Extending accessible chemical space for the identification of novel leads

Chemical Biology Probes from Advanced DNA-encoded Libraries

(2016) Hazem Salamon et al.   ACS Chemical Biology

Six Biophysical Screening Methods Miss a Large Proportion of Crystallographically Discovered Fragment Hits: A Case Study

(2016) Johannes Schiebel et al.   ACS Chemical Biology

De Novo Design at the Edge of Chaos

(2016) Petra Schneider et al.   JOURNAL OF MEDICINAL CHEMISTRY

Computational Exploration of Molecular Scaffolds in Medicinal Chemistry

(2016) Ye Hu et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Chemical Space Project

(2015) Jean-Louis Reymond   ACCOUNTS OF CHEMICAL RESEARCH

ZINC 15 – Ligand Discovery for Everyone

(2015) Teague Sterling et al.   Journal of Chemical Information and Modeling

The re-emergence of natural products for drug discovery in the genomics era

(2015) Alan L. Harvey et al.   NATURE REVIEWS DRUG DISCOVERY

DNA-Encoded Chemical Libraries: Advancing beyond Conventional Small-Molecule Libraries

(2014) Raphael M. Franzini et al.   ACCOUNTS OF CHEMICAL RESEARCH

Chemical space networks: a powerful new paradigm for the description of chemical space

(2014) Gerald M. Maggiora et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Biology-Oriented Synthesis: Harnessing the Power of Evolution

(2014) Hilde van Hattum et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tools and rules for macrocycles

(2014) Christian Heinis   Nature Chemical Biology

Efficient discovery of bioactive scaffolds by activity-directed synthesis

(2014) George Karageorgis et al.   Nature Chemistry

Macrocyclic Drugs and Clinical Candidates: What Can Medicinal Chemists Learn from Their Properties?

(2013) Fabrizio Giordanetto et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of a Family of Spirocyclic Scaffolds: Building Blocks for the Exploration of Chemical Space

(2013) Sarvesh Kumar et al.   JOURNAL OF ORGANIC CHEMISTRY

Stochastic Voyages into Uncharted Chemical Space Produce a Representative Library of All Possible Drug-Like Compounds

(2013) Aaron M. Virshup et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Macrocycles in new drug discovery

(2012) Jamie Mallinson et al.   Future Medicinal Chemistry

Natural-product-derived fragments for fragment-based ligand discovery

(2012) Björn Over et al.   Nature Chemistry

Aspirin

(2011) Valentin Fuster et al.   CIRCULATION

What Do Medicinal Chemists Actually Make? A 50-Year Retrospective

(2011) W. Patrick Walters et al.   JOURNAL OF MEDICINAL CHEMISTRY

Spiroindolones, a Potent Compound Class for the Treatment of Malaria

(2010) M. Rottmann et al.   SCIENCE

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

(2009) Frank Lovering et al.   JOURNAL OF MEDICINAL CHEMISTRY

The rise of fragment-based drug discovery

(2009) Christopher W. Murray et al.   Nature Chemistry