgen receptor by structure-guide design

(2013) Byung Jun Ryu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Homology modeling, molecular docking, and molecular dynamics simulations elucidated α-fetoprotein binding modes

(2013) Jie Shen et al.   BMC BIOINFORMATICS

Molecular Pathways: Targeting Resistance in the Androgen Receptor for Therapeutic Benefit

(2013) E. A. Mostaghel et al.   CLINICAL CANCER RESEARCH

Targeting the Binding Function 3 (BF3) Site of the Androgen Receptor Through Virtual Screening. 2. Development of 2-((2-phenoxyethyl) thio)-1H-benzimidazole Derivatives

(2013) Ravi Shashi Nayana Munuganti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mini-review: Foldosome regulation of androgen receptor action in prostate cancer

(2013) Laia Querol Cano et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

EADB: An Estrogenic Activity Database for Assessing Potential Endocrine Activity

(2013) Jie Shen et al.   TOXICOLOGICAL SCIENCES

A Clinically Relevant Androgen Receptor Mutation Confers Resistance to Second-Generation Antiandrogens Enzalutamide and ARN-509

(2013) J. D. Joseph et al.   Cancer Discovery

Overcoming mutation-based resistance to antiandrogens with rational drug design

(2013) Minna D Balbas et al.   eLife

The Androgen Receptor in Health and Disease

(2012) Takahiro Matsumoto et al.   Annual Review of Physiology

Rat α-Fetoprotein Binding Affinities of a Large Set of Structurally Diverse Chemicals Elucidated the Relationships between Structures and Binding Affinities

(2012) Huixiao Hong et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Androgen action and metabolism in prostate cancer

(2012) Sean M. Green et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

In SilicoDiscovery of Androgen Receptor Antagonists with Activity in Castration Resistant Prostate Cancer

(2012) Howard C. Shen et al.   MOLECULAR ENDOCRINOLOGY

Allosteric Conversation in the Androgen Receptor Ligand-Binding Domain Surfaces

(2012) Solène Grosdidier et al.   MOLECULAR ENDOCRINOLOGY

Increased Survival with Enzalutamide in Prostate Cancer after Chemotherapy

(2012) Howard I. Scher et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanism of Androgen Receptor Antagonism by Bicalutamide in the Treatment of Prostate Cancer

(2011) D. J. Osguthorpe et al.   BIOCHEMISTRY

Clinical Trial Update and Novel Therapeutic Approaches for Metastatic Prostate Cancer

(2011) R. Larsson et al.   CURRENT MEDICINAL CHEMISTRY

Androgen Receptor Rediscovered: The New Biology and Targeting the Androgen Receptor Therapeutically

(2011) Charles J. Ryan et al.   JOURNAL OF CLINICAL ONCOLOGY

Unexpected Binding Orientation of Bulky-B-Ring Anti-Androgens and Implications for Future Drug Targets

(2011) Charles B. Duke et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibitors of Androgen Receptor Activation Function-2 (AF2) Site Identified through Virtual Screening

(2011) Peter Axerio-Cilies et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting the Binding Function 3 (BF3) Site of the Human Androgen Receptor through Virtual Screening.

(2011) Nathan A. Lack et al.   JOURNAL OF MEDICINAL CHEMISTRY

Disruption of androgen receptor signaling in males by environmental chemicals

(2011) Doug C. Luccio-Camelo et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

A conserved surface on the ligand binding domain of nuclear receptors for allosteric control

(2011) Víctor Buzón et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Structural Overview of the Nuclear Receptor Superfamily: Insights into Physiology and Therapeutics

(2010) Pengxiang Huang et al.   Annual Review of Physiology

An interpretation of positional displacement of the helix12 in nuclear receptors: Preexistent swing-up motion triggered by ligand binding

(2010) Chiduru Watanabe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The EDKB: an established knowledge base for endocrine disrupting chemicals

(2010) Don Ding et al.   BMC BIOINFORMATICS

Multitude of binding modes attainable by intrinsically disordered proteins: a portrait gallery of disorder-based complexes

(2010) Vladimir N. Uversky   CHEMICAL SOCIETY REVIEWS

Identification of SRC3/AIB1 as a Preferred Coactivator for Hormone-activated Androgen Receptor

(2010) X. Edward Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNAs Are Mediators of Androgen Action in Prostate and Muscle

(2010) Ramesh Narayanan et al.   PLoS One

Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer

(2010) Karen E. Knudsen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Starving the Addiction: New Opportunities for Durable Suppression of AR Signaling in Prostate Cancer

(2009) K. E. Knudsen et al.   CLINICAL CANCER RESEARCH

The Role of Androgen Receptor Mutations in Prostate Cancer Progression

(2009) G. Brooke et al.   CURRENT GENOMICS

Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement

(2009) Evanthia Diamanti-Kandarakis et al.   ENDOCRINE REVIEWS

Anti-androgens and androgen-depleting therapies in prostate cancer: new agents for an established target

(2009) Yu Chen et al.   LANCET ONCOLOGY

Mechanism of androgen receptor action

(2009) Jin Li et al.   MATURITAS

Kinetic and Thermodynamic Characterization of Dihydrotestosterone-Induced Conformational Perturbations in Androgen Receptor Ligand-Binding Domain

(2009) Ravi Jasuja et al.   MOLECULAR ENDOCRINOLOGY

Androgen Receptor Mutations Associated with Androgen Insensitivity Syndrome: A High Content Analysis Approach Leading to Personalized Medicine

(2009) Adam T. Szafran et al.   PLoS One

Development of a Second-Generation Antiandrogen for Treatment of Advanced Prostate Cancer

(2009) C. Tran et al.   SCIENCE

Chemical Approaches to Nuclear Receptors in Metabolism

(2009) R. N. Margolis et al.   Science Signaling

Structural Characterization of the Native NH2-Terminal Transactivation Domain of the Human Androgen Receptor: A Collapsed Disordered Conformation Underlies Structural Plasticity and Protein-Induced Folding†

(2008) Derek N. Lavery et al.   BIOCHEMISTRY

An amphioxus orthologue of the estrogen receptor that does not bind estradiol: Insights into estrogen receptor evolution

(2008) Mathilde Paris et al.   BMC EVOLUTIONARY BIOLOGY

Consequences of poly-glutamine repeat length for the conformation and folding of the androgen receptor amino-terminal domain

(2008) Philippa Davies et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Structural basis for nuclear receptor corepressor recruitment by antagonist-liganded androgen receptor

(2008) Myles C. Hodgson et al.   MOLECULAR CANCER THERAPEUTICS

Minireview: The Contribution of Different Androgen Receptor Domains to Receptor Dimerization and Signaling

(2008) Margaret M. Centenera et al.   MOLECULAR ENDOCRINOLOGY

Non-genomic actions of androgens

(2007) C.D. Foradori et al.   FRONTIERS IN NEUROENDOCRINOLOGY