Could simvastatin be considered as a potential therapy for chronic lung diseases? A debate on the pros and cons

Dry powder formulation of simvastatin

(2014) Alaa S Tulbah et al.   Expert Opinion on Drug Delivery

Novel Therapeutic Strategies for Adult Obese Asthmatics

(2014) Angela L. Linderholm et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Simultaneous quantification of simvastatin and simvastatin hydroxy acid in blood serum at physiological pH by ultrahigh performance liquid chromatography–tandem mass spectrometry (UHPLC/MS/MS)

(2014) Hilary J. Bews et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Amino Acids as Co-amorphous Excipients for Simvastatin and Glibenclamide: Physical Properties and Stability

(2014) Riikka Laitinen et al.   MOLECULAR PHARMACEUTICS

Simvastatin for the Prevention of Exacerbations in Moderate-to-Severe COPD

(2014) Gerard J. Criner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Simvastatin in the Acute Respiratory Distress Syndrome

(2014) Daniel F. McAuley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease

(2014) Behzad Yeganeh et al.   PHARMACOLOGY & THERAPEUTICS

Effects of simvastatin on cell viability and proinflammatory pathways in lung adenocarcinoma cells exposed to hydrogen peroxide

(2014) Luca Gallelli et al.   BMC Pharmacology & Toxicology

Statins in Lymphangioleiomyomatosis. Simvastatin and Atorvastatin Induce Differential Effects ontuberous sclerosis complex 2–Null Cell Growth and Signaling

(2013) Elena N. Atochina-Vasserman et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Statin use in asthmatics on inhaled corticosteroids is associated with decreased risk of emergency department visits

(2013) Sze Man Tse et al.   CURRENT MEDICAL RESEARCH AND OPINION

Multiple dosing of simvastatin inhibits airway mucus production of epithelial cells: Implications in the treatment of chronic obstructive airway pathologies

(2013) Laura Marin et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Statin therapy does not improve lung function in asthma: A meta-analysis of randomized controlled trials

(2013) Xiao-bei Si et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Thermal Stability of Simvastatin under Different Atmospheres

(2013) Ricardo G. Simões et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Simvastatin decreases the level of heparin-binding protein in patients with acute lung injury

(2013) Daniel F McAuley et al.   BMC Pulmonary Medicine

Statin use and asthma control in patients with severe asthma

(2013) Amir A Zeki et al.   BMJ Open

Airway disease: similarities and differences between asthma, COPD and bronchiectasis

(2012) R Athanazio et al.   Clinics

Tobacco, Inflammation, and Respiratory Tract Cancer

(2012) Javier Milara et al.   CURRENT PHARMACEUTICAL DESIGN

Preparation, characterization, stability andin vitro-in vivoevaluation of pellet-layered Simvastatin nanosuspensions

(2012) Yanfei Luo et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Simvastatin inhibits smoke-induced airway epithelial injury: implications for COPD therapy

(2012) Benjamin B. Davis et al.   EUROPEAN RESPIRATORY JOURNAL

Simvastatin delivery via inhalation attenuates airway inflammation in a murine model of asthma

(2012) Lan Xu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Simvastatin Reduces Endotoxin-Induced Acute Lung Injury by Decreasing Neutrophil Recruitment and Radical Formation

(2012) Jochen Grommes et al.   PLoS One

Statins, systemic inflammation and risk of death in COPD: The Rotterdam study

(2012) Lies Lahousse et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Differential effects of simvastatin on IL-13-induced cytokine gene expression in primary mouse tracheal epithelial cells

(2012) Amir A Zeki et al.   RESPIRATORY RESEARCH

Prevention of Alveolar Destruction and Airspace Enlargement in a Mouse Model of Pulmonary Lymphangioleiomyomatosis (LAM)

(2012) E. A. Goncharova et al.   Science Translational Medicine

Chronic obstructive pulmonary disease: patho-physiology, current methods of treatment and the potential for simvastatin in disease management

(2011) Laura Marin et al.   Expert Opinion on Drug Delivery

Simvastatin improves morphological and functional recovery of sciatic nerve injury in Wistar rats

(2011) A.M. Xavier et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

FORCED DEGRADATION STUDIES OF SIMVASTATIN USING MICROEMULSION LIQUID CHROMATOGRAPHY

(2011) Anđelija Malenović et al.   JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES

mTORC2 Is Required for Proliferation and Survival of TSC2-Null Cells

(2011) E. A. Goncharova et al.   MOLECULAR AND CELLULAR BIOLOGY

Mevalonate Cascade Regulation of Airway Mesenchymal Cell Autophagy and Apoptosis: A Dual Role for p53

(2011) Saeid Ghavami et al.   PLoS One

Long-Term Simvastatin Attenuates Lung Injury and Oxidative Stress in Murine Acute Lung Injury Models Induced by Oleic Acid and Endotoxin

(2011) N. D. Altintas et al.   Respiratory Care

Effects of short-term treatment with atorvastatin in smokers with asthma - a randomized controlled trial

(2011) Georgina Braganza et al.   BMC Pulmonary Medicine

Simvastatin Improves Epithelial Dysfunction and Airway Hyperresponsiveness

(2010) Tanveer Ahmad et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The effect of statin therapy on allergic patients with asthma

(2010) Marina Ostroukhova et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Mannitol-Guided delivery of ciprofloxacin in artificial cystic fibrosis mucus model

(2010) Yan Yang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Anti-inflammatory Agents: Present and Future

(2010) Charles A. Dinarello   CELL

Statin use in patients with asthma - a nationwide population-based study

(2010) Chin-Chou Huang et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Simvastatin attenuates acrolein-induced mucin production in rats: Involvement of the Ras/extracellular signal-regulated kinase pathway

(2010) Ya-Juan Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Formulation strategy and use of excipients in pulmonary drug delivery

(2010) Gabrielle Pilcer et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Apoptotic induction by simvastatin in human lung cancer A549 cells via Akt signaling dependent down-regulation of survivin

(2010) Ki-Eun Hwang et al.   INVESTIGATIONAL NEW DRUGS

Statins enhance the anti-inflammatory effects of inhaled corticosteroids in asthmatic patients through increased induction of indoleamine 2, 3-dioxygenase

(2010) Kittipong Maneechotesuwan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Protective Role of Simvastatin on Lung Damage Caused by Burn and Cotton Smoke Inhalation in Rats

(2010) Sedat Belli et al.   JOURNAL OF SURGICAL RESEARCH

Simvastatin in the treatment of asthma: lack of steroid-sparing effect

(2010) D. C. Cowan et al.   THORAX

Simvastatin inhibits goblet cell hyperplasia and lung arginase in a mouse model of allergic asthma: a novel treatment for airway remodeling?

(2010) Amir A. Zeki et al.   Translational Research

DNA methylation and its involvement incarboxylesterase 1A1(CES1A1) gene expression

(2010) T. Hori et al.   XENOBIOTICA

Simvastatin Inhibits Airway Hyperreactivity

(2009) Amir A. Zeki et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Simvastatin Decreases Lipopolysaccharide-induced Pulmonary Inflammation in Healthy Volunteers

(2009) Murali Shyamsundar et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Advances in Mucous Cell Metaplasia

(2009) David R. Curran et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Stability studies of cholesterol lowering statin drugs in aqueous samples using HPLC and LC–MS

(2009) Małgorzata Piecha et al.   Environmental Chemistry Letters

Simvastatin Stimulates Vascular Endothelial Growth Factor Production by Hypoxia-inducible Factor-1α Upregulation in Endothelial Cells

(2009) Ai Nishimoto-Hazuku et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Chronic bronchitis before age 50 years predicts incident airflow limitation and mortality risk

(2009) S Guerra et al.   THORAX

Endothelial cell barrier protection by simvastatin: GTPase regulation and NADPH oxidase inhibition

(2008) Weiguo Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Reversal of elastase-induced pulmonary emphysema and promotion of alveolar epithelial cell proliferation by simvastatin in mice

(2008) Saeko Takahashi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Effects of Fluticasone with or without Salmeterol on Systemic Biomarkers of Inflammation in Chronic Obstructive Pulmonary Disease

(2008) Don D. Sin et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effects of pravastatin on functional capacity in patients with chronic obstructive pulmonary disease and pulmonary hypertension

(2008) Tsung-Ming Lee et al.   CLINICAL SCIENCE

Physicochemical Properties and Stability of Two Differently Prepared Amorphous Forms of Simvastatin

(2008) Kirsten A. Graeser et al.   CRYSTAL GROWTH & DESIGN

Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction

(2008) K. F. Chung et al.   EUROPEAN RESPIRATORY JOURNAL

Statins may reduce episodes of exacerbation and the requirement for intubation in patients with COPD: evidence from a retrospective cohort study

(2008) A. I. Blamoun et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Magnesium cation effect on passive diffusion of statin molecules: Molecular chromatography approach

(2008) Fatimata Seydou Sarr et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Structure and Catalytic Properties of Carboxylesterase Isozymes Involved in Metabolic Activation of Prodrugs

(2008) Masakiyo Hosokawa   MOLECULES

Statins for the treatment of asthma: a discovery well, dry hole or just snake oil

(2008) B. K Rubin   THORAX

Effects of atorvastatin added to inhaled corticosteroids on lung function and sputum cell counts in atopic asthma

(2008) E J Hothersall et al.   THORAX