Article
Psychiatry
Christopher Pittenger, Brian P. Brennan, Lorrin Koran, Carol A. Mathews, Gerald Nestadt, Michele Pato, Katharine A. Phillips, Carolyn I. Rodriguez, H. Blair Simpson, Petros Skapinakis, Dan J. Stein, Eric A. Storch
Summary: Obsessive-compulsive disorder affects many people and causes a lot of suffering. Diagnosis is often delayed and treatments often do not follow evidence-based guidelines. Specialty standards have been developed to emphasize the importance of integrating pharmacological treatment with clear diagnosis and evidence-based cognitive behavioral therapy.
PSYCHIATRY RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Licia Vellucci, Mariateresa Ciccarelli, Elisabetta Filomena Buonaguro, Michele Fornaro, Giordano D'Urso, Giuseppe De Simone, Felice Iasevoli, Annarita Barone, Andrea de Bartolomeis
Summary: Almost 25% of schizophrenia patients have comorbid obsessive-compulsive symptoms (OCS), which can complicate treatment and affect therapy response. The neurobiological underpinnings of this comorbidity are still unclear, but understanding them is clinically relevant.
Article
Psychiatry
Marjan Shokrani, Sanaz Askari, Negin Eissazade, Seyed Vahid Shariat, Behnam Shariati, Masoomeh Yarahmadi, Mohammadreza Shalbafan
Summary: This study aimed to evaluate the efficacy and safety of agomelatine augmentation of sertraline in the treatment of patients with moderate to severe OCD. The results showed that while agomelatine did not improve OCD symptoms, the combination treatment was safe and effective compared to placebo.
Article
Public, Environmental & Occupational Health
Avital Fischer, Hedy S. Rennert, Gad Rennert
Summary: The study found that the use of SSRIs before and after breast cancer diagnosis is associated with increased mortality in breast cancer patients. Research is needed to further understand the mechanisms behind this association.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Michal Wicinski, Bartlomiej J. Kaluzny, Slawomir Liberski, Daria Marczak, Jakub J. Kaluzny
Summary: Acute angle closure (AAC) is a rare but serious ophthalmological condition, often associated with the use of selective serotonin reuptake inhibitors (SSRIs). AAC in individuals receiving SSRIs is mainly caused by pupillary block mechanism, but may also result from other mechanisms such as uveal effusion.
APPLIED SCIENCES-BASEL
(2021)
Review
Anesthesiology
Li Wang, Joshua Tobe, Emily Au, Cody Tran, Jane Jomy, Yvgeniy Oparin, Rachel J. Couban, James Paul
Summary: The systematic review and meta-analysis found that SSRIs and SNRIs as adjuncts for postoperative pain management significantly reduced postoperative pain, opioid consumption, and improved patient satisfaction without increasing adverse events compared with placebo. SSRIs tend to be less effective than SNRIs, but the effects of SSRIs remain inconclusive due to limited evidence.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Neurosciences
Hikari Hatakama, Nozomi Asaoka, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kaneko
Summary: The study demonstrated that SSRI improved perseverative behavior in QNP-treated mice by modulating inhibitory inputs in the lateral OFC.
Article
Psychology, Clinical
Katherine Parkin, Shanquan Chen, Marjan Biria, James Plaistow, Helen Beckwith, Isaac Jarratt-Barnham, Nuria Segarra, Yulia Worbe, Naomi A. Fineberg, Rudolf N. Cardinal, Trevor W. Robbins, Emilio Fernandez-Egea
Summary: Obsessive-compulsive symptoms (OCS) commonly occur in patients treated with clozapine and can significantly affect subjective wellbeing. This study found that OCS severity had a negative impact on wellbeing scores, independent of depressive and psychotic symptoms. However, OCS did not impair general functioning. Obsessional thinking and hoarding behavior, rather than compulsions, were specifically associated with decreased wellbeing, possibly due to the nature of the compulsions.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Psychiatry
Jiao Xu, Qinjian Hao, Ruiyi Qian, Xingyu Mu, Minhan Dai, Yulu Wu, Yiguo Tang, Min Xie, Qiang Wang
Summary: This study aimed to summarize the optimal dose and dose-response relationship of SRIs in the treatment of OCD. The findings indicated that the optimal dose for efficacy was around 40mg fluoxetine equivalent, while tolerability decreased with increased doses. There was no significant correlation between acceptability and doses of SRIs.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Cardiac & Cardiovascular Systems
Heba M. Kalbouneh, Ahmad A. Toubasi, Farah H. Albustanji, Yazan Y. Obaid, Layla M. Al-Harasis
Summary: The study found that SSRIs are effective in preventing and treating depression, improving anxiety, motor function, cognitive function, and dependence in post-stroke patients. However, treating with SSRIs increased the risk of seizures.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Review
Psychiatry
Rituparna Maiti, Archana Mishra, Anand Srinivasan, Biswa Ranjan Mishra
Summary: This network meta-analysis evaluates and compares the effects of different pharmacological agents as augmentation agents for serotonin reuptake inhibitors (SRIs) in obsessive-compulsive disorder (OCD). The results show that memantine is the most effective augmentation agent for SRIs in OCD, followed by lamotrigine, ondansetron, and granisetron, with moderate certainty of evidence. Symptom reduction is greater in SRI-refractory OCD patients compared to non-refractory OCD.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Psychiatry
Shabir Ahmad Dar, Rayees Ahmad Wani, Inaamul Haq
Summary: The study showed that augmentation of SRIs with olanzapine or aripiprazole significantly improved symptoms in resistant OCD patients, while L-methyl folate was not effective. This suggests that olanzapine and aripiprazole could be promising options for treatment-resistant OCD, while L-methyl folate may not be suitable for this condition.
PSYCHIATRIC QUARTERLY
(2021)
Article
Psychiatry
Gamze Gurcan, Sevin Hun Senol, A. Elif Anil Yagcioglu, Aygun Ertugrul
Summary: This study aimed to investigate the clinical risk factors, phenomenology, and impact of clozapine-induced obsessive-compulsive symptoms (OCS) in patients with schizophrenia. It found that a significant proportion of patients receiving clozapine treatment developed OCS, and the severity of OCS was associated with clozapine and norclozapine plasma levels. There were differences in the types of compulsions between clozapine-induced OCS group and those with a prior history of OCS.
PSYCHIATRY RESEARCH
(2021)
Article
Medicine, Research & Experimental
David D. Kim, Alasdair M. Barr, S. Evelyn Stewart, Randall F. White, William G. Honer, Ric M. Procyshyn
Summary: Evidence suggests that clozapine can induce stressful obsessive-compulsive symptoms (OCS), but the exact mechanism is not fully understood. There is a complex relationship between clozapine dose and OCS severity, potentially involving a biphasic relationship.
MEDICAL HYPOTHESES
(2021)
Article
Pharmacology & Pharmacy
Pascal Le Corre, Gwenole Loas
Summary: The rapid spread of COVID-19 requires urgent drug treatments, especially in vulnerable individuals. Prophylactic vaccines and neutralizing monoclonal antibodies may not be fully effective against emerging variants. Selective serotonin reuptake inhibitors (SSRIs) and other antidepressants have emerged as potential treatments, but should be used with caution.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Enrico Capuzzi, Alice Caldiroli, Martina Capellazzi, Ilaria Tagliabue, Annamaria Auxilia, Giulia Ghilardi, Massimiliano Buoli, Massimo Clerici
Summary: This study aimed to investigate the association between serum lipid levels, neutrophil/lymphocyte ratio (NLR), and violent suicide attempts in patients with mental disorders. The results showed that patients who used a violent suicide method had significantly lower levels of total cholesterol, LDL, VLDL, and NLR compared to those who used a nonviolent method.
Review
Pharmacology & Pharmacy
Alice Caldiroli, Enrico Capuzzi, Ilaria Tagliabue, Luisa Ledda, Massimo Clerici, Massimiliano Buoli
Summary: This review summarizes the efficacy of unlabeled molecules for the treatment of social anxiety disorder (SAD). Pregabalin at high doses appears to be a reliable alternative strategy for SAD treatment. Among the SSRIs not labeled for SAD, citalopram showed the most promising results.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Anna Maria Auxilia, Massimiliano Buoli, Alice Caldiroli, Greta Silvia Carnevali, Agnese Tringali, Roberto Nava, Massimo Clerici, Enrico Capuzzi
Summary: Treatment discontinuation is a challenge in clinical settings. Long acting injectable (LAI) antipsychotics are underutilized despite their potential benefits. This study aimed to identify the factors associated with LAI discontinuation in a real-world setting.
Article
Psychiatry
Cecilia Maria Esposito, Anna Maria Auxilia, Alessandro Ceresa, Francesco Giuseppe Zanvit, Francesco Zanelli Quarantini, Enrico Capuzzi, Alice Caldiroli, Massimo Clerici, Massimiliano Buoli
Summary: The aim of this study was to examine the factors associated with duration of untreated illness (DUI) in borderline personality disorder (BPD). A chart review of 152 patients followed up by community psychiatry services in Milan and Monza, Italy was conducted. Pearson correlation and analyses of variances were used to analyze the association between DUI and socioeconomic and clinical variables. The results showed that a longer DUI was associated with several variables, but these associations were not maintained in the regression analyses. Therefore, DUI does not appear to be significantly associated with specific clinical aspects of BPD or the course and outcome of the disorder. Larger studies are needed to confirm these findings.
EARLY INTERVENTION IN PSYCHIATRY
(2023)
Article
Nutrition & Dietetics
Alice Caldiroli, Davide La Tegola, Letizia Maria Affaticati, Francesca Manzo, Francesca Cella, Alberto Scalia, Enrico Capuzzi, Monica Nicastro, Fabrizia Colmegna, Massimiliano Buoli, Massimo Clerici, Antonios Dakanalis
Summary: Compared to mildly severe anorexia, patients with severe anorexia were older, engaged in more frequent substance misuse, and had a lower neutrophil-to-lymphocyte ratio (NLR). Only a lower NLR was predictive of severe manifestations of anorexia nervosa (AN).
Review
Medicine, General & Internal
Teresa Surace, Cecilia Quitadamo, Alice Caldiroli, Enrico Capuzzi, Fabrizia Colmegna, Guido Nosari, Elisa Borroni, Luca Fedrizzi, Valentina Bollati, Angela Cecilia Pesatori, Michele Carugno, Massimo Clerici, Massimiliano Buoli
Summary: The aim of this study was to summarize available data on the link between air pollution exposure and the onset and severity of psychiatric disorders in pregnant women during the perinatal period. Nine studies were included in the analysis, with most focusing on the association between air pollutant exposure and postpartum depression (PPD) onset. The results showed a significant association between PM2.5 and NO2 exposure and PPD onset, as well as an association between PBDE blood levels and more severe depressive symptoms. One study also observed a link between exposure to PM2.5, PM10 during pregnancy and stressful symptoms.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Alice Caldiroli, Lia Colzani, Enrico Capuzzi, Cecilia Quitadamo, Davide La Tegola, Teresa Surace, Stefania Russo, Mauro Capetti, Silvia Leo, Agnese Tringali, Matteo Marcatili, Francesco Zanelli Quarantini, Fabrizia Colmegna, Antonios Dakanalis, Massimiliano Buoli, Massimo Clerici
Summary: Generalized Anxiety Disorder (GAD) and Panic Disorder (PD) share similar neurobiological mechanisms and clinical features, leading to potential misdiagnosis and delayed treatment. This study aimed to assess the relationship between clinical and socio-demographic markers and GAD/PD diagnosis. Out of 290 outpatients identified with PD or GAD in mental health services in Italy, post-onset psychiatric and medical comorbidities were associated with GAD, while treatment with selective serotonin reuptake inhibitors (SSRIs) was associated with PD. GAD patients had a worse prognosis due to higher comorbidity rates, relapses, and poorer treatment compliance. The association between GAD and psychodynamic psychotherapy was a unique finding of this study.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Enrico Capuzzi, Alice Caldiroli, Cecilia Quitadamo, Francesco Butturini, Teresa Surace, Massimo Clerici, Massimiliano Buoli
Summary: This article provides an updated overview of novel pharmacotherapy targeting positive symptoms in schizophrenia. Promising compounds include lamotrigine, pro-cognitive compounds, and drugs acting partially or totally outside the Central Nervous System. The effectiveness of these compounds suggests that other biological systems may be potential targets for future research.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Review
Nutrition & Dietetics
Alice Caldiroli, Davide La Tegola, Francesca Manzo, Alberto Scalia, Letizia Maria Affaticati, Enrico Capuzzi, Fabrizia Colmegna, Marios Argyrides, Constantinos Giaginis, Leonardo Mendolicchio, Massimiliano Buoli, Massimo Clerici, Antonios Dakanalis
Summary: The aim of this systematic review was to examine the impact of the COVID-19 pandemic on binge eating disorder, including new onset and clinical changes. Twelve studies with 4326 participants were included, and the findings suggest an increase in BED diagnoses and worsening of symptoms during the pandemic. However, the quality of the included studies was weak to moderate, and there was high heterogeneity among the studies, indicating a need for further research to validate these findings and develop preventive strategies and personalized treatments.
Article
Medicine, General & Internal
Cecilia Maria Esposito, Jennifer L. Barkin, Alessandro Ceresa, Guido Nosari, Martina Di Paolo, Francesca Legnani, Luisa Cirella, Teresa Surace, Ilaria Tagliabue, Enrico Capuzzi, Alice Caldiroli, Antonios Dakanalis, Pierluigi Politi, Massimo Clerici, Massimiliano Buoli
Summary: Patients with psychotic BD showed more severe clinical features, fewer metabolic alterations, and higher levels of inflammation compared to those without psychotic symptoms.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Alice Caldiroli, Enrico Capuzzi, Letizia M. M. Affaticati, Teresa Surace, Carla L. L. Di Forti, Antonios Dakanalis, Massimo Clerici, Massimiliano Buoli
Summary: Social anxiety disorder (SAD) is a common psychiatric condition that requires prompt treatment to prevent psychiatric comorbidity and impairment in social and occupational functioning. This study systematically reviewed the literature on potential biomarkers for SAD. While some preliminary evidence suggests the role of certain genes and neuroimaging findings in SAD, the results overall remain inconsistent and need further investigation on larger samples to identify more specific biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Letizia Maria Affaticati, Massimiliano Buoli, Nadia Vaccaro, Francesca Manzo, Alberto Scalia, Sara Coloccini, Tommaso Zuliani, Davide La Tegola, Enrico Capuzzi, Monica Nicastro, Fabrizia Colmegna, Massimo Clerici, Antonios Dakanalis, Alice Caldiroli
Summary: Severe forms of Anorexia Nervosa (AN) are associated with low BMI, higher vitamin B12 and total cholesterol levels, later age at onset, and treatment with medication or poly-therapy. These findings contribute to the early identification of patients at higher risk.
Article
Psychology, Multidisciplinary
Massimiliano Buoli, Enrico Capuzzi, Alice Caldiroli, Alessandro Ceresa, Cecilia Maria Esposito, Cristina Posio, Anna Maria Auxilia, Martina Capellazzi, Ilaria Tagliabue, Teresa Surace, Francesca Legnani, Luisa Cirella, Martina Di Paolo, Guido Nosari, Francesco Zanelli Quarantini, Massimo Clerici, Fabrizia Colmegna, Antonios Dakanalis
Summary: TRD patients were older, had longer illness duration, were more often treated with psychiatric poly-therapy, had more severe depressive symptoms, had lower bilirubin levels, and had more history of suicide attempts and antidepressant treatments. Candidate biomarkers such as bilirubin levels and NLR were associated with TRD, indicating a predisposition to suicidal behaviors. Future research should replicate these findings for new treatment targets and prevention strategies.
BEHAVIORAL SCIENCES
(2022)
Article
Health Care Sciences & Services
Enrico Capuzzi, Martina Capellazzi, Alice Caldiroli, Francesca Cova, Anna Maria Auxilia, Paola Rubelli, Ilaria Tagliabue, Francesco Giuseppe Zanvit, Gianluca Peschi, Massimiliano Buoli, Massimo Clerici
Summary: This study investigated the prevalence of ADHD symptoms in male inmates and examined the relationship between ADHD symptoms and socio-demographic/clinical features. The results showed a high prevalence of ADHD symptoms among inmates, with childhood trauma, cocaine use disorder, prescription of mood stabilizers, and history of emotional abuse significantly associated with ADHD symptoms. Screening for ADHD and appropriate intervention strategies should be implemented.
Article
Nursing
Kaitlyn Barrow, Analise McGreal, Dillon LiVecche, Susan Van Cleve, Chris Sikes, Massimiliano Buoli, Marta Serati, Christy C. Bridges, Amara Ezeamama, Jennifer L. Barkin
Summary: This study aimed to explore barriers and advantages of screening for postpartum depression in the pediatric setting, providers' knowledge of mental health supports in the community, and commonly observed mental health issues in new mothers. The results showed low compliance with screening, with main barriers including lack of time, training, and difficulties in accessing the mother's medical records.
JOURNAL OF THE AMERICAN PSYCHIATRIC NURSES ASSOCIATION
(2022)
