Advances in the use of prodrugs for drug delivery to the eye

Ocular Drug Delivery - New Strategies for Targeting Anterior and Posterior Segments of the Eye

(2016) Joana F. Fangueiro et al.   CURRENT PHARMACEUTICAL DESIGN

Supramolecular nanofibers of self-assembling peptides and proteins for protein delivery

(2015) Huaimin Wang et al.   CHEMICAL COMMUNICATIONS

Lipid Nanocarriers (LNC) and their Applications in Ocular Drug Delivery

(2015) Carmelo Puglia et al.   CURRENT MEDICINAL CHEMISTRY

Prodrug approach to improve absorption of prednisolone

(2015) Ye Sheng et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Amino acid prodrug of quinidine: An approach to circumvent P-glycoprotein mediated cellular efflux

(2014) Mitesh Patel et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Supramolecular nanofibers of triamcinolone acetonide for uveitis therapy

(2014) Xingyi Li et al.   Nanoscale

Internal dynamics of a supramolecular nanofibre

(2014) Julia H. Ortony et al.   NATURE MATERIALS

Pharmacokinetics and Efficacy of the Spleen Tyrosine Kinase Inhibitor R406 after Ocular Delivery for Retinoblastoma

(2014) Eleanor M. Pritchard et al.   PHARMACEUTICAL RESEARCH

“You Shall Not Pass”—tight junctions of the blood brain barrier

(2014) Hans-Christian Bauer et al.   Frontiers in Neuroscience

Design and in vitro assessment of L-lactic acid-based copolymers as prodrug and carrier for intravitreal sustained L-lactate release to reverse retinal arteriolar occlusions

(2013) Marieke Veurink et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Indomethacin-Loaded Solid Lipid Nanoparticles for Ocular Delivery: Development, Characterization, and In Vitro Evaluation

(2013) Ketan Hippalgaonkar et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Ocular Disposition of the Hemiglutarate Ester Prodrug of ∆9-Tetrahydrocannabinol from Various Ophthalmic Formulations

(2013) Tushar Hingorani et al.   PHARMACEUTICAL RESEARCH

Novel Biotinylated Lipid Prodrugs of Acyclovir for the Treatment of Herpetic Keratitis (HK): Transporter Recognition, Tissue Stability and Antiviral Activity

(2013) Aswani Dutt Vadlapudi et al.   PHARMACEUTICAL RESEARCH

Amino acids as promoieties in prodrug design and development

(2012) Balvinder S. Vig et al.   ADVANCED DRUG DELIVERY REVIEWS

Dry Eye Disease

(2012) William Stevenson   ARCHIVES OF OPHTHALMOLOGY

Pharmacokinetics of fostamatinib, a spleen tyrosine kinase (SYK) inhibitor, in healthy human subjects following single and multiple oral dosing in three phase I studies

(2012) Muhammad Baluom et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Recent advances in ocular drug delivery

(2012) Djamila Achouri et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Targeted lipid based drug conjugates: A novel strategy for drug delivery

(2012) Aswani Dutt Vadlapudi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Functional characterization and molecular expression of large neutral amino acid transporter (LAT1) in human prostate cancer cells

(2012) Mitesh Patel et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Transporter-Targeted Lipid Prodrugs of Cyclic Cidofovir: A Potential Approach for the Treatment of Cytomegalovirus Retinitis

(2012) Mitan R. Gokulgandhi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Transporter Targeted Gatifloxacin Prodrugs: Synthesis, Permeability, and Topical Ocular Delivery

(2012) Sunil K. Vooturi et al.   MOLECULAR PHARMACEUTICS

Lipids, curvature stress, and the action of lipid prodrugs: Free fatty acids and lysolipid enhancement of drug transport across liposomal membranes

(2011) Henrik Jespersen et al.   BIOCHIMIE

Solutions as solutions – Synthesis and use of a liquid polyester excipient to dissolve lipophilic drugs and formulate sustained-release parenterals

(2011) Lutz R. Asmus et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

In vivo characterisation of a novel water-soluble Cyclosporine A prodrug for the treatment of dry eye disease

(2011) M. Rodriguez-Aller et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Intraocular Pharmacokinetics of a Crystalline Lipid Prodrug, Octadecyloxyethyl-Cyclic-Cidofovir, for Cytomegalovirus Retinitis

(2011) Lingyun Cheng et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Effect of Ion Pairing on In Vitro Transcorneal Permeability of a Δ9-Tetrahydrocannabinol Prodrug: Potential in Glaucoma Therapy

(2011) Tushar Hingorani et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Regulation of Endothelial Permeability via Paracellular and Transcellular Transport Pathways

(2010) Yulia Komarova et al.   Annual Review of Physiology

Poly(HEMA-Zidovudine) conjugate: A macromolecular pro-drug for improvement in the biopharmaceutical properties of the drug

(2010) Agrawal Neeraj et al.   DRUG DELIVERY

Metabolism of Fostamatinib, the Oral Methylene Phosphate Prodrug of the Spleen Tyrosine Kinase Inhibitor R406 in Humans: Contribution of Hepatic and Gut Bacterial Processes to the Overall Biotransformation

(2010) D. J. Sweeny et al.   DRUG METABOLISM AND DISPOSITION

Codrug: An efficient approach for drug optimization

(2010) N. Das et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Elucidation of the Self-Assembly Pathway of Lanreotide Octapeptide into β-Sheet Nanotubes: Role of Two Stable Intermediates

(2010) Emilie Pouget et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Serine Side Chain-Linked Peptidomimetic Conjugates of Cyclic HPMPC and HPMPA: Synthesis and Interaction with hPEPT1†

(2010) Larryn W. Peterson et al.   MOLECULAR PHARMACEUTICS

Interaction of Ocular Hypotensive Agents (PGF2α Analogs—Bimatoprost, Latanoprost, and Travoprost) With MDR Efflux Pumps on the Rabbit Cornea

(2009) Sudharshan Hariharan et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Vitreal Pharmacokinetics of Biotinylated Ganciclovir: Role of Sodium-Dependent Multivitamin Transporter Expressed on Retina

(2009) Kumar G. Janoria et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Enzyme-Instructed Molecular Self-assembly Confers Nanofibers and a Supramolecular Hydrogel of Taxol Derivative

(2009) Yuan Gao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Self-assembled prodrugs: An enzymatically triggered drug-delivery platform

(2008) Praveen K. Vemula et al.   BIOMATERIALS

Ocular novel drug delivery: impacts of membranes and barriers

(2008) Jaleh Barar et al.   Expert Opinion on Drug Delivery

Development of Prodrug 4-Chloro-3-(5-methyl-3-{[4-(2-pyrrolidin-1-ylethoxy)phenyl]amino}-1,2,4-benzotriazin-7-yl)phenyl Benzoate (TG100801): A Topically Administered Therapeutic Candidate in Clinical Trials for the Treatment of Age-Related Macular Degeneration

(2008) Moorthy S. S. Palanki et al.   JOURNAL OF MEDICINAL CHEMISTRY

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

(2008) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmaceutical and pharmacological importance of peptide transporters

(2008) Matthias Brandsch et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Enhanced Corneal Absorption of Erythromycin by Modulating P-Glycoprotein and MRP Mediated Efflux with Corticosteroids

(2008) Sudharshan Hariharan et al.   PHARMACEUTICAL RESEARCH

Peptide transporters and their roles in physiological processes and drug disposition

(2008) I. Rubio-Aliaga et al.   XENOBIOTICA