Journal
CLINICA CHIMICA ACTA
Volume 518, Issue -, Pages 33-37Publisher
ELSEVIER
DOI: 10.1016/j.cca.2021.03.011
Keywords
PIWI-interacting RNAs; Cardiovascular disease; Noncoding RNAs; Biomarkers
Categories
Funding
- National Natural Science Foundation of China [81670424, 81900424]
- National Natural Science Foundation of Hunan Province [2018JJ2345, 2019JJ40258, 2019JJ50502]
- Scientific Research Fund of Hunan Provincial Health and Family Planning Commission [B20180058, B20180874]
- project of Research Study and Innovative Experiment Program for College Students in University of South China [2018XJXZ375, 2019131]
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piRNAs and PIWI proteins, traditionally considered to be expressed in germline cells, are now emerging as potential biomarkers for diagnosis and treatment of cardiac injury and various forms of CVD. They are associated with molecular and cellular pathways in cardiovascular disease.
Cardiovascular disease (CVD) is still one of the most significant diseases and is a considerable threat to human health globally. PIWI-interacting RNAs (piRNAs) are novel small noncoding RNAs (ncRNAs) traditionally considered to be specifically expressed in the germline of many animal species and involved in the maintenance of germline stem cells and spermatogenesis. Although little is known about the origin and action of piRNAs and PIWI proteins in somatic cells, these molecules are emerging as readily available biomarkers for the diagnosis and treatment of cardiac injury and multiform CVD. Accumulating evidence reveals that piRNAs and PIWI proteins are associated with some molecular and cellular pathways in CVD. Here, we summarize recent evidence and evaluate the molecular mechanism of the involvement of piRNAs and PIWI proteins in CVD.
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